First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 9, 2016, Pages 2394-2399

  Arturo, Emilia C ^a,b   Gupta, Kushol ^c   Héroux, Annie ^d   Stith, Linda ^a   Cross, Penelope J ^e,f   Parker, Emily J ^e,f   Loll, Patrick J ^b   Jaffe, Eileen K ^a  

^a TEMPLE UNIVERSITY HEALTH SYSTEM   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d BROOKHAVEN NATIONAL LABORATORY   (United States)

^e UNIVERSITY OF CANTERBURY   (New Zealand)

^f UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Allosteric regulation; Phenylalanine hydroxylase; Phenylketonuria; Small angle X ray scattering; X ray crystallography

Indexed keywords

PHENYLALANINE 4 MONOOXYGENASE; TETRAMER; BIOPOLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; GENOTYPE PHENOTYPE CORRELATION; NATIVE POLYACRYLAMIDE GEL ELECTROPHORESIS; NONHUMAN; PHENYLKETONURIA; PRIORITY JOURNAL; RAT; SIZE EXCLUSION CHROMATOGRAPHY; X RAY CRYSTALLOGRAPHY; ANIMAL; CHEMISTRY; MOLECULAR MODEL; PROTEIN CONFORMATION;

ANIMALS; BIOPOLYMERS; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; PHENYLALANINE HYDROXYLASE; PROTEIN CONFORMATION; RATS;

EID: 84959486007     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1516967113     Document Type: Article

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