NMR-based metabolic profiling identifies biomarkers of liver regeneration following partial hepatectomy in the rat

Journal of Proteome Research

Volumn 9, Issue 1, 2010, Pages 59-69

  Bollard, Mary E ^a   Contel, Nancy R ^b   Ebbels, Timothy M D ^a   Smith, Leon ^a   Beckonert, Olaf ^a   Cantor, Glenn H ^c   Lehman McKeeman, Lois ^c   Holmes, Elaine C ^a   Lindon, John C ^a   Nicholson, Jeremy K ^a   Keun, Hector C ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b Drug Metabolism Pharmacokinetics Clinical Pharmacology   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

1 carbon metabolism; Fatty liver; Liver regeneration; Metabolomics; Metabonomics; Toxicity

Indexed keywords

2 OXOGLUTARIC ACID; ALANINE; BETAINE; BILE ACID; BIOLOGICAL MARKER; CARBON; CHOLESTEROL; CHOLINE; CITRIC ACID; CREATINE; DIMETHYLGLYCINE; GLUCOSE; GLYCEROPHOSPHORYLCHOLINE; GLYCOGEN; GUANIDINOACETIC ACID; HIPPURIC ACID; HYPOTAURINE; PHOSPHORYLCHOLINE; TAURINE; TRIACYLGLYCEROL; TRIMETHYLAMINE OXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMICS; CARBON METABOLISM; LIVER LEVEL; LIVER REGENERATION; MALE; METABOLITE; METABOLOMICS; METABONOMICS; NON INVASIVE MEASUREMENT; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TRIACYLGLYCEROL BLOOD LEVEL; URINE LEVEL;

ANIMALS; BIOLOGICAL MARKERS; BLOOD CHEMICAL ANALYSIS; BODY WEIGHT; HEPATECTOMY; HISTOCYTOCHEMISTRY; LIVER; LIVER REGENERATION; MALE; METABOLOMICS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; URINE;

ANIMALIA; RATTUS;

EID: 73649083369     PISSN: 15353893     EISSN: None     Source Type: Journal    
DOI: 10.1021/pr900200v     Document Type: Article

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