Metabolomic approach by 1H NMR spectroscopy of serum for the assessment of chronic liver failure in patients with cirrhosis

Journal of Proteome Research

Volumn 10, Issue 7, 2011, Pages 3239-3245

  Amathieu, Roland ^a,b,d   Nahon, Pierre ^b,c   Triba, Mohamed ^a   Bouchemal, Nadia ^a   Trinchet, Jean Claude ^b   Beaugrand, Michel ^b   Dhonneur, Gilles ^b   Le Moyec, Laurence ^a,c  

^a UMR 7244   (France)

^b HÔPITAL JEAN VERDIER   (France)

^c CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

^d UNIVERSITÉ D EVRY VAL D ESSONNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CREATININE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; LACTIC ACID; PHOSPHORYLCHOLINE; PYRUVIC ACID;

ARTICLE; CHRONIC LIVER FAILURE; DISEASE SEVERITY; FEMALE; HUMAN; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; METABOLOMICS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SERUM; STATISTICAL MODEL; BLOOD; CHEMISTRY; END STAGE LIVER DISEASE; HOSPITALIZATION; LIVER; LIVER FUNCTION TEST; METABOLISM; METHODOLOGY; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY; PROGNOSIS; RECEIVER OPERATING CHARACTERISTIC; STATISTICS;

END STAGE LIVER DISEASE; FEMALE; HUMANS; LIVER; LIVER CIRRHOSIS; LIVER FUNCTION TESTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOMICS; MIDDLE AGED; MODELS, STATISTICAL; PROGNOSIS; RESEARCH DESIGN; ROC CURVE; SERUM; SEVERITY OF ILLNESS INDEX;

EID: 79959950881     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr200265z     Document Type: Article

References (28)

1. Kamath, P. S.; Wiesner, R. H.; Malinchoc, M.; Kremers, W.; Therneau, T. M.; Kosberg, C. L.; D'Amico, G.; Dickson, E. R.; Kim, W. R. A model to predict survival in patients with end-stage liver disease Hepatology 2001, 33 (2) 464-70 (Pubitemid 32119037)
2. Pugh, R. N.; Murray-Lyon, I. M.; Dawson, J. L.; Pietroni, M. C.; Williams, R. Transection of the oesophagus for bleeding oesophageal varices Br. J. Surg. 1973, 60 (8) 646-9
3. Kalhan, S. C.; Guo, L.; Edmison, J.; Dasarathy, S.; McCullough, A. J.; Hanson, R. W.; Milburn, M. Plasma metabolomic profile in nonalcoholic fatty liver disease Metabolism 2010, 404-13
4. 1H NMR spectroscopy NMR Biomed. 2006, 19 (1) 90-100 (Pubitemid 43250794)
5. Puri, P.; Wiest, M. M.; Cheung, O.; Mirshahi, F.; Sargeant, C.; Min, H. K.; Contos, M. J.; Sterling, R. K.; Fuchs, M.; Zhou, H.; Watkins, S. M.; Sanyal, A. J. The plasma lipidomic signature of nonalcoholic steatohepatitis Hepatology 2009, 50 (6) 1827-38
6. Yu, K.; Sheng, G.; Sheng, J.; Chen, Y.; Xu, W.; Liu, X.; Cao, H.; Qu, H.; Cheng, Y.; Li, L. A metabonomic investigation on the biochemical perturbation in liver failure patients caused by hepatitis B virus J. Proteome Res. 2007, 6 (7) 2413-9 (Pubitemid 47122338)
7. Bollard, M. E.; Contel, N. R.; Ebbels, T. M.; Smith, L.; Beckonert, O.; Cantor, G. H.; Lehman-McKeeman, L.; Holmes, E. C.; Lindon, J. C.; Nicholson, J. K.; Keun, H. C. NMR-based metabolic profiling identifies biomarkers of liver regeneration following partial hepatectomy in the rat J. Proteome Res. 2009, 9 (1) 59-69
8. Coen, M.; Hong, Y. S.; Cloarec, O.; Rhode, C. M.; Reily, M. D.; Robertson, D. G.; Holmes, E.; Lindon, J. C.; Nicholson, J. K. Heteronuclear 1H-31P statistical total correlation NMR spectroscopy of intact liver for metabolic biomarker assignment: application to galactosamine-induced hepatotoxicity Anal. Chem. 2007, 79 (23) 8956-66 (Pubitemid 350231702)
9. Constantinou, M. A.; Theocharis, S. E.; Mikros, E. Application of metabonomics on an experimental model of fibrosis and cirrhosis induced by thioacetamide in rats Toxicol. Appl. Pharmacol. 2007, 218 (1) 11-9 (Pubitemid 46026839)
10. Serkova, N. J.; Zhang, Y.; Coatney, J. L.; Hunter, L.; Wachs, M. E.; Niemann, C. U.; Mandell, M. S. Early detection of graft failure using the blood metabolic profile of a liver recipient Transplantation 2007, 83 (4) 517-21 (Pubitemid 46667858)
11. 1H NMR spectroscopic study of blood serum for the assessment of liver function in liver transplant patients J. Gastrointestin. Liver Dis. 2009, 18 (3) 329-36
12. 1H NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis Cancer Sci. 2009, 100 (4) 782-5
13. 1H NMR spectroscopy for the prediction of therapeutic outcome in patients with fulminant hepatic failure NMR Biomed. 2006, 19 (5) 521-6
14. Jimenez, B.; Montoliu, C.; MacIntyre, D. A.; Serra, M. A.; Wassel, A.; Jover, M.; Romero-Gomez, M.; Rodrigo, J. M.; Pineda-Lucena, A.; Felipo, V. Serum metabolic signature of minimal hepatic encephalopathy by (1)H-nuclear magnetic resonance J. Proteome Res. 2010, 9 (10) 5180-7
15. 13C NMR spectroscopy of human blood plasma Anal. Chem. 1995, 67 (5) 793-811
16. Broadhurst, D.; Douglas, B. Statistical strategies for avoiding false discoveries in metabolomics and related experiments Metabolomics 2006, 2 (4) 171-196 (Pubitemid 46099798)
17. Cobbold, J. F.; Patel, J. H.; Goldin, R. D.; North, B. V.; Crossey, M. M.; Fitzpatrick, J.; Wylezinska, M.; Thomas, H. C.; Cox, I. J.; Taylor-Robinson, S. D. Hepatic lipid profiling in chronic hepatitis C: an in vitro and in vivo proton magnetic resonance spectroscopy study J. Hepatol. 2008, 52 (1) 16-24
18. Habib, A.; Mihas, A. A.; Abou-Assi, S. G.; Williams, L. M.; Gavis, E.; Pandak, W. M.; Heuman, D. M. High-density lipoprotein cholesterol as an indicator of liver function and prognosis in noncholestatic cirrhotics Clin. Gastroenterol. Hepatol. 2005, 3 (3) 286-91 (Pubitemid 40568735)
19. Jiang, M.; Liu, F.; Xiong, W. J.; Zhong, L.; Xu, W.; Xu, F.; Liu, Y. B. Combined MELD and blood lipid level in evaluating the prognosis of decompensated cirrhosis World J. Gastroenterol. 2010, 16 (11) 1397-401
20. Hickman, I. J.; Macdonald, G. A. Impact of diabetes on the severity of liver disease Am. J. Med. 2007, 120 (10) 829-34 (Pubitemid 47451297)
21. Holstein, A.; Hinze, S.; Thiessen, E.; Plaschke, A.; Egberts, E. H. Clinical implications of hepatogenous diabetes in liver cirrhosis J. Gastroenterol. Hepatol. 2002, 17 (6) 677-81 (Pubitemid 34748159)
22. El-Serag, H. B.; Tran, T.; Everhart, J. E. Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma Gastroenterology 2004, 126 (2) 460-8 (Pubitemid 38182303)
23. Petersen, K. F.; Krssak, M.; Navarro, V.; Chandramouli, V.; Hundal, R.; Schumann, W. C.; Landau, B. R.; Shulman, G. I. Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis Am. J. Physiol. 1999, 276 (3 Pt 1) E529-35
24. Shangraw, R. E.; Rabkin, J. M.; Lopaschuk, G. D. Hepatic pyruvate dehydrogenase activity in humans: effect of cirrhosis, transplantation, and dichloroacetate Am. J. Physiol. 1998, 274 (3 Pt 1) G569-77
25. Morgan, M. Y.; Marshall, A. W.; Milsom, J. P.; Sherlock, S. Plasma amino-acid patterns in liver disease Gut 1982, 23 (5) 362-70 (Pubitemid 12155272)
26. Holecek, M.; Sprongl, L.; Skopec, F.; Andrys, C.; Pecka, M. Leucine metabolism in TNF-alpha- and endotoxin-treated rats: contribution of hepatic tissue Am. J. Physiol. 1997, 273 (6 Pt 1) E1052-8
27. Bosy-Westphal, A.; Petersen, S.; Hinrichsen, H.; Czech, N.; M, J. M. Increased plasma homocysteine in liver cirrhosis Hepatol. Res. 2001, 20 (1) 28-38 (Pubitemid 32294093)
28. Distrutti, E.; Mencarelli, A.; Santucci, L.; Renga, B.; Orlandi, S.; Donini, A.; Shah, V.; Fiorucci, S. The methionine connection: homocysteine and hydrogen sulfide exert opposite effects on hepatic microcirculation in rats Hepatology 2008, 47 (2) 659-67 (Pubitemid 351280734)