A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity

Drug Metabolism and Pharmacokinetics

Volumn 26, Issue 4, 2011, Pages 399-406

  Fukuhara, Kiyoshi ^a   Ohno, Akiko ^a   Ando, Yosuke ^b   Yamoto, Takashi ^b   Okuda, Haruhiro ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

1H NMR; Acetaminophen; Hepatotoxicity; Metabolomics; Phenobarbital

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; PARACETAMOL; PHENOBARBITAL;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG METABOLISM; DRUG STRUCTURE; DRUG URINE LEVEL; ENZYME ACTIVITY; LIVER TOXICITY; MALE; METABOLOMICS; MOLECULAR WEIGHT; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; URINARY EXCRETION;

EID: 80052564438     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-11-RG-005     Document Type: Article

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