Maternal immune activation increases neonatal mouse cortex thickness and cell density

Journal of Neuroimmune Pharmacology

Volumn 7, Issue 3, 2012, Pages 529-532

  Smith, Stephen E P ^a,b   Elliott, Robin M ^a   Anderson, Matthew P ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POLYINOSINIC POLYCYTIDYLIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN CORTEX THICKNESS; BRAIN SIZE; BRAIN TISSUE; CELL COUNT; CELL DENSITY; CELL POPULATION; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; MATERNAL IMMUNE ACTIVATION; MOUSE; NERVE CELL; NEWBORN; NONHUMAN; PREGNANCY; PRIORITY JOURNAL;

ANIMALS; ANIMALS, NEWBORN; CELL COUNT; CEREBRAL CORTEX; FEMALE; MATERNAL-FETAL EXCHANGE; MICE; ORGAN SIZE; POLY I-C; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS;

EID: 84866057053     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-012-9372-1     Document Type: Article

References (18)

1. Atladottir HO, Thorsen P, Ostergaard L, Schendel DE, Lemcke S, Abdallah M, Parner ET (2010) Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. J Autism Dev Disord 40(12):1423-1430
2. Babulas V, Factor-Litvak P, Goetz R, Schaefer CA, Brown AS (2006) Prenatal exposure to maternal genital and reproductive infections and adult schizophrenia. Am J Psychiatry 163(5):927-929 (Pubitemid 44464544)
3. Brown AS (2011) Exposure to prenatal infection and risk of schizophrenia. Front Psychiatry 2:63. doi:10.3389/fpsyt.2011.00063
4. Brown AS, Susser ES (2002) In utero infection and adult schizophrenia. Ment Retard Dev Disabil Res Rev 8(1):51-57 (Pubitemid 34754494)
5. Brown AS, Schaefer CA, Quesenberry CP Jr, Liu L, Babulas VP, Susser ES (2005) Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring. Am J Psychiatry 162(4):767-773 (Pubitemid 40489141)
6. Casanova M, Trippe J (2009) Radial cytoarchitecture and patterns of cortical connectivity in autism. Philos Trans R Soc Lond B Biol Sci 364(1522):1433-1436
7. Chess S (1977) Follow-up report on autism in congenital rubella. J Autism Child Schizophr 7(1):69-81 (Pubitemid 8081958)
8. Ciaranello AL, Ciaranello RD (1995) The neurobiology of infantile autism. Annu Rev Neurosci 18:101-128
9. Courchesne E, Mouton PR, Calhoun ME, Semendeferi K, Ahrens-Barbeau C, Hallet MJ, Barnes CC, Pierce K (2011) Neuron number and size in prefrontal cortex of children with autism. JAMA 306(18):2001-2010
10. Hsiao EY, Patterson PH (2011) Activation of the maternal immune system induces endocrine changes in the placenta via IL-6. Brain Behav Immun 25(4):604-615
11. Mednick SA, Machon RA, Huttunen MO, Bonett D (1988) Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch Gen Psychiatry 45(2):189-192 (Pubitemid 18052851)
12. Meyer U, Nyffeler M, Yee BK, Knuesel I, Feldon J (2008) Adult brain and behavioral pathological markers of prenatal immune challenge during early/middle and late fetal development in mice. Brain Behav Immun 22(4):469-486 (Pubitemid 351451821)
13. Patterson PH (2009) Immune involvement in schizophrenia and autism: etiology, pathology and animal models. Behav Brain Res 204(2):313-321
14. Schumann CM, Nordahl CW (2010) Bridging the gap between MRI and postmortem research in autism. Brain Res 1380:175-186
15. Shi L, Smith SE, Malkova N, Tse D, Su Y, Patterson PH (2009) Activation of the maternal immune system alters cerebellar development in the offspring. Brain Behav Immun 23(1):116-123
16. Smith SE, Li J, Garbett K, Mirnics K, Patterson PH (2007) Maternal immune activation alters fetal brain development through interleukin-6. J Neurosci 27(40):10695-10702 (Pubitemid 47535869)
17. Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA (2005) Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol 57(1):67-81 (Pubitemid 40053317)
18. Voineagu I, Wang X, Johnston P, Lowe JK, Tian Y, Horvath S, Mill J, Cantor RM, Blencowe BJ, Geschwind DH (2011) Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature 474(7351):380-384