-
1
-
-
33845996135
-
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
-
Duvic, M. et al. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood 109, 31-39 (2007).
-
(2007)
Blood
, vol.109
, pp. 31-39
-
-
Duvic, M.1
-
2
-
-
34547683194
-
Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma
-
Olsen, E. A. et al. Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. J. Clin. Oncol. 25, 3109-3115 (2007).
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 3109-3115
-
-
Olsen, E.A.1
-
3
-
-
45549083112
-
Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma
-
Fantin, V. R. et al. Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma. Cancer Res. 68, 3785-3794 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 3785-3794
-
-
Fantin, V.R.1
-
4
-
-
34249941680
-
Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma
-
Lindemann, R. K. et al. Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma. Proc. Natl Acad. Sci. USA 104, 8071-8076 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 8071-8076
-
-
Lindemann, R.K.1
-
5
-
-
58049208190
-
Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitorinduced apoptosis
-
Fotheringham, S. et al. Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitorinduced apoptosis. Cancer Cell 15, 57-66 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 57-66
-
-
Fotheringham, S.1
-
6
-
-
77950877402
-
HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapy
-
Khan, O. et al. HR23B is a biomarker for tumor sensitivity to HDAC inhibitor-based therapy. Proc. Natl Acad. Sci. USA 107, 6532-6537 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 6532-6537
-
-
Khan, O.1
-
7
-
-
78650290829
-
Using large-scale RNAi screens to identify novel drug targets for cancer
-
Nijwening, J. H., Beijersbergen, R. L. Using large-scale RNAi screens to identify novel drug targets for cancer. IDrugs 13, 772-777 (2010).
-
(2010)
IDrugs
, vol.13
, pp. 772-777
-
-
Nijwening, J.H.1
Beijersbergen, R.L.2
-
8
-
-
12144289681
-
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
-
Berns, K. et al. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428, 431-437 (2004).
-
(2004)
Nature
, vol.428
, pp. 431-437
-
-
Berns, K.1
-
9
-
-
70349448673
-
Candidate biomarkers of response to an experimental cancer drug identified through a large-scale RNA interference genetic screen
-
Mullenders, J. et al. Candidate biomarkers of response to an experimental cancer drug identified through a large-scale RNA interference genetic screen. Clin. Cancer Res. 15, 5811-5819 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 5811-5819
-
-
Mullenders, J.1
-
10
-
-
84883054675
-
Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation
-
Tandle, A. T. et al. Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation. Eur. J. Cancer 49, 3020-3028 (2013).
-
(2013)
Eur. J. Cancer
, vol.49
, pp. 3020-3028
-
-
Tandle, A.T.1
-
11
-
-
84877098603
-
A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer
-
Singel, S. M. et al. A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer. Clin. Cancer Res. 19, 2061-2070 (2013).
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 2061-2070
-
-
Singel, S.M.1
-
12
-
-
84881499406
-
A Genome-wide siRNA Screen identifies proteasome addiction as a vulnerability of Basal-like Triple-Negative breast cancer cells
-
Petrocca, F. et al. A Genome-wide siRNA Screen Identifies Proteasome Addiction as a Vulnerability of Basal-like Triple-Negative Breast Cancer Cells. Cancer Cell 24, 182-196 (2013).
-
(2013)
Cancer Cell
, vol.24
, pp. 182-196
-
-
Petrocca, F.1
-
13
-
-
84883325294
-
Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine
-
Fredebohm, J., Wolf, J., Hoheisel, J. D., Boettcher, M. Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine. J. Cell Sci. 126, 3380-3389 (2013).
-
(2013)
J. Cell Sci.
, vol.126
, pp. 3380-3389
-
-
Fredebohm, J.1
Wolf, J.2
Hoheisel, J.D.3
Boettcher, M.4
-
14
-
-
84872022032
-
A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells
-
Xie, L. et al. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. PLoS Genet. 8, e1003151 (2012).
-
(2012)
PLoS Genet.
, vol.8
, pp. e1003151
-
-
Xie, L.1
-
15
-
-
20444419344
-
Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance
-
MacKeigan, J. P., Murphy, L. O., Blenis, J. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat. Cell Bio. 7, 591-600 (2005).
-
(2005)
Nat. Cell Bio.
, vol.7
, pp. 591-600
-
-
MacKeigan, J.P.1
Murphy, L.O.2
Blenis, J.3
-
16
-
-
84922330496
-
A High-throughput, multiplex cell death assay using an RNAi screening approach
-
Falkenberg, K., Saunders, D., Simpson, K. A High-throughput, multiplex cell death assay using an RNAi screening approach. Cold Spring Harb. Protoc. 2014, doi:10.1101/pdb.prot080267 (2014).
-
(2014)
Cold Spring Harb. Protoc.
, vol.2014
-
-
Falkenberg, K.1
Saunders, D.2
Simpson, K.3
-
17
-
-
68349112682
-
Statistical methods for analysis of high-throughput RNA interference screens
-
Birmingham, A. et al. Statistical methods for analysis of high-throughput RNA interference screens. Nat. Methods 6, 569-575 (2009).
-
(2009)
Nat. Methods
, vol.6
, pp. 569-575
-
-
Birmingham, A.1
-
18
-
-
51049121572
-
Identification of genes that regulate epithelial cell migration using an siRNA screening approach
-
Simpson, K. J. et al. Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nat. Cell Bio. 10, 1027-1038 (2008).
-
(2008)
Nat. Cell Bio.
, vol.10
, pp. 1027-1038
-
-
Simpson, K.J.1
-
19
-
-
78149465975
-
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity
-
Chia, N. Y. et al. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature 468, 316-320 (2010).
-
(2010)
Nature
, vol.468
, pp. 316-320
-
-
Chia, N.Y.1
-
20
-
-
77649248469
-
Genome-wide siRNA screen identifies SMCX, EP400, Brd4 as E2-dependent regulators of human papillomavirus oncogene expression
-
Smith, J. A. et al. Genome-wide siRNA screen identifies SMCX, EP400, Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Proc. Natl Acad. Sci. USA 107, 3752-3757 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 3752-3757
-
-
Smith, J.A.1
-
21
-
-
84859885816
-
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
-
Trapnell, C. et al. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat. Protoc. 7, 562-578 (2012).
-
(2012)
Nat. Protoc.
, vol.7
, pp. 562-578
-
-
Trapnell, C.1
-
23
-
-
75249087100
-
EdgeR: A Bioconductor package for differential expression analysis of digital gene expression data
-
Robinson, M. D., McCarthy, D. J., Smyth, G. K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26, 139-140 (2010).
-
(2010)
Bioinformatics
, vol.26
, pp. 139-140
-
-
Robinson, M.D.1
McCarthy, D.J.2
Smyth, G.K.3
-
24
-
-
4544341015
-
Linear models and empirical bayes methods for assessing differential expression in microarray experiments
-
Smyth, G. K. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Molec. Biol. 3, Article3 (2004).
-
(2004)
Stat. Appl. Genet. Molec. Biol.
, vol.3
-
-
Smyth, G.K.1
-
25
-
-
84896735766
-
Voom: Precision weights unlock linear model analysis tools for RNA-seq read counts
-
Law, C. W., Chen, Y., Shi, W., Smyth, G. K. Voom: precision weights unlock linear model analysis tools for RNA-seq read counts. Genome Biol. 15, R29 (2014).
-
(2014)
Genome Biol.
, vol.15
, pp. R29
-
-
Law, C.W.1
Chen, Y.2
Shi, W.3
Smyth, G.K.4
-
26
-
-
39349097864
-
Identification of host proteins required for HIV infection through a functional genomic screen
-
Brass, A. L. et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science 319, 921-926 (2008).
-
(2008)
Science
, vol.319
, pp. 921-926
-
-
Brass, A.L.1
-
27
-
-
84857781943
-
A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response
-
Adamson, B., Smogorzewska, A., Sigoillot, F. D., King, R. W., Elledge, S. J. A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat. Cell Bio. 14, 318-328 (2012).
-
(2012)
Nat. Cell Bio.
, vol.14
, pp. 318-328
-
-
Adamson, B.1
Smogorzewska, A.2
Sigoillot, F.D.3
King, R.W.4
Elledge, S.J.5
-
28
-
-
28644449917
-
How does gene expression clustering work?
-
D'Haeseleer, P. How does gene expression clustering work? Nature Biotechnol. 23, 1499-1501 (2005).
-
(2005)
Nature Biotechnol.
, vol.23
, pp. 1499-1501
-
-
D'Haeseleer, P.1
|