Protective effects of andrographolide derivative AL-1 on high glucose-induced oxidative stress in RIN-m cells

Current Pharmaceutical Design

Volumn 22, Issue 4, 2016, Pages 499-505

  Yan, Hui ^a   Li, Yongmei ^a   Yang, Yali ^a   Zhang, Zaijun ^a   Zhang, Gaoxiao ^a   Sun, Yewei ^a   Yu, Pei ^a   Wang, Yuqiang ^a   Xu, Lipeng ^a  

^a JINAN UNIVERSITY   (China)

Author keywords

Andrographolide; Nrf2; ROS; Lipoic acid

Indexed keywords

ANDROGRAPHOLIDE; ANDROGRAPHOLIDE ALPHA LIPOIC ACID CONJUGATE; CATALASE; GLUCOSE; HEME OXYGENASE 1; INSULIN; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; THIOREDOXIN 1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; DITERPENE; PROTECTIVE AGENT;

ALLOXAN-INDUCED DIABETES MELLITUS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; INSULINOMA; METABOLISM; PANCREAS TUMOR; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; INSULINOMA; OXIDATIVE STRESS; PANCREATIC NEOPLASMS; PROTECTIVE AGENTS; RATS;

EID: 84959346596     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612821666150921110716     Document Type: Article

References (24)

1. Rahimi R, Nikfar S, Larijani B, Abdollahi M. A review on the role of antioxidants in the management of diabetes and its complica- tions. Biomed Pharmacother 2005; 59: 365-373.
2. Rashid MA, Lee S, Tak E, et al. Carbonyl reductase 1 protects pancreatic beta-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity. Free Radic Biol Med 2010; 49: 1522-1533.
3. West IC. Radicals and oxidative stress in diabetes. Diabet Med 2000; 17: 171-80.
4. Liu Z, Li W, Li X, et al. Antidiabetic effects of malonyl ginse-nosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin. J Ethnopharmacol 2013; 145: 233-240.
5. Yokozawa T, Kim YA, Kim HY, Lee YA, Nonaka G. Protective effect of persimmon peel polyphenol against high glucose-induced oxidative stress in LLC-PK(1) cells. Food Chem Toxicol 2007; 45: 1979-1987.
6. Lee SH, Han JS, Heo SJ, Hwang JY, Jeon YJ. Protective effects of dieckol isolated from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells. Toxicol In Vitro 2010; 24: 375-381.
7. Lee JM, Calkins MJ, Chan K, Kan YW, Johnson JA. Identification of the NF-E2-related factor-2-dependent genes conferring protec- tion against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. J Biol Chem 2003; 278: 12029-38.
8. Ishii T, Itoh K, Takahashi S, et al. Transcription factor Nrf2 coor-dinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem 2000; 275: 16023-16029.
9. Yu BC, Hung CR, Chen WC, Cheng JT. Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats. Planta Med 2003; 69: 1075-1079.
10. Koranyi L, James D, Mueckler M, Permutt MA. Glucose trans-porter levels in spontaneously obese (db/db) insulin-resistant mice. J Clin Invest 1990; 85: 962-967.
11. Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM. Lipoic acid as a potential therapy for chronic diseases associated with oxi- dative stress. Curr Med Chem 2004; 11: 1135-1146.
12. Ruhnau KJ, Meissner HP, Finn JR, et al. Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy. Diabetes Med 1999; 16: 1040-1043.
13. Zhang Z, Jiang J, Yu P, Zeng X, Larrick JW, Wang Y. Hypogly-cemic and beta cell protective effects of andrographolide analogue for diabetes treatment. J Transl Med 2009; 7: 62.
14. Sun Y, Yu P, Zhang G, et al. Therapeutic effects of tetramethylpyrazine nitrone in rat ischemic stroke models. J Neuro- sci Res 2012; 90: 1662-9.
15. Morrison F, Johnstone K, Murray A, Locke J, Harries LW. Oxida-tive metabolism genes are not responsive to oxidative stress in ro- dent beta cell lines. Exp Diabetes Res. 2012; [Epub 2012 Feb 20].
16. Yan GR, Zhou HH, Wang Y, Zhong Y, Tan ZL, He QY. Protective effects of andrographolide analogue AL-1 on ROS-induced RIN- mbeta cell death by inducing ROS generation. PLoS One 2013; 8: e63656.
17. Robertson RP. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. J Biol Chem 2004; 279: 42351-42354.
18. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 2000; 408: 239-247.
19. Du X, Wang Z, Zheng Y, Li H, Ni J, Liu Q. Inhibitory effect of selenoprotein P on Cu(+)/Cu(2+)-induced Abeta42 aggregation and toxicity. Inorg Chem 2014; 53: 1672-1678.
20. Hu Y, Cai KY, Luo Z, et al. TiO2 nanotubes as drug nanoreser-voirs for the regulation of mobility and differentiation of mesen- chymal stem cells. Acta Biomater 2012; 8: 439-448.
21. Schriner SE, Linford NJ, Martin GM, et al. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 2005; 308: 1909-1911.
22. Lee JM, Li J, Johnson DA, et al. Nrf2, a multi-organ protector? FASEB J 2005; 19: 1061-1066.
23. Itoh K, Wakabayashi N, Katoh Y, et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 1999; 13: 76-86.
24. Kaspar JW, Niture SK, Jaiswal AK. Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free Radic Biol Med 2009; 47: 1304-1309