Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?

ACS Chemical Neuroscience

Volumn 7, Issue 2, 2016, Pages 161-170

  Dunning, Christopher J ^a,b   McGauran, Gavin ^c   Willén, Katarina ^b   Gouras, Gunnar K ^b   O'Connell, David J ^c   Linse, Sara ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

amyloid beta; Interactome; microarray screen; signaling; target protein

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; DEXTRAN; GLYCOGEN SYNTHASE KINASE 3ALPHA; TAU PROTEIN; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); AMYLOID PRECURSOR PROTEIN; APP PROTEIN, HUMAN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3BETA; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; IN VITRO STUDY; INTRACELLULAR SIGNALING; MOUSE; NERVE CELL; NEURITE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; ANIMAL; BRAIN CORTEX; CELL CULTURE; CONFOCAL MICROSCOPY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; HUMAN; IMMUNOPRECIPITATION; MAMMALIAN EMBRYO; METABOLISM; MUTATION; PHOSPHORYLATION; PHYSIOLOGY; SURFACE PLASMON RESONANCE; TIME FACTOR;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; HUMANS; IMMUNOPRECIPITATION; MICE; MICROSCOPY, CONFOCAL; MUTATION; NEURONS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; SURFACE PLASMON RESONANCE; TAU PROTEINS; TIME FACTORS; TRANSFECTION;

EID: 84959318783     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.5b00262     Document Type: Article

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