Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells

PLoS ONE

Volumn 11, Issue 2, 2016, Pages

  Phang, Chung Weng ^a   Karsani, Saiful Anuar ^a   Sethi, Gautam ^b   Malek, Sri Nurestri Abd ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYTOCHROME C; DEATH RECEPTOR 5; FLAVOKAWAIN C; FLICE INHIBITORY PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INHIBITOR OF APOPTOSIS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLSERINE; PROTEIN BCL XL; PROTEIN KINASE B; RETINOBLASTOMA PROTEIN; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SURVIVIN; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; CASPASE; CHALCONE DERIVATIVE; DEATH RECEPTOR;

A549 CELL LINE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CASKI CELL LINE; CHROMATIN CONDENSATION; COLON CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; HCT116 CELL LINE; HT 29 CELL LINE; HUMAN; HUMAN CELL; MCF 7 CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; PIPER METHYSTICUM; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; S PHASE CELL CYCLE CHECKPOINT; SIGNAL TRANSDUCTION; CELL CYCLE; CELL SURVIVAL; CHEMISTRY; COLONIC NEOPLASMS; DRUG EFFECTS; HCT 116 CELL LINE; HT-29 CELL LINE; MCF-7 CELL LINE; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; CHALCONES; COLONIC NEOPLASMS; DNA FRAGMENTATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HCT116 CELLS; HT29 CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MCF-7 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; PHOSPHATIDYLSERINES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, DEATH DOMAIN; SIGNAL TRANSDUCTION;

EID: 84959317402     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0148775     Document Type: Article

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