Doxycycline and therapeutic targeting of the DNA damage response in cancer cells: Old drug, new purpose

Oncoscience

Volumn 2, Issue 8, 2015, Pages 696-699

  Peiris Pagès, Maria ^a,b   Sotgia, Federica ^a,b   Lisanti, Michael P ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Antibiotics for cancer therapy; Cancer metabolism; Cancer stem cells; DNA damage response; DNA PK; Doxycycline; Drug repurposing; Mitochondria

Indexed keywords

EID: 84959305448     PISSN: None     EISSN: 23314737     Source Type: Journal    
DOI: 10.18632/oncoscience.215     Document Type: Article

References (20)

1. Cojoc M, Mabert K, Muders MH and Dubrovska A. A role for cancer stem cells in therapy resistance: cellular and molecular mechanisms. Seminars in cancer biology. 2015; 31:16-27.
2. Lamb R, Ozsvari B, Lisanti CL, Tanowitz HB, Howell A, Martinez-Outschoorn UE, Sotgia F and Lisanti MP. Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease. Oncotarget. 2015; 6(7):4569-4584.
3. Gupta PB, Onder TT, Jiang G, Tao K, Kuperwasser C, Weinberg RA and Lander ES. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009; 138(4):645-659.
4. Cuyas E, Martin-Castillo B, Corominas-Faja B, Massaguer A, Bosch-Barrera J and Menendez JA. Anti-protozoal and anti-bacterial Antibiotics that inhibit protein synthesis kill Cancer subtypes enriched for stem cell-like properties. Cell cycle. 2015. [Epub ahead of print]
5. Lamb R, Fiorillo M, Chadwick A, Ozsvari B, Reeves KJ, Smith DL, Clarke RB, Howell SJ, Cappello AR, Martinez-Outschoorn UE, Peiris-Pages M, Sotgia F and Lisanti MP. Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy. Oncotarget. 2015; 6(16):14005-14025.
6. Davis AJ, Chen BP and Chen DJ. DNA-PK: a dynamic enzyme in a versatile DSB repair pathway. DNA repair. 2014; 17:21-29.
7. Papeta N, Zheng Z, Schon EA, Brosel S, Altintas MM, Nasr SH, Reiser J, D'Agati VD and Gharavi AG. Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice. The Journal of clinical investigation. 2010; 120(11):4055-4064.
8. Ciszewski WM, Tavecchio M, Dastych J and Curtin NJ. DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin. Breast cancer research and treatment. 2014; 143(1):47-55.
9. Fofaria NM and Srivastava SK. STAT3 induces anoikis resistance, promotes cell invasion and metastatic potential in pancreatic cancer cells. Carcinogenesis. 2015; 36(1):142-150.
10. Frisch SM, Schaller M and Cieply B. Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis. Journal of cell science. 2013; 126(Pt 1):21-29.
11. Kandala PK and Srivastava SK. Diindolylmethane-mediated Gli1 protein suppression induces anoikis in ovarian cancer cells in vitro and blocks tumor formation ability in vivo. The Journal of biological chemistry. 2012; 287(34):28745-28754.
12. Kwon O-J, Valdez JM, Zhang L, Zhang B, Wei X, Su Q, Ittmann MM, Creighton CJ and Xin L. Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells. Nat Commun. 2014; 5:4416.
13. Paoli P, Giannoni E and Chiarugi P. Anoikis molecular pathways and its role in cancer progression. Biochimica et biophysica acta. 2013; 1833(12):3481-3498.
14. Yu M, Ting DT, Stott SL, Wittner BS, Ozsolak F, Paul S, Ciciliano JC, Smas ME, Winokur D, Gilman AJ, Ulman MJ, Xega K, Contino G, Alagesan B, Brannigan BW, Milos PM, et al. RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis. Nature. 2012; 487(7408):510-513.
15. Shimomura A, Takasaki A, Nomura R, Hayashi N and Senda T. Identification of DNA-dependent protein kinase catalytic subunit as a novel interaction partner of lymphocyte enhancer factor 1. Medical molecular morphology. 2013; 46(1):14-19.
16. Skvortsov S, Debbage P, Lukas P and Skvortsova I. Crosstalk between DNA repair and cancer stem cell (CSC) associated intracellular pathways. Seminars in cancer biology. 2015; 31:36-42.
17. Ferreri AJ, Ponzoni M, Guidoboni M, Resti AG, Politi LS, Cortelazzo S, Demeter J, Zallio F, Palmas A, Muti G, Dognini GP, Pasini E, Lettini AA, Sacchetti F, De Conciliis C, Doglioni C, et al. Bacteria-eradicating therapy with doxycycline in ocular adnexal MALT lymphoma: a multicenter prospective trial. Journal of the National Cancer Institute. 2006; 98(19):1375-1382.
18. Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, Spence S, Balakrishnan V, Jordan C, Poligone B, Casulo C, Burack R, Shapiro JL, Bernstein S, Friedberg JW, Deshaies RJ, et al. Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline. Oncotarget. 2015; 6(17):14796-14813.
19. Brown JS and Jackson SP. Ubiquitylation, neddylation and the DNA damage response. Open biology. 2015; 5(4):150018.
20. Griffin MO, Fricovsky E, Ceballos G and Villarreal F. Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature. American journal of physiology Cell physiology. 2010; 299(3):C539-548.