메뉴 건너뛰기




Volumn 146, Issue 2, 2016, Pages 358-367

Human milk oligosaccharides and synthetic galactosyloligosaccharides contain 3'-, 4-, and 6'-galactosyllactose and attenuate inflammation in human T84, NCM-460, and H4 cells and intestinal tissue ex vivo1,2

Author keywords

Colostrum; Enteric infection; Galactosyllactose; Human intestinal epithelium; Human milk oligosaccharides; Mucosal immune response

Indexed keywords

3' GALACTOSYLLACTOSE; 4 GALACTOSYLLACTOSE; 6' GALACTOSYLLACTOSE; GALACTOSE OLIGOSACCHARIDE; INTERLEUKIN 1BETA; INTERLEUKIN 8; LACTOSE; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; OLIGOSACCHARIDE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 3'-GALACTOSYLLACTOSE; ANTIINFLAMMATORY AGENT; AUTACOID; CYTOKINE; TRISACCHARIDE;

EID: 84959303967     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.115.220749     Document Type: Article
Times cited : (82)

References (49)
  • 1
    • 84869801840 scopus 로고    scopus 로고
    • Human milk composition: nutrients and bioactive factors
    • Ballard O, Morrow AL. Human milk composition: nutrients and bioactive factors. Pediatr Clin North Am 2013;60:49-74.
    • (2013) Pediatr Clin North Am , vol.60 , pp. 49-74
    • Ballard, O.1    Morrow, A.L.2
  • 2
    • 10844244470 scopus 로고    scopus 로고
    • The regulation of functional development of the small intestine
    • Delvin E, Lentze MJ, editors. Vevey, Nestlé/Philadelphia: Lippincott Williams & Wilkins
    • Nanthakumar NN. The regulation of functional development of the small intestine. In: Delvin E, Lentze MJ, editors. Gastrointestinal functions. Nestlé Nutrition Workshop Series. Vol. 46. Vevey, Nestlé/Philadelphia: Lippincott Williams & Wilkins; 2001. p. 39-58.
    • (2001) Gastrointestinal functions. Nestlé Nutrition Workshop Series , vol.46 , pp. 39-58
    • Nanthakumar, N.N.1
  • 3
    • 33846953590 scopus 로고    scopus 로고
    • Protection of the neonate by the innate immune system of developing gut and of human milk
    • Newburg DS, Walker WA. Protection of the neonate by the innate immune system of developing gut and of human milk. Pediatr Res 2007;61:2-8.
    • (2007) Pediatr Res , vol.61 , pp. 2-8
    • Newburg, D.S.1    Walker, W.A.2
  • 4
    • 23944482922 scopus 로고    scopus 로고
    • Human milk glycans protect infants against enteric pathogens
    • Newburg DS, Ruiz-Palacios GM, Morrow AL. Human milk glycans protect infants against enteric pathogens. Annu Rev Nutr 2005;25:37-58.
    • (2005) Annu Rev Nutr , vol.25 , pp. 37-58
    • Newburg, D.S.1    Ruiz-Palacios, G.M.2    Morrow, A.L.3
  • 6
    • 84880271074 scopus 로고    scopus 로고
    • Glycobiology of human milk
    • Newburg DS. Glycobiology of human milk. Biochemistry (Mosc) 2013;78:771-85.
    • (2013) Biochemistry (Mosc) , vol.78 , pp. 771-785
    • Newburg, D.S.1
  • 7
    • 84885987505 scopus 로고    scopus 로고
    • Glucocorticoids and microbiota regulate ontogeny of intestinal fucosyltransferase 2 requisite for gut homeostasis
    • Nanthakumar NN, Meng D, Newburg DS. Glucocorticoids and microbiota regulate ontogeny of intestinal fucosyltransferase 2 requisite for gut homeostasis. Glycobiology 2013;23:1131-41.
    • (2013) Glycobiology , vol.23 , pp. 1131-1141
    • Nanthakumar, N.N.1    Meng, D.2    Newburg, D.S.3
  • 8
    • 84898988775 scopus 로고    scopus 로고
    • Recent advances in human milk glycobiology
    • Newburg DS, Grave G. Recent advances in human milk glycobiology. Pediatr Res 2014;75:675-9.
    • (2014) Pediatr Res , vol.75 , pp. 675-679
    • Newburg, D.S.1    Grave, G.2
  • 9
    • 84908158844 scopus 로고    scopus 로고
    • Human colostrum oligosaccharides modulate major immunologic pathways of immature human intestine
    • He Y, Liu S, Leone S, Newburg DS. Human colostrum oligosaccharides modulate major immunologic pathways of immature human intestine. Mucosal Immunol 2014;7:1326-39.
    • (2014) Mucosal Immunol , vol.7 , pp. 1326-1339
    • He, Y.1    Liu, S.2    Leone, S.3    Newburg, D.S.4
  • 10
    • 84886032272 scopus 로고    scopus 로고
    • Utilization of major fucosylated and sialylated human milk oligosaccharides by isolated human gut microbes
    • Yu ZT, Chen CC, Newburg DS. Utilization of major fucosylated and sialylated human milk oligosaccharides by isolated human gut microbes. Glycobiology 2013;23:1281-92.
    • (2013) Glycobiology , vol.23 , pp. 1281-1292
    • Yu, Z.T.1    Chen, C.C.2    Newburg, D.S.3
  • 11
    • 84864358611 scopus 로고    scopus 로고
    • A molecular basis for bifidobacterial enrichment in the infant gastrointestinal tract
    • Garrido D, Baril D, Mills DA. A molecular basis for bifidobacterial enrichment in the infant gastrointestinal tract. Adv Nutr 2012;3:415S-21S.
    • (2012) Adv Nutr , vol.3 , pp. 415S-421S
    • Garrido, D.1    Baril, D.2    Mills, D.A.3
  • 12
    • 0015970761 scopus 로고
    • Undialyzable growth factors for Lactobacillus bifidus var. pennsylvanicus. Protective effect of sialic acid bound to glycoproteins and oligosaccharides against bacterial degradation
    • György P, Jeanloz RW, von Nicolai H, Zilliken F. Undialyzable growth factors for Lactobacillus bifidus var. pennsylvanicus. Protective effect of sialic acid bound to glycoproteins and oligosaccharides against bacterial degradation. Eur J Biochem 1974;43:29-33.
    • (1974) Eur J Biochem , vol.43 , pp. 29-33
    • György, P.1    Jeanloz, R.W.2    von Nicolai, H.3    Zilliken, F.4
  • 13
    • 77955655135 scopus 로고    scopus 로고
    • The normal microbiota of the human gastrointestinal tract: history of analysis, succession, and dietary influences
    • Ouwehand AC, Vaughan EE, editors. New York: CRC press
    • McCartney AL, Gibson GR. The normal microbiota of the human gastrointestinal tract: history of analysis, succession, and dietary influences. In: Ouwehand AC, Vaughan EE, editors. Gastrointestinal microbiology. New York: CRC press; 2013. p. 51-74.
    • (2013) Gastrointestinal microbiology , pp. 51-74
    • McCartney, A.L.1    Gibson, G.R.2
  • 14
    • 77956415615 scopus 로고    scopus 로고
    • Galacto-oligosaccharide prebiotics
    • Charalampopoulos D, Rastall RA, editors. New York: Springer
    • Tzortzis G, Vulevic J. Galacto-oligosaccharide prebiotics. In: Charalampopoulos D, Rastall RA, editors. Prebiotics and probiotics science and technology. New York: Springer; 2009. p. 207-244.
    • (2009) Prebiotics and probiotics science and technology , pp. 207-244
    • Tzortzis, G.1    Vulevic, J.2
  • 15
    • 0034705053 scopus 로고    scopus 로고
    • Inflammation in the developing human intestine: A possible pathophysiologic contribution to necrotizing enterocolitis
    • Nanthakumar NN, Fusunyan RD, Sanderson I, Walker WA. Inflammation in the developing human intestine: A possible pathophysiologic contribution to necrotizing enterocolitis. Proc Natl Acad Sci USA 2000;97:6043-8.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6043-6048
    • Nanthakumar, N.N.1    Fusunyan, R.D.2    Sanderson, I.3    Walker, W.A.4
  • 19
    • 84880788557 scopus 로고    scopus 로고
    • Pattern recognition receptor function in neutrophils
    • Thomas CJ, Schroder K. Pattern recognition receptor function in neutrophils. Trends Immunol 2013;34:317-28.
    • (2013) Trends Immunol , vol.34 , pp. 317-328
    • Thomas, C.J.1    Schroder, K.2
  • 20
    • 79955746123 scopus 로고    scopus 로고
    • The control of adaptive immune responses by the innate immune system
    • Schenten D, Medzhitov R. The control of adaptive immune responses by the innate immune system. Adv Immunol 2011;109:87-124.
    • (2011) Adv Immunol , vol.109 , pp. 87-124
    • Schenten, D.1    Medzhitov, R.2
  • 21
    • 0034080318 scopus 로고    scopus 로고
    • The biology of chemokines and their receptors
    • Rossi D, Zlotnik A. The biology of chemokines and their receptors. Annu Rev Immunol 2000;18:217-42.
    • (2000) Annu Rev Immunol , vol.18 , pp. 217-242
    • Rossi, D.1    Zlotnik, A.2
  • 22
    • 79960829290 scopus 로고    scopus 로고
    • Neutrophils in the activation and regulation of innate and adaptive immunity
    • Mantovani A, Cassatella MA, Costantini C, Jaillon S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol 2011;11:519-31.
    • (2011) Nat Rev Immunol , vol.11 , pp. 519-531
    • Mantovani, A.1    Cassatella, M.A.2    Costantini, C.3    Jaillon, S.4
  • 23
    • 16544392539 scopus 로고    scopus 로고
    • The capacity of nondigestible carbohydrates to stimulate fecal bifidobacteria in healthy humans: a double-blind, randomized, placebo-controlled, parallel-group, dose-response relation study
    • Bouhnik Y, Raskine L, Simoneau G, Vicaut E, Neut C, Flourié B, Brouns F, Bornet FR. The capacity of nondigestible carbohydrates to stimulate fecal bifidobacteria in healthy humans: a double-blind, randomized, placebo-controlled, parallel-group, dose-response relation study. Am J Clin Nutr 2004;80:1658-64.
    • (2004) Am J Clin Nutr , vol.80 , pp. 1658-1664
    • Bouhnik, Y.1    Raskine, L.2    Simoneau, G.3    Vicaut, E.4    Neut, C.5    Flourié, B.6    Brouns, F.7    Bornet, F.R.8
  • 24
    • 0030891419 scopus 로고    scopus 로고
    • Administration of transgalacto-oligosaccharides increases fecal bifidobacteria and modifies colonic fermentation metabolism in healthy humans
    • Bouhnik Y, Flourié B, D'Agay-Abensour L, Pochart P, Gramet G, Durand M, Rambaud JC. Administration of transgalacto-oligosaccharides increases fecal bifidobacteria and modifies colonic fermentation metabolism in healthy humans. J Nutr 1997;127:444-8.
    • (1997) J Nutr , vol.127 , pp. 444-448
    • Bouhnik, Y.1    Flourié, B.2    D'Agay-Abensour, L.3    Pochart, P.4    Gramet, G.5    Durand, M.6    Rambaud, J.C.7
  • 25
    • 0141988697 scopus 로고    scopus 로고
    • Effects of the consumption of Bifidobacterium lactis HN019 (DR10TM) and galactooligosaccharides on the microflora of the gastrointestinal tract in human subjects
    • Gopal KP, Prosad J, Gill HS. Effects of the consumption of Bifidobacterium lactis HN019 (DR10TM) and galactooligosaccharides on the microflora of the gastrointestinal tract in human subjects. Nutr Res 2003;23:1313-28.
    • (2003) Nutr Res , vol.23 , pp. 1313-1328
    • Gopal, K.P.1    Prosad, J.2    Gill, H.S.3
  • 26
    • 0037392977 scopus 로고    scopus 로고
    • Nondigestible oligosaccharides enhance bacterial colonization resistance against Clostridium difficile in vitro
    • Hopkins MJ, Macfarlane GT. Nondigestible oligosaccharides enhance bacterial colonization resistance against Clostridium difficile in vitro. Appl Environ Microbiol 2003;69:1920-7.
    • (2003) Appl Environ Microbiol , vol.69 , pp. 1920-1927
    • Hopkins, M.J.1    Macfarlane, G.T.2
  • 27
    • 58149512629 scopus 로고    scopus 로고
    • A mixture containing galactooligosaccharide, produced by the enzymic activity of Bifidobacterium bifidum, reduces Salmonella enterica serovar Typhimurium infection in mice
    • Searle LEJ, Best A, Nunez A, Salguero FJ, Johnson L, Weyer U, Dugdale AH, Cooley WA, Carter B, Jones G, et al. A mixture containing galactooligosaccharide, produced by the enzymic activity of Bifidobacterium bifidum, reduces Salmonella enterica serovar Typhimurium infection in mice. J Med Microbiol 2009;58:37-48.
    • (2009) J Med Microbiol , vol.58 , pp. 37-48
    • Searle, L.E.J.1    Best, A.2    Nunez, A.3    Salguero, F.J.4    Johnson, L.5    Weyer, U.6    Dugdale, A.H.7    Cooley, W.A.8    Carter, B.9    Jones, G.10
  • 28
    • 0036742349 scopus 로고    scopus 로고
    • Galactooligosaccharides stimulate the growth of bifidobacteria but fail to attenuate inflammation in experimental colitis in rats
    • Holma R, Juvonen P, Asmawi MZ, Vapaatalo H, Korpela R. Galactooligosaccharides stimulate the growth of bifidobacteria but fail to attenuate inflammation in experimental colitis in rats. Scand J Gastroenterol 2002;37:1042-7.
    • (2002) Scand J Gastroenterol , vol.37 , pp. 1042-1047
    • Holma, R.1    Juvonen, P.2    Asmawi, M.Z.3    Vapaatalo, H.4    Korpela, R.5
  • 31
    • 84869204704 scopus 로고    scopus 로고
    • Quantification of neutral human milk oligosaccharides by graphitic carbon high-performance liquid chromatography with tandem mass spectrometry
    • Bao Y, Chen C, Newburg DS. Quantification of neutral human milk oligosaccharides by graphitic carbon high-performance liquid chromatography with tandem mass spectrometry. Anal Biochem 2013;433:28-35.
    • (2013) Anal Biochem , vol.433 , pp. 28-35
    • Bao, Y.1    Chen, C.2    Newburg, D.S.3
  • 32
    • 0033806481 scopus 로고    scopus 로고
    • Salmonella enterica serovar typhimurium-dependent regulation of inducible nitric oxide synthase expression in macrophages by invasins SipB, SipC, and SipD and effector SopE2
    • Cherayil BJ, McCormick BA, Bosley J. Salmonella enterica serovar typhimurium-dependent regulation of inducible nitric oxide synthase expression in macrophages by invasins SipB, SipC, and SipD and effector SopE2. Infect Immun 2000;68:5567-74.
    • (2000) Infect Immun , vol.68 , pp. 5567-5574
    • Cherayil, B.J.1    McCormick, B.A.2    Bosley, J.3
  • 33
    • 0037406727 scopus 로고    scopus 로고
    • Coordinate regulation of Salmonella enterica serovar Typhimurium invasion of epithelial cells by the Arp2/3 complex and Rho GTPases
    • Criss AK, Casanova JE. Coordinate regulation of Salmonella enterica serovar Typhimurium invasion of epithelial cells by the Arp2/3 complex and Rho GTPases. Infect Immun 2003;71:2885-91.
    • (2003) Infect Immun , vol.71 , pp. 2885-2891
    • Criss, A.K.1    Casanova, J.E.2
  • 35
    • 2442616098 scopus 로고    scopus 로고
    • Developmentally regulated IkB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation
    • Claud EC, Lu L, Anton PM, Savidge T, Walker WA, Cherayil BJ. Developmentally regulated IkB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation. Proc Natl Acad Sci USA 2004;101:7404-8.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 7404-7408
    • Claud, E.C.1    Lu, L.2    Anton, P.M.3    Savidge, T.4    Walker, W.A.5    Cherayil, B.J.6
  • 36
    • 84859979309 scopus 로고    scopus 로고
    • TGF-b2 induces maturation of immature human intestinal epithelial cells and inhibits inflammatory cytokine responses induced via the NFkB pathway
    • Rautava S, Lu L, Nanthakumar NN, Dubert-Ferrandon A, Walker WA. TGF-b2 induces maturation of immature human intestinal epithelial cells and inhibits inflammatory cytokine responses induced via the NFkB pathway. J Pediatr Gastroenterol Nutr 2012;54:630-8.
    • (2012) J Pediatr Gastroenterol Nutr , vol.54 , pp. 630-638
    • Rautava, S.1    Lu, L.2    Nanthakumar, N.N.3    Dubert-Ferrandon, A.4    Walker, W.A.5
  • 42
    • 0035057564 scopus 로고    scopus 로고
    • Neutrophil-epithelial crosstalk at the intestinal lumenal surface mediated by reciprocal secretion of adenosine and IL-6
    • Sitaraman SV, Merlin D, Wang L, Wong M, Gewirtz AT, Si-Tahar M, Madara JL. Neutrophil-epithelial crosstalk at the intestinal lumenal surface mediated by reciprocal secretion of adenosine and IL-6. J Clin Invest 2001;107:861-9.
    • (2001) J Clin Invest , vol.107 , pp. 861-869
    • Sitaraman, S.V.1    Merlin, D.2    Wang, L.3    Wong, M.4    Gewirtz, A.T.5    Si-Tahar, M.6    Madara, J.L.7
  • 43
    • 0035860817 scopus 로고    scopus 로고
    • Investigations of the in vitro transport of human milk oligosaccharides by a Caco-2 monolayer using a novel high performance liquid chromatography-mass spectrometry technique
    • Gnoth MJ, RudloffS, Kunz C, Kinne RK. Investigations of the in vitro transport of human milk oligosaccharides by a Caco-2 monolayer using a novel high performance liquid chromatography-mass spectrometry technique. J Biol Chem 2001;276:34363-70.
    • (2001) J Biol Chem , vol.276 , pp. 34363-34370
    • Gnoth, M.J.1    Rudloff, S.2    Kunz, C.3    Kinne, R.K.4
  • 44
    • 84857048152 scopus 로고    scopus 로고
    • The mammalian intestinal epithelium as integral player in the establishment and maintenance of hostmicrobial homeostasis
    • Duerr CU, Hornef MW. The mammalian intestinal epithelium as integral player in the establishment and maintenance of hostmicrobial homeostasis. Semin Immunol 2012;24:25-35.
    • (2012) Semin Immunol , vol.24 , pp. 25-35
    • Duerr, C.U.1    Hornef, M.W.2
  • 45
    • 84876696987 scopus 로고    scopus 로고
    • The role of the intestinal microbiota in the pathogenesis of necrotizing enterocolitis
    • Grishin A, Papillon S, Bell B, Wang J, Ford HR. The role of the intestinal microbiota in the pathogenesis of necrotizing enterocolitis. Semin Pediatr Surg 2013;22:69-75.
    • (2013) Semin Pediatr Surg , vol.22 , pp. 69-75
    • Grishin, A.1    Papillon, S.2    Bell, B.3    Wang, J.4    Ford, H.R.5
  • 46
    • 0028214086 scopus 로고
    • Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches
    • Jones BD, Ghori N, Falkow S. Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches. J Exp Med 1994;180:15-23.
    • (1994) J Exp Med , vol.180 , pp. 15-23
    • Jones, B.D.1    Ghori, N.2    Falkow, S.3
  • 49
    • 0029745347 scopus 로고    scopus 로고
    • A new PrfA-regulated gene of Listeria monocytogenes encoding a small, secreted protein which belongs to the family of internalins
    • Engelbrecht F, Chun S-K, Ochs C, Hess J, Lottspeich F, Goebel W, Sokolovic Z. A new PrfA-regulated gene of Listeria monocytogenes encoding a small, secreted protein which belongs to the family of internalins. Mol Microbiol 1996;21:823-37.
    • (1996) Mol Microbiol , vol.21 , pp. 823-837
    • Engelbrecht, F.1    Chun, S.-K.2    Ochs, C.3    Hess, J.4    Lottspeich, F.5    Goebel, W.6    Sokolovic, Z.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.