Thymoquinone strongly inhibits fMLF-induced neutrophil functions and exhibits anti-inflammatory properties in vivo

Biochemical Pharmacology

Volumn 104, Issue , 2016, Pages 62-73

  Boudiaf, Kaouthar ^a,b,c,d   Hurtado Nedelec, Margarita ^a,b   Belambri, Sahra Amel ^a,b   Marie, Jean Claude ^a,b   Derradji, Yacine ^e   Benboubetra, Mustapha ^d   El Benna, Jamel ^a,b   Dang, Pham My Chan ^a,b  

^a CENTRE DE RECHERCHE SUR L INFLAMMATION   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c UNIVERSITY OF BATNA   (Algeria)

^d FERHAT ABBAS UNIVERSITY   (Algeria)

^e UNIVERSITY OF BISKRA   (Algeria)

Author keywords

Abbreviations AIR auto inhibitory region; DFP Diisopropyl fluorophosphate; ECL enhanced chemiluminescence; ERK extracellular signal regulated kinase; fMLF N formyl methionyl leucyl phenylalanine; HBSS Hank's balanced salt solution; IBD inflammatory bowel disease; MAPK mitogen activated protein kinase; MPO myeloperoxidase; NOX neutrophil oxidase; PKC Protein Kinase C; PMA phorbol myristate acetate; PMN polymorphonuclear neutrophil; RA rheumatoid arthritis; ROS reactive oxygen species; SH3 Src homology 3; SOD superoxide dismutase; TQ thymoquinone; XO xanthine oxidase

Indexed keywords

ANTIINFLAMMATORY AGENT; CD11B ANTIGEN; ESSENTIAL OIL; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GLYCOPROTEIN GP 91; MITOGEN ACTIVATED PROTEIN KINASE; MYELOPEROXIDASE; PROTEIN KINASE C; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; THYMOQUINONE; XANTHINE OXIDASE; BENZOQUINONE DERIVATIVE; CALCIUM; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLACK CUMIN; CARRAGEENAN-INDUCED PLEURISY; CONTROLLED STUDY; EXOCYTOSIS; HUMAN; HUMAN CELL; IN VIVO STUDY; NEUTROPHIL; NONHUMAN; NORMAL HUMAN; PLEURA CAVITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL MEMBRANE; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; FLOW CYTOMETRY; IMMUNOLOGY; ISOLATION AND PURIFICATION; MALE; METABOLISM; PLEURISY; POLYACRYLAMIDE GEL ELECTROPHORESIS; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ADULT; ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZOQUINONES; BLOTTING, WESTERN; CALCIUM; CELL MEMBRANE; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLOW CYTOMETRY; HUMANS; MALE; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NADP; NEUTROPHILS; NIGELLA SATIVA; PLEURISY; RATS, SPRAGUE-DAWLEY; SUPEROXIDES;

EID: 84959224317     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2016.01.006     Document Type: Article

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