Thymoquinone inhibits TNF-α-induced inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulation

Toxicology and Applied Pharmacology

Volumn 287, Issue 3, 2015, Pages 299-305

  Umar, Sadiq ^a   Hedaya, Omar ^a   Singh, Anil K ^a   Ahmed, Salahuddin ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

ASK1; MAP kinase; Rheumatoid arthritis; Synovial fibroblasts; Thymoquinone; TNF

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; CADHERIN; CADHERIN 11; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; JANUS KINASE; THYMOQUINONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; ANTIINFLAMMATORY AGENT; AUTACOID; BENZOQUINONE DERIVATIVE; CELL ADHESION MOLECULE; IL6 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; MAP3K5 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; TUMOR NECROSIS FACTOR;

APOPTOSIS; ARTICLE; CELL ADHESION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG MECHANISM; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN CELL; INFLAMMATION; INTRACELLULAR SIGNALING; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; ARTHRITIS, RHEUMATOID; CELL CULTURE; DOSE RESPONSE; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SYNOVIUM;

NIGELLA SATIVA;

ANTI-INFLAMMATORY AGENTS; ARTHRITIS, RHEUMATOID; BENZOQUINONES; CELL ADHESION; CELL ADHESION MOLECULES; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; INTERLEUKIN-8; MAP KINASE KINASE KINASE 5; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84939568978     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2015.06.017     Document Type: Article

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