Effects of tempol, a membrane-permeable radical scavenger, in a rodent model of carrageenan-induced pleurisy

European Journal of Pharmacology

Volumn 390, Issue 1-2, 2000, Pages 209-222

  Cuzzocrea, Salvatore ^a   McDonald, Michelle C ^b   Filipe, Helder Mota ^b   Costantino, Giuseppina ^a   Mazzon, Emanuela ^a   Santagati, Sabrina ^c   Caputi, Achille P ^a   Thiemermann, Christoph ^b  

^a UNIVERSITY OF MESSINA   (Italy)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^c Sch of Med University of Messina ^*

Author keywords

Carrageenan; Inflammation; Nitric oxide (NO); Peroxynitrite; Superoxide dismutase; Tempol

Indexed keywords

3 NITROTYROSINE; CARRAGEENAN; HYDROGEN PEROXIDE; MALONALDEHYDE; MYELOPEROXIDASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE SYNTHASE; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; SCAVENGER; TEMPOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL LEVEL; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; DRUG MECHANISM; ENDOTHELIUM CELL; EXUDATE; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEUKOCYTE MIGRATION; LUNG; LUNG INJURY; MALE; MEMBRANE PERMEABILITY; MITOCHONDRIAL RESPIRATION; NONHUMAN; PATHOPHYSIOLOGY; PLEURA FLUID; PLEURISY; PRIORITY JOURNAL; RAT; STAINING;

ANIMALS; CARRAGEENAN; CELLS, CULTURED; CYCLIC N-OXIDES; DNA DAMAGE; FREE RADICAL SCAVENGERS; HYDROGEN PEROXIDE; LUNG; MACROPHAGES; MALE; MITOCHONDRIA; NITRATES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OXIDANTS; OXYGEN CONSUMPTION; PERMEABILITY; PLEURISY; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY; SPIN LABELS; TYROSINE;

EID: 0034712003     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00910-3     Document Type: Article

References (52)

1. Beckman J.S. Oxidative damage and tyrosine nitration from peroxynitrite. Chem. Res. Toxicol. 9:1996;836-844.
2. Beckman J.S., Beckman T.W., Chen J., Marshall P.A., Freman B.A. Apparent hydroxyl radical production by peroxynitrite: implication for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. U. S. A. 87:1990;1620-1624.
3. Crow J.P., Beckman J.S. The role of peroxynitrite in nitric oxide-mediated toxicity. Curr. Top. Microbiol. Immunol. 196:1995;57-73.
4. Cuzzocrea S., Caputi A.P., Zingarelli B. Peroxynitrite-mediated DNA strand breakage activates poly (ADP-ribose) synthetase and causes cellular energy depletion in carrageenan-induced pleurisy. Immunology. 93:1998;96-101.
5. Cuzzocrea S., Costantino G., Mazzon E., Caputi A.P. Beneficial effects of raxofelast (IRFI 016), a new hydrophilic vitamin e-like antioxidant, in carrageenan-induced pleurisy. Br. J. Pharmacol. 126:1999;407-414.
6. Cuzzocrea S., Zingarelli B., Costantino G., Caputi A.P. Beneficial effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in carrageenan-pleurisy. Free Radical Biol. Med. 26:1999;26-33.
7. Cuzzocrea S., Zingarelli B., Gilard E., Hake P., Salzman A.L., Szabó C. Protective effect of melatonin in carrageenan-induced models of local inflammation. J. Pineal Res. 23:1997;106-116.
8. Cuzzocrea S., Zingarelli B., Gilard E., Hake P., Salzman A.L., Szabó C. Anti-inflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation. Free Radical Biol. Med. 24:1998;450-459.
9. Cuzzocrea S., Zingarelli B., Gilard E., Hake P., Salzman A.L., Szabó C. Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in carrageenan-induced models of local inflammation. Eur. J. Pharmacol. 342:1998;67-76.
10. Da Motta J.I., Cunha F.Q., Vargaftig B.B., Ferreira S.H. Drug modulation of antigen-induced paw oedema in guinea-pigs: effects of lipopolysaccharide, tumour necrosis factor and leucocyte depletion. Br. J. Pharmacol. 112:1994;111-116.
11. Darley-Usmar V., Halliwell B. Reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system. Pharm. Res. 13:1996;649-651.
12. Dawson J., Sedgwick A.D., Edwards J.C., Lees P. A comparative study of the cellular, exudative and histological responses to carrageenan, dextran and zymosan in the mouse. Int. J. Tissue React. 13:1991;171-185.
13. Eiserich J.P., Hristova M., Cross C.E., Jones A.D., Freeman B.A., Halliwell B., Van der Vliet A. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature. 391:1998;393-397.
14. Fridovich I. Superoxide radical and superoxide dismutases. Annu. Rev. Biochem. 64:1995;97-112.
15. Goode H.F., Webster N.R. Free radicals and antioxidants in sepsis. Crit. Care Med. 21:1993;1770-1776.
16. Hamburger S.A., Mccay P.B. Endotoxin-induced mortality in rats is reduced by nitrones. Circ. Shock. 29:1989;329-334.
17. Heller B., Wang Z.Q., Wagner E.F., Radons J., Burkle A., Fehsel K., Burkart V., Kolb H. Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J. Biol. Chem. 270:1995;11176.
18. Inoue S., Kawanishi S. Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide. FEBS Lett. 371:1995;86-88.
19. Laight D.W., Andrews T.J., Haj-Yehia A.I., Carrier M.J., Anggard E.E. Microassay of superoxide anion scavenging activity in vitro. Environ. Toxicol. Pharmacol. 3:1997;65-68.
20. Leach M., Frank S., Olbrich A., Pfeilschifter J. Decline in the expression of copper/zinc superoxide dismutase in the kidney of rats with endotoxic shock: effects of the superoxide anion radical scavenger, tempol, on organ injury. Br. J. Pharmacol. 125:1998;817-825.
21. Mccord J. Oxygen-derived free radicals. New Horizons. 1:1993;70-76.
22. Mckechnie K., Furman B.L., Parratt J.R. Modification by oxygen free radical scavengers of the metabolic and cardiovascular effects of endotoxin infusion in conscious rats. Circ. Shock. 19:1986;429-439.
23. Miller M.J.S., Thompson J.H., Zhang X.J., Sadowska-Krowicka H., Kakkis J.L., Munshi U.K., Sandoval M., Rossi J., Elobi-Childress S., Beckman J., Ye Y.Z., Rodi C.P., Manning P., Currie M., Clark D.A. Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis. Gastroenterology. 109:1995;1475-1483.
24. Moncada S., Palmer R.M.J., Higgs E.A. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43:1991;109-142.
25. Monti E., Cova D., Guido E., Morelli R., Oliva C. Protective effect of the nitroxide tempol against the cardiotoxicity of adriamycin. Free Radical Biol. Med. 21:1996;463-470.
26. Mullane K.M., Kraemer R., Smith B. Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J. Pharmacol. Methods. 14:1985;157-167.
27. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:1996;3051-3064.
28. Novelli G.P. Oxygen-radicals in experimental shock: effects of spin-trapping nitrones in ameliorating shock pathophysiology. Crit. Care Med. 20:1992;499-507.
29. Novelli G.P., Angiolini P., Tani R., Consales G., Bordi L. Phenyl-T-butyl-nitrone is active against traumatic shock in rats. Free Radical Res. Commun. 1:1986;321-327.
30. Oh-ishi S., Hayashi I., Hayashi M., Yamaki K., Utsunomiya I. Pharmacological demonstration of inflammatory mediators using experimental inflammatory models: rat pleurisy induced by carrageenin and phorbol myristate acetate. Dermatologica. 179(Suppl. 1):1989;68-71.
31. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95:1979;351-358.
32. Peskar B.M., Trautmann M., Nowak P., Peskar B.A. Release of 15-hydroxy-5,8,11,13-eicosatetraenoic acid and cysteinyl-leukotrienes in carrageenin-induced inflammation: effect of non-steroidal anti-inflammatory drugs. Agents Actions. 33:1991;240-246.
33. Phelps D.T., Ferro T.J., Higgins P.J., Shankar R., Parker D.M., Johnson M. TNF-alpha induces peroxynitrite-mediated depletion of lung endothelial glutathione via protein kinase C. Am. J. Physiol. 269:1995;L551-L559.
34. Pryor W., Squadrito G. The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am. J. Physiol. 268:1995;L699-L772.
35. 2-induced injury. Lens Eye Toxic. Res. 9:1992;385-393.
36. Rubbo H., Radi R., Trujillo M., Telleri R., Kalyanaraman B., Barnes S., Kirk M., Freeman B.A. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. J. Biol. Chem. 269:1994;26066-26075.
37. Salgo M.G., Bermudez E., Squadrito G., Pryor W. DNA damage and oxidation of thiols peroxynitrite causes in rat thymocytes. Arch. Biochem. Biophys. 322:1995;500-505.
38. Salvemini D., Wang Z.Q., Stern M.K., Currie M.G., Misko T.P. Peroxynitrite decomposition catalysts: therapeutics for peroxynitrite-mediated pathology. Proc. Natl. Acad. Sci. U. S. A. 95:1998;2659-2663.
39. Salvemini D., Wang Z.Q., Wyatt P., Bourdon D.M., Marino M.H., Manning P.T., Currie M.G. Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br. J. Pharmacol. 118:1996;829-838.
40. Schraufstatter I.U., Hinshaw D.B., Hyslop P.A., Spragg R.G., Cochrane C.G. Oxidant injury of cells: DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J. Clin. Invest. 77:1986;1312-1320.
41. Szabó C., Lim L.H.K., Cuzzocrea S., Getting S.J., Zingarelli B., Flower R.J., Salzman A.L., Perretti M. Inhibition of poly (ADP-ribose) synthetase exerts anti-inflammatory effects and inhibits neutrophil recruitment. J. Exp. Med. 186:1997;1041-1049.
42. Szabó C., Mitchell J.A., Thiemermann C., Vane J.R. Nitric oxide-mediated hyporectivity to norepinephrine precedes the induction of nitric oxide synthase in endotoxin shock. Br. J. Pharmacol. 108:1993;786-794.
43. Szabó C., Viràg L., Cuzzocrea S., Scott G.S., Hake P., O'Connor M., Zingarelli B., Ma Y., Hirsch R., Boiovin G.P., Salzman A.L., Kun E. Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly (ADP-Ribose) synthetase. Proc. Natl. Acad. Sci. U. S. A. 95:1998;3867-3872.
44. Tomlinson A., Appleton I., Moore A.R., Gilroy D.W., Willis D., Mitchell J.A., Willoughby D.A. Cyclo-oxygenase and nitric oxide isoforms in rat carrageenin-induced pleurisy. Br. J. Pharmacol. 113:1994;693-698.
45. G-monomethylarginine, reduces carrageenan-induced pleurisy in the rat. J. Pharmacol. Exp. Ther. 273:1995;1295-1299.
46. Vane J., Botting R. Inflammation and the mechanism of action of antiinflammatory drugs. FASEB J. 1:1987;89-96.
47. Villa L.M., Salas E., Darley-Usmar M., Radomski M.W., Moncada S. Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heart. Proc. Natl. Acad. Sci. U. S. A. 91:1994;12383-12387.
48. Wei X.Q., Charles I.G., Smith A., Ure J., Feng G.J., Huang F.P., Xu D., Muller W., Moncada S., Liew F.Y. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature. 375:1995;408-411.
49. Yim M.B., Chock P.B., Stadtman E.R. Copper, zinc superoxide dismutase catalyses hydroxyl radical production from hydrogen peroxide. Proc. Natl. Acad. Sci. U. S. A. 87:1990;5006-5010.
50. Youn Y.K., Lalonde C., Demling R. Use of antioxidant therapy in shock and trauma. Circ. Shock. 35:1991;245-249.
51. Zingarelli B., Day B.J., Crapo J., Salzman A.L., Szabó C. The potential involvement of peroxynitrite in the pathogenesis of endotoxic shock. Br. J. Pharmacol. 120:1997;259-267.
52. Zingarelli B., O'Connor M., Wong H., Salzman A.L., Szabó C. Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide. J. Immunol. 156:1996;350-358.