메뉴 건너뛰기




Volumn 35, Issue , 2016, Pages 95-104

Characterizing MttA as a mitochondrial cis-aconitic acid transporter by metabolic engineering

Author keywords

Aconitate; Aspergillus niger; Aspergillus terreus; Doxycycline; Itaconate; Itaconic acid; Mitochondrial carrier protein; Trans aconitic acid

Indexed keywords

ASPERGILLUS; BIOCHEMISTRY; FLUORESCENCE MICROSCOPY; METABOLISM; PROTEINS; STRAIN;

EID: 84959222878     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2016.02.003     Document Type: Article
Times cited : (44)

References (50)
  • 1
    • 79953280488 scopus 로고    scopus 로고
    • Deletion or overexpression of mitochondrial NAD+carriers in Saccharomyces cerevisiae alters cellular NAD and ATP contents and affects mitochondrial metabolism and the rate of glycolysis
    • Agrimi G., Brambilla L., Frascotti G., Pisano I., Porro D., Vai M., Palmieri L. Deletion or overexpression of mitochondrial NAD+carriers in Saccharomyces cerevisiae alters cellular NAD and ATP contents and affects mitochondrial metabolism and the rate of glycolysis. Appl. Environ. Microbiol. 2011, 77:2239-2246. 10.1128/AEM.01703-10.
    • (2011) Appl. Environ. Microbiol. , vol.77 , pp. 2239-2246
    • Agrimi, G.1    Brambilla, L.2    Frascotti, G.3    Pisano, I.4    Porro, D.5    Vai, M.6    Palmieri, L.7
  • 2
    • 77956260639 scopus 로고    scopus 로고
    • The yeast mitochondrial citrate transport protein: molecular determinants of its substrate specificity
    • Aluvila S., Kotaria R., Sun J., Mayor J.A., Walters D.E., Harrison D.H.T., Kaplan R.S. The yeast mitochondrial citrate transport protein: molecular determinants of its substrate specificity. J. Biol. Chem. 2010, 285:27314-27326. 10.1074/jbc.M110.137364.
    • (2010) J. Biol. Chem. , vol.285 , pp. 27314-27326
    • Aluvila, S.1    Kotaria, R.2    Sun, J.3    Mayor, J.A.4    Walters, D.E.5    Harrison, D.H.T.6    Kaplan, R.S.7
  • 3
    • 0001705636 scopus 로고
    • The effect of pH on the stability of cis-aconitic acid in dilute solution
    • Ambler J.A., Roberts E.J. The effect of pH on the stability of cis-aconitic acid in dilute solution. J. Org. Chem. 1948, 13:399-408. 10.1021/jo01161a013.
    • (1948) J. Org. Chem. , vol.13 , pp. 399-408
    • Ambler, J.A.1    Roberts, E.J.2
  • 4
    • 66449127673 scopus 로고    scopus 로고
    • Systemic analysis of the response of Aspergillus niger to ambient pH
    • Andersen M.R., Lehmann L., Nielsen J. Systemic analysis of the response of Aspergillus niger to ambient pH. Genome Biol. 2009, 10:R47. 10.1186/gb-2009-10-5-r47.
    • (2009) Genome Biol. , vol.10 , pp. R47
    • Andersen, M.R.1    Lehmann, L.2    Nielsen, J.3
  • 6
    • 84855887130 scopus 로고    scopus 로고
    • Using non-homologous end-joining-deficient strains for functional gene analyses in filamentous fungi
    • Arentshorst M., Ram A.F.J., Meyer V. Using non-homologous end-joining-deficient strains for functional gene analyses in filamentous fungi. Methods Mol. Biol. 2012, 835:133-150. 10.1007/978-1-61779-501-5_9.
    • (2012) Methods Mol. Biol. , vol.835 , pp. 133-150
    • Arentshorst, M.1    Ram, A.F.J.2    Meyer, V.3
  • 7
    • 84877256074 scopus 로고    scopus 로고
    • Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols
    • Avalos J.L., Fink G.R., Stephanopoulos G. Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols. Nat. Biotechnol. 2013, 31. 10.1038/nbt.2509.
    • (2013) Nat. Biotechnol. , pp. 31
    • Avalos, J.L.1    Fink, G.R.2    Stephanopoulos, G.3
  • 8
    • 70350164165 scopus 로고    scopus 로고
    • Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism
    • Bender K., Maechler P., McClenaghan N.H., Flatt P.R., Newsholme P. Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism. Clin. Sci. 2009, 117:321-330. 10.1042/CS20090126.
    • (2009) Clin. Sci. , vol.117 , pp. 321-330
    • Bender, K.1    Maechler, P.2    McClenaghan, N.H.3    Flatt, P.R.4    Newsholme, P.5
  • 9
    • 84879292930 scopus 로고    scopus 로고
    • Targeting enzymes to the right compartment: metabolic engineering for itaconic acid production by Aspergillus niger
    • Blumhoff M.L., Steiger M.G., Mattanovich D., Sauer M. Targeting enzymes to the right compartment: metabolic engineering for itaconic acid production by Aspergillus niger. Metab. Eng. 2013, 19:26-32. 10.1016/j.ymben.2013.05.003.
    • (2013) Metab. Eng. , vol.19 , pp. 26-32
    • Blumhoff, M.L.1    Steiger, M.G.2    Mattanovich, D.3    Sauer, M.4
  • 12
    • 77952919496 scopus 로고    scopus 로고
    • Identification and functional characterization of a novel mitochondrial carrier for citrate and oxoglutarate in Saccharomyces cerevisiae
    • Castegna A., Scarcia P., Agrimi G., Palmieri L., Rottensteiner H., Spera I., Germinario L., Palmieri F. Identification and functional characterization of a novel mitochondrial carrier for citrate and oxoglutarate in Saccharomyces cerevisiae. J. Biol. Chem. 2010, 285:17359-17370. 10.1074/jbc.M109.097188.
    • (2010) J. Biol. Chem. , vol.285 , pp. 17359-17370
    • Castegna, A.1    Scarcia, P.2    Agrimi, G.3    Palmieri, L.4    Rottensteiner, H.5    Spera, I.6    Germinario, L.7    Palmieri, F.8
  • 13
    • 84937572123 scopus 로고    scopus 로고
    • Itaconic acid: the surprising role of an industrial compound as a mammalian antimicrobial metabolite
    • Cordes T., Michelucci A., Hiller K. Itaconic acid: the surprising role of an industrial compound as a mammalian antimicrobial metabolite. Annu. Rev. Nutr. 2014, 35. 10.1146/annurev-nutr-071714-034243.
    • (2014) Annu. Rev. Nutr. , vol.35
    • Cordes, T.1    Michelucci, A.2    Hiller, K.3
  • 14
    • 0036054538 scopus 로고    scopus 로고
    • Purification and characterization of cis-aconitic acid decarboxylase from Aspergillus terreus TN484-M1
    • Dwiarti L., Yamane K., Yamatani H., Kahar P., Okabe M. Purification and characterization of cis-aconitic acid decarboxylase from Aspergillus terreus TN484-M1. J. Biosci. Bioeng. 2002, 94:29-33.
    • (2002) J. Biosci. Bioeng. , vol.94 , pp. 29-33
    • Dwiarti, L.1    Yamane, K.2    Yamatani, H.3    Kahar, P.4    Okabe, M.5
  • 15
    • 65849183178 scopus 로고    scopus 로고
    • Golden gate shuffling: a one-pot DNA shuffling method based on type IIs restriction enzymes
    • Engler C., Gruetzner R., Kandzia R., Marillonnet S. Golden gate shuffling: a one-pot DNA shuffling method based on type IIs restriction enzymes. PLoS One 2009, 4:e5553. 10.1371/journal.pone.0005553.
    • (2009) PLoS One , vol.4
    • Engler, C.1    Gruetzner, R.2    Kandzia, R.3    Marillonnet, S.4
  • 16
    • 0033572643 scopus 로고    scopus 로고
    • Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family
    • Fiermonte G., Dolce V., Arrigoni R., Runswick M.J., Walker J.E., Palmieri F. Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family. Biochem. J. 1999, 344:953-960. 10.1042/bj3440953.
    • (1999) Biochem. J. , vol.344 , pp. 953-960
    • Fiermonte, G.1    Dolce, V.2    Arrigoni, R.3    Runswick, M.J.4    Walker, J.E.5    Palmieri, F.6
  • 18
    • 0036375569 scopus 로고    scopus 로고
    • Intracellular pH homeostasis in the filamentous fungus Aspergillus niger
    • Hesse S.J.a, Ruijter G.J.G., Dijkema C., Visser J. Intracellular pH homeostasis in the filamentous fungus Aspergillus niger. Eur. J. Biochem. 2002, 269:3485-3494. 10.1046/j.1432-1033.2002.03042.x.
    • (2002) Eur. J. Biochem. , vol.269 , pp. 3485-3494
    • Hesse, S.J.A.1    Ruijter, G.J.G.2    Dijkema, C.3    Visser, J.4
  • 20
    • 0026092347 scopus 로고
    • The subcellular organization of itaconate biosynthesis Aspergillus terreus
    • Jaklitsch W.M., Kubicek C.P., Scrutton M.C. The subcellular organization of itaconate biosynthesis Aspergillus terreus. J. Gen. Microbiol. 1991, 137:533-539.
    • (1991) J. Gen. Microbiol. , vol.137 , pp. 533-539
    • Jaklitsch, W.M.1    Kubicek, C.P.2    Scrutton, M.C.3
  • 21
    • 39849090022 scopus 로고    scopus 로고
    • Enhanced citrate production through gene insertion in Aspergillus niger
    • de Jongh W.A., Nielsen J. Enhanced citrate production through gene insertion in Aspergillus niger. Metab. Eng. 2008, 10:87-96. 10.1016/j.ymben.2007.11.002.
    • (2008) Metab. Eng. , vol.10 , pp. 87-96
    • de Jongh, W.A.1    Nielsen, J.2
  • 22
    • 0027441813 scopus 로고
    • The mitochondrial tricarboxylate transport protein
    • Kaplan R.S., Mayor J.A., Woodv D. The mitochondrial tricarboxylate transport protein. Biochemistry 1993, 268:13682-13690.
    • (1993) Biochemistry , vol.268 , pp. 13682-13690
    • Kaplan, R.S.1    Mayor, J.A.2    Woodv, D.3
  • 23
    • 0028917910 scopus 로고
    • High level expression and characterization of the mitochondrial citrate transport protein from the yeast Saccharomyces cerevisiae
    • Kaplan R.S., Mayor J.A., Gremse D.A., Wood D.O. High level expression and characterization of the mitochondrial citrate transport protein from the yeast Saccharomyces cerevisiae. J. Biol. Chem. 1995, 10.1074/jbc.270.8.4108.
    • (1995) J. Biol. Chem.
    • Kaplan, R.S.1    Mayor, J.A.2    Gremse, D.A.3    Wood, D.O.4
  • 24
    • 0038364357 scopus 로고    scopus 로고
    • Aspergillus niger citric acid accumulation: do we understand this well working black box?
    • Karaffa L., Kubicek C.P. Aspergillus niger citric acid accumulation: do we understand this well working black box?. Appl. Microbiol. Biotechnol. 2003, 61:189-196. 10.1007/s00253-002-1201-7.
    • (2003) Appl. Microbiol. Biotechnol. , vol.61 , pp. 189-196
    • Karaffa, L.1    Kubicek, C.P.2
  • 25
    • 33749577638 scopus 로고    scopus 로고
    • Expression analysis of alternative oxidase gene (aox1) with enhanced green fluorescent protein as marker in citric acid-producing Aspergillus niger
    • Kirimura K., Ogawa S., Hattori T., Kino K. Expression analysis of alternative oxidase gene (aox1) with enhanced green fluorescent protein as marker in citric acid-producing Aspergillus niger. J. Biosci. Bioeng. 2006, 102:210-214. 10.1263/jbb.102.210.
    • (2006) J. Biosci. Bioeng. , vol.102 , pp. 210-214
    • Kirimura, K.1    Ogawa, S.2    Hattori, T.3    Kino, K.4
  • 26
    • 0028277913 scopus 로고
    • Crystal structures of aconitase with trans-aconitate and nitrocitrate bound
    • Lauble H., Kennedy M.C., Beinert H., Stout C.D. Crystal structures of aconitase with trans-aconitate and nitrocitrate bound. J. Mol. Biol. 1994, 237:437-451. 10.1006/jmbi.1994.1246.
    • (1994) J. Mol. Biol. , vol.237 , pp. 437-451
    • Lauble, H.1    Kennedy, M.C.2    Beinert, H.3    Stout, C.D.4
  • 27
    • 79954632227 scopus 로고    scopus 로고
    • A clone-based transcriptomics approach for the identification of genes relevant for itaconic acid production in Aspergillus
    • Li A., van Luijk N., ter Beek M., Caspers M., Punt P., van der Werf M. A clone-based transcriptomics approach for the identification of genes relevant for itaconic acid production in Aspergillus. Fungal Genet. Biol. 2011, 48:602-611. 10.1016/j.fgb.2011.01.013.
    • (2011) Fungal Genet. Biol. , vol.48 , pp. 602-611
    • Li, A.1    van Luijk, N.2    ter Beek, M.3    Caspers, M.4    Punt, P.5    van der Werf, M.6
  • 28
    • 84885900438 scopus 로고    scopus 로고
    • Reduced by-product formation and modified oxygen availability improve itaconic acid production in Aspergillus niger
    • Li A., Pfelzer N., Zuijderwijk R., Brickwedde A., van Zeijl C., Punt P. Reduced by-product formation and modified oxygen availability improve itaconic acid production in Aspergillus niger. Appl. Microbiol. Biotechnol. 2013, 97:3901-3911. 10.1007/s00253-012-4684-x.
    • (2013) Appl. Microbiol. Biotechnol. , vol.97 , pp. 3901-3911
    • Li, A.1    Pfelzer, N.2    Zuijderwijk, R.3    Brickwedde, A.4    van Zeijl, C.5    Punt, P.6
  • 29
    • 84917739915 scopus 로고    scopus 로고
    • Compartmentalizing metabolic pathway in Candida glabrata for acetoin production
    • Li S., Liu L., Chen J. Compartmentalizing metabolic pathway in Candida glabrata for acetoin production. Metab. Eng 2014, 28C:1-7. 10.1016/j.ymben.2014.11.008.
    • (2014) Metab. Eng , vol.28C , pp. 1-7
    • Li, S.1    Liu, L.2    Chen, J.3
  • 30
    • 79955603480 scopus 로고    scopus 로고
    • Fungal gene expression on demand: an inducible, tunable, and metabolism-independent expression system for Aspergillus niger
    • Meyer V., Wanka F., van Gent J., Arentshorst M., van den Hondel C.A.M.J.J., Ram A.F.J. Fungal gene expression on demand: an inducible, tunable, and metabolism-independent expression system for Aspergillus niger. Appl. Environ. Microbiol. 2011, 77:2975-2983. 10.1128/AEM.02740-10.
    • (2011) Appl. Environ. Microbiol. , vol.77 , pp. 2975-2983
    • Meyer, V.1    Wanka, F.2    van Gent, J.3    Arentshorst, M.4    van den Hondel, C.A.5    Ram, A.F.6
  • 32
    • 69949136867 scopus 로고    scopus 로고
    • Biotechnological production of itaconic acid and its biosynthesis in Aspergillus terreus
    • Okabe M., Lies D., Kanamasa S., Park E.Y. Biotechnological production of itaconic acid and its biosynthesis in Aspergillus terreus. Appl. Microbiol. Biotechnol. 2009, 84:597-606. 10.1007/s00253-009-2132-3.
    • (2009) Appl. Microbiol. Biotechnol. , vol.84 , pp. 597-606
    • Okabe, M.1    Lies, D.2    Kanamasa, S.3    Park, E.Y.4
  • 33
    • 0015521765 scopus 로고
    • Kinetic study of the tricarboxylate carrier in rat liver mitochondria
    • Palmieri F., Stipani I., Quagliariello E. Kinetic study of the tricarboxylate carrier in rat liver mitochondria. Eur. J. Biochem. 1972, 26:587-594. 10.1111/j.1432-1033.1972.tb01801.x.
    • (1972) Eur. J. Biochem. , vol.26 , pp. 587-594
    • Palmieri, F.1    Stipani, I.2    Quagliariello, E.3
  • 34
    • 79953249623 scopus 로고    scopus 로고
    • Evolution, structure and function of mitochondrial carriers: a review with new insights
    • Palmieri F., Pierri C.L., De Grassi A., Nunes-Nesi A., Fernie A.R. Evolution, structure and function of mitochondrial carriers: a review with new insights. Plant J. 2011, 66:161-181. 10.1111/j.1365-313X.2011.04516.x.
    • (2011) Plant J. , vol.66 , pp. 161-181
    • Palmieri, F.1    Pierri, C.L.2    De Grassi, A.3    Nunes-Nesi, A.4    Fernie, A.R.5
  • 35
    • 0030664759 scopus 로고    scopus 로고
    • Identification of the yeast ACR1 gene product as a succinate-fumarate transporter essential for growth on ethanol or acetate
    • Palmieri L., Lasorsa F.M., De Palma A., Palmieri F., Runswick M.J., Walker J.E. Identification of the yeast ACR1 gene product as a succinate-fumarate transporter essential for growth on ethanol or acetate. FEBS Lett. 1997, 417:114-118. 10.1016/S0014-5793(97)01269-6.
    • (1997) FEBS Lett. , vol.417 , pp. 114-118
    • Palmieri, L.1    Lasorsa, F.M.2    De Palma, A.3    Palmieri, F.4    Runswick, M.J.5    Walker, J.E.6
  • 36
    • 0032904532 scopus 로고    scopus 로고
    • The mitochondrial dicarboxylate carrier is essential for the growth of Saccharomyces cerevisiae on ethanol or acetate as the sole carbon source
    • Palmieri L., Vozza A., Honlinger A., Dietmeier K., Palmisano A., Zara V., Palmieri F. The mitochondrial dicarboxylate carrier is essential for the growth of Saccharomyces cerevisiae on ethanol or acetate as the sole carbon source. Mol. Microbiol. 1999, 31:569-577. 10.1046/j.1365-2958.1999.01197.x.
    • (1999) Mol. Microbiol. , vol.31 , pp. 569-577
    • Palmieri, L.1    Vozza, A.2    Honlinger, A.3    Dietmeier, K.4    Palmisano, A.5    Zara, V.6    Palmieri, F.7
  • 37
    • 0037025338 scopus 로고    scopus 로고
    • Identification of a novel transporter for dicarboxylates and tricarboxylates in plant mitochondria: Bacterial expression, reconstitution, functional characterization, and tissue distribution
    • Picault N., Palmieri L., Pisano I., Hodges M., Palmieri F. Identification of a novel transporter for dicarboxylates and tricarboxylates in plant mitochondria: Bacterial expression, reconstitution, functional characterization, and tissue distribution. J. Biol. Chem. 2002, 277:24204-24211. 10.1074/jbc.M202702200.
    • (2002) J. Biol. Chem. , vol.277 , pp. 24204-24211
    • Picault, N.1    Palmieri, L.2    Pisano, I.3    Hodges, M.4    Palmieri, F.5
  • 38
    • 0028106180 scopus 로고
    • Kinetics of enzymes with iso-mechanisms: dead-end inhibition of fumarase and carbonic anhydrase II
    • Rebholz K.L., Northrop D.B. Kinetics of enzymes with iso-mechanisms: dead-end inhibition of fumarase and carbonic anhydrase II. Arch. Biochem. Biophys. 1994, 312:227-233. 10.1006/abbi.1994.1303.
    • (1994) Arch. Biochem. Biophys. , vol.312 , pp. 227-233
    • Rebholz, K.L.1    Northrop, D.B.2
  • 39
    • 24344441532 scopus 로고    scopus 로고
    • Yeast aconitase in two locations and two metabolic pathways: seeing small amounts is believing
    • Regev-Rudzki N., Karniely S., Ben-Haim N.N., Pines O. Yeast aconitase in two locations and two metabolic pathways: seeing small amounts is believing. Mol. Biol. Cell 2005, 16:4163-4171. 10.1091/mbc.E04-11-1028.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 4163-4171
    • Regev-Rudzki, N.1    Karniely, S.2    Ben-Haim, N.N.3    Pines, O.4
  • 42
    • 84921755213 scopus 로고    scopus 로고
    • TPpred2: improving the prediction of mitochondrial targeting peptide cleavage sites by exploiting sequence motifs
    • Savojardo C., Martelli P.L., Fariselli P., Casadio R. TPpred2: improving the prediction of mitochondrial targeting peptide cleavage sites by exploiting sequence motifs. Bioinformatics 2014, 30:2973-2974. 10.1093/bioinformatics/btu411.
    • (2014) Bioinformatics , vol.30 , pp. 2973-2974
    • Savojardo, C.1    Martelli, P.L.2    Fariselli, P.3    Casadio, R.4
  • 48
    • 84930205130 scopus 로고    scopus 로고
    • Cloning and characterization of heterologous transporters in Saccharomyces cerevisiae and identification of important amino acids for xylose utilization
    • Wang C., Bao X., Li Y., Jiao C., Hou J., Zhang Q., Zhang W., Liu W., Shen Y. Cloning and characterization of heterologous transporters in Saccharomyces cerevisiae and identification of important amino acids for xylose utilization. Metab. Eng. 2015, 30:79-88. 10.1016/j.ymben.2015.04.007.
    • (2015) Metab. Eng. , vol.30 , pp. 79-88
    • Wang, C.1    Bao, X.2    Li, Y.3    Jiao, C.4    Hou, J.5    Zhang, Q.6    Zhang, W.7    Liu, W.8    Shen, Y.9
  • 49
    • 84858135658 scopus 로고    scopus 로고
    • Fast track assembly of multigene constructs using golden gate cloning and the MoClo system
    • Werner S., Engler C., Weber E., Gruetzner R., Marillonnet S. Fast track assembly of multigene constructs using golden gate cloning and the MoClo system. Bioeng. Bugs 2012, 3:38-43. 10.4161/bbug.3.1.18223.
    • (2012) Bioeng. Bugs , vol.3 , pp. 38-43
    • Werner, S.1    Engler, C.2    Weber, E.3    Gruetzner, R.4    Marillonnet, S.5
  • 50
    • 0034886321 scopus 로고    scopus 로고
    • Biotechnological production of itaconic acid
    • Willke T., Vorlop K.-D. Biotechnological production of itaconic acid. Appl. Microbiol. Biotechnol. 2001, 56:289-295. 10.1007/s002530100685.
    • (2001) Appl. Microbiol. Biotechnol. , vol.56 , pp. 289-295
    • Willke, T.1    Vorlop, K.-D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.