Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal β-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism

Clinical Science

Volumn 117, Issue 9, 2009, Pages 321-330

  Bender, Katrin ^a   Maechler, Pierre ^b   McClenaghan, Neville H ^c   Flatt, Peter R ^c   Newsholme, Philip ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

Amino acid; Aspartate glutamate carrier 1 (Aralar1); Glucose; Insulin secretion; Malate aspartate shuttle; NADH; Pancreatic cell

Indexed keywords

ALANINE; CARRIER PROTEIN; GLUTAMIC ACID; GLUTAMINE; GLYCOGEN; LACTIC ACID; PROTEIN ARALAR1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ARTICLE; CELL LEVEL; CELL METABOLISM; CELL VIABILITY; CONTROLLED STUDY; GENE OVEREXPRESSION; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; INSULIN RELEASE; MOLECULAR CLONING; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADENOVIRIDAE; ALANINE; ANIMALS; CELL LINE; GENETIC VECTORS; GLUCOSE; GLUTAMINE; GLYCOGEN; INSULIN; INSULIN-SECRETING CELLS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL PROTEINS; RATS; TRANSDUCTION, GENETIC; TRIGLYCERIDES;

EID: 70350164165     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20090126     Document Type: Article

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