Matthew jonathan murray and stefan schönberger

Pediatric Oncology

Volumn 1, Issue , 2014, Pages 1-15

  Murray, M J ^a,b   Schonberger S ^c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84959208337     PISSN: 16135318     EISSN: 21910812     Source Type: Book Series    
DOI: 10.1007/978-3-642-38971-9_1     Document Type: Article

References (90)

1. Addeo R, Crisci S, D’Angelo V, Vincenzi B, Casale F, Pettinato G et al (2007) Bax mutation and overexpression inversely correlate with immature phenotype and prognosis of childhood germ cell tumors. Oncol Rep 17:1155-1161
2. Alagaratnam S, Lind GE, Kraggerud SM, Lothe RA, Skotheim RI (2011) The testicular germ cell tumour transcriptome. Int J Androl 34:e133-e150; discussion e50-e51
3. Atkin NB, Baker MC (1982) Specifi c chromosome change, i(12p), in testicular tumours? Lancet 2:1349
4. Atkin NB, Baker MC (1983) i(12p): specifi c chromosomal marker in seminoma and malignant teratoma of the testis? Cancer Genet Cytogenet 10:199-204
5. Bamberg M, Kortmann RD, Calaminus G, Becker G, Meisner C, Harms D et al (1999) Radiation therapy for intracranial germinoma: results of the German cooperative prospective trials MAKEI 83/86/89. J Clin Oncol 17:2585-2592
6. Belge G, Dieckmann KP, Spiekermann M, Balks T, Bullerdiek J (2012) Serum levels of microRNAs miR- 371- 3: a novel class of serum biomarkers for testicular germ cell tumors? Eur Urol 61:1068-1069
7. Biermann K, Heukamp LC, Steger K, Zhou H, Franke FE, Sonnack V et al (2007) Genome-wide expression profiling reveals new insights into pathogenesis and progression of testicular germ cell tumors. Cancer Genomics Proteomics 4:359-367
8. Bokemeyer C, Kuczyk MA, Dunn T, Serth J, Hartmann K, Jonasson J et al (1996) Expression of stem-cell factor and its receptor c-kit protein in normal testicular tissue and malignant germ-cell tumours. J Cancer Res Clin Oncol 122:301-306
9. Bussey KJ, Lawce HJ, Himoe E, Shu XO, Heerema NA, Perlman EJ et al (2001) SNRPN methylation patterns in germ cell tumors as a refl ection of primordial germ cell development. Genes Chromosomes Cancer 32: 342-352
10. Calaminus G, Bamberg M, Harms D, Jürgens H, Kortmann RD, Sorensen N et al (2005) AFP/beta- HCG secreting CNS germ cell tumors: long-term outcome with respect to initial symptoms and primary tumor resection. Results of the cooperative trial MAKEI 89. Neuropediatrics 36:71-77
11. Calaminus G, Schneider DT, Weissbach L, Schönberger S, Okpanyi V, Leuschner I et al (2009) Survival after an antiangiogenetic therapy and surgery in a wide spread growing teratoma originating from a testicular mixed malignant germ cell tumor. Klin Padiatr 221: 136-140
12. Cao D, Allan RW, Cheng L, Peng Y, Guo CC, Dahiya N et al (2011a) RNA-binding protein LIN28 is a marker for testicular germ cell tumors. Hum Pathol 42: 710-718
13. Cao D, Liu A, Wang F, Allan RW, Mei K, Peng Y et al (2011b) RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases. Mod Pathol 24: 288-296
14. Cheng L, Roth LM, Zhang S, Wang M, Morton MJ, Zheng W et al (2011) KIT gene mutation and amplifi - cation in dysgerminoma of the ovary. Cancer 117: 2096-2103
15. Doitsidou M, Reichman-Fried M, Stebler J, Koprunner M, Dorries J, Meyer D et al (2002) Guidance of primordial germ cell migration by the chemokine SDF-1. Cell 111:647-659
16. Einhorn LH, Brames MJ, Heinrich MC, Corless CL, Madani A (2006) Phase II study of imatinib mesylate in chemotherapy refractory germ cell tumors expressing KIT. Am J Clin Oncol 29:12-13
17. Fritsch MK, Schneider DT, Schuster AE, Murdoch FE, Perlman EJ (2006) Activation of Wnt/beta-catenin signaling in distinct histologic subtypes of human germ cell tumors. Pediatr Dev Pathol 9:115-131
18. Fukuda S, Shirahama T, Imazono Y, Tsushima T, Ohmori H, Kayajima T et al (1999) Expression of vascular endothelial growth factor in patients with testicular germ cell tumors as an indicator of metastatic disease. Cancer 85:1323-1330
19. Furukawa S, Haruta M, Arai Y, Honda S, Ohshima J, Sugawara W et al (2009) Yolk sac tumor but not seminoma or teratoma is associated with abnormal epigenetic reprogramming pathway and shows frequent hypermethylation of various tumor suppressor genes. Cancer Sci 100:698-708
20. Fustino N, Rakheja D, Ateek CS, Neumann JC, Amatruda JF (2011) Bone morphogenetic protein signalling activity distinguishes histological subsets of paediatric germ cell tumours. Int J Androl 34:e218-e233
21. Gilbert DC, Chandler I, McIntyre A, Goddard NC, Gabe R, Huddart RA et al (2009) Clinical and biological signifi cance of CXCL12 and CXCR4 expression in adult testes and germ cell tumours of adults and adolescents. J Pathol 217:94-102
22. Gillis AJ, Stoop HJ, Hersmus R, Oosterhuis JW, Sun Y, Chen C et al (2007) High-throughput microRNAome analysis in human germ cell tumours. J Pathol 213: 319-328
23. Gillis AJ, Stoop H, Biermann K, van Gurp RJ, Swartzman E, Cribbes S et al (2011) Expression and interdependencies of pluripotency factors LIN28, OCT3/4, NANOG and SOX2 in human testicular germ cells and tumours of the testis. Int J Androl 34:e160-e174
24. Göbel U, Schneider DT, Calaminus G, Jürgens H, Spaar HJ, Sternschulte W et al (2001) Multimodal treatment of malignant sacrococcygeal germ cell tumors: a prospective analysis of 66 patients of the German cooperative protocols MAKEI 83/86 and 89. J Clin Oncol 19:1943-1950
25. Göbel U, Calaminus G, Schneider DT, Schmidt P, Haas RJ (2002) Management of germ cell tumors in children: approaches to cure. Onkologie 25:14-22
26. Gu Y, Runyan C, Shoemaker A, Surani A, Wylie C (2009) Steel factor controls primordial germ cell survival and motility from the time of their specifi cation in the allantois, and provides a continuous niche throughout their migration. Development 136:1295-1303
27. Gu Y, Runyan C, Shoemaker A, Surani MA, Wylie C (2011) Membrane-bound steel factor maintains a high local concentration for mouse primordial germ cell motility, and defi nes the region of their migration. PLoS One 6:e25984
28. Harms D, Zahn S, Göbel U, Schneider DT (2006) Pathology and molecular biology of teratomas in childhood and adolescence. Klin Padiatr 218: 296-302
29. Hoffman HJ, Otsubo H, Hendrick EB, Humphreys RP, Drake JM, Becker LE et al (1991) Intracranial germcell tumors in children. J Neurosurg 74:545-551
30. Honecker F, Wermann H, Mayer F, Gillis AJ, Stoop H, van Gurp RJ et al (2009) Microsatellite instability, mismatch repair defi ciency, and BRAF mutation in treatmentresistant germ cell tumors. J Clin Oncol 27:2129-2136
31. Honorio S, Agathanggelou A, Wernert N, Rothe M, Maher ER, Latif F (2003) Frequent epigenetic inactivation of the RASSF1A tumour suppressor gene in testicular tumours and distinct methylation profi les of seminoma and nonseminoma testicular germ cell tumours. Oncogene 22:461-466
32. Jeyapalan JN, Noor DA, Lee SH, Tan CL, Appleby VA, Kilday JP et al (2011) Methylator phenotype of malignant germ cell tumours in children identifi es strong candidates for chemotherapy resistance. Br J Cancer 105:575-585
33. Jones A, Fujiyama C, Turner K, Fuggle S, Cranston D, Turley H et al (2000) Angiogenesis and lymphangiogenesis in stage 1 germ cell tumours of the testis. BJU Int 86:80-86
34. Kaatsch P (2004) German Childhood Cancer Registry and its favorable setting. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47:437-443
35. Kato N, Tamura G, Fukase M, Shibuya H, Motoyama T (2003) Hypermethylation of the RUNX3 gene promoter in testicular yolk sac tumor of infants. Am J Pathol 163:387-391
36. Kato N, Shibuya H, Fukase M, Tamura G, Motoyama T (2006) Involvement of adenomatous polyposis coli (APC) gene in testicular yolk sac tumor of infants. Hum Pathol 37:48-53
37. Kemmer K, Corless CL, Fletcher JA, McGreevey L, Haley A, Griffi th D et al (2004) KIT mutations are common in testicular seminomas. Am J Pathol 164:305-313
38. Korkola JE, Houldsworth J, Chadalavada RS, Olshen AB, Dobrzynski D, Reuter VE et al (2006) Downregulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors. Cancer Res 66:820-827
39. Koul S, McKiernan JM, Narayan G, Houldsworth J, Bacik, Dobrzynski DL et al (2004) Role of promoter hypermethylation in Cisplatin treatment response of male germ cell tumors. Mol Cancer 3:16
40. Kraggerud SM, Szymanska J, Abeler VM, Kaern J, Eknaes M, Heim S et al (2000) DNA copy number changes in malignant ovarian germ cell tumors. Cancer Res 60:3025-3030
41. LeBron C, Pal P, Brait M, Dasgupta S, Guerrero-Preston R, Looijenga LH et al (2011) Genome-wide analysis of genetic alterations in testicular primary seminomausing high resolution single nucleotide polymorphism arrays. Genomics 97:341-349
42. Lee SH, Appleby V, Jeyapalan JN, Palmer RD, Nicholson JC, Sottile V et al (2011) Variable methylation of the imprinted gene, SNRPN, supports a relationship between intracranial germ cell tumours and neural stem cells. J Neurooncol 101:419-428
43. Looijenga LH, de Leeuw H, van Oorschot M, van Gurp RJ, Stoop H, Gillis AJ et al (2003) Stem cell factor receptor (c-KIT) codon 816 mutations predict development of bilateral testicular germ-cell tumors. Cancer Res 63:7674-7678
44. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D et al (2005) MicroRNA expression profi les classify human cancers. Nature 435:834-838
45. Lu TY, Lu RM, Liao MY, Yu J, Chung CH, Kao CF et al (2010) Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. J Biol Chem 285:8719-8732
46. Mann JR, Raafat F, Robinson K, Imeson J, Gornall P, Sokal M et al (2000) The United Kingdom Children’s Cancer Study Group’s second germ cell tumor study: carboplatin, etoposide, and bleomycin are effective treatment for children with malignant extracranial germ cell tumors, with acceptable toxicity. J Clin Oncol 18:3809-3818
47. Marina N, London WB, Frazier AL, Lauer S, Rescorla F, Cushing B et al (2006) Prognostic factors in children with extragonadal malignant germ cell tumors: a pediatric intergroup study. J Clin Oncol 24: 2544-2548
48. Masque-Soler N, Szczepanowski M, Leuschner I, Vokuhl C, Haag J, Calaminus G et al (2012) Absence of BRAF mutation in pediatric and adolescent germ cell tumors indicate biological differences to adult tumors. Pediatr Blood Cancer 59:732-735
49. McIntyre A, Summersgill B, Spendlove HE, Huddart R, Houlston R, Shipley J (2005) Activating mutations and/or expression levels of tyrosine kinase receptors GRB7, RAS, and BRAF in testicular germ cell tumors. Neoplasia 7:1047-1052
50. Molyneaux KA, Zinszner H, Kunwar PS, Schaible K, Stebler J, Sunshine MJ et al (2003) The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival. Development 130:4279-4286
51. Murray MJ, Coleman N (2012) Testicular cancer: a new generation of biomarkers for malignant germ cell tumours. Nat Rev Urol 9:298-300
52. Murray MJ, Nicholson JC (2010) Germ cell tumours in children and adolescents. Paediatr Child Health 20: 109-116
53. Murray MJ, Nicholson JC (2011) Alpha-fetoprotein. Arch Dis Child Educ Pract Ed 96:141-147
54. Murray MJ, Fern LA, Stark DP, Eden TO, Nicholson JC (2009) Breaking down barriers: improving outcomes for teenagers and young adults with germ cell tumours. Oncol Rev 3:201-206
55. Murray MJ, Saini HK, van Dongen S, Palmer RD, Muralidhar B, Pett MR et al (2010) The two most common histological subtypes of malignant germ cell tumour are distinguished by global microRNA profiles, associated with differential transcription factor expression. Mol Cancer 9:290
56. Murray MJ, Halsall DJ, Hook CE, Williams DM, Nicholson JC, Coleman N (2011) Identifi cation of microRNAs from the miR-371~373 and miR-302 clusters as potential serum biomarkers of malignant germ cell tumors. Am J Clin Pathol 135:119-125
57. Murray MJ, Saini HK, Siegler CA, Hanning JE, Barker EM, van Dongen S et al (2013) LIN28 expression in malignant germ cell tumors downregulates let-7 and increases oncogene levels. Cancer Res 17th June, Epub ahead of print
58. Nakai Y, Nonomura N, Oka D, Shiba M, Arai Y, Nakayama M et al (2005) KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors. Biochem Biophys Res Commun 337:289-296
59. Ng VY, Ang SN, Chan JX, Choo AB (2010) Characterization of epithelial cell adhesion molecule as a surface marker on undifferentiated human embryonic stem cells. Stem Cells 28:29-35
60. Nicholson JC, Palmer RD (2010) Germ cell tumors. In: Estlin EJ, Gilbertson RJ, Wynn RF (eds) Pediatric hematology and oncology. Wiley-Blackwell Publishing Ltd, Oxford, pp 275-305
61. Nikolaou M, Valavanis C, Aravantinos G, Fountzilas G, Tamvakis N, Lekka I et al (2007) Kit expression in male germ cell tumors. Anticancer Res 27: 1685-1688
62. Okpanyi V, Schneider DT, Zahn S, Sievers S, Calaminus G, Nicholson JC et al (2011) Analysis of the adenomatous polyposis coli (APC) gene in childhood and adolescent germ cell tumors. Pediatr Blood Cancer 56:384-391
63. Palmer RD, Foster NA, Vowler SL, Roberts I, Thornton CM, Hale JP et al (2007) Malignant germ cell tumours of childhood: new associations of genomic imbalance. Br J Cancer 96:667-676
64. Palmer RD, Barbosa-Morais NL, Gooding EL, Muralidhar B, Thornton CM, Pett MR et al (2008) Pediatric malignant germ cell tumors show characteristic transcriptome profi les. Cancer Res 68:4239-4247
65. Palmer RD, Murray MJ, Saini HK, van Dongen S, Abreu-Goodger C, Muralidhar B et al (2010) Malignant germ cell tumors display common microRNA profiles resulting in global changes in expression of messenger RNA targets. Cancer Res 70:2911-2923
66. Perlman EJ, Hu J, Ho D, Cushing B, Lauer S, Castleberry RP (2000) Genetic analysis of childhood endodermal sinus tumors by comparative genomic hybridization. J Pediatr Hematol Oncol 22:100-105
67. Port M, Glaesener S, Ruf C, Riecke A, Bokemeyer C, Meineke V et al (2011) Micro-RNA expression in cisplatin resistant germ cell tumor cell lines. Mol Cancer 10:52
68. Poulos C, Cheng L, Zhang S, Gersell DJ, Ulbright TM (2006) Analysis of ovarian teratomas for isochromosome 12p: evidence supporting a dual histogenetic pathway for teratomatous elements. Mod Pathol 19:766-771
69. Poveda A, Kaye SB, McCormack R, Wang S, Parekh T, Ricci D et al (2011) Circulating tumor cells predict progression free survival and overall survival in patients with relapsed/recurrent advanced ovarian cancer. Gynecol Oncol 122:567-572
70. Schittenhelm MM, Shiraga S, Schroeder A, Corbin AS, Griffi th D, Lee FY et al (2006) Dasatinib (BMS- 354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res 66:473-481
71. Schneider DT, Schuster AE, Fritsch MK, Hu J, Olson T, Lauer S et al (2001a) Multipoint imprinting analysis indicates a common precursor cell for gonadal and nongonadal pediatric germ cell tumors. Cancer Res 61:7268-7276
72. Schneider DT, Schuster AE, Fritsch MK, Calaminus G, Harms D, Göbel U et al (2001b) Genetic analysis of childhood germ cell tumors with comparative genomic hybridization. Klin Padiatr 213:204-211
73. Schneider DT, Schuster AE, Fritsch MK, Calaminus G, Göbel U, Harms D et al (2002) Genetic analysis of mediastinal nonseminomatous germ cell tumors in children and adolescents. Genes Chromosomes Cancer 34:115-125
74. Schneider DT, Calaminus G, Koch S, Teske C, Schmidt P, Haas RJ et al (2004) Epidemiologic analysis of 1,442 children and adolescents registered in the German germ cell tumor protocols. Pediatr Blood Cancer 42:169-175
75. Schneider DT, Zahn S, Sievers S, Alemazkour K, Reifenberger G, Wiestler OD et al (2006) Molecular genetic analysis of central nervous system germ cell tumors with comparative genomic hybridization. Mod Pathol 19:864-873
76. Schönberger S, Okpanyi V, Alemazkour K, Looijenga LH, Nicholson JC, Borkhardt A et al (2010) Extracellular regulators of the WNT signalling pathway in childhood germ cell tumors: methylation of the SFRP2 promoter leads to WNT activation and ß-Catenin accumulation. Pediatr Blood Cancer 55:804
77. Schönberger S, Okpanyi V, Calaminus G, Heikaus S, Leuschner I, Nicholson JC et al (2013) EPCAM-A novel molecular target for the treatment of pediatric and adult germ cell tumors. Genes Chromosomes Cancer 52(1):24-32
78. Sievers S, Alemazkour K, Zahn S, Perlman EJ, Gillis AJ, Looijenga LH et al (2005) IGF2/H19 imprinting analysis of human germ cell tumors (GCTs) using the methylation-sensitive single-nucleotide primer extension method refl ects the origin of GCTs in different stages of primordial germ cell development. Genes Chromosomes Cancer 44:256-264
79. Silva MV, Motamedinia P, Badalato GM, Hruby G, McKiernan JM (2012) Diagnostic radiation exposure risk in a contemporary cohort of male patients with germ cell tumor. J Urol 187:482-486
80. Sommerer F, Hengge UR, Markwarth A, Vomschloss S, Stolzenburg JU, Wittekind C et al (2005) Mutations of BRAF and RAS are rare events in germ cell tumours. Int J Cancer 113:329-335
81. Stang A, Trabert B, Wentzensen N, Cook MB, Rusner C, Oosterhuis JW et al (2012) Gonadal and extragonadal germ cell tumours in the United States, 1973-2007. Int J Androl 35:616-625
82. Stanley MA, Pett MR, Coleman N (2007) HPV: from infection to cancer. Biochem Soc Trans 35: 1456-1460
83. Staton AA, Knaut H, Giraldez AJ (2011) miRNA regulation of Sdf1 chemokine signaling provides genetic robustness to germ cell migration. Nat Genet 43: 204-211
84. Tarin TV, Sonn G, Shinghal R (2009) Estimating the risk of cancer associated with imaging related radiation during surveillance for stage I testicular cancer using computerized tomography. J Urol 181:627-632; discussion 32-33
85. Teilum G (1965) Classifi cation of endodermal sinus tumour (mesoblatoma vitellinum) and so-called “embryonal carcinoma” of the ovary. Acta Pathol Microbiol Scand 64:407-429
86. Viswanathan SR, Daley GQ, Gregory RI (2008) Selective blockade of microRNA processing by Lin28. Science 320:97-100
87. Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S et al (2009) Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet 41:843-848
88. Voorhoeve PM, le Sage C, Schrier M, Gillis AJ, Stoop H, Nagel R et al (2006) A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 124:1169-1181
89. West JA, Viswanathan SR, Yabuuchi A, Cunniff K, Takeuchi A, Park IH et al (2009) A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature 460:909-913
90. Xue D, Peng Y, Wang F, Allan RW, Cao D (2011) RNAbinding protein LIN28 is a sensitive marker of ovarian primitive germ cell tumours. Histopathology 59: 452-459