Membrane-bound steel factor maintains a high local concentration for mouse primordial germ cell motility, and defines the region of their migration

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Gu, Ying ^a,b   Runyan, Christopher ^a   Shoemaker, Amanda ^a   Surani, M Azim ^c   Wylie, Christopher ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT PROTEIN; STEEL FACTOR; UVOMORULIN; MESSENGER RNA; STEM CELL FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL AGGREGATION; CELL COUNT; CELL FUNCTION; CELL MIGRATION; CELL MOTILITY; CELL SURVIVAL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYO CULTURE; FEMALE; FETUS; FETUS MEMBRANE; MEMBRANE BINDING; MOUSE; NONHUMAN; PRIMORDIAL GERM CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; ANIMAL; CELL MEMBRANE; CELL MOTION; CHEMISTRY; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; GERM CELL; METABOLISM; MUTATION; PROTEIN BINDING; SOLUBILITY;

ALLANTOIS; ANIMALS; CELL COUNT; CELL MEMBRANE; CELL MOVEMENT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GERM CELLS; MICE; MUTATION; PROTEIN BINDING; RECOMBINANT PROTEINS; RNA, MESSENGER; SOLUBILITY; STEM CELL FACTOR;

EID: 80053594592     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025984     Document Type: Article

References (30)

1. Hayashi K, de Sousa Lopes SM, Surani MA, (2007) Germ cell specification in mice. Science 316: 394-396.
2. Ohinata Y, Payer B, O'Carroll D, Ancelin K, Ono Y, et al. (2005) Blimp1 is a critical determinant of the germ cell lineage in mice. Nature 436: 207-213.
3. Anderson R, Copeland TK, Scholer H, Heasman J, Wylie C, (2000) The onset of germ cell migration in the mouse embryo. Mech Dev 91: 61-68.
4. Gu Y, Runyan C, Shoemaker A, Surani A, Wylie C, (2009) Steel factor controls primordial germ cell survival and motility from the time of their specification in the allantois, and provides a continuous niche throughout their migration. Development 136: 1295-1303.
5. Molyneaux KA, Stallock J, Schaible K, Wylie C, (2001) Time-lapse analysis of living mouse germ cell migration. Dev Biol 240: 488-498.
6. Stallock J, Molyneaux K, Schaible K, Knudson CM, Wylie C, (2003) The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo. Development 130: 6589-6597.
7. Runyan C, Schaible K, Molyneaux K, Wang Z, Levin L, et al. (2006) Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration. Development 133: 4861-4869.
8. Bennett D, (1956) Developmental analysis of a mutation withe pleiotropic effects in the mouse. J Morph 98: 57-70.
9. Besmer P, Manova K, Duttlinger R, Huang EJ, Packer A, et al. (1993) The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis. Dev Suppl pp. 125-137.
10. Buehr M, McLaren A, Bartley A, Darling S, (1993) Proliferation and migration of primordial germ cells in We/We mouse embryos. Dev Dyn 198: 182-189.
11. Mahakali Zama A, Hudson FP 3rd, Bedell MA, (2005) Analysis of hypomorphic KitlSl mutants suggests different requirements for KITL in proliferation and migration of mouse primordial germ cells. Biol Reprod 73: 639-647.
12. McCoshen JA, McCallion DJ, (1975) A study of the primordial germ cells during their migratory phase in Steel mutant mice. Experientia 31: 589-590.
13. Mintz B, Russell ES, (1957) Gene-induced embryological modifications of primordial germ cells in the mouse. J Exp Zool 134: 207-237.
14. Dolci S, Williams DE, Ernst MK, Resnick JL, Brannan CI, et al. (1991) Requirement for mast cell growth factor for primordial germ cell survival in culture. Nature 352: 809-811.
15. Godin I, Deed R, Cooke J, Zsebo K, Dexter M, et al. (1991) Effects of the steel gene product on mouse primordial germ cells in culture. Nature 352: 807-809.
16. Matsui Y, Toksoz D, Nishikawa S, Williams D, Zsebo K, et al. (1991) Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture. Nature 353: 750-752.
17. Flanagan JG, Chan DC, Leder P, (1991) Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant. Cell 64: 1025-1035.
18. Huang EJ, Nocka KH, Buck J, Besmer P, (1992) Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2. Mol Biol Cell 3: 349-362.
19. Miyazawa K, Williams DA, Gotoh A, Nishimaki J, Broxmeyer HE, et al. (1995) Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form. Blood 85: 641-649.
20. Kinashi T, Springer TA, (1994) Steel factor and c-kit regulate cell-matrix adhesion. Blood 83: 1033-1038.
21. Friel J, Itoh K, Bergholz U, Jucker M, Stocking C, et al. (2002) Hierarchy of stroma-derived factors in supporting growth of stroma-dependent hemopoietic cells: membrane-bound SCF is sufficient to confer stroma competence to epithelial cells. Growth Factors 20: 35-51.
22. Wehrle-Haller B, Weston JA, (1995) Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway. Development 121: 731-742.
23. Brannan CI, Lyman SD, Williams DE, Eisenman J, Anderson DM, et al. (1991) Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains. Proc Natl Acad Sci U S A 88: 4671-4674.
24. Toksoz D, Zsebo KM, Smith KA, Hu S, Brankow D, et al. (1992) Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor. Proc Natl Acad Sci U S A 89: 7350-7354.
25. Bendel-Stenzel MR, Gomperts M, Anderson R, Heasman J, Wylie C, (2000) The role of cadherins during primordial germ cell migration and early gonad formation in the mouse. Mech Dev 91: 143-152.
26. Galli SJ, Tsai M, Gordon JR, Geissler EN, Wershil BK, (1992) Analyzing mast cell development and function using mice carrying mutations at W/c-kit or Sl/MGF (SCF) loci. Ann N Y Acad Sci 664: 69-88.
27. Iemura A, Tsai M, Ando A, Wershil BK, Galli SJ, (1994) The c-kit ligand, stem cell factor, promotes mast cell survival by suppressing apoptosis. Am J Pathol 144: 321-328.
28. Yee NS, Paek I, Besmer P, (1994) Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: basis for radiosensitivity of white spotting and steel mutant mice. J Exp Med 179: 1777-1787.
29. Zsebo KM, Williams DA, Geissler EN, Broudy VC, Martin FH, et al. (1990) Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 63: 213-224.
30. Payer B, Chuva de Sousa Lopes SM, Barton SC, Lee C, Saitou M, et al. (2006) Generation of stella-GFP transgenic mice: a novel tool to study germ cell development. Genesis 44: 75-83.