Engineering microdeletions and microduplications by targeting segmental duplications with CRISPR

Nature Neuroscience

Volumn 19, Issue 3, 2016, Pages 517-522

  Tai, Derek J C ^a,b   Ragavendran, Ashok ^a   Manavalan, Poornima ^a   Stortchevoi, Alexei ^a   Seabra, Catarina M ^a,b,c   Erdin, Serkan ^a   Collins, Ryan L ^a   Blumenthal, Ian ^a   Chen, Xiaoli ^d   Shen, Yiping ^e   Sahin, Mustafa ^e   Zhang, Chengsheng ^f   Lee, Charles ^f,g   Gusella, James F ^a,b,h   Talkowski, Michael E ^a,b,h  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF PORTO   (Portugal)

^d CAPITAL INSTITUTE OF PEDIATRICS   (China)

^e BOSTON CHILDREN S HOSPITAL   (United States)

^f JACKSON LABORATORY   (United States)

^g Ewha Womans University   (South Korea)

^h BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTOME;

ARTICLE; CHROMOSOME 15; CHROMOSOME 16; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; COPY NUMBER VARIATION; CRISPR CAS SYSTEM; DNA STRAND BREAKAGE; FLUORESCENCE ACTIVATED CELL SORTING; GENETIC TRANSFECTION; GENOTYPE; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INDEL MUTATION; MICROARRAY ANALYSIS; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; RNA SEQUENCE; SEGMENTAL DUPLICATION; WESTERN BLOTTING; AUTISM; CHROMOSOME DELETION; CHROMOSOME DISORDER; GENE DELETION; GENETIC ENGINEERING; GENETICS; INTELLECTUAL IMPAIRMENT; PROCEDURES; SEIZURE;

AUTISTIC DISORDER; CHROMOSOME DELETION; CHROMOSOME DISORDERS; CHROMOSOMES, HUMAN, PAIR 15; CHROMOSOMES, HUMAN, PAIR 16; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-CAS SYSTEMS; DNA COPY NUMBER VARIATIONS; GENETIC ENGINEERING; HUMANS; INTELLECTUAL DISABILITY; SEGMENTAL DUPLICATIONS, GENOMIC; SEIZURES; SEQUENCE DELETION;

EID: 84959154058     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.4235     Document Type: Article

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