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Volumn 55, Issue 2, 2016, Pages 651-663

The effect of flaxseed dose on circulating concentrations of alpha-linolenic acid and secoisolariciresinol diglucoside derived enterolignans in young, healthy adults

Author keywords

Alpha linolenic acid; Cardiovascular disease; Enterolignans; Flaxseed; Platelets

Indexed keywords

11 OXOTHROMBOXANE B2; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; ENTEROLIGNAN DERIVATIVE; ICOSAPENTAENOIC ACID; LIGNAN DERIVATIVE; LINOLENIC ACID; MONOUNSATURATED FATTY ACID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; SATURATED FATTY ACID; SECOISOLARICIRESINOL; SECOISOLARICIRESINOL DIGLUCOSIDE; THROMBOXANE; THROMBOXANE B2; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; 11-DEHYDRO-THROMBOXANE B2; BUTANEDIOL; CHOLESTEROL; GLUCOSIDE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLANT MEDICINAL PRODUCT; UNSATURATED FATTY ACID;

EID: 84959138055     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-015-0885-2     Document Type: Article
Times cited : (29)

References (70)
  • 1
    • 70449507509 scopus 로고    scopus 로고
    • Flaxseed and cardiovascular health
    • COI: 1:CAS:528:DC%2BD1MXhsVersL3J
    • Prasad K (2009) Flaxseed and cardiovascular health. J Cardiovasc Pharmacol 54:369–377. doi:10.1097/FJC.0b013e3181af04e5
    • (2009) J Cardiovasc Pharmacol , vol.54 , pp. 369-377
    • Prasad, K.1
  • 2
    • 1042301257 scopus 로고    scopus 로고
    • Flaxseed and cardiovascular risk
    • Bloedon LT, Szapary PO (2004) Flaxseed and cardiovascular risk. Nutr Rev 62:18–27
    • (2004) Nutr Rev , vol.62 , pp. 18-27
    • Bloedon, L.T.1    Szapary, P.O.2
  • 6
    • 10044229531 scopus 로고    scopus 로고
    • Dietary flaxseed protects against ventricular fibrillation induced by ischemia-reperfusion in normal and hypercholesterolemic Rabbits
    • COI: 1:CAS:528:DC%2BD2cXhtVyitbnM
    • Ander BP, Weber AR, Rampersad PP, Gilchrist JS, Pierce GN, Lukas A (2004) Dietary flaxseed protects against ventricular fibrillation induced by ischemia-reperfusion in normal and hypercholesterolemic Rabbits. J Nutr 134:3250–3256
    • (2004) J Nutr , vol.134 , pp. 3250-3256
    • Ander, B.P.1    Weber, A.R.2    Rampersad, P.P.3    Gilchrist, J.S.4    Pierce, G.N.5    Lukas, A.6
  • 7
    • 11144355579 scopus 로고    scopus 로고
    • Flaxseed reduces plasma cholesterol and atherosclerotic lesion formation in ovariectomized Golden Syrian hamsters
    • COI: 1:CAS:528:DC%2BD2cXivVWkt7o%3D
    • Lucas EA, Lightfoot SA, Hammond LJ, Devareddy L, Khalil DA, Daggy BP, Smith BJ, Westcott N, Mocanu V et al (2004) Flaxseed reduces plasma cholesterol and atherosclerotic lesion formation in ovariectomized Golden Syrian hamsters. Atherosclerosis 173:223–229. doi:10.1016/j.atherosclerosis.2003.12.032
    • (2004) Atherosclerosis , vol.173 , pp. 223-229
    • Lucas, E.A.1    Lightfoot, S.A.2    Hammond, L.J.3    Devareddy, L.4    Khalil, D.A.5    Daggy, B.P.6    Smith, B.J.7    Westcott, N.8    Mocanu, V.9
  • 9
    • 84910144862 scopus 로고    scopus 로고
    • Flaxseed for hypertension: implications for blood pressure regulation
    • Caligiuri SP, Edel AL, Aliani M, Pierce GN (2014) Flaxseed for hypertension: implications for blood pressure regulation. Curr Hypertens Rep 16:499. doi:10.1007/s11906-014-0499-8
    • (2014) Curr Hypertens Rep , vol.16 , pp. 499
    • Caligiuri, S.P.1    Edel, A.L.2    Aliani, M.3    Pierce, G.N.4
  • 10
    • 67949109601 scopus 로고    scopus 로고
    • Meta-analysis of the effects of flaxseed interventions on blood lipids
    • COI: 1:CAS:528:DC%2BD1MXpt1Wqs7k%3D
    • Pan A, Yu D, Demark-Wahnefried W, Franco OH, Lin X (2009) Meta-analysis of the effects of flaxseed interventions on blood lipids. Am J Clin Nutr 90:288–297. doi:10.3945/ajcn.2009.27469
    • (2009) Am J Clin Nutr , vol.90 , pp. 288-297
    • Pan, A.1    Yu, D.2    Demark-Wahnefried, W.3    Franco, O.H.4    Lin, X.5
  • 11
    • 84928529226 scopus 로고    scopus 로고
    • Dietary flaxseed independently lowers circulating cholesterol and lowers it beyond the effects of cholesterol-lowering medications alone in patients with peripheral artery disease
    • Edel AL, Rodriguez-Leyva D, Maddaford TG, Caligiuri SPB, Alejandro Austria J, Weighell W, Guzman R, Aliani M, Pierce GN (2015) Dietary flaxseed independently lowers circulating cholesterol and lowers it beyond the effects of cholesterol-lowering medications alone in patients with peripheral artery disease. J Nutr. doi:10.3945/jn.114.204594
    • (2015) J Nutr
    • Edel, A.L.1    Rodriguez-Leyva, D.2    Maddaford, T.G.3    Caligiuri, S.P.B.4    Alejandro Austria, J.5    Weighell, W.6    Guzman, R.7    Aliani, M.8    Pierce, G.N.9
  • 12
    • 34948818691 scopus 로고    scopus 로고
    • Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients
    • COI: 1:CAS:528:DC%2BD2sXhtFWht7jI
    • Paschos GK, Magkos F, Panagiotakos DB, Votteas V, Zampelas A (2007) Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. Eur J Clin Nutr 61:1201–1206. doi:10.1038/sj.ejcn.1602631
    • (2007) Eur J Clin Nutr , vol.61 , pp. 1201-1206
    • Paschos, G.K.1    Magkos, F.2    Panagiotakos, D.B.3    Votteas, V.4    Zampelas, A.5
  • 13
    • 36048993913 scopus 로고    scopus 로고
    • Antihypertensive effect and safety of dietary alpha-linolenic acid in subjects with high-normal blood pressure and mild hypertension
    • COI: 1:CAS:528:DC%2BD2sXntlKnu7Y%3D
    • Takeuchi H, Sakurai C, Noda R, Sekine S, Murano Y, Wanaka K, Kasai M, Watanabe S, Aoyama T, Kondo K (2007) Antihypertensive effect and safety of dietary alpha-linolenic acid in subjects with high-normal blood pressure and mild hypertension. J Oleo Sci 56:347–360
    • (2007) J Oleo Sci , vol.56 , pp. 347-360
    • Takeuchi, H.1    Sakurai, C.2    Noda, R.3    Sekine, S.4    Murano, Y.5    Wanaka, K.6    Kasai, M.7    Watanabe, S.8    Aoyama, T.9    Kondo, K.10
  • 14
    • 14644396188 scopus 로고    scopus 로고
    • Dietary linolenic acid is associated with a lower prevalence of hypertension in the NHLBI family heart study
    • Djoussé L, Arnett DK, Pankow JS, Hopkins PN, Province MA, Ellison RC (2005) Dietary linolenic acid is associated with a lower prevalence of hypertension in the NHLBI family heart study. Hypertension 45:368–373. doi:10.1161/01.HYP.0000154679.41568.e6
    • (2005) Hypertension , vol.45 , pp. 368-373
    • Djoussé, L.1    Arnett, D.K.2    Pankow, J.S.3    Hopkins, P.N.4    Province, M.A.5    Ellison, R.C.6
  • 15
    • 33748188128 scopus 로고    scopus 로고
    • Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan
    • COI: 1:CAS:528:DC%2BD28XpvFOluro%3D
    • Thompson LU, Boucher BA, Liu Z, Cotterchio M, Kreiger N (2006) Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan. Nutr Cancer 54:184–201. doi:10.1207/s15327914nc5402_5
    • (2006) Nutr Cancer , vol.54 , pp. 184-201
    • Thompson, L.U.1    Boucher, B.A.2    Liu, Z.3    Cotterchio, M.4    Kreiger, N.5
  • 16
    • 28944433022 scopus 로고    scopus 로고
    • Quantification of lignans in food using isotope dilution gas chromatography/mass spectrometry
    • COI: 1:CAS:528:DC%2BD2MXhtFCitb%2FN
    • Penalvo JL, Haajanen KM, Botting N, Adlercreutz H (2005) Quantification of lignans in food using isotope dilution gas chromatography/mass spectrometry. J Agric Food Chem 53:9342–9347. doi:10.1021/jf051488w
    • (2005) J Agric Food Chem , vol.53 , pp. 9342-9347
    • Penalvo, J.L.1    Haajanen, K.M.2    Botting, N.3    Adlercreutz, H.4
  • 18
    • 0031953504 scopus 로고    scopus 로고
    • Isoflavonoids and lignans in legumes: nutritional and health aspects in humans
    • COI: 1:CAS:528:DyaK1cXis1SrtrY%3D
    • Mazur W, Duke J, Wähälä K, Rasku S, Adlercreutz H (1998) Isoflavonoids and lignans in legumes: nutritional and health aspects in humans. J Nutr Biochem 9:193–200. doi:10.1016/S0955-2863(97)00184-8
    • (1998) J Nutr Biochem , vol.9 , pp. 193-200
    • Mazur, W.1    Duke, J.2    Wähälä, K.3    Rasku, S.4    Adlercreutz, H.5
  • 19
    • 0019395189 scopus 로고
    • The excretion of lignans in rats—evidence for an intestinal bacterial source for this new group of compounds
    • COI: 1:CAS:528:DyaL3MXktl2ks70%3D
    • Axelson M, Setchell KDR (1981) The excretion of lignans in rats—evidence for an intestinal bacterial source for this new group of compounds. FEBS Lett 123:337–342
    • (1981) FEBS Lett , vol.123 , pp. 337-342
    • Axelson, M.1    Setchell, K.D.R.2
  • 20
    • 0023612656 scopus 로고
    • Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG)
    • COI: 1:CAS:528:DyaL1cXptleqsA%3D%3D
    • Adlercreutz H, Hockerstedt K, Bannwart C, Bloigu S, Hamalainen E, Fotsis T, Ollus A (1987) Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG). J Steroid Biochem 27:1135–1144
    • (1987) J Steroid Biochem , vol.27 , pp. 1135-1144
    • Adlercreutz, H.1    Hockerstedt, K.2    Bannwart, C.3    Bloigu, S.4    Hamalainen, E.5    Fotsis, T.6    Ollus, A.7
  • 21
    • 84896892709 scopus 로고    scopus 로고
    • Metabolism of secoisolariciresinol-diglycoside the dietary precursor to the intestinally derived lignan enterolactone in humans
    • COI: 1:CAS:528:DC%2BC2cXjt12js7g%3D
    • Setchell KDR, Brown NM, Zimmer-Nechemias L, Wolfe B, Jha P, Heubi JE (2014) Metabolism of secoisolariciresinol-diglycoside the dietary precursor to the intestinally derived lignan enterolactone in humans. Food Funct 5:491–501. doi:10.1039/C3FO60402K
    • (2014) Food Funct , vol.5 , pp. 491-501
    • Setchell, K.D.R.1    Brown, N.M.2    Zimmer-Nechemias, L.3    Wolfe, B.4    Jha, P.5    Heubi, J.E.6
  • 22
    • 0033400047 scopus 로고    scopus 로고
    • Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone
    • COI: 1:CAS:528:DC%2BD3cXhsFGjurk%3D
    • Kitts DD, Yuan YV, Wijewickreme AN, Thompson LU (1999) Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. Mol Cell Biochem 202:91–100
    • (1999) Mol Cell Biochem , vol.202 , pp. 91-100
    • Kitts, D.D.1    Yuan, Y.V.2    Wijewickreme, A.N.3    Thompson, L.U.4
  • 24
    • 42649116145 scopus 로고    scopus 로고
    • Effects of a flaxseed-derived lignan supplement in type 2 diabetic patients: a randomized, double-blind, cross-over trial
    • Pan A, Sun J, Chen Y, Ye X, Li H, Yu Z, Wang Y, Gu W, Zhang X et al (2007) Effects of a flaxseed-derived lignan supplement in type 2 diabetic patients: a randomized, double-blind, cross-over trial. PLoS ONE 2:e1148. doi:10.1371/journal.pone.0001148
    • (2007) PLoS ONE , vol.2 , pp. 1148
    • Pan, A.1    Sun, J.2    Chen, Y.3    Ye, X.4    Li, H.5    Yu, Z.6    Wang, Y.7    Gu, W.8    Zhang, X.9
  • 25
    • 45549104369 scopus 로고    scopus 로고
    • Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects
    • COI: 1:CAS:528:DC%2BD1cXmtFakurc%3D
    • Zhang W, Wang X, Liu Y, Tian H, Flickinger B, Empie MW, Sun SZ (2008) Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects. Br J Nutr 99:1301–1309. doi:10.1017/S0007114507871649
    • (2008) Br J Nutr , vol.99 , pp. 1301-1309
    • Zhang, W.1    Wang, X.2    Liu, Y.3    Tian, H.4    Flickinger, B.5    Empie, M.W.6    Sun, S.Z.7
  • 27
    • 42649086808 scopus 로고    scopus 로고
    • Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial
    • COI: 1:CAS:528:DC%2BD1cXmtlOgtL4%3D
    • Bloedon LT, Balikai S, Chittams J, Cunnane SC, Berlin JA, Rader DJ, Szapary PO (2008) Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial. J Am Coll Nutr 27:65–74
    • (2008) J Am Coll Nutr , vol.27 , pp. 65-74
    • Bloedon, L.T.1    Balikai, S.2    Chittams, J.3    Cunnane, S.C.4    Berlin, J.A.5    Rader, D.J.6    Szapary, P.O.7
  • 28
    • 0032944280 scopus 로고    scopus 로고
    • Cholesterol-lowering effects of dietary fiber: a meta-analysis
    • COI: 1:CAS:528:DyaK1MXjvFSmsg%3D%3D
    • Brown L, Rosner B, Willett WW, Sacks FM (1999) Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr 69:30–42
    • (1999) Am J Clin Nutr , vol.69 , pp. 30-42
    • Brown, L.1    Rosner, B.2    Willett, W.W.3    Sacks, F.M.4
  • 30
    • 31544470587 scopus 로고    scopus 로고
    • The relative bioavailability of enterolignans in humans is enhanced by milling and crushing of flaxseed
    • COI: 1:CAS:528:DC%2BD2MXhtlalsLrO
    • Kuijsten A, Arts IC, van’t Veer P, Hollman PC (2005) The relative bioavailability of enterolignans in humans is enhanced by milling and crushing of flaxseed. J Nutr 135:2812–2816
    • (2005) J Nutr , vol.135 , pp. 2812-2816
    • Kuijsten, A.1    Arts, I.C.2    van’t Veer, P.3    Hollman, P.C.4
  • 31
    • 70449560974 scopus 로고    scopus 로고
    • Fatty acids and lignans in unground whole flaxseed and sesame seed are bioavailable but have minimal antioxidant and lipid-lowering effects in postmenopausal women
    • COI: 1:CAS:528:DC%2BD1MXhtlyqu7vP
    • Coulman KD, Liu Z, Michaelides J, Quan Hum W, Thompson LU (2009) Fatty acids and lignans in unground whole flaxseed and sesame seed are bioavailable but have minimal antioxidant and lipid-lowering effects in postmenopausal women. Mol Nutr Food Res 53:1366–1375. doi:10.1002/mnfr.200900032
    • (2009) Mol Nutr Food Res , vol.53 , pp. 1366-1375
    • Coulman, K.D.1    Liu, Z.2    Michaelides, J.3    Quan Hum, W.4    Thompson, L.U.5
  • 33
    • 84875680831 scopus 로고    scopus 로고
    • Effects of flaxseed consumption on systemic inflammation and serum lipid profile in hemodialysis patients with lipid abnormalities
    • Khalatbari Soltani S, Jamaluddin R, Tabibi H, Mohd Yusof BN, Atabak S, Loh S-P, Rahmani L (2013) Effects of flaxseed consumption on systemic inflammation and serum lipid profile in hemodialysis patients with lipid abnormalities. Hemodial Int 17:275–281. doi:10.1111/j.1542-4758.2012.00754.x
    • (2013) Hemodial Int , vol.17 , pp. 275-281
    • Khalatbari Soltani, S.1    Jamaluddin, R.2    Tabibi, H.3    Mohd Yusof, B.N.4    Atabak, S.5    Loh, S.-P.6    Rahmani, L.7
  • 34
    • 41449086781 scopus 로고    scopus 로고
    • Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women
    • Patade A, Devareddy L, Lucas E, Korlagunta K, Daggy B, Arjmandi B (2008) Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women. J Womens Health 17:355–366. doi:10.1089/jwh.2007.0359
    • (2008) J Womens Health , vol.17 , pp. 355-366
    • Patade, A.1    Devareddy, L.2    Lucas, E.3    Korlagunta, K.4    Daggy, B.5    Arjmandi, B.6
  • 35
    • 15944405724 scopus 로고    scopus 로고
    • The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial
    • COI: 1:CAS:528:DC%2BD2MXisVOhs7Y%3D
    • Dodin S, Lemay A, Jacques H, Légaré F, Forest J-C, Mâsse B (2005) The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial. J Clin Endocrinol Metab 90:1390–1397. doi:10.1210/jc.2004-1148
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1390-1397
    • Dodin, S.1    Lemay, A.2    Jacques, H.3    Légaré, F.4    Forest, J.-C.5    Mâsse, B.6
  • 39
    • 80555148653 scopus 로고    scopus 로고
    • An open-label study on the effect of flax seed powder (Linum usitatissimum) supplementation in the management of diabetes mellitus
    • COI: 1:CAS:528:DC%2BC3MXhs1SlsLvI
    • Mani UV, Mani I, Biswas M, Kumar SN (2011) An open-label study on the effect of flax seed powder (Linum usitatissimum) supplementation in the management of diabetes mellitus. J Diet Suppl 8:257–265. doi:10.3109/19390211.2011.593615
    • (2011) J Diet Suppl , vol.8 , pp. 257-265
    • Mani, U.V.1    Mani, I.2    Biswas, M.3    Kumar, S.N.4
  • 41
    • 84878150618 scopus 로고    scopus 로고
    • Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study
    • COI: 1:CAS:528:DC%2BC3sXltFCltbs%3D
    • Hutchins AM, Brown BD, Cunnane SC, Domitrovich SG, Adams ER, Bobowiec CE (2013) Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study. Nutr Res 33:367–375. doi:10.1016/j.nutres.2013.02.012
    • (2013) Nutr Res , vol.33 , pp. 367-375
    • Hutchins, A.M.1    Brown, B.D.2    Cunnane, S.C.3    Domitrovich, S.G.4    Adams, E.R.5    Bobowiec, C.E.6
  • 43
    • 0033005792 scopus 로고    scopus 로고
    • Human metabolism of mammalian lignan precursors in raw and processed flaxseed
    • COI: 1:CAS:528:DyaK1MXhslWntrw%3D
    • Nesbitt PD, Lam Y, Thompson LU (1999) Human metabolism of mammalian lignan precursors in raw and processed flaxseed. Am J Clin Nutr 69:549–555
    • (1999) Am J Clin Nutr , vol.69 , pp. 549-555
    • Nesbitt, P.D.1    Lam, Y.2    Thompson, L.U.3
  • 44
    • 0033792636 scopus 로고    scopus 로고
    • Flaxseed influences urinary lignan excretion in a dose-dependent manner in postmenopausal women
    • COI: 1:CAS:528:DC%2BD3cXnslCntLs%3D
    • Hutchins AM, Martini MC, Olson BA, Thomas W, Slavin JL (2000) Flaxseed influences urinary lignan excretion in a dose-dependent manner in postmenopausal women. Cancer Epidemiol Biomark Prev 9:1113–1118
    • (2000) Cancer Epidemiol Biomark Prev , vol.9 , pp. 1113-1118
    • Hutchins, A.M.1    Martini, M.C.2    Olson, B.A.3    Thomas, W.4    Slavin, J.L.5
  • 45
    • 79955633472 scopus 로고    scopus 로고
    • Effect of flax addition on the flavor profile of muffins and snack bars
    • COI: 1:CAS:528:DC%2BC3MXhtVCnsb7E
    • Aliani M, Ryland D, Pierce GN (2011) Effect of flax addition on the flavor profile of muffins and snack bars. Food Res Int 44:2489–2496. doi:10.1016/J.Foodres.2011.01.044
    • (2011) Food Res Int , vol.44 , pp. 2489-2496
    • Aliani, M.1    Ryland, D.2    Pierce, G.N.3
  • 46
    • 0022548964 scopus 로고
    • Direct transesterification of all classes of lipids in a one-step reaction
    • COI: 1:CAS:528:DyaL28XhtVGgsLg%3D
    • Lepage G, Roy CC (1986) Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res 27:114–120
    • (1986) J Lipid Res , vol.27 , pp. 114-120
    • Lepage, G.1    Roy, C.C.2
  • 47
    • 84870879232 scopus 로고    scopus 로고
    • Supported liquid extraction in the quantitation of plasma enterolignans using isotope dilution GC/MS with application to flaxseed consumption in healthy adults
    • COI: 1:CAS:528:DC%2BC3sXhvVertw%3D%3D
    • Edel AL, Aliani M, Pierce GN (2013) Supported liquid extraction in the quantitation of plasma enterolignans using isotope dilution GC/MS with application to flaxseed consumption in healthy adults. J Chromatogr B Anal Biomed Life Sci 912:24–32. doi:10.1016/j.jchromb.2012.10.030
    • (2013) J Chromatogr B Anal Biomed Life Sci , vol.912 , pp. 24-32
    • Edel, A.L.1    Aliani, M.2    Pierce, G.N.3
  • 48
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • COI: 1:CAS:528:DyaE38Xkslagsbw%3D
    • Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502
    • (1972) Clin Chem , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 49
    • 0015921296 scopus 로고
    • Determination of serum creatinine by a direct colorimetric method
    • COI: 1:CAS:528:DyaE3sXotFOitA%3D%3D
    • Heinegard D, Tiderstrom G (1973) Determination of serum creatinine by a direct colorimetric method. Clin Chim Acta 43:305–310
    • (1973) Clin Chim Acta , vol.43 , pp. 305-310
    • Heinegard, D.1    Tiderstrom, G.2
  • 50
    • 23844442838 scopus 로고    scopus 로고
    • Contribution of cyclooxygenase-2 to elevated biosynthesis of thromboxane A2 and prostacyclin in cigarette smokers
    • COI: 1:CAS:528:DC%2BD2MXntVOnurc%3D
    • McAdam BF, Byrne D, Morrow JD, Oates JA (2005) Contribution of cyclooxygenase-2 to elevated biosynthesis of thromboxane A2 and prostacyclin in cigarette smokers. Circulation 112:1024–1029. doi:10.1161/circulationaha.105.542696
    • (2005) Circulation , vol.112 , pp. 1024-1029
    • McAdam, B.F.1    Byrne, D.2    Morrow, J.D.3    Oates, J.A.4
  • 53
    • 36849058160 scopus 로고    scopus 로고
    • Flaxseed on cardiovascular disease markers in healthy menopausal women: a randomized, double-blind, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BD2sXhsVWjsrrP
    • Dodin S, Cunnane SC, Mâsse B, Lemay A, Jacques H, Asselin G, Tremblay-Mercier J, Marc I, Lamarche B et al (2008) Flaxseed on cardiovascular disease markers in healthy menopausal women: a randomized, double-blind, placebo-controlled trial. Nutrition 24:23–30. doi:10.1016/j.nut.2007.09.003
    • (2008) Nutrition , vol.24 , pp. 23-30
    • Dodin, S.1    Cunnane, S.C.2    Mâsse, B.3    Lemay, A.4    Jacques, H.5    Asselin, G.6    Tremblay-Mercier, J.7    Marc, I.8    Lamarche, B.9
  • 54
    • 77956463431 scopus 로고    scopus 로고
    • Dietary milled flaxseed and flaxseed oil improve n-3 fatty acid status and do not affect glycemic control in individuals with well-controlled type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3cXhtVSksrnP
    • Taylor CG, Noto AD, Stringer DM, Froese S, Malcolmson L (2010) Dietary milled flaxseed and flaxseed oil improve n-3 fatty acid status and do not affect glycemic control in individuals with well-controlled type 2 diabetes. J Am Coll Nutr 29:72–80
    • (2010) J Am Coll Nutr , vol.29 , pp. 72-80
    • Taylor, C.G.1    Noto, A.D.2    Stringer, D.M.3    Froese, S.4    Malcolmson, L.5
  • 55
    • 31544469205 scopus 로고    scopus 로고
    • Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans
    • COI: 1:CAS:528:DC%2BD28XivFSnsA%3D%3D
    • Harper CR, Edwards MJ, DeFilipis AP, Jacobson TA (2006) Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. J Nutr 136:83–87
    • (2006) J Nutr , vol.136 , pp. 83-87
    • Harper, C.R.1    Edwards, M.J.2    DeFilipis, A.P.3    Jacobson, T.A.4
  • 56
    • 33747407706 scopus 로고    scopus 로고
    • Conversion of α-linolenic acid in humans is influenced by the absolute amounts of α-linolenic acid and linoleic acid in the diet and not by their ratio
    • COI: 1:CAS:528:DC%2BD28XntVertbo%3D
    • Goyens PL, Spilker ME, Zock PL, Katan MB, Mensink RP (2006) Conversion of α-linolenic acid in humans is influenced by the absolute amounts of α-linolenic acid and linoleic acid in the diet and not by their ratio. Am J Clin Nutr 84:44–53
    • (2006) Am J Clin Nutr , vol.84 , pp. 44-53
    • Goyens, P.L.1    Spilker, M.E.2    Zock, P.L.3    Katan, M.B.4    Mensink, R.P.5
  • 57
    • 33846867711 scopus 로고    scopus 로고
    • Dietary α-linolenic acid inhibits proinflammatory cytokine production by peripheral blood mononuclear cells in hypercholesterolemic subjects
    • COI: 1:CAS:528:DC%2BD2sXhvFWhu74%3D
    • Zhao G, Etherton TD, Martin KR, Gillies PJ, West SG, Kris-Etherton PM (2007) Dietary α-linolenic acid inhibits proinflammatory cytokine production by peripheral blood mononuclear cells in hypercholesterolemic subjects. Am J Clin Nutr 85:385–391
    • (2007) Am J Clin Nutr , vol.85 , pp. 385-391
    • Zhao, G.1    Etherton, T.D.2    Martin, K.R.3    Gillies, P.J.4    West, S.G.5    Kris-Etherton, P.M.6
  • 58
    • 65349120595 scopus 로고    scopus 로고
    • Dietary α-linolenic acid, EPA, and DHA have differential effects on LDL fatty acid composition but similar effects on serum lipid profiles in normolipidemic humans
    • COI: 1:CAS:528:DC%2BD1MXhtlCltrzO
    • Egert S, Kannenberg F, Somoza V, Erbersdobler HF, Wahrburg U (2009) Dietary α-linolenic acid, EPA, and DHA have differential effects on LDL fatty acid composition but similar effects on serum lipid profiles in normolipidemic humans. J Nutr 139:861–868. doi:10.3945/jn.108.103861
    • (2009) J Nutr , vol.139 , pp. 861-868
    • Egert, S.1    Kannenberg, F.2    Somoza, V.3    Erbersdobler, H.F.4    Wahrburg, U.5
  • 59
    • 51749101297 scopus 로고    scopus 로고
    • Flaxseed oil and fish-oil capsule consumption alters human red blood cell n-3 fatty acid composition: a multiple-dosing trial comparing 2 sources of n-3 fatty acid
    • Barceló-Coblijn G, Murphy EJ, Othman R, Moghadasian MH, Kashour T, Friel JK (2008) Flaxseed oil and fish-oil capsule consumption alters human red blood cell n-3 fatty acid composition: a multiple-dosing trial comparing 2 sources of n-3 fatty acid. Am J Clin Nutr 88:801–809
    • (2008) Am J Clin Nutr , vol.88 , pp. 801-809
    • Barceló-Coblijn, G.1    Murphy, E.J.2    Othman, R.3    Moghadasian, M.H.4    Kashour, T.5    Friel, J.K.6
  • 60
    • 0033668024 scopus 로고    scopus 로고
    • Involvement of lipoxygenase pathway in docosapentaenoic acid-induced inhibition of platelet aggregation
    • COI: 1:CAS:528:DC%2BD3cXnvVyhsb0%3D
    • Akiba S, Murata T, Kitatani K, Sato T (2000) Involvement of lipoxygenase pathway in docosapentaenoic acid-induced inhibition of platelet aggregation. Biol Pharm Bull 23:1293–1297
    • (2000) Biol Pharm Bull , vol.23 , pp. 1293-1297
    • Akiba, S.1    Murata, T.2    Kitatani, K.3    Sato, T.4
  • 61
    • 0037733126 scopus 로고    scopus 로고
    • Docosapentaenoic acid (22:5, n-3) suppressed tube-forming activity in endothelial cells induced by vascular endothelial growth factor
    • COI: 1:CAS:528:DC%2BD3sXjtVKhsL4%3D
    • Tsuji M, Murota SI, Morita I (2003) Docosapentaenoic acid (22:5, n-3) suppressed tube-forming activity in endothelial cells induced by vascular endothelial growth factor. Prostaglandins Leukot Essent Fatty Acids 68:337–342
    • (2003) Prostaglandins Leukot Essent Fatty Acids , vol.68 , pp. 337-342
    • Tsuji, M.1    Murota, S.I.2    Morita, I.3
  • 62
    • 78650700860 scopus 로고    scopus 로고
    • Docosapentaenoic acid (22:5n-3): a review of its biological effects
    • COI: 1:CAS:528:DC%2BC3cXhs1WktL7O
    • Kaur G, Cameron-Smith D, Garg M, Sinclair AJ (2011) Docosapentaenoic acid (22:5n-3): a review of its biological effects. Prog Lipid Res 50:28–34. doi:10.1016/j.plipres.2010.07.004
    • (2011) Prog Lipid Res , vol.50 , pp. 28-34
    • Kaur, G.1    Cameron-Smith, D.2    Garg, M.3    Sinclair, A.J.4
  • 63
    • 84871018338 scopus 로고    scopus 로고
    • Effects of serum n-3 to n-6 polyunsaturated fatty acids ratios on coronary atherosclerosis in statin-treated patients with coronary artery disease
    • COI: 1:CAS:528:DC%2BC38XhsVCnsLbL
    • Nozue T, Yamamoto S, Tohyama S, Fukui K, Umezawa S, Onishi Y, Kunishima T, Sato A, Nozato T et al (2013) Effects of serum n-3 to n-6 polyunsaturated fatty acids ratios on coronary atherosclerosis in statin-treated patients with coronary artery disease. Am J Cardiol 111:6–11. doi:10.1016/j.amjcard.2012.08.038
    • (2013) Am J Cardiol , vol.111 , pp. 6-11
    • Nozue, T.1    Yamamoto, S.2    Tohyama, S.3    Fukui, K.4    Umezawa, S.5    Onishi, Y.6    Kunishima, T.7    Sato, A.8    Nozato, T.9
  • 64
    • 0037992850 scopus 로고    scopus 로고
    • Risk of cardiovascular disease-related and all-cause death according to serum concentrations of enterolactone: Kuopio Ischaemic Heart Disease Risk Factor Study
    • COI: 1:CAS:528:DC%2BD3sXkt1alt74%3D
    • Vanharanta M, Voutilainen S, Rissanen TH, Adlercreutz H, Salonen JT (2003) Risk of cardiovascular disease-related and all-cause death according to serum concentrations of enterolactone: Kuopio Ischaemic Heart Disease Risk Factor Study. Arch Intern Med 163:1099–1104. doi:10.1001/archinte.163.9.1099
    • (2003) Arch Intern Med , vol.163 , pp. 1099-1104
    • Vanharanta, M.1    Voutilainen, S.2    Rissanen, T.H.3    Adlercreutz, H.4    Salonen, J.T.5
  • 65
    • 0027998442 scopus 로고
    • Determination of lignans and isoflavonoids in human female plasma following dietary supplementation
    • COI: 1:CAS:528:DyaK2cXlsFKns7g%3D
    • Morton MS, Wilcox G, Wahlqvist ML, Griffiths K (1994) Determination of lignans and isoflavonoids in human female plasma following dietary supplementation. J Endocrinol 142:251–259
    • (1994) J Endocrinol , vol.142 , pp. 251-259
    • Morton, M.S.1    Wilcox, G.2    Wahlqvist, M.L.3    Griffiths, K.4
  • 66
    • 85031864839 scopus 로고    scopus 로고
    • Summary of Health Canada’s assessment of a health claim about ground whole flaxseed and blood cholesterol lowering
    • Bureau of Nutritional Sciences Food Directorate, Health Products and Food Branch (2014) Summary of Health Canada’s assessment of a health claim about ground whole flaxseed and blood cholesterol lowering. Ontario (Canada) Bureau of Nutritional Sciences; [cited 2015 February 17]. http://www.hc-sc.gc.ca/fn-an/alt_formats/pdf/label-etiquet/claims-reclam/assess-evalu/flaxseed-graines-de-lin-eng.pdf
    • (2014) Ontario (Canada) Bureau of Nutritional Sciences; [cited 2015 February 17]
  • 67
    • 0032125212 scopus 로고    scopus 로고
    • Whole flaxseed consumption lowers serum LDL-cholesterol and lipoprotein(a) concentrations in postmenopausal women
    • COI: 1:CAS:528:DyaK1cXktFCms7w%3D
    • Arjmandi BH, Khan DA, Juma S, Drum ML, Venkatesh S, Sohn E, Wei L, Derman R (1998) Whole flaxseed consumption lowers serum LDL-cholesterol and lipoprotein(a) concentrations in postmenopausal women. Nutr Res 18:1203–1214. doi:10.1016/S0271-5317(98)00100-6
    • (1998) Nutr Res , vol.18 , pp. 1203-1214
    • Arjmandi, B.H.1    Khan, D.A.2    Juma, S.3    Drum, M.L.4    Venkatesh, S.5    Sohn, E.6    Wei, L.7    Derman, R.8
  • 69
    • 85007447252 scopus 로고    scopus 로고
    • Flaxseed oil and lipoprotein (a) significantly increase bleeding time in type 2 diabetes patients in Cape Breton, Nova Scotia, Canada
    • COI: 1:CAS:528:DC%2BD2MXkslOkurY%3D
    • Barre DE, Griscti O, Mizier-Barre KA, Hafez K (2005) Flaxseed oil and lipoprotein (a) significantly increase bleeding time in type 2 diabetes patients in Cape Breton, Nova Scotia, Canada. J Oleo Sci 54:347–354
    • (2005) J Oleo Sci , vol.54 , pp. 347-354
    • Barre, D.E.1    Griscti, O.2    Mizier-Barre, K.A.3    Hafez, K.4
  • 70
    • 84889834568 scopus 로고    scopus 로고
    • National nutrient database for standard reference
    • United States Department of Agriculture (USDA) Agricultural Research Service (2007) National nutrient database for standard reference, Release 27 [cited 2015 February 17]. http://ndb.nal.usda.gov/ndb/foods/show/3745?fg=&man=&lfacet=&format=&count=&max=25&offset=&sort=&qlookup=flaxseed
    • (2007) Release , vol.27 , Issue.[cited 2015 February 17]


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