Bioavailability of α-linolenic acid from flaxseed diets as a function of the age of the subject

European Journal of Clinical Nutrition

Volumn 63, Issue 9, 2009, Pages 1123-1129

  Patenaude, A ^a,b   Rodriguez Leyva, D ^c   Edel, A L ^a,b   Dibrov, E ^a,b   Dupasquier, C M C ^a,b   Austria, J A ^a,b   Richard, M N ^a,b   Chahine, M N ^a,b   Malcolmson, L J ^d   Pierce, G N ^a,b  

^a ST BONIFACE GENERAL HOSPITAL   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c VI Lenin University Hospital   (Cuba)

^d Canadian International Grains Institute   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ICOSAPENTAENOIC ACID; LINOLENIC ACID; LINSEED OIL; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG METABOLISM; FATTY ACID BLOOD LEVEL; FEMALE; FOOD COMPOSITION; HUMAN; LINSEED; LIPOPROTEIN BLOOD LEVEL; MALE; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE AGGREGATION; TRIACYLGLYCEROL BLOOD LEVEL; UNSPECIFIED SIDE EFFECT;

ADOLESCENT; ADULT; AGED; AGING; ALPHA-LINOLENIC ACID; BIOLOGICAL AVAILABILITY; DIET; DIETARY FATS; DOUBLE-BLIND METHOD; EICOSAPENTAENOIC ACID; FLAX; HUMANS; INTESTINAL ABSORPTION; MIDDLE AGED; PLANT PREPARATIONS; SEEDS; TRIGLYCERIDES; YOUNG ADULT;

EID: 70249122692     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2009.41     Document Type: Article

References (32)

1. Akabas SR, Deckelbaum RJ (2006). Summary of a workshop on n-3 fatty acids: Current status of recommendations and future directions. Am J Clin Nutr 83 (suppl), 1536S-1538S.
2. Allman MA, Pena NM, Pang D (1995). Supplementation with flaxseed oil versus sunflower oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur J Clin Nutr 49, 169-178.
3. Ander BP, Weber AR, Rampersad PP, Gilchrist JS, Pierce GN, Lukas A (2004). Dietary flaxseed protects against ventricular fibrillation induced by ischemia-reperfusion in normal and hypercholesterolemic rabbits. J Nutr 134, 3250-3256.
4. Arjmandi BH, Khan DA, Juma S, Drum ML, Venkatesh S, Sohn E et al. (1998). Whole flaxseed consumption lowers serum LDL-cholesterol and lipoprotein(a) concentrations in postmenopausal women. Nutr Res 18, 203-1214.
5. Arterburn LM, Hall EB, Oken H (2006). Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr 83 (suppl), 1467S-1476S.
6. Austria JA, Richard MN, Chahine MN, Edel AL, Malcolmson LJ, Dupasquier CMC et al. (2008). Bioavailability of alpha-linolenic acid in subjects after ingestion of three different forms of flaxseed. J Am Coll Nutr. 27, 214-221.
7. Cardinal DC, Flower RJ (1980). The electronic aggregometer: A novel device for assessing platelet behavior in blood. J Pharmacol Methods 3, 135-158.
8. Clark WF, Kortas C, Heidenheim AP, Garland J, Spanner E, Parbtani A (2001). Flaxseed in lupus nephritis: A two-year nonplacebo-controlled crossover study. J Am Coll Nutr 20, 143-148.
9. Clark WF, Parbtani A, Huff MW, Spanner E, De Saus H, Chin-Yee I et al. (1995). Flaxseed: A potential treatment for lupus nephritis. Kidney Int 48, 475-480.
10. Cunnane SC, Hamadeh MJ, Liede AC, Thompson LU, Wolever TM, Jenkins DJ (1995). Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr 61, 62-68.
11. de Lorgeril M, Renaud S, Mamelle N, Salen P, Martin JL, Monjaud I et al. (1994). Mediterranean á-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 343, 1454-1459.
12. de Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, Mamelle N (1999). Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: Final report of the Lyon Diet Heart Study. Circulation 99, 779-785.
13. Djoussé L, Hunt SC, Arnett DK, Province MA, Eckfeldt JH, Ellison RC (2003). Dietary linolenic acid is inversely associated with plasma triacylglycerol: The NHLBI Family Heart Study. Am J Clin Nutr 78, 1098-1102.
14. Dupasquier CMC, Dibrov E, Kneesh AL, Cheung PKM, Lee KGY, Alexander HK et al. (2007). Dietary flaxseed inhibits atherosclerosis in the LDL receptor deficient mouse in part through anti-proliferative and anti-inflammatory actions. Am J Physiol 293, H2394-H2402.
15. Dupasquier CM, Weber AM, Ander BP, Rampersad PP, Steigerwald S, Wigle JT et al. (2006). Effects of dietary flaxseed on vascular contractile function and atherosclerosis during prolonged hypercholesterolemia in rabbits. Am J Physiol Heart Circ Physiol 291, H2987-H2996.
16. Erkkilä AT, Lehto S, Pyörälä K, Uusitupa MIJ (2003). n-3 fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease. J Clin Nutr 78, 65-71.
17. Finnegan YE, Howarth D, Minihane AM, Kew S, Miller GJ, Calder FC et al. (2003). Plant and marine derived (n-3) polyunsaturated fatty acids do not affect blood coagulation and fibrinolytic factors in moderately hyperlipidemic humans. J Nutr 133, 2210-2213.
18. Finnegan YE, Minihane AM, Leigh-Firbank EC, Kew S, Meijer GW, Muggli R et al. (2003). Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. Am J Clin Nutr 77, 783-795.
19. Francois CA, Connor SL, Bolewicz LC, Connor WE (2003). Supplementing lactating women with flaxseed oil does not increase docosahexaenoic acid in their milk. Am J Clin Nutr 277, 226-233.
20. Freese R, Mutanen M (1997). Linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. Am J Clin Nutr 66, 591-598.
21. Goyens PL, Mensink RP (2006). Effects of alpha-linolenic acid versus those of EPA/DHA on cardiovascular risk markers in healthy elderly subjects. Eur J Clin Nutr 60, 978-984.
22. Harper CR, Edwards MJ, DeFilipis AP, Jacobson TA (2006a). Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. J Nutr 136, 83-87.
23. Harper CR, Edwards MC, Jacobson TA (2006b). Flaxseed oil supplementation does not affect lipoprotein concentration or particle size in human subjects. J Nutr 136, 2844-2848.
24. Kaul N, Kreml R, Austria JA, Landry MN, Edel AL, Dibrov E et al. (2008). A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 27, 51-58.
25. Kelly DS, Nelson JG, Love JE, Branch LB, Taylor PC, Schmidt PC et al. (1993). Dietary alpha-linolenic acid alters tissue fatty acid composition, but not blood lipids, lipoproteins or coagulation status in humans. Lipids 28, 533-537.
26. Lemay A, Dodin S, Kadri N, Jacques H, Forest JC (2002). Flaxseed dietary supplement versus hormone replacement therapy in hypercholesterolemic menopausal women. Obstet Gynecol 100, 495-504.
27. Metcalf RG, James MJ, Mantzioris E, Cleland LG (2003). A practical approach to increasing intakes of n-3 polyunsaturated fatty acids: Use of novel foods enriched with n-3 fats. Eur J Clin Nutr 57, 1605-1612.
28. Nestel PJ, Pomeroy SE, Sasahara T, Yamashita T, Liang YL, Dart AM et al. (1997). Arterial compliance in obese subjects is improved with dietary plant n-3 fatty acid from flaxseed oil despite increased LDL oxidizability. Arterioscler Thromb Vasc Biol 17, 1163-1170.
29. Rallidis LS, Paschos G, Liakos GK, Velissaridou AH, Anastasiadis G, Zampelas A (2003). Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. Atherosclerosis 167, 237-242.
30. Singer P, Berger I,Wirth M, GodickeW, JaegerW, Voigt S (1986). Slow desaturation and elongation of linoleic and alpha-linolenic acids as a rationale of eicosapentaenoic acid-rich diet to lower blood pressure and serum lipids in normal, hypertensive and hyperlipemic subjects. Prostaglandins Leukot Med 24, 173-193.
31. Wallace FA, Miles EA, Calder PC (2003). Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects. Br J Nutr 89, 679-689.
32. Zhao G, Etherton TD, Martin KR, West SG, Gillies PJ, Kris-Etherton PM (2004). Dietary alpha- linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women. J Nutr 134, 2991-2997.