Rapamycin reduces severity of senile osteoporosis by activating osteocyte autophagy

Osteoporosis International

Volumn 27, Issue 3, 2016, Pages 1093-1101

  Luo, D ^a   Ren, H ^b   Li, T ^a   Lian, K ^a   Lin, D ^a  

^a Digestive Endoscopy Center of Nanjing Military Command   (China)

^b THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

Author keywords

Autophagy; Male rats; Osteoporosis; Rapamycin

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; BECLIN 1; CASPASE 3; DIMETHYL SULFOXIDE; FLUOROCHROME; LC3 II; OSTEOCALCIN; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; RAPAMYCIN; ULK1 PROTEIN; UNCLASSIFIED DRUG; BONE DENSITY CONSERVATION AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; BONE DENSITY; BONE MICROSTRUCTURE; BONE STRUCTURE; BONE TURNOVER; CONTROLLED STUDY; DISEASE SEVERITY; IMMUNOHISTOCHEMISTRY; MALE; MICRO-COMPUTED TOMOGRAPHY; MINERAL APPOSITION RATE; MUSCULOSKELETAL SYSTEM PARAMETERS; NONHUMAN; OSTEOCLAST; OSTEOCYTE; OSTEOLYSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; SENILE OSTEOPOROSIS; TRABECULAR BONE; TUNEL ASSAY; WESTERN BLOTTING; ANIMAL; DIAGNOSTIC IMAGING; DRUG EFFECTS; HUMAN; LUMBAR VERTEBRA; OSTEOPOROSIS; PATHOLOGY; PATHOPHYSIOLOGY; PRECLINICAL STUDY; PROCEDURES; SPRAGUE DAWLEY RAT; TIBIA;

ANIMALS; APOPTOSIS; AUTOPHAGY; BONE DENSITY CONSERVATION AGENTS; DRUG EVALUATION, PRECLINICAL; HUMANS; LUMBAR VERTEBRAE; MALE; OSTEOCYTES; OSTEOPOROSIS; RATS, SPRAGUE-DAWLEY; SIROLIMUS; TIBIA; X-RAY MICROTOMOGRAPHY;

EID: 84959116094     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-015-3325-5     Document Type: Article

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