Antioxidant tert-butylhydroquinone ameliorates arsenic-induced intracellular damages and apoptosis through induction of Nrf2-dependent antioxidant responses as well as stabilization of anti-apoptotic factor Bcl-2 in human keratinocytes

Free Radical Biology and Medicine

Volumn 94, Issue , 2016, Pages 74-87

  Duan, Xiaoxu ^a   Li, Jinlong ^a   Li, Wei ^a,b   Xing, Xiaoyue ^a   Zhang, Yang ^a   Zhao, Lu ^a   Sun, Guifan ^a   Gao, Xing Hua ^a   Li, Bing ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b Maternal and Child Health Care Center of Cangzhou   (China)

Author keywords

Apoptosis; Arsenic; Bcl 2; Human keratinocytes; NRF2; Oxidative stress; tBHQ

Indexed keywords

ARSENIC; CASPASE 3; CATALASE; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYTOCHROME C; HEME OXYGENASE 1; NAD(P)H QUINONE OXIDOREDUCTASE 1; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SUPEROXIDE DISMUTASE; TERT BUTYLHYDROQUINONE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; 2-TERT-BUTYLHYDROQUINONE; ANTIOXIDANT; BAX PROTEIN, HUMAN; CDK4 PROTEIN, HUMAN; HMOX1 PROTEIN, HUMAN; HYDROQUINONE DERIVATIVE; NFE2L2 PROTEIN, HUMAN; NQO1 PROTEIN, HUMAN; PROTEIN BAX;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DEPOLARIZATION; ENZYME ACTIVITY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; KERATINOCYTE; LIPID PEROXIDATION; M PHASE CELL CYCLE CHECKPOINT; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; UPREGULATION; CELL SURVIVAL; DRUG EFFECTS; GENETICS; METABOLISM; MITOCHONDRION; OXIDATIVE STRESS; PATHOLOGY;

ANTIOXIDANTS; APOPTOSIS; ARSENIC; BCL-2-ASSOCIATED X PROTEIN; CATALASE; CELL SURVIVAL; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; CYTOPLASM; HEME OXYGENASE-1; HUMANS; HYDROQUINONES; KERATINOCYTES; MITOCHONDRIA; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

EID: 84959113081     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2016.02.009     Document Type: Article

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