메뉴 건너뛰기




Volumn 75, Issue 11, 2016, Pages 2022-2028

Antibodies to native and citrullinated RA33 (hnRNP A2/B1) challenge citrullination as the inciting principle underlying loss of tolerance in rheumatoid arthritis

Author keywords

Ant CCP; Autoantibodies; Rheumatoid Arthritis

Indexed keywords

AUTOANTIGEN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A2; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN B1; PROTEIN ANTIBODY; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; AUTOANTIBODY; CITRULLINE; CYCLIC CITRULLINATED PEPTIDE; CYCLOPEPTIDE; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN GROUP A B; HNRNP A2;

EID: 84959099710     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2015-208529     Document Type: Article
Times cited : (52)

References (40)
  • 1
    • 0031974911 scopus 로고    scopus 로고
    • Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies
    • Schellekens GA, de Jong BA, van den Hoogen FH, et al. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest 1998;101:273-81.
    • (1998) J Clin Invest , vol.101 , pp. 273-281
    • Schellekens, G.A.1    De Jong, B.A.2    Van Den Hoogen, F.H.3
  • 2
    • 84921813332 scopus 로고    scopus 로고
    • The multifactorial role of neutrophils in rheumatoid arthritis
    • Wright HL, Moots RJ, Edwards SW. The multifactorial role of neutrophils in rheumatoid arthritis. Nat Rev Rheumatol 2014;10:593-601.
    • (2014) Nat Rev Rheumatol , vol.10 , pp. 593-601
    • Wright, H.L.1    Moots, R.J.2    Edwards, S.W.3
  • 3
    • 1042290337 scopus 로고    scopus 로고
    • Specific autoantibodies precede the symptoms of rheumatoid arthritis: A study of serial measurements in blood donors
    • Nielen MM, van Schaardenburg D, Reesink HW, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: A study of serial measurements in blood donors. Arthritis Rheum 2004;50:380-6.
    • (2004) Arthritis Rheum , vol.50 , pp. 380-386
    • Nielen, M.M.1    Van Schaardenburg, D.2    Reesink, H.W.3
  • 4
    • 84855172814 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis
    • McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011;365:2205-19.
    • (2011) N Engl J Med , vol.365 , pp. 2205-2219
    • McInnes, I.B.1    Schett, G.2
  • 5
    • 0008614497 scopus 로고
    • Interaction of the rheumatoid factor with antigen-Antibody complexes and aggregated gamma globulin
    • Edelman GM, Kunkel HG, Franklin EC. Interaction of the rheumatoid factor with antigen-Antibody complexes and aggregated gamma globulin. J Exp Med 1958;108:105-20.
    • (1958) J Exp Med , vol.108 , pp. 105-120
    • Edelman, G.M.1    Kunkel, H.G.2    Franklin, E.C.3
  • 6
    • 0026669341 scopus 로고
    • Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex
    • Steiner G, Hartmuth K, Skriner K, et al. Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. J Clin Invest 1992;90:1061-6.
    • (1992) J Clin Invest , vol.90 , pp. 1061-1066
    • Steiner, G.1    Hartmuth, K.2    Skriner, K.3
  • 7
    • 0029093073 scopus 로고
    • Autoantibodies to calpastatin (an endogenous inhibitor for calcium-dependent neutral protease, calpain) in systemic rheumatic diseases
    • Mimori T, Suganuma K, Tanami Y, et al. Autoantibodies to calpastatin (an endogenous inhibitor for calcium-dependent neutral protease, calpain) in systemic rheumatic diseases. Proc Natl Acad Sci USA 1995;92:7267-71.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7267-7271
    • Mimori, T.1    Suganuma, K.2    Tanami, Y.3
  • 8
    • 0036199752 scopus 로고    scopus 로고
    • Autoantibody systems in rheumatoid arthritis: Specificity, sensitivity and diagnostic value
    • van Boekel MA, Vossenaar ER, van den Hoogen FH, et al. Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value. Arthritis Res 2002;4:87-93.
    • (2002) Arthritis Res , vol.4 , pp. 87-93
    • Van Boekel, M.A.1    Vossenaar, E.R.2    Van Den Hoogen, F.H.3
  • 9
    • 47249163722 scopus 로고    scopus 로고
    • Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis
    • Harris ML, Darrah E, Lam GK, et al. Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis. Arthritis Rheum 2008;58:1958-67.
    • (2008) Arthritis Rheum , vol.58 , pp. 1958-1967
    • Harris, M.L.1    Darrah, E.2    Lam, G.K.3
  • 10
    • 0034091322 scopus 로고    scopus 로고
    • The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide
    • Schellekens GA, Visser H, de Jong BA, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum 2000;43:155-63.
    • (2000) Arthritis Rheum , vol.43 , pp. 155-163
    • Schellekens, G.A.1    Visser, H.2    De Jong, B.A.3
  • 11
    • 73449110537 scopus 로고    scopus 로고
    • Autoantibody profiling in patients with very early rheumatoid arthritis: A follow-up study
    • Nell-Duxneuner V, Machold K, Stamm T, et al. Autoantibody profiling in patients with very early rheumatoid arthritis: A follow-up study. Ann Rheum Dis 2010;69:169-74.
    • (2010) Ann Rheum Dis , vol.69 , pp. 169-174
    • Nell-Duxneuner, V.1    Machold, K.2    Stamm, T.3
  • 12
    • 84878321478 scopus 로고    scopus 로고
    • Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity
    • Darrah E, Giles JT, Ols ML, et al. Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity. Sci Transl Med 2013;5:186ra65.
    • (2013) Sci Transl Med , vol.5 , pp. 186ra65
    • Darrah, E.1    Giles, J.T.2    Ols, M.L.3
  • 13
    • 84902661123 scopus 로고    scopus 로고
    • Association of cross-reactive antibodies targeting peptidyl-Arginine deiminase 3 and 4 with rheumatoid arthritis-Associated interstitial lung disease
    • Giles JT, Darrah E, Danoff S, et al. Association of cross-reactive antibodies targeting peptidyl-Arginine deiminase 3 and 4 with rheumatoid arthritis-Associated interstitial lung disease. PLoS ONE 2014;9:e98794.
    • (2014) PLoS ONE , vol.9 , pp. e98794
    • Giles, J.T.1    Darrah, E.2    Danoff, S.3
  • 14
    • 84918497151 scopus 로고    scopus 로고
    • The effects of rheumatoid factor and anticitrullinated peptide antibodies on bone erosions in rheumatoid arthritis
    • van Steenbergen HW, Ajeganova S, Forslind K, et al. The effects of rheumatoid factor and anticitrullinated peptide antibodies on bone erosions in rheumatoid arthritis. Ann Rheum Dis 2015;74:e3.
    • (2015) Ann Rheum Dis , vol.74 , pp. e3
    • Van Steenbergen, H.W.1    Ajeganova, S.2    Forslind, K.3
  • 15
    • 84901640926 scopus 로고    scopus 로고
    • Peptidylarginine deiminase 4 contributes to tumor necrosis factor alpha-induced inflammatory arthritis
    • Shelef MA, Sokolove J, Lahey LJ, et al. Peptidylarginine deiminase 4 contributes to tumor necrosis factor alpha-induced inflammatory arthritis. Arthritis Rheumatol 2014;66:1482-91.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 1482-1491
    • Shelef, M.A.1    Sokolove, J.2    Lahey, L.J.3
  • 16
    • 29144516274 scopus 로고    scopus 로고
    • Aberrant expression of the autoantigen heterogeneous nuclear ribonucleoprotein-A2 (RA33) and spontaneous formation of rheumatoid arthritis-Associated anti-RA33 autoantibodies in TNF-Alpha transgenic mice
    • Hayer S, Tohidast-Akrad M, Haralambous S, et al. Aberrant expression of the autoantigen heterogeneous nuclear ribonucleoprotein-A2 (RA33) and spontaneous formation of rheumatoid arthritis-Associated anti-RA33 autoantibodies in TNF-Alpha transgenic mice. J Immunol 2005;175:8327-36.
    • (2005) J Immunol , vol.175 , pp. 8327-8336
    • Hayer, S.1    Tohidast-Akrad, M.2    Haralambous, S.3
  • 17
    • 38849099736 scopus 로고    scopus 로고
    • The rheumatoid arthritis-Associated autoantigen hnRNP-A2 (RA33) is a major stimulator of autoimmunity in rats with pristane-induced arthritis
    • Hoffmann MH, Tuncel J, Skriner K, et al. The rheumatoid arthritis-Associated autoantigen hnRNP-A2 (RA33) is a major stimulator of autoimmunity in rats with pristane-induced arthritis. J Immunol 2007;179:7568-76.
    • (2007) J Immunol , vol.179 , pp. 7568-7576
    • Hoffmann, M.H.1    Tuncel, J.2    Skriner, K.3
  • 18
    • 84907412964 scopus 로고    scopus 로고
    • Insights into the significance of peptidylarginine deiminase 4 and antibodies against citrullinated antigens in the absence of "true ACPAs an experimental model of arthritis: Comment on the article by Shelef et al
    • Konig MF, Darrah E, Andrade F. Insights into the significance of peptidylarginine deiminase 4 and antibodies against citrullinated antigens in the absence of "true ACPAs" in an experimental model of arthritis: comment on the article by Shelef et al. Arthritis Rheumatol 2014;66:2642-4.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 2642-2644
    • Konig, M.F.1    Darrah, E.2    Andrade, F.3
  • 19
    • 84926686349 scopus 로고    scopus 로고
    • Anticarbamylated protein antibodies can be detected in animal models of arthritis that require active involvement of the adaptive immune system
    • Stoop JN, Fischer A, Hayer S, et al. Anticarbamylated protein antibodies can be detected in animal models of arthritis that require active involvement of the adaptive immune system. Ann Rheum Dis 2015;74:949-50.
    • (2015) Ann Rheum Dis , vol.74 , pp. 949-950
    • Stoop, J.N.1    Fischer, A.2    Hayer, S.3
  • 21
    • 63849105627 scopus 로고    scopus 로고
    • Coronary arterial calcification in rheumatoid arthritis: Comparison with the Multi-Ethnic Study of Atherosclerosis
    • Giles JT, Szklo M, Post W, et al. Coronary arterial calcification in rheumatoid arthritis: comparison with the Multi-Ethnic Study of Atherosclerosis. Arthritis Res Ther 2009;11:R36.
    • (2009) Arthritis Res Ther , vol.11 , pp. R36
    • Giles, J.T.1    Szklo, M.2    Post, W.3
  • 22
    • 84933685184 scopus 로고    scopus 로고
    • Defining the role of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) in rheumatoid arthritis through the study of PPAD biology
    • Konig MF, Paracha AS, Moni M, et al. Defining the role of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) in rheumatoid arthritis through the study of PPAD biology. Ann Rheum Dis 2015;74:2054-61.
    • (2015) Ann Rheum Dis , vol.74 , pp. 2054-2061
    • Konig, M.F.1    Paracha, A.S.2    Moni, M.3
  • 23
    • 0024825945 scopus 로고
    • Demonstration of a new antinuclear antibody (anti-RA33) that is highly specific for rheumatoid arthritis
    • Hassfeld W, Steiner G, Hartmuth K, et al. Demonstration of a new antinuclear antibody (anti-RA33) that is highly specific for rheumatoid arthritis. Arthritis Rheum 1989;32:1515-20.
    • (1989) Arthritis Rheum , vol.32 , pp. 1515-1520
    • Hassfeld, W.1    Steiner, G.2    Hartmuth, K.3
  • 24
    • 84855259722 scopus 로고    scopus 로고
    • Heterogeneous nuclear RNPs as targets of autoantibodies in systemic rheumatic diseases
    • Op De Beéck K, Maes L, Van den Bergh K, et al. Heterogeneous nuclear RNPs as targets of autoantibodies in systemic rheumatic diseases. Arthritis Rheum 2012;64:213-21.
    • (2012) Arthritis Rheum , vol.64 , pp. 213-221
    • Op De Beéck, K.1    Maes, L.2    Van Den Bergh, K.3
  • 25
    • 84901772776 scopus 로고    scopus 로고
    • Anti-hnRNP B1 (RA33) autoantibodies are associated with the clinical phenotype in Russian patients with rheumatoid arthritis and systemic sclerosis
    • Maslyanskiy A, Lazareva N, Olinek P, et al. Anti-hnRNP B1 (RA33) autoantibodies are associated with the clinical phenotype in Russian patients with rheumatoid arthritis and systemic sclerosis. J Immunol Res 2014;2014:516593.
    • (2014) J Immunol Res 2014 , pp. 516593
    • Maslyanskiy, A.1    Lazareva, N.2    Olinek, P.3
  • 26
    • 84902105413 scopus 로고    scopus 로고
    • Assessing the citrullinome in rheumatoid arthritis synovial fluid with and without enrichment of citrullinated peptides
    • Tutturen AE, Fleckenstein B, de Souza GA. Assessing the citrullinome in rheumatoid arthritis synovial fluid with and without enrichment of citrullinated peptides. J Proteome Res 2014;13:2867-73.
    • (2014) J Proteome Res , vol.13 , pp. 2867-2873
    • Tutturen, A.E.1    Fleckenstein, B.2    De Souza, G.A.3
  • 27
    • 84940109040 scopus 로고    scopus 로고
    • Inhibition of inflammation and bone erosion by RNA Interference-mediated silencing of heterogeneous nuclear RNP A2/B1 in Two experimental models of rheumatoid arthritis
    • Herman S, Fischer A, Presumey J, et al. Inhibition of Inflammation and Bone Erosion by RNA Interference-Mediated Silencing of Heterogeneous Nuclear RNP A2/B1 in Two Experimental Models of Rheumatoid Arthritis. Arthritis Rheumatol 2015;67:2536-46.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 2536-2546
    • Herman, S.1    Fischer, A.2    Presumey, J.3
  • 28
    • 77954755277 scopus 로고    scopus 로고
    • Differential subcellular distributions and trafficking functions of hnRNP A2/B1 spliceoforms
    • Han SP, Friend LR, Carson JH, et al. Differential subcellular distributions and trafficking functions of hnRNP A2/B1 spliceoforms. Traffic 2010;11:886-98.
    • (2010) Traffic , vol.11 , pp. 886-898
    • Han, S.P.1    Friend, L.R.2    Carson, J.H.3
  • 29
    • 0036095626 scopus 로고    scopus 로고
    • Presence of autoantibodies to the glycolytic enzyme alpha-enolase in sera from patients with early rheumatoid arthritis
    • Saulot V, Vittecoq O, Charlionet R, et al. Presence of autoantibodies to the glycolytic enzyme alpha-enolase in sera from patients with early rheumatoid arthritis. Arthritis Rheum 2002;46:1196-201.
    • (2002) Arthritis Rheum , vol.46 , pp. 1196-1201
    • Saulot, V.1    Vittecoq, O.2    Charlionet, R.3
  • 30
    • 0028275351 scopus 로고
    • The Sa system: A novel antigen-Antibody system specific for rheumatoid arthritis
    • Després N, Boire G, Lopez-Longo FJ, et al. The Sa system: A novel antigen-Antibody system specific for rheumatoid arthritis. J Rheumatol 1994;21:1027-33.
    • (1994) J Rheumatol , vol.21 , pp. 1027-1033
    • Després, N.1    Boire, G.2    Lopez-Longo, F.J.3
  • 31
    • 0025119609 scopus 로고
    • Specificity of antibodies to type II collagen in rheumatoid arthritis
    • Terato K, Shimozuru Y, Katayama K, et al. Specificity of antibodies to type II collagen in rheumatoid arthritis. Arthritis Rheum 1990;33:1493-500.
    • (1990) Arthritis Rheum , vol.33 , pp. 1493-1500
    • Terato, K.1    Shimozuru, Y.2    Katayama, K.3
  • 32
    • 0036870572 scopus 로고    scopus 로고
    • Autoantibodies against cytoskeletal proteins in rheumatoid arthritis
    • Shrivastav M, Mittal B, Aggarwal A, et al. Autoantibodies against cytoskeletal proteins in rheumatoid arthritis. Clin Rheumatol 2002;21:505-10.
    • (2002) Clin Rheumatol , vol.21 , pp. 505-510
    • Shrivastav, M.1    Mittal, B.2    Aggarwal, A.3
  • 33
    • 80054806901 scopus 로고    scopus 로고
    • Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage
    • Shi J, Knevel R, Suwannalai P, et al. Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage. Proc Natl Acad Sci USA 2011;108:17372-7.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 17372-17377
    • Shi, J.1    Knevel, R.2    Suwannalai, P.3
  • 34
    • 84923622074 scopus 로고    scopus 로고
    • Editorial: Citrullination, and carbamylation, and malondialdehyde-Acetaldehyde! Oh my! Entering the forest of autoantigen modifications in rheumatoid arthritis
    • Darrah E, Andrade F. Editorial: citrullination, and carbamylation, and malondialdehyde-Acetaldehyde! Oh my! Entering the forest of autoantigen modifications in rheumatoid arthritis. Arthritis Rheumatol 2015;67:604-8.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 604-608
    • Darrah, E.1    Andrade, F.2
  • 35
    • 84902249788 scopus 로고    scopus 로고
    • The autoantibody repertoire in periodontitis: A role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis? Antibodies against uncitrullinated peptides seem to occur prior to the antibodies to the corresponding citrullinated peptides
    • Brink M, Hansson M, Rönnelid J, et al. The autoantibody repertoire in periodontitis: A role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis? Antibodies against uncitrullinated peptides seem to occur prior to the antibodies to the corresponding citrullinated peptides. Ann Rheum Dis 2014;73: e46.
    • (2014) Ann Rheum Dis , vol.73 , pp. e46
    • Brink, M.1    Hansson, M.2    Rönnelid, J.3
  • 36
    • 84893735642 scopus 로고    scopus 로고
    • The autoantibody repertoire in periodontitis: A role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis?
    • de Pablo P, Dietrich T, Chapple IL, et al. The autoantibody repertoire in periodontitis: A role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis? Ann Rheum Dis 2014;73:580-6.
    • (2014) Ann Rheum Dis , vol.73 , pp. 580-586
    • De Pablo, P.1    Dietrich, T.2    Chapple, I.L.3
  • 37
    • 84940118292 scopus 로고    scopus 로고
    • Bronchiectasis is a model for chronic bacterial infection inducing Autoimmunity in Rheumatoid Arthritis
    • Quirke AM, Perry E, Cartwright A, et al. Bronchiectasis is a Model for Chronic Bacterial Infection Inducing Autoimmunity in Rheumatoid Arthritis. Arthritis Rheumatol 2015;67:2335-42.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 2335-2342
    • Quirke, A.M.1    Perry, E.2    Cartwright, A.3
  • 38
    • 84890017303 scopus 로고    scopus 로고
    • Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis
    • Romero V, Fert-Bober J, Nigrovic PA, et al. Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis. Sci Transl Med 2013;5:209ra150.
    • (2013) Sci Transl Med , vol.5 , pp. 209ra150
    • Romero, V.1    Fert-Bober, J.2    Nigrovic, P.A.3
  • 39
    • 84861465962 scopus 로고    scopus 로고
    • Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis
    • Sokolove J, Bromberg R, Deane KD, et al. Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis. PLoS ONE 2012;7: e35296.
    • (2012) PLoS ONE , vol.7 , pp. e35296
    • Sokolove, J.1    Bromberg, R.2    Deane, K.D.3
  • 40
    • 84922347461 scopus 로고    scopus 로고
    • Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: Association with cigarette smoking and HLA-DRB1 shared epitope alleles
    • Wagner CA, Sokolove J, Lahey LJ, et al. Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: Association with cigarette smoking and HLA-DRB1 shared epitope alleles. Ann Rheum Dis 2015;74:579-86.
    • (2015) Ann Rheum Dis , vol.74 , pp. 579-586
    • Wagner, C.A.1    Sokolove, J.2    Lahey, L.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.