Inhibition of inflammation and bone erosion by RNA interference-mediated silencing of heterogeneous nuclear RNP A2/B1 in two experimental models of rheumatoid arthritis

Arthritis and Rheumatology

Volumn 67, Issue 9, 2015, Pages 2536-2546

  Herman, Sonja ^a   Fischer, Anita ^a   Presumey, Jessy ^b   Hoffmann, Markus ^a   Koenders, Marije I ^c   Escriou, Virginie ^d   Apparailly, Florence ^b   Steiner, Guenter ^e  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MONTPELLIER UNIVERSITY HOSPITAL   (France)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d INSERM   (France)

^e Ludwig Boltzmann Institut of Health Technology Assessment   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; COLLAGEN ANTIBODY; COLLAGEN TYPE 2; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A2; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; LIPOSOME; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTOANTIBODY; CYTOKINE; HNRNP A2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ARTICLE; BONE EROSION; CELL COUNT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL MODEL; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INNATE IMMUNITY; INTERFERON GAMMA RELEASE ASSAY; LYMPHOID ORGAN; MACROPHAGE; MONOCYTE; MONONUCLEAR PHAGOCYTE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; OSTEOCLAST; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; RNA INTERFERENCE; SYNOVIOCYTE; WESTERN BLOTTING; ANIMAL; DISEASE MODEL; EXPERIMENTAL ARTHRITIS; GENETICS; IMMUNOLOGY; INFLAMMATION; MACROPHAGE ACTIVATION; T LYMPHOCYTE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; CYTOKINES; DISEASE MODELS, ANIMAL; GENE SILENCING; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN GROUP A-B; INFLAMMATION; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MONOCYTES; RNA INTERFERENCE; T-LYMPHOCYTES;

EID: 84940109040     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.39223     Document Type: Article

References (34)

1. Klareskog L, Catrina AI, Paget S., Rheumatoid arthritis. Lancet 2009; 373: 659-72.
2. McInnes IB, O'Dell JR., State-of-the-art: rheumatoid arthritis. Ann Rheum Dis 2010; 69: 1898-906.
3. Smolen JS, Aletaha D, Redlich K., The pathogenesis of rheumatoid arthritis: new insights from old clinical data? Nat Rev Rheumatol 2012; 8: 235-43.
4. Redlich K, Smolen JS., Inflammatory bone loss: pathogenesis and therapeutic intervention. Nat Rev Drug Dis 2012; 11: 234-50.
5. Schett G, Gravallese E., Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment. Nat Rev Rheumatol 2012; 8: 656-64.
6. Klareskog L, Ronnelid J, Lundberg K, Padyukov L, Alfredsson L., Immunity to citrullinated proteins in rheumatoid arthritis. Annu Rev Immunol 2008; 26: 651-75.
7. Willemze A, Trouw LA, Toes RE, Huizinga TW., The influence of ACPA status and characteristics on the course of RA. Nat Rev Rheumatol 2012; 8: 144-52.
8. Steiner G., Auto-antibodies and autoreactive T-cells in rheumatoid arthritis: pathogenetic players and diagnostic tools. Clin Rev Allergy Immunol 2007; 32: 23-36.
9. Han SP, Tang YH, Smith R., Functional diversity of the hnRNPs: past, present and perspectives. Biochem J 2010; 430: 379-92.
10. Nell VP, Machold KP, Stamm TA, Eberl G, Heinzl H, Uffmann M, et al., Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis. Ann Rheum Dis 2005; 64: 1731-6.
11. Hoffmann MH, Trembleau S, Muller S, Steiner G., Nucleic acid-associated autoantigens: pathogenic involvement and therapeutic potential. J Autoimmun 2010; 34: 178-206.
12. Fritsch R, Eselbock D, Skriner K, Jahn-Schmid B, Scheinecker C, Bohle B, et al., Characterization of autoreactive T cells to the autoantigens heterogeneous nuclear ribonucleoprotein A2 (RA33) and filaggrin in patients with rheumatoid arthritis. J Immunol 2002; 169: 1068-76.
13. Trembleau S, Hoffmann M, Meyer B, Nell V, Radner H, Zauner W, et al., Immunodominant T-cell epitopes of hnRNP-A2 associated with disease activity in patients with rheumatoid arthritis. Eur J Immunol 2010; 40: 1795-808.
14. Hayer S, Tohidast-Akrad M, Haralambous S, Jahn-Schmid B, Skriner K, Trembleau S, et al., Aberrant expression of the autoantigen heterogeneous nuclear ribonucleoprotein-A2 (RA33) and spontaneous formation of rheumatoid arthritis-associated anti-RA33 autoantibodies in TNF-α transgenic mice. J Immunol 2005; 175: 8327-36.
15. Hoffmann MH, Tuncel J, Skriner K, Tohidast-Akrad M, Turk B, Pinol-Roma S, et al., The rheumatoid arthritis-associated autoantigen hnRNP-A2 (RA33) is a major stimulator of autoimmunity in rats with pristane-induced arthritis. J Immunol 2007; 179: 7568-76.
16. Hoffmann MH, Skriner K, Herman S, Baumann C, Steiner CW, Ospelt C, et al., Nucleic acid-stimulated antigen-presenting cells trigger T cells to induce disease in a rat transfer model of inflammatory arthritis. J Autoimmun 2011; 36: 288-300.
17. Khoury M, Escriou V, Courties G, Galy A, Yao R, Largeau C, et al., Efficient suppression of murine arthritis by combined anticytokine small interfering RNA lipoplexes. Arthritis Rheum 2008; 58: 2356-67.
18. Khoury M, Louis-Plence P, Escriou V, Noel D, Largeau C, Cantos C, et al., Efficient new cationic liposome formulation for systemic delivery of small interfering RNA silencing tumor necrosis factor α in experimental arthritis. Arthritis Rheum 2006; 54: 1867-77.
19. Bluml S, Bonelli M, Niederreiter B, Puchner A, Mayr G, Hayer S, et al., Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice. Arthritis Rheum 2011; 63: 1281-8.
20. Redlich K, Hayer S, Ricci R, David JP, Tohidast-Akrad M, Kollias G, et al., Osteoclasts are essential for TNF-α-mediated joint destruction. J Clin Invest 2002; 110: 1419-27.
21. Presumey J, Courties G, Louis-Plence P, Escriou V, Scherman D, Pers YM, et al., Nicotinamide phosphoribosyltransferase/visfatin expression by inflammatory monocytes mediates arthritis pathogenesis. Ann Rheum Dis 2013; 72: 1717-24.
22. Courties G, Seiffart V, Presumey J, Escriou V, Scherman D, Zwerina J, et al., In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cells. Blood 2010; 116: 3505-16.
23. Kyburz D, Corr M., The KRN mouse model of inflammatory arthritis. Springer Sem in Immunopathol 2003; 25: 79-90.
24. Monach PA, Mathis D, Benoist C., The K/BxN arthritis model. Curr Protoc Immunol 2008;Chapter 15:Unit 15.22.
25. He Y, Rothnagel JA, Epis MR, Leedman PJ, Smith R., Downstream targets of heterogeneous nuclear ribonucleoprotein A2 mediate cell proliferation. Mol Carcinog 2009; 48: 167-79.
26. He Y, Brown MA, Rothnagel JA, Saunders NA, Smith R., Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation. J Cell Sci 2005; 118: 3173-83.
27. Fielding P, Turnbull L, Prime W, Walshaw M, Field JK., Heterogeneous nuclear ribonucleoprotein A2/B1 up-regulation in bronchial lavage specimens: a clinical marker of early lung cancer detection. Clin Cancer Res 1999; 5: 4048-52.
28. Pino I, Pio R, Toledo G, Zabalegui N, Vicent S, Rey N, et al., Altered patterns of expression of members of the heterogeneous nuclear ribonucleoprotein (hnRNP) family in lung cancer. Lung Cancer 2003; 41: 131-43.
29. Carpenter B, MacKay C, Alnabulsi A, MacKay M, Telfer C, Melvin WT, et al., The roles of heterogeneous nuclear ribonucleoproteins in tumour development and progression. Biochim Biophys Acta 2006; 1765: 85-100.
30. Rambaruth ND, Greenwell P, Dwek MV., The lectin Helix pomatia agglutinin recognizes O-GlcNAc containing glycoproteins in human breast cancer. Glycobiology 2012; 22: 839-48.
31. Guha M, Tang W, Sondheimer N, Avadhani NG., Role of calcineurin, hnRNP A2 and Akt in mitochondrial respiratory stress-mediated transcription activation of nuclear gene targets. Biochim Biophys Acta 2010; 1797: 1055-65.
32. Guha M, Fang JK, Monks R, Birnbaum MJ, Avadhani NG., Activation of Akt is essential for the propagation of mitochondrial respiratory stress signaling and activation of the transcriptional coactivator heterogeneous ribonucleoprotein A2. Mol Biol Cell 2010; 21: 3578-89.
33. Cloonan SM, Choi AM., Mitochondria: commanders of innate immunity and disease? Curr Opin Immunol 2012; 24: 32-40.
34. Shilo A, Ben Hur V, Denichenko P, Stein I, Pikarsky E, Rauch J, et al., Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development. RNA 2014; 20: 505-15.