Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis

Science Translational Medicine

Volumn 5, Issue 209, 2013, Pages

  Romero, Violeta ^a   Fert Bober, Justyna ^a   Nigrovic, Peter A ^b,c,d   Darrah, Erika ^a   Haque, Uzma J ^a   Lee, David M ^b,e   Van Eyk, Jennifer ^a   Rosen, Antony ^a   Andrade, Felipe ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Immunology and Allergy   (Canada)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CASPASE 3; CD14 ANTIGEN; CITRULLINATED AUTOANTIGEN; COMPLEMENT COMPONENT C9; COMPLEMENT MEMBRANE ATTACK COMPLEX; GRANZYME B; MYELOBLASTIN; PERFORIN; PROTEIN ARGININE DEIMINASE; PROTEIN BID; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL MEDIATED CYTOTOXICITY; CELLULAR HYPERCITRULLINATION; CLINICAL ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; MEMBRANOLYSIS; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN PROCESSING; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID;

APOPTOSIS; ARTHRITIS, RHEUMATOID; AUTOANTIGENS; CELLS, CULTURED; CITRULLINE; COMPLEMENT ACTIVATION; COMPLEMENT MEMBRANE ATTACK COMPLEX; GRANZYMES; HUMANS; NEUTROPHILS; SYNOVIAL FLUID;

EID: 84890017303     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3006869     Document Type: Article

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