Insights into the significance of peptidylarginine deiminase 4 and antibodies against citrullinated antigens in the absence of "true ACPAs" in an experimental model of arthritis: Comment on the article by Shelef et al

Arthritis and Rheumatology

Volumn 66, Issue 9, 2014, Pages 2642-2644

  Konig, Maximilian F ^a   Darrah, Erika ^a   Andrade, Felipe ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; HISTONE H2B; IMMUNOGLOBULIN G; PEPTIDYLARGININE DEIMINASE 4; PROTEIN ARGININE DEIMINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIMENTIN;

ANTIBODY SPECIFICITY; ARTHRITIS; DISEASE COURSE; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; LETTER; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ARTHRITIS, EXPERIMENTAL; HYDROLASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84907412964     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38719     Document Type: Letter

References (5)

1. Shelef MA, Sokolove J, Lahey LJ, Wagner CA, Sackmann EK, Warner TF, et al. Peptidylarginine deiminase 4 contributes to tumor necrosis factor α-induced inflammatory arthritis. Arthritis Rheumatol 2014;66:1482-91.
2. Hoffmann M, Hayer S, Steiner G. Immmunopathogenesis of rheumatoid arthritis: induction of arthritogenic autoimmune responses by proinflammatory stimuli. Ann N Y Acad Sci 2009;1173:391-400.
3. Hayer S, Tohidast-Akrad M, Haralambous S, Jahn-Schmid B, Skriner K, Trembleau S, et al. Aberrant expression of the autoantigen heterogeneous nuclear ribonucleoprotein-A2 (RA33) and spontaneous formation of rheumatoid arthritis-associated anti-RA33 autoantibodies in TNF-α transgenic mice. J Immunol 2005;175:8327-36. (Pubitemid 41798399)
4. Cantaert T, Teitsma C, Tak PP, Baeten D. Presence and role of anti-citrullinated protein antibodies in experimental arthritis models. Arthritis Rheum 2013;65:939-48.
5. Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest 1998;101:273-81. (Pubitemid 28058927)