Formulation, physicochemical characterization and stability study of lithium-loaded microemulsion system

International Journal of Pharmaceutics

Volumn 502, Issue 1-2, 2016, Pages 117-124

  Mouri, Abdelkader ^a,c   Legrand, Philippe ^a   Ghzaoui, Abdeslam El ^b   Dorandeu, Christophe ^a   Maurel, Jean Claude ^c   Devoisselle, Jean Marie ^a  

^a INSTITUT CHARLES GERHARDT   (France)

^b UNIVERSITÉ DE MONTPELLIER   (France)

^c Medesis Pharma   (France)

Author keywords

Binding process; Lecithin; Lithium; Phase diagram; W O microemulsion

Indexed keywords

ALCOHOL; LITHIUM ION; PHOSPHATIDYLCHOLINE; WATER; CITRIC ACID; EMULSION; EXCIPIENT; LITHIUM CITRATE; OLEIC ACID; PECEOL;

ARTICLE; CENTRIFUGATION; CONDUCTANCE; CONDUCTOMETRY; DRUG FORMULATION; DRUG STABILITY; ELECTRIC CONDUCTIVITY; FLOW KINETICS; MICROEMULSION; MICROSCOPY; PHYSICAL CHEMISTRY; POTENTIOMETRIC TITRATION; PRIORITY JOURNAL; SHEAR RATE; SHEAR STRESS; VISCOSITY; CHEMISTRY; EMULSION; MEDICINAL CHEMISTRY; SOLUBILITY;

CHEMISTRY, PHARMACEUTICAL; CITRATES; DRUG STABILITY; EMULSIONS; ETHANOL; EXCIPIENTS; LECITHINS; OLEIC ACIDS; SOLUBILITY; WATER;

EID: 84959091457     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2016.01.072     Document Type: Article

References (67)

1. P. Abhang, and et al. Transmucosal drug delivery - an overview Drug Deliv. Lett. 4 1 2014 26 37
2. V.K. Bansal, D.O. Shah, and J.P. O'Connell Influence of alkyl chain length compatibility on microemulsion structure and solubilization J. Colloid Interface Sci. 75 2 1980 462 475
3. R. Bartucci, N. Gulfo, and L. Sportelli Effect of high electrolyte concentration on the phase transition behaviour of DPPC vesicles: A spin label study Biochimica et Biophysica Acta (BBA)-Biomembranes 1025 2 1990 117 121
4. H. Binder, and O. Zschornig The effect of metal cations on the phase behavior and hydration characteristics of phospholipid membranes Chem. Phys. Lipids 115 1-2 2002 39 61
5. J.E. Bowcott, and J.H. Schulman Emulsions control of droplet size and phase continuity in transparent oil?water dispersions stabilized with soap and alcohol Zeitschrift für Elektrochemie, Berichte der Bunsengesellschaft für physikalische Chemie 59 1955 283 290
6. A. Bumajdad, and J. Eastoe Conductivity of water-in-oil microemulsions stabilized by mixed surfactants J. Colloid Interface Sci. 274 1 2004 268 276
7. H.L. Casal, and et al. Infrared studies of fully hydrated unsaturated phosphatidylserine bilayers. Effect of lithium and calcium Biochemistry 26 23 1987 7395 7401
8. H.L. Casal, H.H. Mantsch, and H. Hauser Infrared studies of fully hydrated saturated phosphatidylserine bilayers. Effect of lithium and calcium Biochemistry 26 14 1987 4408 4416
9. R.-W. Chen, and D.-M. Chuang Long term lithium treatment suppresses p53 and bax expression but increases bcl-2 expression: A prominent role in neuroprotection against excitotoxicity J. Biol. Chem. 274 10 1999 6039 6042
10. C.-T. Chiu, and D.-M. Chuang Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders Pharmacol. Ther. 128 2 2010 281 304
11. C.-T. Chiu, and et al. Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder Pharmacol. Rev. 65 1 2013 105 142
12. G.N. Christodoulou, A. Siafakas, and P.M. Rinieris Side-effects of lithium Acta Psychiatr. Belg. 77 2 1977 260 266
13. D.-M. Chuang, and et al. Neuroprotective effects of lithium in cultured cells and animal models of diseases Bipolar Disord. 4 2 2002 129 136
14. A. Cordomi, O. Edholm, and J.J. Perez Effect of ions on a dipalmitoyl phosphatidylcholine bilayer. a molecular dynamics simulation study J. Phys. Chem. B 112 5 2008 1397 1408
15. T. Cserhati, and M. Szogyi Interaction between phospholipids and monovalent cations studied by a new thin-layer chromatographic method Chem. Phys. Lipids 34 1 1983 93 99
16. J.M. Di Meglio, M. Dvolaitzky, and C. Taupin Determination of the rigidity constant of the amphiphilic film in birefringent microemulsions; the role of the cosurfactant J. Phys. Chem. 89 5 1985 871 874
17. B.S. Diniz, R. Machado-Vieira, and O.V. Forlenza Lithium and neuroprotection: translational evidence and implications for the treatment of neuropsychiatric disorders Neuropsychiatr. Dis. Treat. 9 2013 493 500
18. L. Djekic, and et al. Investigation of surfactant/cosurfactant synergism impact on ibuprofen solubilization capacity and drug release characteristics of nonionic microemulsions Int. J. Pharm. 433 1-2 2012 25 33
19. B. Ehrlich, and J. Diamond Lithium, membranes, and manic-depressive illness J. Membr. Biol. 52 3 1980 187 200
20. M. Fanun Colloids in Drug Delivery 2010 Taylor and Francis New York
21. S. Garcia-Manyes, G. Oncins, and F. Sanz Effect of ion-Binding and chemical phospholipid structure on the nanomechanics of lipid bilayers studied by force spectroscopy Biophys. J. 89 3 2005 1812 1826
22. S. Gershon, B. Shopsin, and N. Kline A narrative account of lithium usage in psychiatry Lithium 1973 Springer US 5 13
23. M. Giustini, S. Murgia, and G. Palazzo Does the schulman's titration of microemulsions really provide meaningful parameters? Langmuir 20 18 2004 7381 7384
24. A. Gomez-Puyou Biomolecules in Organic Solvents 1992 CRC press
25. R. Hashimoto, and et al. Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: An essential step for neuroprotection against glutamate excitotoxicity Neuropharmacology 43 7 2002 1173 1179
26. V. Hearnden, and et al. New developments and opportunities in oral mucosal drug delivery for local and systemic disease Adv. Drug Deliv. Rev. 64 1 2012 16 28
27. J. Hestbech, and et al. Chronic renal lesions following long-term treatment with lithium Kidney Int. 12 3 1977 205 213
28. J.N. Israelachvili, D.J. Mitchell, and B.W. Ninham Theory of self-assembly of hydrocarbon amphiphiles into micelles and bilayers J. Chem. Soc. Faraday Trans. 2 72 1976 1525 1568
29. F.N. Johnson, and P. Mannisto Endocrine Side-Effects of Lithium, in Handbook of Lithium Therapy 1980 Springer Netherlands 310 322
30. J. Kane, and et al. Extrapyramidal side effects with lithium treatment Am. J. Psychiatry 135 7 1978 851 853
31. B. Klasczyk, and et al. Interactions of alkali metal chlorides with phosphatidylcholine vesicles Langmuir 26 24 2010 18951 18958
32. M.L. Klossek, and et al. The extension of microemulsion regions by combining ethanol with other cosurfactants Colloids Surf. A 427 0 2013 95 100
33. J.J. Lopez Cascales, and J. Garcia de la Torre Effect of lithium and sodium ions on a charged membrane of dipalmitoylphosphatidylserine: A study by molecular dynamics simulation Biochimica et Biophysica Acta (BBA)-Biomembranes 1330 2 1997 145 156
34. F. Marmol Lithium: bipolar disorder and neurodegenerative diseases possible cellular mechanisms of the therapeutic effects of lithium Prog. Neuropsychopharmacol. Biol. Psychiatry 32 2008 1761 1771
35. J.C. Maurel U.S. Patent No. 20130052279 2013 U.S. Patent and Trademark Office Washington, DC 2013
36. J.C. Maurel U.S. Patent No. 20130065944 2013 U.S. Patent and Trademark Office Washington, DC 2013
37. R.F. McKnight, and et al. Lithium toxicity profile: A systematic review and meta-analysis Lancet 379 9817 2012 721 728
38. D.G. Moscovich Lithium neurotoxicity at normal therapeutic levels Br. J. Psychiatry 163 1993 410 412
39. ® J. Colloid Interface Sci. 416 0 2014 139 146
40. ®, lecithin and ethanol Int. J. Pharm. 475 1-2 2014 324 334
41. A.S. Narang, D. Delmarre, and D. Gao Stable drug encapsulation in micelles and microemulsions Int. J. Pharm. 345 1-2 2007 9 25
42. S. Nonaka, and D.-M. Chuang Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats Neuroreport 9 9 1998 2081 2084
43. P.W. Oakley, I.M. Whyte, and G.L. Carter Lithium toxicity: An iatrogenic problem in susceptible individuals Aust. N. Z. J. Psychiatry 35 6 2001 833 840
44. V. Papadimitriou, T.G. Sotiroudis, and A. Xenakis Olive oil microemulsions: enzymatic activities and structural characteristics Langmuir 23 4 2007 2071 2077
45. A. Petelska, and Z. Figaszewski The equilibria between monovalent ions and phosphatidylcholine monolayer at the air/water interface J. Membr. Biol. 246 6 2013 467 471
46. Y.K. Pithapurwala, and D.O. Shah Interfacial composition of microemulsions: modified schulman-Bowcott model Chem. Eng. Commun. 29 1-6 1984 101 112
47. M.A. Pouladi, and et al. NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease Neurobiol. Dis. 48 3 2012 282 289
48. C.O. Rangel-Yagui, A. Pessoa Jr., and L.C. Tavares Micellar solubilization of drugs J. Pharm. Pharm. Sci. 8 2 2005 147 165
49. Rappolt Michael, and et al. L α-phase separation in phosphatidylcholine-water systems induced by alkali chlorides Biochimica et Biophysica Acta (BBA)-Biomembranes 1372 2 1998 389 393
50. M. Roux, and M. Bloom Calcium, magnesium, lithium, sodium, and potassium distributions in the headgroup region of binary membranes of phosphatidylcholine and phosphatidylserine as seen by deuterium NMR Biochemistry 29 30 1990 7077 7089
51. M.K. Rowe, and D.-M. Chuang Lithium neuroprotection: molecular mechanisms and clinical implications Expert Rev. Mol. Med. 6 21 2004 1 18
52. G.S. Sachs, and et al. Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD) Biol. Psychiatry 53 11 2003 1028 1042
53. M. Schou Perspectives on lithium treatment of bipolar disorder: Action, efficacy, effect on suicidal behavior Bipolar Disord. 1 1 1999 5 10
54. M. Schou Lithium treatment at 52 J. Affect. Disord. 67 1-3 2001 21 32
55. S. Schreier, S.n.V.P. Malheiros, and E. de Paula Surface active drugs: self-association and interaction with membranes and surfactants. Physicochemical and biological aspects Biochimica et Biophysica Acta (BBA) - Biomembranes 1508 1-2 2000 210 234
56. J. Seelig, P.M. MacDonald, and P.G. Scherer Phospholipid head groups as sensors of electric charge in membranes Biochemistry 26 24 1987 7535 7541
57. D.O. Shah, and J.H. Schulman Binding of metal ions to monolayers of lecithins, plasmalogen, cardiolipin, and dicetyl phosphate J. Lipid Res. 6 3 1965 341 349
58. M. Sheard Lithium in the treatment of aggression J. Nerv. Ment. Dis. 160 1-2 1975 108 118
59. G.L. Sheean Lithium neurotoxicity Clin. Exp. Neurol. 28 1991 112 127
60. A.H. Shojaei Buccal mucosa as a route for systemic drug delivery: A review J. Pharm. Pharm. Sci. 1 1 1998 15 30
61. J.J. Silber, and et al. Interactions of small molecules with reverse micelles Adv. Colloid Interface Sci. 82 1-3 1999 189 252
62. O. Soderman, and et al. The interactions between monovalent ions and phosphatidyl cholines in aqueous bilayers Eur. J. Biochem. 134 2 1983 309 314
63. M. Suwalsky, and et al. Effects of lithium on the human erythrocyte membrane and molecular models Biophys. Chem. 129 1 2007 36 42
64. S.A. Tatulian Binding of alkaline-earth metal cations and some anions to phosphatidylcholine liposomes Eur. J. Biochem. 170 1-2 1987 413 420
65. P. Vestergaard, A. Amdisen, and M. Schou Clinically significant side effects of lithium treatment a survey of 237 patients in long-term tretement Acta Psychiatr. Scand. 62 3 1980 193 200
66. A. Wada Lithium and neuropsychiatric therapeutics: neuroplasticity via glycogen synthase kinase-3beta, beta-catenin, and neurotrophin cascades J. Pharmacol. Sci. 110 1 2009 14 28
67. Zhang Hao, Jie Zhang, and James B. Streisand Oral mucosal drug delivery Clin. Pharmacokinet. 9 2002 661 680