Lentiviral-mediated overexpression of long non-coding RNA GAS5 reduces invasion by mediating MMP2 expression and activity in human melanoma cells

International Journal of Oncology

Volumn 48, Issue 4, 2016, Pages 1509-1518

  Chen, Long ^a   Yang, Huixin ^a   Xiao, Yanbin ^a   Tang, Xiaoxia ^a   Li, Yuqian ^a   Han, Qiaoqiao ^a   Fu, Junping ^a   Yang, Yuye ^a   Zhu, Yuechun ^a  

^a KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

growth arrest specific transcript 5; invasion; long non coding RNA; malignant melanoma

Indexed keywords

ANTINEOPLASTIC AGENT; GELATINASE A; LENTIVIRUS VECTOR; LONG UNTRANSLATED RNA; LONG UNTRANSLATED RNA GAS5; UNCLASSIFIED DRUG; GAS5 LONG NON-CODING RNA, HUMAN; MMP2 PROTEIN, HUMAN;

ARTICLE; CELL NUCLEUS; CYTOPLASM; DOWN REGULATION; ENZYME ACTIVITY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MELANOMA CELL; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA STRUCTURE; TUMOR INVASION; CELL MOTION; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; LENTIVIRINAE; MELANOMA; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL MOVEMENT; CELL NUCLEUS; CYTOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LENTIVIRUS; MATRIX METALLOPROTEINASE 2; MELANOMA; NEOPLASM INVASIVENESS; RNA, LONG NONCODING;

EID: 84959010498     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2016.3377     Document Type: Article

References (53)

1. Siegel RL, Miller KD, and Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 65: 5-29, 2015.
2. Lo JA, and Fisher DE. The melanoma revolution: From UV carcinogenesis to a new era in therapeutics. Science. 346: 945-949, 2014.
3. Guil S, and Esteller M. RNA-RNA interactions in gene regulation: The coding, and noncoding players. Trends Biochem Sci. 40: 248-256, 2015.
4. Bonasio R, and Shiekhattar R. Regulation of transcription by long noncoding RNAs. Annu Rev Genet. 48: 433-455, 2014.
5. Pickard MR, and Williams GT. Molecular, and cellular mechanisms of action of tumour suppressor GAS5 LncRNA. Genes (Basel). 6: 484-499, 2015.
6. Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 464: 1071-1076, 2010.
7. Mercer TR, and Mattick JS. Structure, and function of long noncoding RNAs in epigenetic regulation. Nat Struct Mol Biol. 20: 300-307, 2013.
8. Mercer TR, Dinger ME, and Mattick JS. Long non-coding RNAs: Insights into functions. Nat Rev Genet. 10: 155-159, 2009.
9. Smith CM, and Steitz JA. Classification of gas5 as a multismall-nucleolar-RNA (snoRNA) host gene, and a member of the 5'-Terminal oligopyrimidine gene family reveals common features of snoRNA host genes. Mol Cell Biol. 18: 6897-6909, 1998.
10. Schneider C, King RM, and Philipson L. Genes specifically expressed at growth arrest of mammalian cells. Cell. 54: 787-793, 1988.
11. Zhang Z, Zhu Z, Watabe K, Zhang X, Bai C, Xu M, Wu F, and Mo YY. Negative regulation of lncRNA GAS5 by miR-21. Cell Death Differ. 20: 1558-1568, 2013.
12. Romanuik TL, Wang G, Morozova O, Delaney A, Marra MA, and Sadar MD. LNCaP Atlas: Gene expression associated with in vivo progression to castration-recurrent prostate cancer. BMC Med Genomics. 3: 43, 2010.
13. Zhang XQ, Sun S, Lam KF, Kiang KM, Pu JK, Ho AS, Lui WM, Fung CF, Wong TS, and Leung GK. A long non-coding RNA signature in glioblastoma multiforme predicts survival. Neurobiol Dis. 58: 123-131, 2013.
14. Liu Z, Wang W, Jiang J, Bao E, Xu D, Zeng Y, Tao L, and Qiu J. Downregulation of GAS5 promotes bladder cancer cell proliferation, partly by regulating CDK6. PLoS One. 8: e73991, 2013.
15. Tu ZQ, Li RJ, Mei JZ, and Li XH. Down-regulation of long non-coding RNA GAS5 is associated with the prognosis of hepatocellular carcinoma. Int J Clin Exp Pathol. 7: 4303-4309, 2014.
16. Lu X, Fang Y, Wang Z, Xie J, Zhan Q, Deng X, Chen H, Jin J, Peng C, Li H, et al. Downregulation of gas5 increases pancreatic cancer cell proliferation by regulating CDK6. Cell Tissue Res. 354: 891-896, 2013.
17. Shi X, Sun M, Liu H, Yao Y, Kong R, Chen F, and Song Y. A critical role for the long non-coding RNA GAS5 in proliferation, and apoptosis in non-small-cell lung cancer. Mol Carcinog 54 (Suppl 1): E1-E12, 2015.
18. Renganathan A, Kresoja-Rakic J, Echeverry N, Ziltener G, Vrugt B, Opitz I, Stahel RA, and Felley-Bosco E. GAS5 long noncoding RNA in malignant pleural mesothelioma. Mol Cancer. 13: 119, 2014.
19. Sun M, Jin FY, Xia R, Kong R, Li JH, Xu TP, Liu YW, Zhang EB, Liu XH, and De W. Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis, and promotes cell proliferation in gastric cancer. BMC Cancer. 14: 319, 2014.
20. Yin D, He X, Zhang E, Kong R, De W, and Zhang Z. Long noncoding RNA GAS5 affects cell proliferation, and predicts a poor prognosis in patients with colorectal cancer. Med Oncol. 31: 253, 2014.
21. Cao S, Liu W, Li F, Zhao W, and Qin C. Decreased expression of lncRNA GAS5 predicts a poor prognosis in cervical cancer. Int J Clin Exp Pathol. 7: 6776-6783, 2014.
22. Jacob A, and Prekeris R. The regulation of MMP targeting to invadopodia during cancer metastasis. Front Cell Dev Biol. 3: 4, 2015.
23. Shi H, Liu L, Liu L, Geng J, Zhou Y, and Chen L. β-Elemene inhibits the metastasis of B16F10 melanoma cells by downregulation of the expression of uPA, uPAR, MMP-2 and MMP-9. Melanoma Res. 24: 99-107, 2014.
24. Toschi E, Rota R, Antonini A, Melillo G, and Capogrossi MC. Wild-Type p53 gene transfer inhibits invasion, and reduces matrix metalloproteinase-2 levels in p53-mutated human melanoma cells. J Invest Dermatol. 114: 1188-1194, 2000.
25. Airola K, Karonen T, Vaalamo M, Lehti K, Lohi J, Kariniemi AL, Keski-Oja J, and Saarialho-Kere UK. Expression of collagenases-1, and -3, and their inhibitors TIMP-1, and -3 correlates with the level of invasion in malignant melanomas. Br J Cancer. 80: 733-743, 1999.
26. Zigrino P, Kuhn I, Bäuerle T, Zamek J, Fox JW, Neumann S, Licht A, Schorpp-Kistner M, Angel P, and Mauch C. Stromal expression of MMP-13 is required for melanoma invasion, and metastasis. J Invest Dermatol. 129: 2686-2693, 2009.
27. Corte MD, Gonzalez LO, Corte MG, Quintela I, Pidal I, Bongera M, and Vizoso F. Collagenase-3 (MMP-13) expression in cutaneous malignant melanoma. Int J Biol Markers. 20: 242-248, 2005.
28. Zhao X, Sun B, Li Y, Liu Y, Zhang D, Wang X, Gu Q, Zhao J, Dong X, Liu Z, et al. Dual effects of collagenase-3 on melanoma: Metastasis promotion, and disruption of vasculogenic mimicry. Oncotarget. 6: 8890-8899, 2015.
29. Houghton AN, Real FX, Davis LJ, Cordon-Cardo C, and Old LJ. Phenotypic heterogeneity of melanoma. Relation to the differentiation program of melanoma cells. J Exp Med. 165: 812-829, 1987.
30. Albino AP, Juan G, Traganos F, Reinhart L, Connolly J, Rose DP, and Darzynkiewicz Z. Cell cycle arrest, and apoptosis of melanoma cells by docosahexaenoic acid: Association with decreased pRb phosphorylation. Cancer Res. 60: 4139-4145, 2000.
31. Corazzari M, Rapino F, Ciccosanti F, Giglio P, Antonioli M, Conti B, Fimia GM, Lovat PE, and Piacentini M. Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy, and apoptotic resistance of cutaneous melanoma. Cell Death Differ. 22: 946-958, 2015.
32. Tabolacci C, Cordella M, Turcano L, Rossi S, Lentini A, Mariotti S, Nisini R, Sette G, Eramo A, Piredda L, et al. Aloe-emodin exerts a potent anticancer, and immunomodulatory activity on BRAF-mutated human melanoma cells. Eur J Pharmacol. 762: 283-292, 2015.
33. Li J, Cheng Y, Tai D, Martinka M, Welch DR, and Li G. Prognostic significance of BRMS1 expression in human melanoma, and its role in tumor angiogenesis. Oncogene. 30: 896-906, 2011.
34. Hofacker IL. RNA secondary structure analysis using the Vienna RNA package. Curr Prot Bioinform: Jun 1, 2009. doi: 10.1002/0471250953.bi1202s26.
35. Hofacker IL. Vienna RNA secondary structure server. Nucleic Acids Res. 31: 3429-3431, 2003.
36. Du Y, Zhu H, Li D, Wang L, Zhang L, Luo Y, Pan D, and Huang M. Lentiviral-mediated overexpression of Akt1 reduces anoxia-reoxygenation injury in cardiomyocytes. Cell Biol Int. 38: 488-496, 2014.
37. Li Z, Wang H, Huang S, Zhou L, Wang L, Du C, and Wang C. Establishment of stable MRP1 knockdown by lentivirus-delivered shRNA in the mouse testis Sertoli TM4 cell line. Toxicol Mech Methods. 25: 81-90, 2015.
38. Li L, Li B, Zhang H, Bai S, Wang Y, Zhao B, and Jonas JB. Lentiviral vector-mediated PAX6 overexpression promotes growth, and inhibits apoptosis of human retinoblastoma cells. Invest Ophthalmol Vis Sci. 52: 8393-8400, 2011.
39. Khaitan D, Dinger ME, Mazar J, Crawford J, Smith MA, Mattick JS, and Perera RJ. The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis, and invasion. Cancer Res. 71: 3852-3862, 2011.
40. Gibb EA, Brown CJ, and Lam WL. The functional role of long non-coding RNA in human carcinomas. Mol Cancer. 10: 38-55, 2011.
41. Spizzo R, Almeida MI, Colombatti A, and Calin GA. Long non-coding RNAs, and cancer: A new frontier of translational research?. Oncogene. 31: 4577-4587, 2012.
42. Smedley D, Sidhar S, Birdsall S, Bennett D, Herlyn M, Cooper C, and Shipley J. Characterization of chromosome 1 abnormalities in malignant melanomas. Genes Chromosomes Cancer. 28: 121-125, 2000.
43. Flockhart RJ, Webster DE, Qu K, Mascarenhas N, Kovalski J, Kretz M, and Khavari PA. BRAFV600E remodels the melanocyte transcriptome, and induces BANCR to regulate melanoma cell migration. Genome Res. 22: 1006-1014, 2012.
44. Tian Y, Zhang X, Hao Y, Fang Z, and He Y. Potential roles of abnormally expressed long noncoding RNA UCA1, and Malat-1 in metastasis of melanoma. Melanoma Res. 24: 335-341, 2014.
45. Wapinski O, and Chang HY. Long noncoding RNAs, and human disease. Trends Cell Biol. 21: 354-361, 2011.
46. Bonnans C, Chou J, and Werb Z. Remodelling the extracellular matrix in development, and disease. Nat Rev Mol Cell Biol. 15: 786-801, 2014.
47. Shay G, Lynch CC, and Fingleton B. Moving targets: Emerging roles for MMPs in cancer progression, and metastasis. Matrix Biol 44-46: 200-206, 2015.
48. Rotte A, Martinka M, and Li G. MMP2 expression is a prognostic marker for primary melanoma patients. Cell Oncol (Dordr). 35: 207-216, 2012.
49. Ray JM, and Stetler-Stevenson WG. Gelatinase A activity directly modulates melanoma cell adhesion, and spreading. EMBO J. 14: 908-917, 1995.
50. Brown GT, and Murray GI. Current mechanistic insights into the roles of matrix metalloproteinases in tumour invasion, and metastasis. J Pathol. 237: 273-281, 2015.
51. Zhang B, Gunawardane L, Niazi F, Jahanbani F, Chen X, and Valadkhan S. A novel RNA motif mediates the strict nuclear localization of a long noncoding RNA. Mol Cell Biol. 34: 2318-2329, 2014.
52. Mourtada-Maarabouni M, Pickard MR, Hedge VL, Farzaneh F, and Williams GT. GAS5, a non-protein-coding RNA, controls apoptosis, and is downregulated in breast cancer. Oncogene. 28: 195-208, 2009.
53. Köhler A, and Hurt E. Exporting RNA from the nucleus to the cytoplasm. Nat Rev Mol Cell Biol. 8: 761-773, 2007.