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Volumn 24, Issue 2, 2014, Pages 99-107

β-Elemene inhibits the metastasis of B16F10 melanoma cells by downregulation of the expression of uPA, uPAR, MMP-2, and MMP-9

Author keywords

Matrix metalloproteinase 2; Matrix metalloproteinase 9; Melanoma cell; Urokinase type plasminogen activator; Urokinase type plasminogen activator receptor; elemene

Indexed keywords

BETA ELEMENE; GELATINASE A; GELATINASE B; MESSENGER RNA; UROKINASE; UROKINASE RECEPTOR; BETA-ELEMENE; MMP2 PROTEIN, MOUSE; MMP9 PROTEIN, MOUSE; SESQUITERPENE;

EID: 84896394861     PISSN: 09608931     EISSN: 14735636     Source Type: Journal    
DOI: 10.1097/CMR.0000000000000043     Document Type: Article
Times cited : (46)

References (49)
  • 2
    • 33746273995 scopus 로고    scopus 로고
    • Successful palliation with octreotide of a neuroendocrine syndrome from malignant melanoma
    • Jahng AW, Liao SS. Successful palliation with octreotide of a neuroendocrine syndrome from malignant melanoma. J Pain Symptom Manage 2006; 32: 191-195.
    • (2006) J Pain Symptom Manage , vol.32 , pp. 191-195
    • Jahng, A.W.1    Liao, S.S.2
  • 3
    • 63149172139 scopus 로고    scopus 로고
    • Adjuvant radiation therapy for high-risk nodal metastases from cutaneous melanoma
    • Guadagnolo BA, Zagars GK. Adjuvant radiation therapy for high-risk nodal metastases from cutaneous melanoma. Lancet Oncol 2009; 10: 409-416.
    • (2009) Lancet Oncol , vol.10 , pp. 409-416
    • Guadagnolo, B.A.1    Zagars, G.K.2
  • 4
    • 79954429002 scopus 로고    scopus 로고
    • Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor mediated angiogenesis
    • ChenW, Lu Y,Wu J, Gao M,Wang A, Xu B. Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor mediated angiogenesis. Cancer Chemother Pharmacol 2011; 67: 799-808.
    • (2011) Cancer Chemother Pharmacol , vol.67 , pp. 799-808
    • Chen, W.1    Lu, Y.2    Wu, J.3    Gao, M.4    Wang, A.5    Xu, B.6
  • 5
    • 79960555687 scopus 로고    scopus 로고
    • Anti-cancer natural products isolated from Chinese medicinal herbs
    • Tan W, Lu J, Huang M, Li Y, Chen M, Wu G, et al. Anti-cancer natural products isolated from Chinese medicinal herbs. Chin Med 2011; 6: 27-41.
    • (2011) Chin Med , vol.6 , pp. 27-41
    • Tan, W.1    Lu, J.2    Huang, M.3    Li, Y.4    Chen, M.5    Wu, G.6
  • 6
    • 84872678018 scopus 로고    scopus 로고
    • Molecular bases of cutaneous and uveal melanomas
    • Gaudi S, Messina JL. Molecular bases of cutaneous and uveal melanomas. Patholog Res Int 2011; 10: 4061-4069.
    • (2011) Patholog Res Int , vol.10 , pp. 4061-4069
    • Gaudi, S.1    Messina, J.L.2
  • 7
    • 67549104876 scopus 로고    scopus 로고
    • Expression of urokinase plasminogen activator and its receptor in advanced epithelial ovarian cancer patients
    • Wang L, Madigan MC, Chen H, Liu F, Patterson KI, Beretov J, et al. Expression of urokinase plasminogen activator and its receptor in advanced epithelial ovarian cancer patients. Gynecol Oncol 2009; 114: 265-272.
    • (2009) Gynecol Oncol , vol.114 , pp. 265-272
    • Wang, L.1    Madigan, M.C.2    Chen, H.3    Liu, F.4    Patterson, K.I.5    Beretov, J.6
  • 8
    • 77951883821 scopus 로고    scopus 로고
    • The urokinase receptor: Focused cell surface proteolysis, cell adhesion and signaling
    • Blasi F, Sidenius N. The urokinase receptor: focused cell surface proteolysis, cell adhesion and signaling. FEBS Lett 2010; 584: 1923-1930.
    • (2010) FEBS Lett , vol.584 , pp. 1923-1930
    • Blasi, F.1    Sidenius, N.2
  • 9
    • 0033824172 scopus 로고    scopus 로고
    • Urokinase receptor and integrin partnership: Coordination of signaling for cell adhesion, migration and growth
    • Ossowski L, Aguirre-Ghiso JA. Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth. Cur Opin Cell Biol 2000; 12: 613-620.
    • (2000) Cur Opin Cell Biol , vol.12 , pp. 613-620
    • Ossowski, L.1    Aguirre-Ghiso, J.A.2
  • 10
    • 0036906177 scopus 로고    scopus 로고
    • UPAR: A versatile signaling orchestrator
    • Blasi F, Carmeliet P. uPAR: a versatile signaling orchestrator. Nat Rev Mol Cell Biol 2002; 3: 932-943.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 932-943
    • Blasi, F.1    Carmeliet, P.2
  • 11
    • 0032478829 scopus 로고    scopus 로고
    • Binding of urokinase type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility
    • Nguyen DH, Hussaini IM, Gonias SL. Binding of urokinase type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility. J Biol Chem 1998; 273: 8502-8507.
    • (1998) J Biol Chem , vol.273 , pp. 8502-8507
    • Nguyen, D.H.1    Hussaini, I.M.2    Gonias, S.L.3
  • 12
    • 0002460807 scopus 로고    scopus 로고
    • Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling
    • Aguirre Ghiso JA, Kovalski K, Ossowski L. Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. J Cell Biol 1999; 147: 89-104.
    • (1999) J Cell Biol , vol.147 , pp. 89-104
    • Aguirre Ghiso, J.A.1    Kovalski, K.2    Ossowski, L.3
  • 13
    • 0029943568 scopus 로고    scopus 로고
    • Plasminogen activators and matrix metalloproteinases in angiogenesis
    • Mignatti P, Rifkin DB. Plasminogen activators and matrix metalloproteinases in angiogenesis. Enzyme Protein 1996; 49: 117-137.
    • (1996) Enzyme Protein , vol.49 , pp. 117-137
    • Mignatti, P.1    Rifkin, D.B.2
  • 14
    • 24744449559 scopus 로고    scopus 로고
    • Targeting of urokinase plasminogen activator receptor in human pancreatic carcinoma cells inhibits c-Met - And insulin-like growth factor-I receptor-mediated migration and invasion and orthotopic tumor growth in mice
    • Bauer TW, Liu W, Fan F, Camp ER, Yang A, Somcio RJ, et al. Targeting of urokinase plasminogen activator receptor in human pancreatic carcinoma cells inhibits c-Met - and insulin-like growth factor-I receptor-mediated migration and invasion and orthotopic tumor growth in mice. Cancer Res 2005; 65: 7775-7781.
    • (2005) Cancer Res , vol.65 , pp. 7775-7781
    • Bauer, T.W.1    Liu, W.2    Fan, F.3    Camp, E.R.4    Yang, A.5    Somcio, R.J.6
  • 15
    • 77953924040 scopus 로고    scopus 로고
    • The in vitro and in vivo experimental evidences disclose the chemopreventive effects of Ganoderma lucidum on cancer invasion and metastasis
    • Weng CJ, Yen GC. The in vitro and in vivo experimental evidences disclose the chemopreventive effects of Ganoderma lucidum on cancer invasion and metastasis. Clin Exp Metastasis 2010; 27: 361-369.
    • (2010) Clin Exp Metastasis , vol.27 , pp. 361-369
    • Weng, C.J.1    Yen, G.C.2
  • 16
    • 84896389119 scopus 로고    scopus 로고
    • In vitro anticancer activity of chamaejasmenin B and neochamaejasmin C isolated from the root of Stellera chamaejasme L
    • Zhang C, Zhou SS, Feng LY, Zhang DY, Lin NM, Zhang LH, et al. In vitro anticancer activity of chamaejasmenin B and neochamaejasmin C isolated from the root of Stellera chamaejasme L. Acta Pharmacol Sin 2012; 10: 1038-1058.
    • (2012) Acta Pharmacol Sin , vol.10 , pp. 1038-1058
    • Zhang, C.1    Zhou, S.S.2    Feng, L.Y.3    Zhang, D.Y.4    Lin, N.M.5    Zhang, L.H.6
  • 17
    • 79956202882 scopus 로고    scopus 로고
    • B-Elemene induced autophagy protects human gastric cancer cells from undergoing apoptosis
    • Liu J, Zhang Y. b-Elemene induced autophagy protects human gastric cancer cells from undergoing apoptosis. BMC Cancer 2011; 11: 183.
    • (2011) BMC Cancer , vol.11 , pp. 183
    • Liu, J.1    Zhang, Y.2
  • 18
    • 77953597703 scopus 로고    scopus 로고
    • Downregulation of IL-17 and IFN-g in the optic nerve by b-elemene in experimental autoimmune encephalomyelitis
    • Zhang R, Tian A, Shi X, Yu H, Chen L. Downregulation of IL-17 and IFN-g in the optic nerve by b-elemene in experimental autoimmune encephalomyelitis. Int Immunopharmacol 2011; 10: 738-743.
    • (2011) Int Immunopharmacol , vol.10 , pp. 738-743
    • Zhang, R.1    Tian, A.2    Shi, X.3    Yu, H.4    Chen, L.5
  • 19
    • 68249162541 scopus 로고    scopus 로고
    • B-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemo-sensitivity of lung tumor cells by triggering apoptosis
    • Li QQ, Wang G, Zhang M, Cuff CF, Huang L, Reed E. b-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemo-sensitivity of lung tumor cells by triggering apoptosis. Oncol Rep 2009; 22: 161-170.
    • (2009) Oncol Rep , vol.22 , pp. 161-170
    • Li, Q.Q.1    Wang, G.2    Zhang, M.3    Cuff, C.F.4    Huang, L.5    Reed, E.6
  • 20
    • 18544369255 scopus 로고    scopus 로고
    • Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death
    • Wang G, Li X, Huang F, Zhao J, Ding H, Cunningham C, et al. Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death. Cell Mol Life Sci 2005; 62: 881-893.
    • (2005) Cell Mol Life Sci , vol.62 , pp. 881-893
    • Wang, G.1    Li, X.2    Huang, F.3    Zhao, J.4    Ding, H.5    Cunningham, C.6
  • 21
    • 70450162214 scopus 로고    scopus 로고
    • Cell apoptosis induced by delta elemene in colorectal adenocarcinoma cells via a mitochondrialmediated pathway
    • Xie CY, Yang W, Li M, Ying J, Tao SJ, Li K, et al. Cell apoptosis induced by delta elemene in colorectal adenocarcinoma cells via a mitochondrialmediated pathway. Yakugaku Zasshi 2009; 129: 1403-1413.
    • (2009) Yakugaku Zasshi , vol.129 , pp. 1403-1413
    • Xie, C.Y.1    Yang, W.2    Li, M.3    Ying, J.4    Tao, S.J.5    Li, K.6
  • 22
    • 42649116109 scopus 로고    scopus 로고
    • Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation
    • Yao YQ, Ding X, Jia YC, Huang CX, Wang YZ, Xu YH. Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation. Cancer Lett 2008; 264: 127-134.
    • (2008) Cancer Lett , vol.264 , pp. 127-134
    • Yao, Y.Q.1    Ding, X.2    Jia, Y.C.3    Huang, C.X.4    Wang, Y.Z.5    Xu, Y.H.6
  • 23
    • 0030274757 scopus 로고    scopus 로고
    • Phase III clinical trial of elemene emulsion in the management of malignant pleural and peritoneal effusions
    • Wang J, Zhang H, Sun Y. Phase III clinical trial of elemene emulsion in the management of malignant pleural and peritoneal effusions. Zhonghua Zhong Liu Za Zhi 1996; 18: 464-467.
    • (1996) Zhonghua Zhong Liu Za Zhi , vol.18 , pp. 464-467
    • Wang, J.1    Zhang, H.2    Sun, Y.3
  • 24
    • 0034286088 scopus 로고    scopus 로고
    • Clinical study on treatment of 40 cases of malignant brain tumor by elemene emulsion injection
    • Tan P, ZhongW, CaiW. Clinical study on treatment of 40 cases of malignant brain tumor by elemene emulsion injection. Zhongguo Zhong Xi Yi Jie He Za Zhi 2000; 20: 645-648.
    • (2000) Zhongguo Zhong Xi Yi Jie He Za Zhi , vol.20 , pp. 645-648
    • Tan, P.1    Caiw, Z.2
  • 25
    • 18544381215 scopus 로고    scopus 로고
    • Antiproliferative effect of beta-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase
    • Li X,Wang G, Zhao J, Ding H, Cunningham C, Chen F, et al. Antiproliferative effect of beta-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase. Cell Mol Life Sci 2005; 62: 894-904.
    • (2005) Cell Mol Life Sci , vol.62 , pp. 894-904
    • Li Xwang, G.1    Zhao, J.2    Ding, H.3    Cunningham, C.4    Chen, F.5
  • 26
    • 78649537934 scopus 로고    scopus 로고
    • Evaluation of cisplatin in combination with beta-elemene as a regimen for prostate cancer chemotherapy
    • Li QQ, Wang G, Reed E, Huang L, Cuff CF. Evaluation of cisplatin in combination with beta-elemene as a regimen for prostate cancer chemotherapy. Basic Clin Pharmacol Toxicol 2010; 107: 868-876.
    • (2010) Basic Clin Pharmacol Toxicol , vol.107 , pp. 868-876
    • Li, Q.Q.1    Wang, G.2    Reed, E.3    Huang, L.4    Cuff, C.F.5
  • 27
    • 78650268952 scopus 로고    scopus 로고
    • Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway
    • Yang HL, Kuo YH, Tsai CT, Huang YT, Chen SC, Chang HW, et al. Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway. Food Chem Toxicol 2011; 49: 290-298.
    • (2011) Food Chem Toxicol , vol.49 , pp. 290-298
    • Yang, H.L.1    Kuo, Y.H.2    Tsai, C.T.3    Huang, Y.T.4    Chen, S.C.5    Chang, H.W.6
  • 28
  • 29
    • 78751487154 scopus 로고    scopus 로고
    • Inhibition of tumor growth and vasculogenic mimicry by curcumin through downregulation of the EphA2/PI3K/MMP pathway in a murine choroidal melanoma model
    • Chen LX, He YJ, Zhao SZ,Wu JG,Wang JT, Zhu LM, et al. Inhibition of tumor growth and vasculogenic mimicry by curcumin through downregulation of the EphA2/PI3K/MMP pathway in a murine choroidal melanoma model. Cancer Biol Ther 2011; 11: 229-235.
    • (2011) Cancer Biol Ther , vol.11 , pp. 229-235
    • Chen, L.X.1    He, Y.J.2    Zhao, S.Z.3    Wu, J.G.4    Wang, J.T.5    Zhu, L.M.6
  • 30
    • 18144425158 scopus 로고    scopus 로고
    • Breast cancer metastasis suppressor i inhibits gene expression by targeting nuclear factorkappaB activity
    • Cicek M, Fukuyama R, Welch DR, Sizemore N, Casey G. Breast cancer metastasis suppressor I inhibits gene expression by targeting nuclear factorkappaB activity. Cancer Res 2005; 65: 3586-3595.
    • (2005) Cancer Res , vol.65 , pp. 3586-3595
    • Cicek, M.1    Fukuyama, R.2    Welch, D.R.3    Sizemore, N.4    Casey, G.5
  • 31
    • 84896394230 scopus 로고    scopus 로고
    • BRMS1 negatively regulates NF-kB-dependent uPA expression following recruitment of HDAC1 to the NF-kB binding site of the uPA promoter
    • Cicek M, Fukuyama R, Cicek MS, Sizemore S,Welch DR, Sizemore N, et al. BRMS1 negatively regulates NF-kB-dependent uPA expression following recruitment of HDAC1 to the NF-kB binding site of the uPA promoter. Clin Exp Metastasis 2009; 26: 29-37.
    • (2009) Clin Exp Metastasis , vol.26 , pp. 29-37
    • Cicek, M.1    Fukuyama, R.2    Cicek, M.S.3    Sizemore Swelch, D.R.4    Sizemore, N.5
  • 32
    • 16244388218 scopus 로고    scopus 로고
    • Immunocytochemistry for drugs containing an aliphatic primary amino group in the molecule, anticancer antibiotic Daunomycin as a model
    • Fujiwara K, Takatsu H, Tsukamoto K. Immunocytochemistry for drugs containing an aliphatic primary amino group in the molecule, anticancer antibiotic Daunomycin as a model. J Histochem Cytochem 2005; 53: 467-474.
    • (2005) J Histochem Cytochem , vol.53 , pp. 467-474
    • Fujiwara, K.1    Takatsu, H.2    Tsukamoto, K.3
  • 33
    • 79961232250 scopus 로고    scopus 로고
    • Selenium effectively inhibits 1,2-dihydroxynaphthaleneinduced apoptosis in human lens epithelial cells through activation of PI3-K/Akt pathway
    • Zhu X, Guo K, Lu Y. Selenium effectively inhibits 1,2- dihydroxynaphthaleneinduced apoptosis in human lens epithelial cells through activation of PI3-K/Akt pathway. Mol Vis 2011; 17: 2019-2027.
    • (2011) Mol Vis , vol.17 , pp. 2019-2027
    • Zhu, X.1    Guo, K.2    Lu, Y.3
  • 34
    • 84873581745 scopus 로고    scopus 로고
    • Anti-metastatic effects on B16F10 melanoma cells of extracts and two prenylated xanthones isolated from Maclura amboinensis Bl roots
    • Siripong P, Rassamee K, Piyaviriyakul S, Yahuafai J, Kanokmedhakul K. Anti-metastatic effects on B16F10 melanoma cells of extracts and two prenylated xanthones isolated from Maclura amboinensis Bl roots. Asian Pac J Cancer Prev 2012; 13: 3519-3528.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 3519-3528
    • Siripong, P.1    Rassamee, K.2    Piyaviriyakul, S.3    Yahuafai, J.4    Kanokmedhakul, K.5
  • 36
    • 72249088570 scopus 로고    scopus 로고
    • De-N-acetyl GM3 promotes melanoma cell migration and invasion through urokinase plasminogen activator receptor signaling dependent MMP-2 activation
    • Liu JW, Sun P, Yan Q, Paller AS, Gerami P, Ho N, et al. De-N-acetyl GM3 promotes melanoma cell migration and invasion through urokinase plasminogen activator receptor signaling dependent MMP-2 activation. Cancer Res 2009; 69: 8662-8669.
    • (2009) Cancer Res , vol.69 , pp. 8662-8669
    • Liu, J.W.1    Sun, P.2    Yan, Q.3    Paller, A.S.4    Gerami, P.5    Ho, N.6
  • 37
    • 0036329807 scopus 로고    scopus 로고
    • New insights into the role of extracellular matrix during tumor onset and progression
    • Pupa SM, Mé nard S, Forti S, Tagliabue E. New insights into the role of extracellular matrix during tumor onset and progression. J Cell Physiol 2002; 192: 259-267.
    • (2002) J Cell Physiol , vol.192 , pp. 259-267
    • Pupa, S.M.1    Ménard, S.2    Forti, S.3    Tagliabue, E.4
  • 38
    • 34250685355 scopus 로고    scopus 로고
    • Interaction between cancer cells and stromal fibroblasts is required for activation of the uPAR-uPA-MMP-2 cascade in pancreatic cancer metastasis
    • He Y, Liu XD, Chen ZY, Zhu J, Xiong Y, Li K, et al. Interaction between cancer cells and stromal fibroblasts is required for activation of the uPAR-uPA-MMP-2 cascade in pancreatic cancer metastasis. Clin Cancer Res 2007; 13: 3115-3124.
    • (2007) Clin Cancer Res , vol.13 , pp. 3115-3124
    • He, Y.1    Liu, X.D.2    Chen, Z.Y.3    Zhu, J.4    Xiong, Y.5    Li, K.6
  • 39
    • 0347917028 scopus 로고    scopus 로고
    • The urokinase plasminogen activator system: Role in malignancy
    • Duffy MJ. The urokinase plasminogen activator system: role in malignancy. Curr Pharm Des 2004; 10: 9-49.
    • (2004) Curr Pharm des , vol.10 , pp. 9-49
    • Duffy, M.J.1
  • 40
    • 0142188116 scopus 로고    scopus 로고
    • Urokinase plasminogen activator system: A multi functional role in tumor progression and metastasis
    • Choong PF, Nadesapillai AP. Urokinase plasminogen activator system: a multi functional role in tumor progression and metastasis. Clin Orthop Relat Res 2003; 415: S46-S58.
    • (2003) Clin Orthop Relat Res , vol.415
    • Choong, P.F.1    Nadesapillai, A.P.2
  • 41
    • 0030788411 scopus 로고    scopus 로고
    • The urokinase-type plasminogen activator system in cancer metastasis: A review
    • Andreasen PA, Kjøller L, Christensen L, Duffy MJ. The urokinase-type plasminogen activator system in cancer metastasis: a review. Int J Cancer 1997; 72: 1-22.
    • (1997) Int J Cancer , vol.72 , pp. 1-22
    • Andreasen, P.A.1    Kjøller, L.2    Christensen, L.3    Duffy, M.J.4
  • 42
    • 18844375381 scopus 로고    scopus 로고
    • Pleiotropic functions of the plasminogen activator inhibitor-1
    • Lijnen HR. Pleiotropic functions of the plasminogen activator inhibitor-1. J Thromb Haemost 2005; 3: 35-45.
    • (2005) J Thromb Haemost , vol.3 , pp. 35-45
    • Lijnen, H.R.1
  • 43
    • 0038364216 scopus 로고    scopus 로고
    • The urokinase plasminogen activator system in cancer: Recent advances and implication for prognosis and therapy
    • Sidenius N, Blasi F. The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy. Cancer Metastasis Rev 2003; 22: 205-222.
    • (2003) Cancer Metastasis Rev , vol.22 , pp. 205-222
    • Sidenius, N.1    Blasi, F.2
  • 44
    • 16844386886 scopus 로고    scopus 로고
    • Plasminogen activation and cancer
    • Danø K, Behrendt N. Plasminogen activation and cancer. Thromb Haemost 2005; 93: 676-681.
    • (2005) Thromb Haemost , vol.93 , pp. 676-681
    • Danø, K.1    Behrendt, N.2
  • 45
    • 0035721955 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases and plasminogen activator plasmin system in angiogenesis
    • Pepper MS. Role of matrix metalloproteinases and plasminogen activator plasmin system in angiogenesis. Arterioscler Thromb Vasc Biol 2001; 21: 1104-1117.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1104-1117
    • Pepper, M.S.1
  • 46
    • 62549113036 scopus 로고    scopus 로고
    • The urokinase plasminogen activator system: A target for anti-cancer therapy
    • Ulisse1 S, Baldini E. The urokinase plasminogen activator system: a target for anti-cancer therapy. Curr Cancer Drug Targets 2009; 9: 32-71.
    • (2009) Curr Cancer Drug Targets , vol.9 , pp. 32-71
    • Ulisse, S.1    Baldini, E.2
  • 47
    • 41149092837 scopus 로고    scopus 로고
    • Urokinase directly activates matrix metalloproteinases-9: A potential role in glioblastoma invasion
    • Zhao Y, Lyons CE Jr, Xiao A, Templeton DJ, Sang QA, Brew K, et al. Urokinase directly activates matrix metalloproteinases-9: a potential role in glioblastoma invasion. Biochem Biophy Res Commun 2008; 369: 1215-1220.
    • (2008) Biochem Biophy Res Commun , vol.369 , pp. 1215-1220
    • Zhao, Y.1    Lyons Jr., C.E.2    Xiao, A.3    Templeton, D.J.4    Sang, Q.A.5    Brew, K.6
  • 49
    • 0034892043 scopus 로고    scopus 로고
    • Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer
    • Schmalfeldt B, Prechtel D, Hä rting K, Spä the K, Rutke S, Konik E, et al. Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer. Clin Cancer Res 2001; 7: 2396-2404.
    • (2001) Clin Cancer Res , vol.7 , pp. 2396-2404
    • Schmalfeldt, B.1    Prechtel, D.2    Härting, K.3    Späthe, K.4    Rutke, S.5    Konik, E.6


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