메뉴 건너뛰기




Volumn 52, Issue 11, 2011, Pages 8393-8400

Lentiviral vector-mediated PAX6 overexpression promotes growth and inhibits apoptosis of human retinoblastoma cells

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYCLIN DEPENDENT KINASE 1; CYCLINE; LENTIVIRUS VECTOR; PROTEIN P21; PROTEIN P27; PROTEIN P53; TRANSCRIPTION FACTOR PAX6; CDC2 PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CYCLIN B; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; EYE PROTEIN; HOMEODOMAIN PROTEIN; PAIRED BOX TRANSCRIPTION FACTOR; REPRESSOR PROTEIN;

EID: 84855372392     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-8139     Document Type: Article
Times cited : (34)

References (38)
  • 1
    • 0023767249 scopus 로고
    • Identification of germline and somatic mutations affecting the retinoblastoma gene
    • Dunn JM, Phillips RA, Becker AJ, Gallie BL. Identification of germline and somatic mutations affecting the retinoblastoma gene. Science. 1988;241(4874):1797-1800.
    • (1988) Science , vol.241 , Issue.4874 , pp. 1797-1800
    • Dunn, J.M.1    Phillips, R.A.2    Becker, A.J.3    Gallie, B.L.4
  • 2
    • 34249004558 scopus 로고    scopus 로고
    • One hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma
    • Corson TW, Gallie BL. One hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma. Genes Chromosomes Cancer. 2007;46(7):617-634.
    • (2007) Genes Chromosomes Cancer , vol.46 , Issue.7 , pp. 617-634
    • Corson, T.W.1    Gallie, B.L.2
  • 3
    • 13444249786 scopus 로고    scopus 로고
    • The search for the retinoblastoma cell of origin
    • Dyer MA, Bremner R. The search for the retinoblastoma cell of origin. Nat Rev Cancer. 2005;5(2):91-101.
    • (2005) Nat Rev Cancer , vol.5 , Issue.2 , pp. 91-101
    • Dyer, M.A.1    Bremner, R.2
  • 4
    • 9744274770 scopus 로고    scopus 로고
    • The first knockout mouse model of retinoblastoma
    • Zhang J, Schweers B, Dyer MA. The first knockout mouse model of retinoblastoma. Cell Cycle. 2004;3(7):952-959.
    • (2004) Cell Cycle , vol.3 , Issue.7 , pp. 952-959
    • Zhang, J.1    Schweers, B.2    Dyer, M.A.3
  • 5
    • 35348922996 scopus 로고    scopus 로고
    • Identification of tumorigenic retinal stem-like cells in human solid retinoblastomas
    • Zhong X, Li Y, Peng F, et al. Identification of tumorigenic retinal stem-like cells in human solid retinoblastomas. Int J Cancer. 2007; 121(10):2125-2131.
    • (2007) Int J Cancer , vol.121 , Issue.10 , pp. 2125-2131
    • Zhong, X.1    Li, Y.2    Peng, F.3
  • 8
    • 0344255673 scopus 로고    scopus 로고
    • Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival
    • Muratovska A, Zhou C, He S, Goodyer P, Eccles MR. Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival. Oncogene. 2003;22(39):7989-7997.
    • (2003) Oncogene , vol.22 , Issue.39 , pp. 7989-7997
    • Muratovska, A.1    Zhou, C.2    He, S.3    Goodyer, P.4    Eccles, M.R.5
  • 9
    • 34347207607 scopus 로고    scopus 로고
    • Mechanisms controlling Pax6 isoform expression in the retina have been conserved between teleosts and mammals
    • Lakowski J, Majumder A, Lauderdale JD. Mechanisms controlling Pax6 isoform expression in the retina have been conserved between teleosts and mammals. Dev Biol. 2007;307(2):498-520.
    • (2007) Dev Biol , vol.307 , Issue.2 , pp. 498-520
    • Lakowski, J.1    Majumder, A.2    Lauderdale, J.D.3
  • 10
    • 67349228464 scopus 로고    scopus 로고
    • Expression of the homeobox genes PAX6, OTX2, and OTX1 in the early human fetal retina
    • Larsen KB, Lutterodt M, Rath MF, Møller M. Expression of the homeobox genes PAX6, OTX2, and OTX1 in the early human fetal retina. Int J Dev Neurosci. 2009;27(5):485-492.
    • (2009) Int J Dev Neurosci , vol.27 , Issue.5 , pp. 485-492
    • Larsen, K.B.1    Lutterodt, M.2    Rath, M.F.3    Møller, M.4
  • 11
    • 47749138860 scopus 로고    scopus 로고
    • Pax6 promotes neurogenesis in human neural stem cells
    • Kallur T, Gisler R, Lindvall O, Kokaia Z. Pax6 promotes neurogenesis in human neural stem cells. Mol Cell Neurosci. 2008;38(4): 616-628.
    • (2008) Mol Cell Neurosci , vol.38 , Issue.4 , pp. 616-628
    • Kallur, T.1    Gisler, R.2    Lindvall, O.3    Kokaia, Z.4
  • 12
    • 67651208830 scopus 로고    scopus 로고
    • The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis
    • Sansom SN, Griffiths DS, Faedo A, et al. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009; 5(6):e1000511.
    • (2009) PLoS Genet , vol.5 , Issue.6
    • Sansom, S.N.1    Griffiths, D.S.2    Faedo, A.3
  • 13
    • 80052346365 scopus 로고    scopus 로고
    • Pax6 regulates proliferation and apoptosis of human retinoblastoma cells
    • Bai SW, Li B, Zhang H, et al. Pax6 regulates proliferation and apoptosis of human retinoblastoma cells. Invest Ophthalmol Vis Sci. 2011;52(7):4560-4570.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , Issue.7 , pp. 4560-4570
    • Bai, S.W.1    Li, B.2    Zhang, H.3
  • 14
    • 0036200735 scopus 로고    scopus 로고
    • Comparison of various envelope proteins for their ability to pseudotype lentiviral vectors and transduce primitive hematopoietic cells from human blood
    • Hanawa H, Kelly PF, Nathwani AC, et al. Comparison of various envelope proteins for their ability to pseudotype lentiviral vectors and transduce primitive hematopoietic cells from human blood. Mol Ther. 2002;5(3):242-251.
    • (2002) Mol Ther , vol.5 , Issue.3 , pp. 242-251
    • Hanawa, H.1    Kelly, P.F.2    Nathwani, A.C.3
  • 15
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) Method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) Method. Methods. 2001;25(4):402-408.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 16
    • 70350446683 scopus 로고    scopus 로고
    • PAX6 is expressed in pancreatic cancer and actively participates in cancer progression through activation of the MET tyrosine kinase receptor gene
    • Mascarenhas JB, Young KP, Littlejohn EL, Yoo BK, Salgia R, Lang D. PAX6 is expressed in pancreatic cancer and actively participates in cancer progression through activation of the MET tyrosine kinase receptor gene. J Biol Chem. 2009;284(40):27524-27532.
    • (2009) J Biol Chem , vol.284 , Issue.40 , pp. 27524-27532
    • Mascarenhas, J.B.1    Young, K.P.2    Littlejohn, E.L.3    Yoo, B.K.4    Salgia, R.5    Lang, D.6
  • 17
    • 38949143332 scopus 로고    scopus 로고
    • PAX6 is expressed in pancreatic adenocarcinoma and is downregulated during induction of terminal differentiation
    • Lang D, Mascarenhas JB, Powell SK, Halegoua J, Nelson M, Ruggeri BA. PAX6 is expressed in pancreatic adenocarcinoma and is downregulated during induction of terminal differentiation. Mol Carcinog. 2008;47(2):148-156.
    • (2008) Mol Carcinog , vol.47 , Issue.2 , pp. 148-156
    • Lang, D.1    Mascarenhas, J.B.2    Powell, S.K.3    Halegoua, J.4    Nelson, M.5    Ruggeri, B.A.6
  • 18
    • 20144379648 scopus 로고    scopus 로고
    • PAX6 suppresses growth of human glioblastoma cells
    • Zhou YH, Wu X, Tan F, et al. PAX6 suppresses growth of human glioblastoma cells. J Neurooncol. 2005;71(3):223-229.
    • (2005) J Neurooncol , vol.71 , Issue.3 , pp. 223-229
    • Zhou, Y.H.1    Wu, X.2    Tan, F.3
  • 19
    • 33750559852 scopus 로고    scopus 로고
    • PAX6 suppresses the invasiveness of glioblastoma cells and the expression of the matrix metalloproteinase-2 gene
    • Mayes DA, Hu Y, Teng Y, et al. PAX6 suppresses the invasiveness of glioblastoma cells and the expression of the matrix metalloproteinase-2 gene. Cancer Res. 2006;66(20):9809-9817.
    • (2006) Cancer Res , vol.66 , Issue.20 , pp. 9809-9817
    • Mayes, D.A.1    Hu, Y.2    Teng, Y.3
  • 20
    • 73449131887 scopus 로고    scopus 로고
    • Tumor suppressor PAX6 functions as androgen receptor co-repressor to inhibit prostate cancer growth
    • Shyr CR, Tsai MY, Yeh S, et al. Tumor suppressor PAX6 functions as androgen receptor co-repressor to inhibit prostate cancer growth. Prostate. 2010;70(2):190-199.
    • (2010) Prostate , vol.70 , Issue.2 , pp. 190-199
    • Shyr, C.R.1    Tsai, M.Y.2    Yeh, S.3
  • 21
    • 0000463651 scopus 로고    scopus 로고
    • The structural and mechanical complexity of cell-growth control
    • Huang S, Ingber DE. The structural and mechanical complexity of cell-growth control. Nat Cell Biol. 1999;1(5):E131-E138.
    • (1999) Nat Cell Biol , vol.1 , Issue.5
    • Huang, S.1    Ingber, D.E.2
  • 22
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000; 100(1):57-70.
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 23
    • 34047160933 scopus 로고    scopus 로고
    • The proliferation and expansion of retinal stem cells require functional Pax6
    • Xu S, Sunderland ME, Coles BL, et al. The proliferation and expansion of retinal stem cells require functional Pax6. Dev Biol. 2007; 304(2):713-721.
    • (2007) Dev Biol , vol.304 , Issue.2 , pp. 713-721
    • Xu, S.1    Sunderland, M.E.2    Coles, B.L.3
  • 24
    • 70349218248 scopus 로고    scopus 로고
    • Dynamic Pax6 expression during the neurogenic cell cycle influences proliferation and cell fate choices of retinal progenitors
    • Hsieh YW, Yang XJ. Dynamic Pax6 expression during the neurogenic cell cycle influences proliferation and cell fate choices of retinal progenitors. Neural Dev. 2009;4:32.
    • (2009) Neural Dev , vol.4 , pp. 32
    • Hsieh, Y.W.1    Yang, X.J.2
  • 25
    • 75049084713 scopus 로고    scopus 로고
    • PAX6 suppression of glioma angiogenesis and the expression of vascular endothelial growth factor A
    • Zhou YH, Hu Y, Mayes D, et al. PAX6 suppression of glioma angiogenesis and the expression of vascular endothelial growth factor A. J Neurooncol. 2010;96(2):191-200.
    • (2010) J Neurooncol , vol.96 , Issue.2 , pp. 191-200
    • Zhou, Y.H.1    Hu, Y.2    Mayes, D.3
  • 26
    • 18344365862 scopus 로고    scopus 로고
    • Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities
    • He G, Siddik ZH, Huang Z, et al. Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities. Oncogene. 2005;24(18):2929-2943.
    • (2005) Oncogene , vol.24 , Issue.18 , pp. 2929-2943
    • He, G.1    Siddik, Z.H.2    Huang, Z.3
  • 27
    • 0032556952 scopus 로고    scopus 로고
    • p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells
    • Cayrol C, Knibiehler M, Ducommun B. p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells. Oncogene. 1998;16(3):311-320.
    • (1998) Oncogene , vol.16 , Issue.3 , pp. 311-320
    • Cayrol, C.1    Knibiehler, M.2    Ducommun, B.3
  • 28
    • 0141960298 scopus 로고    scopus 로고
    • Human proliferating cell nuclear antigen, poly (ADP-ribose) polymerase-1, and p21waf1/ cip1: A dynamic exchange of partners
    • Frouin I, Maga G, Denegri M, et al. Human proliferating cell nuclear antigen, poly (ADP-ribose) polymerase-1, and p21waf1/ cip1: a dynamic exchange of partners. J Biol Chem. 2003;278(41): 39265-39268.
    • (2003) J Biol Chem , vol.278 , Issue.41 , pp. 39265-39268
    • Frouin, I.1    Maga, G.2    Denegri, M.3
  • 29
    • 0032553485 scopus 로고    scopus 로고
    • Requirement for p53 and p21 to sustain G2 arrest after DNA damage
    • Bunz F, Dutriaux A, Lengauer C, et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science. 1998; 282(5393):1497-1501.
    • (1998) Science , vol.282 , Issue.5393 , pp. 1497-1501
    • Bunz, F.1    Dutriaux, A.2    Lengauer, C.3
  • 30
    • 0035810054 scopus 로고    scopus 로고
    • Regulation of the G2/M transition by p53
    • Taylor WR, Stark GR. Regulation of the G2/M transition by p53. Oncogene. 2001;20(15):1803-1815.
    • (2001) Oncogene , vol.20 , Issue.15 , pp. 1803-1815
    • Taylor, W.R.1    Stark, G.R.2
  • 31
    • 0033842355 scopus 로고    scopus 로고
    • P27 in cell cycle control and cancer
    • Møller MB. P27 in cell cycle control and cancer. Leuk Lymphoma. 2000;39(1-2):19-27.
    • (2000) Leuk Lymphoma , vol.39 , Issue.1-2 , pp. 19-27
    • Møller, M.B.1
  • 32
    • 0037304898 scopus 로고    scopus 로고
    • New roles for p21 and p27 cell-cycle inhibitors: A function for each cell compartment
    • Coqueret O. New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment? Trends Cell Biol. 2003;13(2): 65-70.
    • (2003) Trends Cell Biol , vol.13 , Issue.2 , pp. 65-70
    • Coqueret, O.1
  • 33
    • 27944510555 scopus 로고    scopus 로고
    • Expression of p27(KIP1) and cell proliferation in human retina and retinoblastoma
    • Kase S, Yoshida K, Ohgami K, Shiratori K, Harada T, Ohno S. Expression of p27(KIP1) and cell proliferation in human retina and retinoblastoma. Anticancer Res. 2005;25(6B):3843-3846.
    • (2005) Anticancer Res , vol.25 , Issue.6 B , pp. 3843-3846
    • Kase, S.1    Yoshida, K.2    Ohgami, K.3    Shiratori, K.4    Harada, T.5    Ohno, S.6
  • 34
    • 33644932621 scopus 로고    scopus 로고
    • Expression of cdc2 and p27(KIP1) phosphorylation in mitotic cells of the human retinoblastoma
    • Kase S, Yoshida K, Ohgami K, et al. Expression of cdc2 and p27(KIP1) phosphorylation in mitotic cells of the human retinoblastoma. Int J Mol Med. 2006;17(3):465-468.
    • (2006) Int J Mol Med , vol.17 , Issue.3 , pp. 465-468
    • Kase, S.1    Yoshida, K.2    Ohgami, K.3
  • 37
    • 39749182234 scopus 로고    scopus 로고
    • Apoptosis: Controlled demolition at the cellular level
    • Taylor RC, Cullen SP, Martin SJ. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol. 2008;9(3):231-241.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , Issue.3 , pp. 231-241
    • Taylor, R.C.1    Cullen, S.P.2    Martin, S.J.3
  • 38
    • 33745639275 scopus 로고    scopus 로고
    • Pax6 overexpression suppresses cell proliferation and retards the cell cycle in corneal epithelial cells
    • Ouyang J, Shen YC, Yeh LK, et al. Pax6 overexpression suppresses cell proliferation and retards the cell cycle in corneal epithelial cells. Invest Ophthalmol Vis Sci. 2006;47(6):2397-2407.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , Issue.6 , pp. 2397-2407
    • Ouyang, J.1    Shen, Y.C.2    Yeh, L.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.