Long noncoding RNA-MEG3 is involved in diabetes mellitus-related microvascular dysfunction

Biochemical and Biophysical Research Communications

Volumn 471, Issue 1, 2016, Pages 135-141

  Qiu, Gui Zhen ^a   Tian, Wei ^b   Fu, Hai Tao ^a   Li, Chao Peng ^c   Liu, Ban ^d  

^a SHANDONG UNIVERSITY   (China)

^b Linyi Oncosurgical Hospital   (China)

^c Xuzhou Eye Institute   (China)

^d TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Diabetic retinopathy; Long noncoding RNA; Microvascular dysfunction; PI3k Akt signaling

Indexed keywords

COMPLEMENTARY DNA; GLUCOSE; LONG UNTRANSLATED RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; MEG3 NON-CODING RNA, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD RETINA BARRIER; CELL MIGRATION ASSAY; CELL PROLIFERATION; CELL VIABILITY ASSAY; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC MICROANGIOPATHY; DIABETIC RETINOPATHY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; GENE EXPRESSION; GENE LOCUS; IN VITRO STUDY; IN VIVO STUDY; MATERNALLY EXPRESSED GENE 3; MICROVASCULATURE; MOUSE; MTT ASSAY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RETINA BLOOD VESSEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; DOWN REGULATION; METABOLISM; PATHOPHYSIOLOGY;

ANIMALS; DIABETIC RETINOPATHY; DOWN-REGULATION; MICE; MICE, INBRED C57BL; MICROVESSELS; RETINAL VESSELS; RNA, LONG NONCODING;

EID: 84958880086     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.01.164     Document Type: Article

References (30)

1. J.W. Yau, S.L. Rogers, R. Kawasaki, E.L. Lamoureux, J.W. Kowalski, T. Bek, S.J. Chen, J.M. Dekker, A. Fletcher, and J. Grauslund Global prevalence and major risk factors of diabetic retinopathy Diabetes. Care 2012 DC-111909
2. R.A. Feit-Leichman, R. Kinouchi, M. Takeda, Z. Fan, S. Mohr, T.S. Kern, and D.F. Chen Vascular damage in a mouse model of diabetic retinopathy: relation to neuronal and glial changes Investig. Ophthalmol. Vis. Sci. 46 2005 4281 4287
3. A.J. Barber, T.W. Gardner, and S.F. Abcouwer The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy Investig. Ophthalmol. Vis. Sci. 52 2011 1156
4. C. Chu, K. Qu, F.L. Zhong, S.E. Artandi, and H.Y. Chang Genomic maps of long non-coding RNA occupancy reveal principles of RNA-chromatin interactions Mol. Cell 44 2011 667 678
5. C.P. Ponting, P.L. Oliver, and W. Reik Evolution and functions of long non-coding RNAs Cell 136 2009 629 641
6. B. Yan, Z.F. Tao, X.M. Li, H. Zhang, J. Yao, and Q. Jiang Aberrant expression of long non-coding RNAs in early diabetic retinopathy Investig. Ophthalmol. Vis. Sci. 55 2014 941 951
7. L.M. Villeneuve, and R. Natarajan The role of epigenetics in the pathology of diabetic complications Am. J. Physiol. Renal. 299 2010 F14 F25
8. B. Yan, J. Yao, J.Y. Liu, X.M. Li, X.Q. Wang, Y.J. Li, Z.F. Tao, Y.C. Song, Q. Chen, and Q. Jiang lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA Circ. Res. 116 2015 1143 1156
9. N. Jaé, and S. Dimmeler Long non-coding RNAs in diabetic retinopathy Circ. Res. 116 2015 1104 1106
10. Y. Zhou, X. Zhang, and A. Klibanski MEG3 non-coding RNA: a tumor suppressor J. Mol. Endocrinol. 48 2012 R45 R53
11. T. Mondal, S. Subhash, R. Vaid, S. Enroth, S. Uday, B. Reinius, S. Mitra, A. Mohammed, A.R. James, and E. Hoberg MEG3 long non-coding RNA regulates the TGF-[beta] pathway genes through formation of RNA-DNA triplex structures Nat. Commun. 6 2015
12. C. Wallace, D.J. Smyth, M. Maisuria-Armer, N.M. Walker, J.A. Todd, and D.G. Clayton The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes Nat. Genet. 42 2010 68 71
13. V. Kameswaran, N.C. Bramswig, L.B. McKenna, M. Penn, J. Schug, N.J. Hand, Y. Chen, I. Choi, A. Vourekas, and K.J. Won Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets Cell Metab. 19 2014 135 145
14. P.M. Martin, P. Roon, T.K. Van Ells, V. Ganapathy, and S.B. Smith Death of retinal neurons in streptozotocin-induced diabetic mice Investig. Ophthalmol. Vis. Sci. 45 2004 3330 3336
15. Q. Xu, T. Qaum, and A.P. Adamis Sensitive blood-retinal barrier breakdown quantitation using Evans blue Investig. Ophthalmol. Vis. Sci. 42 2001 789 794
16. Z. Dagher, Y.S. Park, V. Asnaghi, T. Hoehn, C. Gerhardinger, and M. Lorenzi Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy Diabetes 53 2004 2404 2411
17. O. Caspi, A. Lesman, Y. Basevitch, A. Gepstein, G. Arbel, I.H.M. Habib, L. Gepstein, and S. Levenberg Tissue engineering of vascularized cardiac muscle from human embryonic stem cells Circ. Res. 100 2007 263 272
18. A.M. Joussen, V. Poulaki, M.L. Le, K. Koizumi, C. Esser, H. Janicki, U. Schraermeyer, N. Kociok, S. Fauser, and B. Kirchhof A central role for inflammation in the pathogenesis of diabetic retinopathy FASEB J. 18 2004 1450 1452
19. M.R. Abid, S. Guo, T. Minami, K.C. Spokes, K. Ueki, C. Skurk, K. Walsh, and W.C. Aird Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells Arterioscler. Thromb. Vasc. Biol. 24 2004 294 300
20. S. Varma, B.K. Lal, R. Zheng, J.W. Breslin, S. Saito, P.J. Pappas, R.W. Hobson, and W.N. Durán Hyperglycemia alters PI3k and Akt signaling and leads to endothelial cell proliferative dysfunction Am. J. Physiol. Heart. C 289 2005 H1744 H1751
21. R.D. Bell, X. Long, M. Lin, J.H. Bergmann, V. Nanda, S.L. Cowan, Q. Zhou, Y. Han, D.L. Spector, and D. Zheng Identification and initial functional characterization of a human vascular cell-enriched long non-coding RNA Arterioscler. Thromb. Vasc. Biol. 34 2014 1249 1259
22. J. Liu, J. Yao, X. Li, Y. Song, X. Wang, Y. Li, B. Yan, and Q. Jiang Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus Cell Death Dis. 5 2014 e1506
23. A. Leung, and R. Natarajan Non-coding RNAs in vascular disease Curr. Opin. Cardiol. 29 2014 199 206
24. F. Giacco, and M. Brownlee Oxidative stress and diabetic complications Circ. Res. 107 2010 1058 1070
25. K.H. Lu, W. Li, X.H. Liu, M. Sun, M.L. Zhang, W.Q. Wu, W.P. Xie, and Y.Y. Hou Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression BMC Cancer 13 2013 461
26. R. Qin, Z. Chen, Y. Ding, J. Hao, J. Hu, and F. Guo Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis Neoplasma 60 2012 486 492
27. W. Peng, S. Si, Q. Zhang, C. Li, F. Zhao, F. Wang, J. Yu, and R. Ma Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression J. Exp. Clin. Cancer Res. 34 2015 1
28. S.D. Modali, V.I. Parekh, E. Kebebew, and S.K. Agarwal Epigenetic regulation of the lncRNA MEG3 and its target c-MET in pancreatic neuroendocrine tumors Mol. Endocrinol. 29 2015 224 237
29. I. Shiojima, and K. Walsh Role of Akt signaling in vascular homeostasis and angiogenesis Circ. Res. 90 2002 1243 1250
30. T. Franke PI3K/Akt: getting it right matters Oncogene 27 2008 6473 6488