Centrally acting drugmoxonidine decreases reactive oxygen species via inactivation of the phosphoinositide-3 kinase signaling in the rostral ventrolateralmedulla in hypertensive rats

Journal of Hypertension

Volumn 34, Issue 5, 2016, Pages 993-1004

  Wang, Yang Kai ^a   Yu, Qiang ^b   Tan, Xing ^a   Wu, Zhao Tang ^a   Zhang, Ru Wen ^a   Yang, Ya Hong ^a   Yuan, Wen Jun ^b   Hu, Qi Kuan ^b   Wang, Wei Zhong ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b NINGXIA MEDICAL UNIVERSITY   (China)

Author keywords

Angiotensin II; Centrally antihypertensive mechanism; Hypertension; Lentivirus; Oxidative stress

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; EFAROXAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MOXONIDINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SHORT HAIRPIN RNA; SUPEROXIDE DISMUTASE; TEMPOL; YOHIMBINE; ANTIHYPERTENSIVE AGENT; BENZOFURAN DERIVATIVE; IMIDAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME INACTIVATION; HYPERTENSION; IN VIVO STUDY; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ROSTRAL VENTROLATERAL MEDULLA; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; DISEASE MODEL; DRUG EFFECTS; MEDULLA OBLONGATA; METABOLISM; PATHOPHYSIOLOGY; SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR KYOTO RAT;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BENZOFURANS; DISEASE MODELS, ANIMAL; HYPERTENSION; IMIDAZOLES; MALE; MEDULLA OBLONGATA; PHOSPHATIDYLINOSITOL 3-KINASES; RATS; RATS, INBRED SHR; RATS, INBRED WKY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84958793897     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0000000000000887     Document Type: Article

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