Identification of IRAS/Nischarin as an I1-imidazoline receptor in PC12 rat pheochromocytoma cells

Journal of Neurochemistry

Volumn 101, Issue 1, 2007, Pages 99-108

  Sun, Zheng ^a   Chang, Chung Ho ^a   Ernsberger, Paul ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antisense; Efaroxan; ERK; Insulin; Moxonidine

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; IMIDAZOLINE I1 RECEPTOR; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; MOXONIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL LYSATE; CELL STRAIN; CONTROLLED STUDY; ENZYME ACTIVATION; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC TRANSFECTION; IMIDAZOLINE RECEPTOR ANTISERA SELECTED GENE; NISCHARIN GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RAT; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BASE SEQUENCE; BINDING SITES; BLOOD PRESSURE; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION; HUMANS; IMIDAZOLES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NEURONS; OLIGONUCLEOTIDES, ANTISENSE; PC12 CELLS; RATS; RECEPTORS, DRUG; SEQUENCE HOMOLOGY, AMINO ACID;

RATTUS;

EID: 33947253238     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04413.x     Document Type: Article

References (47)

1. Alahari S. K. (2003) Nischarin inhibits Rac induced migration and invasion of epithelial cells by affecting signaling cascades involving PAK. Exp. Cell Res. 288, 415-424.
2. Alahari S. K. and Nasrallah H. (2004) A membrane proximal region of the integrin alpha5 subunit is important for its interaction with nischarin. Biochem. J. 377, 449-457.
3. Alahari S. K., Lee J. W. and Juliano R. L. (2000) Nischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migration. J. Cell Biol. 151, 1141-1154.
4. Bennai F., Greney H., Vonthron C., Bousquet P. and Dontenwill M. (1996) Polyclonal anti-idiotypic antibodies to idazoxan and their interaction with human brain imidazoline binding sites. Eur. J. Pharmacol. 306, 211-218.
5. Bousquet P., Feldman J., Bloch R. and Schwartz J. (1984) Central cardiovascular effects of α-adrenergic drugs: differences between catecholamines and imidazolines. J. Pharmacol. Exp. Ther. 230, 232-236.
6. 2-adrenergic receptors in the antihypertensive responses evoked by central administration of clonidine analogs in conscious spontaneously hypertensive rats. J. Pharmacol. Exp. Ther. 273, 1162-1171.
7. Ceulemans H., De Maeyer M., Stalmans W. and Bollen M. (1999) A capping domain for LRR protein interaction modules. FEBS Lett. 456, 349-351.
8. Chan C. K. S., Burke S. L., Zhu H., Piletz J. E. and Head G. A. (2005) Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine. Neuroscience 132, 991-1007.
9. Chen S. R. and MacLennan D. H. (1994) Identification of calmodulin-, Ca(2+)-, and ruthenium red-binding domains in the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum. J. Biol. Chem. 269, 22 698-22 704.
10. Dontenwill M., Pascal G., Piletz J. E. et al. (2003a) IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells. Cell Death Differ. 10, 933-935.
11. Dontenwill M., Piletz J. E., Chen M., Baldwin J., Pascal G., Ronde P., Dupuy L., Greney H., Takeda K. and Bousquetd P. (2003b) IRAS is an anti-apoptotic protein. Ann. N. Y. Acad. Sci. 1009, 400-412.
12. Dupuy L., Urosevic D., Greney H., Quaglia W., Pigini M., Brasili L., Dontenwill M. and Bousquet P. (2004) I1 imidazoline receptor-mediated effects on apoptotic processes in PC12 cells. Cell Death Differ. 11, 1049-1052.
13. Edwards L. and Ernsberger P. (2003) The I(1)-imidazoline receptor in PC12 pheochromocytoma cells reverses NGF-induced ERK activation and induces MKP-2 phosphatase. Brain Res. 980, 71-79.
14. Edwards L., Fishman D., Horowitz P., Bourbon N., Kester M. and Ernsberger P. (2001) The I(1)-imidazoline receptor in PC12 pheochromocytoma cells activates protein kinases C, extracellular signal-regulated kinase (ERK) and c- jun N-terminal kinase (JNK). J. Neurochem. 79, 931-940.
15. Eglen R. M., Hudson A. L., Kendall D. A., Nutt D. J., Morgan N. G., Wilson V. G. and Dillon M. P. (1998) 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. Trends Pharmacol. Sci. 19, 381-390.
16. 1-imidazoline receptors. J. Auton. Nerv. Syst. 72, 147-154.
17. Ernsberger P. (1999) The I(1)-imidazoline receptor and its cellular signaling pathways. Ann. N. Y. Acad. Sci. 881, 35-53.
18. 1-imidazoline binding sites. Neurochem. Int. 30, 17-23.
19. Ernsberger P., Meeley M. P., Mann J. J. and Reis D. J. (1987) Clonidine binds to imidazole binding sites as well as α(2)-adrenoceptors in the ventrolateral medulla. Eur. J. Pharmacol. 134, 1-13.
20. 1-imidazoline sites. Ann. N. Y. Acad. Sci. 763, 163-168.
21. Escriba P. V., Ozaita A., Miralles A., Reis D. J. and Garcia-Sevilla J. A. (1995) Molecular characterization and isolation of a 45-kilodalton imidazoline receptor protein from the rat brain. Brain Res. Mol. Brain Res. 32, 187-196.
22. Evinger M. J., Ernsberger P., Regunathan S. and Reis D. J. (1995) Regulation of phenylethanolamine N-methyltransferase gene expression by imidazoline receptors in adrenal chromaffin cells. J. Neurochem. 65, 988-997.
23. García-Sevilla J. A., Escribá P. V., Sastre M., Walzer C., Busquets X., Jaquet G., Reis D. J. and Guimón J. (1996) Immunodetection and quantitation of imidazoline receptor proteins in platelets of patients with major depression and in brains of suicide victims. Arch. Gen. Psychiatry 53, 803-810.
24. 1-imidazoline receptors in the rostral ventrolateral medulla. J. Cardiovasc. Pharmacol. 24(Suppl. 1), S1-S8.
25. Heemskerk F. M., Dontenwill M., Greney H., Vonthron C. and Bousquet P. (1998) Evidence for the existence of imidazoline-specific binding sites in synaptosomal plasma membranes of the bovine brainstem. J. Neurochem. 71, 2193-2202.
26. Ivanov T. R., Feng Y., Wang H., Regunathan S., Reis D. J., Chikkala D. N., Gupta P., Jones J. C. and Piletz J. E. (1998a) Imidazoline receptor proteins are regulated in platelet-precursor MEG-01 cells by agonists and antagonists. J. Psychiatr. Res. 32, 65-79.
27. Ivanov T. R., Jones J. C., Dontenwill M., Bousquet P. and Piletz J. E. (1998b) Characterization of a partial cDNA clone detected by imidazoline receptor-selective antisera. J. Auton. Nerv. Syst. 72, 98-110.
28. Ivanov T. R., Zhu H., Regunathan S., Reis D. J., Dontenwill M., Vonthron C., Bousquet P. and Piletz J. E. (1998c) Co-detection by two imidazoline receptor protein antisera of a novel 85 kilodalton protein. Biochem. Pharmacol. 55, 649-655.
29. Lim K. P. and Hong W. (2004) Human nischarin/imidazoline receptor antisera-selected protein is targeted to the endosomes by a combined action of a PX domain and a coiled-coil region. J. Biol. Chem. 279, 54 770-54 782.
30. 2- adrenoceptor states plus a non-adrenergic site on human platelet plasma membranes. Biochem. Pharmacol. 42, 569-584.
31. Piletz J. E., Jones J. C., Zhu H., Bishara O. and Ernsberger P. (1999) Imidazoline receptor antisera-selected cDNA clone and mRNA distribution. Ann. N. Y. Acad. Sci. 881, 1-7.
32. Piletz J. E., Ivanov T. R., Sharp J. D. et al. (2000) Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization. DNA Cell Biol. 19, 319-329.
33. Piletz J. E., Deleersnijder W., Roth B. L., Ernsberger P., Zhu H. and Ziegler D. (2003a) IRAS splice variants. Ann. N. Y. Acad. Sci. 1009, 419-426.
34. Piletz J. E., Wang G. and Zhu H. (2003b) Cell signaling by imidazoline-1 receptor candidate, IRAS, and the nischarin homologue. Ann. N. Y. Acad. Sci. 1009, 392-399.
35. Prell G. D., Martinelli G. P., Holstein G. R., Matulic-Adamic J., Watanabe K. A., Chan S. L., Morgan N. G., Haxhiu M. A. and Ernsberger P. (2004) Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors. Proc. Natl Acad. Sci. USA 101, 13 677-13 682.
36. Raddatz R., Parini A. and Lanier S. M. (1995) Imidazoline/guanidinium binding domains on monoamine oxidases - relationship to subtypes of imidazoline-binding proteins and tissue-specific interaction of imidazoline ligands with monoamine oxidase B. J. Biol. Chem. 270, 27 961-27 968.
37. Sano H., Liu S. C., Lane W. S., Piletz J. E. and Lienhard G. E. (2002) Insulin receptor substrate 4 associates with the protein IRAS. J. Biol. Chem. 277, 19 439-19 447.
38. 1-imidazoline receptors to diacylglyceride accumulation in PC12 rat pheochromocytoma cells. Mol. Pharmacol. 49, 668-675.
39. 1-imidazoline receptors in PC12 cells and rostral ventrolateral medulla. Brain Res. 749, 335-339.
40. Sun Z., Chang C.-H. and Ernsberger P. (2004) Does IRAS Encode the I(1)-imidazoline receptor? Effects of IRAS antisense FASEB J. 18, A223.
41. Van Oekelen D., Luyten W. H. and Leysen J. E. (2003) Ten years of antisense inhibition of brain G-protein-coupled receptor function. Brain Res. Brain Res. Rev. 42, 123-142.
42. Wang H., Regunathan S., Ruggiero D. A. and Reis D. J. (1993) Production and characterization of antibodies specific for the imidazoline receptor protein. Mol. Pharmacol. 43, 509-515.
43. Worby C. A. and Dixon J. E. (2002) Sorting out the cellular functions of sorting nexins. Nat. Rev. Mol. Cell Biol. 3, 919-931.
44. Xu Y., Seet L. F., Hanson B. and Hong W. (2001) The Phox homology (PX) domain, a new player in phosphoinositide signalling. Biochem. J. 360, 513-530.
45. Zhang J. and Abdel-Rahman A. A. (2006) Nischarin as a functional imidazoline (I1) receptor. FEBS Lett. 580, 3070-3074.
46. Zhang J., El Mas M. M. and Abdel-Rahman A. A. (2001) Imidazoline I(1) receptor-induced activation of phosphatidylcholine- specific phospholipase C elicits mitogen-activated protein kinase phosphorylation in PC12 cells. Eur. J. Pharmacol. 415, 117-125.
47. Zhu H., Hayes J., Chen M., Baldwin J. and Piletz J. E. (2003) Relationship between platelet imidazoline receptor-binding peptides and candidate imidazoline-1 receptor, IRAS. Ann. N. Y. Acad. Sci. 1009, 439-446.