Aspirin suppresses cardiac fibroblast proliferation and collagen formation through downregulation of angiotensin type 1 receptor transcription

Toxicology and Applied Pharmacology

Volumn 259, Issue 3, 2012, Pages 346-354

  Wang, Xianwei ^a   Lu, Jingjun ^a   Khaidakov, Magomed ^a   Mitra, Sona ^a   Ding, Zufeng ^a   Raina, Sameer ^a   Goyal, Tanu ^a   Mehta, Jawahar L ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Angiotensin II; Aspirin; Cardiac fibroblast; Collagen; Matrix metalloproteinases; NADPH oxidase

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; CALCIUM ION; COLLAGEN; HYDROGEN PEROXIDE; LOSARTAN; MATRIX METALLOPROTEINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN P22; PROTEIN P47; PROTEIN P67; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; TRANSCRIPTION FACTOR RELA; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ARTICLE; ATTENUATION; CALCIUM CELL LEVEL; CELL COUNT; CELL CULTURE; CELL GROWTH; CELL ISOLATION; CELL PROLIFERATION; CELL STIMULATION; CELL VIABILITY; COLLAGEN SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SUBUNIT; FIBROBLAST; HEART MUSCLE CELL; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROVOCATION TEST; QUANTITATIVE ANALYSIS; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANGIOTENSIN II; ANIMALS; ASPIRIN; CELL PROLIFERATION; COLLAGEN; DOWN-REGULATION; FIBROBLASTS; LOSARTAN; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED C57BL; NADPH OXIDASE; NF-KAPPA B; REACTIVE OXYGEN SPECIES; RECEPTOR, ANGIOTENSIN, TYPE 1; TRANSCRIPTION, GENETIC;

EID: 84862796754     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.01.013     Document Type: Article

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