A genome-wide association study of pulmonary tuberculosis in Morocco

Human Genetics

Volumn 135, Issue 3, 2016, Pages 299-307

  Grant, A V ^a,b   Sabri, A ^c,d   Abid, A ^c   Abderrahmani Rhorfi, I ^c   Benkirane, M ^c   Souhi, H ^c   Naji Amrani, H ^c   Alaoui Tahiri, K ^c   Gharbaoui, Y ^c   Lazrak, F ^e   Sentissi, I ^e   Manessouri, M ^e   Belkheiri, S ^e   Zaid, S ^e   Bouraqadi, A ^e   El Amraoui, N ^f   Hakam, M ^f   Belkadi, A ^a,b   Orlova, M ^g   Boland, A ^h   Deswarte, C ^a,b   Amar, L ^a,b   Bustamante, J ^a,b,i   Boisson Dupuis, S ^a,b,j   Casanova, J L ^a,b,j,k   Schurr, E ^g   El Baghdadi, J ^c   Abel, L ^a,b,i   more..

^a IMAGINE INSTITUTE   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c MILITARY HOSPITAL MOHAMMED V   (Morocco)

^d IBN TOFAIL UNIVERSITY   (Morocco)

^e Centre de Diagnostic de la tuberculose et des Maladies Respiratoires CDTMR   (Morocco)

^f National Blood Transfusion Center   (Morocco)

^g RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^h DIF   (France)

ⁱ ROCKEFELLER UNIVERSITY   (United States)

^j HÔPITAL NECKER ENFANTS MALADES   (France)

^k HOWARD HUGHES MEDICAL INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AFRICA SOUTH OF THE SAHARA; AGED; AGMO GENE; ARTICLE; AUTOSOME; CONTROLLED STUDY; EFFECT SIZE; FEMALE; FOXP1 GENE; GENE; GENE LOCATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HUMAN; LUNG TUBERCULOSIS; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MOROCCO; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; RUSSIAN (PEOPLE); SINGLE NUCLEOTIDE POLYMORPHISM; ALLELE; CASE CONTROL STUDY; CHILD; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPING TECHNIQUE; INFANT; INTRON; METABOLISM; MICROBIOLOGY; MIDDLE AGED; ONSET AGE; PRESCHOOL CHILD; REPRODUCIBILITY; RISK FACTOR; YOUNG ADULT;

FORKHEAD TRANSCRIPTION FACTOR; FOXP1 PROTEIN, HUMAN; GLYCERYL-ETHER MONOOXYGENASE; MIXED FUNCTION OXIDASE; REPRESSOR PROTEIN;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; ALLELES; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENETIC LOCI; GENOME-WIDE ASSOCIATION STUDY; GENOTYPING TECHNIQUES; HUMANS; INFANT; INTRONS; MALE; MIDDLE AGED; MIXED FUNCTION OXYGENASES; MOROCCO; MYCOBACTERIUM TUBERCULOSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRESSOR PROTEINS; REPRODUCIBILITY OF RESULTS; RISK FACTORS; TUBERCULOSIS, PULMONARY; YOUNG ADULT;

EID: 84958765076     PISSN: 03406717     EISSN: 14321203     Source Type: Journal    
DOI: 10.1007/s00439-016-1633-2     Document Type: Article

References (45)

1. Abel L, Alcaïs A, Schurr E (2014a) The dissection of complex susceptibility to infectious disease: bacterial, viral and parasitic infections. Curr Opin Immunol 30C:72–78. doi:10.1016/j.coi.2014.07.002
2. Abel L, El-Baghdadi J, Bousfiha AA et al (2014b) Human genetics of tuberculosis: a long and winding road. Philos Trans R Soc Lond B Biol Sci 369:20130428. doi:10.1098/rstb.2013.0428
3. Alcaïs A, Fieschi C, Abel L, Casanova J-L (2005) Tuberculosis in children and adults: two distinct genetic diseases. J Exp Med 202:1617–1621. doi:10.1084/jem.20052302
4. Azad AK, Sadee W, Schlesinger LS (2012) Innate immune gene polymorphisms in tuberculosis. Infect Immun 80:3343–3359. doi:10.1128/IAI.00443-12
5. Baghdadi JE, Orlova M, Alter A et al (2006) An autosomal dominant major gene confers predisposition to pulmonary tuberculosis in adults. J Exp Med 203:1679–1684. doi:10.1084/jem.20060269
6. Barreiro LB, Tailleux L, Pai AA et al (2012) Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection. Proc Natl Acad Sci USA 109:1204–1209. doi:10.1073/pnas.1115761109
7. Bellamy R, Ruwende C, Corrah T et al (1998) Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans. N Engl J Med 338:640–644. doi:10.1056/NEJM199803053381002
8. Berry MPR, Graham CM, McNab FW et al (2010) An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 466:973–977. doi:10.1038/nature09247
9. Boisson-Dupuis S, El Baghdadi J, Parvaneh N et al (2011) IL-12Rβ1 deficiency in two of fifty children with severe tuberculosis from Iran, Morocco, and Turkey. PLoS One 6:e18524. doi:10.1371/journal.pone.0018524
10. Boisson-Dupuis S, Bustamante J, El-Baghdadi J et al (2015) Inherited and acquired immunodeficiencies underlying tuberculosis in childhood. Immunol Rev 264:103–120. doi:10.1111/imr.12272
11. Casanova J-L, Abel L (2002) Genetic dissection of immunity to mycobacteria: the human model. Annu Rev Immunol 20:581–620. doi:10.1146/annurev.immunol.20.081501.125851
12. Chimusa ER, Zaitlen N, Daya M et al (2014) Genome-wide association study of ancestry-specific TB risk in the South African Coloured population. Hum Mol Genet 23:796–809. doi:10.1093/hmg/ddt462
13. Cobat A, Gallant CJ, Simkin L et al (2009) Two loci control tuberculin skin test reactivity in an area hyperendemic for tuberculosis. J Exp Med 206:2583–2591. doi:10.1084/jem.20090892
14. Cobat A, Gallant CJ, Simkin L et al (2010) High heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease. J Infect Dis 201:15–19. doi:10.1086/648611
15. Cobat A, Barrera LF, Henao H et al (2012) Tuberculin skin test reactivity is dependent on host genetic background in Colombian tuberculosis household contacts. Clin Infect Dis Off Publ Infect Dis Soc Am 54:968–971. doi:10.1093/cid/cir972
16. Cobat A, Abel L, Alcaïs A, Schurr E (2014a) A general efficient and flexible approach for genome-wide association analyses of imputed genotypes in family-based designs. Genet Epidemiol 38:560–571. doi:10.1002/gepi.21842
17. Cobat A, Poirier C, Hoal E et al (2014b) Tuberculin skin test negativity is under tight genetic control of the chromosomal region 11p14-15 in settings of different TB endemicity. J Infect Dis. doi:10.1093/infdis/jiu446
18. Cochran WG (1954) The combination of estimates from different experiments. Biometrics 10:101–129
19. Curtis J, Luo Y, Zenner HL et al (2015) Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration. Nat Genet. doi:10.1038/ng.3248
20. Dai Y, Zhang X, Pan H et al (2011) Fine mapping of genetic polymorphisms of pulmonary tuberculosis within chromosome 18q11.2 in the Chinese population: a case-control study. BMC Infect Dis 11:282. doi:10.1186/1471-2334-11-282
21. Ernst JD (2012) The immunological life cycle of tuberculosis. Nat Rev Immunol 12:581–591. doi:10.1038/nri3259
22. Grant AV, El Baghdadi J, Sabri A et al (2013) Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region. Am J Hum Genet 92:407–414. doi:10.1016/j.ajhg.2013.01.013
23. Hamdan FF, Daoud H, Rochefort D et al (2010) De novo mutations in FOXP1 in cases with intellectual disability, autism, and language impairment. Am J Hum Genet 87:671–678. doi:10.1016/j.ajhg.2010.09.017
24. Horvath S, Xu X, Laird NM (2001) The family based association test method: strategies for studying general genotype–phenotype associations. Eur J Hum Genet EJHG 9:301–306. doi:10.1038/sj.ejhg.5200625
25. Jepson A, Fowler A, Banya W et al (2001) Genetic regulation of acquired immune responses to antigens of Mycobacterium tuberculosis: a study of twins in West Africa. Infect Immun 69:3989–3994. doi:10.1128/IAI.69.6.3989-3994.2001
26. Kaufmann SHE, Lange C, Rao M et al (2014) Progress in tuberculosis vaccine development and host-directed therapies—a state of the art review. Lancet Respir Med 2:301–320. doi:10.1016/S2213-2600(14)70033-5
27. Mägi R, Morris AP (2010) GWAMA: software for genome-wide association meta-analysis. BMC Bioinformatics 11:288. doi:10.1186/1471-2105-11-288
28. Mahasirimongkol S, Yanai H, Mushiroda T et al (2012) Genome-wide association studies of tuberculosis in Asians identify distinct at-risk locus for young tuberculosis. J Hum Genet 57:363–367. doi:10.1038/jhg.2012.35
29. Malik S, Abel L, Tooker H et al (2005) Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease. Proc Natl Acad Sci USA 102:12183–12188. doi:10.1073/pnas.0503368102
30. Meyer CG, Thye T (2014) Host genetic studies in adult pulmonary tuberculosis. Semin Immunol 26:445–453. doi:10.1016/j.smim.2014.09.005
31. Möller M, Hoal EG (2010) Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis. Tuberc Edinb Scotl 90:71–83. doi:10.1016/j.tube.2010.02.002
32. O’Garra A, Redford PS, McNab FW et al (2013) The immune response in tuberculosis. Annu Rev Immunol 31:475–527. doi:10.1146/annurev-immunol-032712-095939
33. Png E, Alisjahbana B, Sahiratmadja E et al (2012) A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians. BMC Med Genet 13:5. doi:10.1186/1471-2350-13-5
34. Puffer RR (1944) Familial susceptibility to tuberculosis: its importance as a public health problem. Harvard University Press
35. Purcell S, Neale B, Todd-Brown K et al (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81:559–575. doi:10.1086/519795
36. Sabri A, Grant AV, Cosker K et al (2014) Association study of genes controlling IL-12-dependent IFN-γ immunity: STAT4 alleles increase risk of pulmonary tuberculosis in Morocco. J Infect Dis 210:611–618. doi:10.1093/infdis/jiu140
37. Sepulveda RL, Heiba IM, Navarrete C et al (1994) Tuberculin reactivity after newborn BCG immunization in mono- and dizygotic twins. Tuber Lung Dis Off J Int Union Tuberc Lung Dis 75:138–143. doi:10.1016/0962-8479(94)90043-4
38. Shi C, Sakuma M, Mooroka T et al (2008) Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function. Blood 112:4699–4711. doi:10.1182/blood-2008-01-137018
39. Thye T, Vannberg FO, Wong SH et al (2010) Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nat Genet 42:739–741. doi:10.1038/ng.639
40. Thye T, Owusu-Dabo E, Vannberg FO et al (2012) Common variants at 11p13 are associated with susceptibility to tuberculosis. Nat Genet 44:257–259. doi:10.1038/ng.1080
41. Tokuoka SM, Kita Y, Shindou H, Shimizu T (2013) Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages. Biochem Biophys Res Commun 436:306–312. doi:10.1016/j.bbrc.2013.05.099
42. Vidal SM, Malo D, Vogan K et al (1993) Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell 73:469–485
43. Wang X, Tang NLS, Leung CC et al (2013) Association of polymorphisms in the Chr18q11.2 locus with tuberculosis in Chinese population. Hum Genet 132:691–695. doi:10.1007/s00439-013-1282-7
44. World Health Organization (WHO) (2011) Global tuberculosis control 2011. In: WHO. http://www.who.int/tb/publications/global_report/en/. Accessed 23 Apr 2012
45. World Health Organization (WHO) (2013) Global tuberculosis report 2013. In: WHO. http://www.who.int/tb/publications/global_report/en/. Accessed 7 Aug 2014