Tuberculin skin test reactivity is dependent on host genetic background in Colombian tuberculosis household contacts

Clinical Infectious Diseases

Volumn 54, Issue 7, 2012, Pages 968-971

  Cobat, Aurélie ^a,b   Barrera, Luis F ^c   Henao, Hanna ^c   Arbeláez, Patricia ^c   Abel, Laurent ^d,e,f   García, Luis F ^c   Schurr, Erwin ^a,b   Alcaïs, Alexandre ^d,e,f  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^d Necker Branch   (United States)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CONTACT EXAMINATION; FEMALE; GENETIC ANALYSIS; GENETIC VARIABILITY; HOUSEHOLD; HUMAN; LATENT TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; TUBERCULIN TEST;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; COLOMBIA; FAMILY CHARACTERISTICS; FEMALE; GENETIC VARIATION; HUMANS; INFANT; LATENT TUBERCULOSIS; MALE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; TUBERCULIN TEST; YOUNG ADULT;

EID: 84858136544     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cir972     Document Type: Article

References (12)

1. Vukmanovic-Stejic M, Reed JR, Lacy KE, Rustin MH, Akbar AN. Mantoux test as a model for a secondary immune response in humans. Immunol Lett 2006; 107:93-101. (Pubitemid 44779813)
2. Gallant CJ, Cobat A, Simkin L, et al. Tuberculin skin test and in vitro assays provide complementary measures of antimycobacterial immunity in children and adolescents. Chest 2010; 137:1071-7.
3. Sepulveda RL, Heiba IM, King A, Gonzalez B, Elston RC, Sorensen RU. Evaluation of tuberculin reactivity in BCG-immunized siblings. Am J Respir Crit Care Med 1994; 149:620-4. (Pubitemid 24082216)
4. Jepson A, Fowler A, Banya W, et al. Genetic regulation of acquired immune responses to antigens of Mycobacterium tuberculosis: a study of twins in West Africa. Infect Immun 2001; 69:3989-94. (Pubitemid 32493322)
5. Thye T, Browne EN, Chinbuah MA, et al. IL10 haplotype associated with tuberculin skin test response but not with pulmonary TB. PLoS One 2009; 4:e5420.
6. Zembrzuski VM, Basta PC, Callegari-Jacques SM, et al. Cytokine genes are associated with tuberculin skin test response in a native Brazilian population. Tuberculosis (Edinb) 2010; 90:44-9.
7. Cobat A, Gallant CJ, Simkin L, et al. Two loci control tuberculin skin test reactivity in an area hyperendemic for tuberculosis. J Exp Med 2009; 206:2583-91.
8. del Corral H, Paris SC, Marin ND, et al. IFNgamma response to Mycobacterium tuberculosis, risk of infection and disease in household contacts of tuberculosis patients in Colombia. PLoS One 2009; 4:e8257.
9. Royston P, Ambler G, Sauerbrei W. The use of fractional polynomials to model continuous risk variables in epidemiology. Int J Epidemiol 1999; 28:964-74. (Pubitemid 29525041)
10. Bonney GE. On the statistical determination of major gene mechanisms in continuous human traits: regressive models. Am J Med Genet 1984; 18:731-49. (Pubitemid 14075001)
11. Gallant CJ, Cobat A, Simkin L, et al. Impact of age and sex on mycobacterial immunity in an area of high tuberculosis incidence. Int J Tuberc Lung Dis 2010; 14:952-9.
12. Cobat A, Gallant CJ, Simkin L, et al. High heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease. J Infect Dis 2010; 201:15-9.