Antioxidative and anti-inflammatory effect of thymoquinone in an acute pseudomonas prostatitis rat model

Urologia Internationalis

Volumn 91, Issue 4, 2013, Pages 474-481

  Rifaioglu, Murat Mehmet ^a   Nacar, Ahmet ^b   Yuksel, Rana ^b   Yonden, Zafer ^b   Karcioglu, Murat ^a   Unal Zorba, O ^c   Davarci, Isil ^a   Sefil, Nebiat K ^b  

^a MUSTAFA KEMAL UNIVERSITY   (Turkey)

^b Department of Histology and Embryology ^*  (Turkey)

^c RECEP TAYYIP ERDOGAN UNIVERSITY   (Turkey)

Author keywords

Acute bacterial prostatitis; Pseudomonas aeruginosa; Rat; Thymoquinone

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CATALASE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; NITRIC OXIDE; SUPEROXIDE DISMUTASE; THYMOQUINONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROSTATITIS; PROTEIN DETERMINATION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; RAT; SCORING SYSTEM; FOLLOW UP; LEUKOCYTE AGGREGATION; LIPID PEROXIDATION; PROSTATE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BENZOQUINONES; CATALASE; DISEASE MODELS, ANIMAL; GLUTATHIONE PEROXIDASE; INFLAMMATION; MALE; MALONDIALDEHYDE; NITRIC OXIDE; PROSTATITIS; PSEUDOMONAS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE;

EID: 84890056169     PISSN: 00421138     EISSN: 14230399     Source Type: Journal    
DOI: 10.1159/000351261     Document Type: Article

References (43)

1. Krieger JN, Nyberg L Jr, Nickel JC: NIH consensus definition and classification of prostatitis. JAMA 1999; 282: 236-237.
2. Schaeffer AJ: Prostatitis: US perspective. Int J Antimicrob Agents 1999; 11: 205-211, discussion 213-206.
3. Millan-Rodriguez F, Palou J, Bujons-Tur A, Musquera-Felip M, Sevilla-Cecilia C, Serrallach-Orejas M, Baez-Angles C, Villavicencio-Mavrich H: Acute bacterial prostatitis: two different sub-categories according to a previous manipulation of the lower urinary tract. World J Urol 2006; 24: 45-50.
4. Skerk V, Krhen I, Schonwald S, Cajic V, Markovinovic L, Roglic S, Zekan S, Andracevic AT, Kruzic V: The role of unusual pathogens in prostatitis syndrome. Int J Antimicrob Agents 2004; 24(suppl 1):S53-S56.
5. Nagy V, Kubej D: Acute bacterial prostatitis in humans: current microbiological spectrum, sensitivity to antibiotics and clinical findings. Urol Int 2012; 89: 445-450.
6. Yamamichi F, Shigemura K, Matsumoto M, Nakano Y, Tanaka K, Arakawa S, Fujisawa M: Relationship between urinary tract infection categorization and pathogens' antimicrobial susceptibilities. Urol Int 2012; 88: 198-208.
7. Wagenlehner FM, Naber KG: Current challenges in the treatment of complicated urinary tract infections and prostatitis. Clin Microbiol Infect 2006; 12(suppl 3):67-80.
8. Ashraf SS, Rao MV, Kaneez FS, Qadri S, Al-Marzouqi AH, Chandranath IS, Adem A: Nigella sativa extract as a potent antioxidant for petrochemical-induced oxidative stress. J Chromatogr Sci 2011; 49: 321-326.
9. Badr G, Alwasel S, Ebaid H, Mohany M, Alhazza I: Perinatal supplementation with thymoquinone improves diabetic complications and t cell immune responses in rat offspring. Cell Immunol 2011; 267: 133-140.
10. Budancamanak M, Kanter M, Demirel A, Ocakci A, Uysal H, Karakaya C: Protective effects of thymoquinone and methotrexate on the renal injury in collagen-induced arthritis. Arch Toxicol 2006; 80: 768-776.
11. Nelson LK, D'Amours GH, Sproule-Willoughby KM, Morck DW, Ceri H: Pseudomonas aeruginosa las and rhl quorum-sensing systems are important for infection and inflammation in a rat prostatitis model. Microbiology 2009; 155: 2612-2619.
12. Al-Ali A, Alkhawajah AA, Randhawa MA, Shaikh NA: Oral and intraperitoneal LD50 of thymoquinone, an active principle of nigella sativa, in mice and rats. J Ayub Med Coll Abbottabad 2008; 20: 25-27.
13. Seo SI, Lee SJ, Kim JC, Choi YJ, Sw SW, Hwang TK, Cho YH: Effects of androgen deprivation on chronic bacterial prostatitis in a rat model. Int J Urol 2003; 10: 485-491.
14. Boehm BJ, Colopy SA, Jerde TJ, Loftus CJ, Bushman W: Acute bacterial inflammation of the mouse prostate. Prostate 2012; 72: 307-317.
15. Evirgen OGA, Ozturk H, Nacar E, Onlen Y, Ozer B, Motor VK: Effect of thymoquinone on oxidative stress in Escherichia coli-induced pyelonephritis in rats. Curr Ther Res 2011; 72: 204-215.
16. Esterbauer H, Cheeseman KH: Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 1990; 186: 407-421.
17. Cortas NK, Wakid NW: Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin Chem 1990; 36: 1440-1443.
18. Agha AH, Schechter E, Roy JB, Culkin DJ: Prostate specific antigen is metabolized in the liver. J Urol 1996; 155: 1332-1335.
19. Aebi H: Catalase; in Bergmeyer HU (ed): Methods of Enzymatic Analysis. New York, Academic Press, 1974, pp 673-677.
20. Paglia DE, Valentine WN: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 70: 158-169.
21. Sun Y, Oberley LW, Li Y: A simple method for clinical assay of superoxide dismutase. Clin Chem 1988; 34: 497-500.
22. De Marzo AM, Platz EA, Sutcliffe S, Xu J, Gronberg H, Drake CG, Nakai Y, Isaacs WB, Nelson WG: Inflammation in prostate carcinogenesis. Nat Rev Cancer 2007; 7: 256-269.
23. Maeda H, Akaike T: Nitric oxide and oxygen radicals in infection, inflammation, and cancer. Biochemistry (Mosc) 1998; 63: 854-865.
24. Omabe M, Ezeani M: Infection, inflammation and prostate carcinogenesis. Infect Genet Evol 2011; 11: 1195-1198.
25. Kim DS, Lee EJ, Cho KS, Yoon SJ, Lee YH, Hong SJ: Preventive effects of oligomerized polyphenol on estradiol-induced prostatitis in rats. Yonsei Med J 2009; 50: 391-398.
26. Lou JG, Dong J, Zheng YC, Zhang SM, Xiao WQ, Zhou JF: Increased oxidative stress and damage in patients with chronic bacterial prostatitis. Biomed Environ Sci 2006; 19: 481-486.
27. Zhou JF, Xiao WQ, Zheng YC, Dong J, Zhang SM: Increased oxidative stress and oxidative damage associated with chronic bacterial prostatitis. Asian J Androl 2006; 8: 317-323.
28. Janero DR, Hreniuk D, Sharif HM: Hydrogen peroxide-induced oxidative stress to the mammalian heart-muscle cell (cardiomyocyte): lethal peroxidative membrane injury. J Cell Physiol 1991; 149: 347-364.
29. Orsilles MA, Depiante-Depaoli M: Oxidative stress-related parameters in prostate of rats with experimental autoimmune prostatitis. Prostate 1998; 34: 270-274.
30. Inci M, Davarci M, Motor S, Yalcinkaya F, Nacar E, Aydin M, Sefil N, Zararsiz I: Antiinflammatory and antioxidant activity of thymoquinone in a rat model of acute bacterial prostatitis. Hum Exp Toxicol 2013; 32: 354-361.
31. Badary OA, Nagi MN, al-Shabanah OA, al-Sawaf HA, al-Sohaibani MO, al-Bekairi AM: Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity. Can J Physiol Pharmacol 1997; 75: 1356-1361.
32. El-Abhar HS, Abdallah DM, Saleh S: Gastroprotective activity of Nigella sativa oil and its constituent, thymoquinone, against gastric mucosal injury induced by ischaemia/reperfusion in rats. J Ethnopharmacol 2003; 84: 251-258.
33. Alenzi FQ, El-Bolkiny Yel S, Salem ML: Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anticancer drug cyclophosphamide. Br J Biomed Sci 2010; 67: 20-28.
34. Helal GK: Thymoquinone supplementation ameliorates acute endotoxemia-induced liver dysfunction in rats. Pak J Pharm Sci 2010; 23: 131-137.
35. Fouda AM, Daba MH, Dahab GM, Sharaf El-Din OA: Thymoquinone ameliorates renal oxidative damage and proliferative response induced by mercuric chloride in rats. Basic Clin Pharmacol Toxicol 2008; 103: 109-118.
36. Sies H: Damage to plasmid DNA by singlet oxygen and its protection. Mutat Res 1993; 299: 183-191.
37. Santini SA, Marra G, Giardina B, Cotroneo P, Mordente A, Martorana GE, Manto A, Ghirlanda G: Defective plasma antioxidant defenses and enhanced susceptibility to lipid peroxidation in uncomplicated iddm. Diabetes 1997; 46: 1853-1858.
38. Badary OA, Taha RA, Gamal el-Din AM, Abdel-Wahab MH: Thymoquinone is a potent superoxide anion scavenger. Drug Chem Toxicol 2003; 26: 87-98.
39. Shoskes DA, Nickel JC: Quercetin for chronic prostatitis/chronic pelvic pain syndrome. Urol Clin North Am 2011; 38: 279-284.
40. Burk DR, Senechal-Willis P, Lopez LC, Hogue BG, Daskalova SM: Suppression of lipopolysaccharide-induced inflammatory responses in raw 264.7 murine macrophages by aqueous extract of Clinopodium vulgare l. (Lamiaceae). J Ethnopharmacol 2009; 126: 397-405.
41. Wertz K: Lycopene effects contributing to prostate health. Nutr Cancer 2009; 61: 775-783.
42. Quintar AA, Doll A, Leimgruber C, Palmeri CM, Roth FD, Maccioni M, Maldonado CA: Acute inflammation promotes early cellular stimulation of the epithelial and stromal compartments of the rat prostate. Prostate 2010; 70: 1153-1165.
43. Simsir A, Kismali E, Mammadov R, Gunaydin G, Cal C: Is it possible to predict sepsis, the most serious complication in prostate biopsy? Urol Int 2010; 84: 395-399.