Thymoquinone inhibits phorbol ester-induced activation of NF-κB and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo

Biochemical and Biophysical Research Communications

Volumn 438, Issue 4, 2013, Pages 721-727

  Kundu, Joydeb Kumar ^a   Liu, Lijia ^b,c   Shin, Jun Wan ^b   Surh, Young Joon ^b  

^a Keimyung University   (South Korea)

^b Seoul National University   (South Korea)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Cyclooxygenase 2; Cytoprotective enzymes; Mouse skin; Nuclear factor kappaB; Thymoquinone

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CYCLOOXYGENASE 2; ENZYME; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NADPH QUINONEOXIDOREDUCTASE 1; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STRESS ACTIVATED PROTEIN KINASE; THYMOQUINONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BIODEGRADATION; CONTROLLED STUDY; DERMATITIS; DNA BINDING; DRUG MECHANISM; FEMALE; HAIRLESS MOUSE; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

CYCLOOXYGENASE-2; CYTOPROTECTIVE ENZYMES; MOUSE SKIN; NUCLEAR FACTOR-KAPPAB; THYMOQUINONE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BENZOQUINONES; CYCLOOXYGENASE 2; CYTOPROTECTION; FEMALE; GENE EXPRESSION REGULATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICE, HAIRLESS; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SKIN; TETRADECANOYLPHORBOL ACETATE;

NIGELLA SATIVA;

EID: 84883294242     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.07.110     Document Type: Article

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