The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration

Cellular Signalling

Volumn 27, Issue 12, 2015, Pages 2579-2588

  Peeters, Miriam C ^a,b   Fokkelman, Michiel ^b   Boogaard, Bob ^b   Egerod, Kristoffer L ^a   van de Water, Bob ^b   IJzerman, Ad P ^b   Schwartz, Thue W ^a  

^a Capital Region   (Denmark)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Activation mechanism; ADGRG2 GPR64; Adhesion G protein coupled receptor; Breast cancer; Cell adhesion; Cell migration

Indexed keywords

ADHESION G PROTEIN COUPLED RECEPTOR G2; G PROTEIN COUPLED RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; GPR64 PROTEIN, HUMAN; RELB PROTEIN, HUMAN; SRE PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELB;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPROTEOLYSIS; BREAST CANCER CELL LINE; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE SILENCING; GENETIC TRANSFECTION; HEK293 CELL LINE; HS578T CELL LINE; INTRACELLULAR SIGNALING; MDA MB 231 CELL LINE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; SERUM RESPONSIVE ELEMENT; STRUCTURE ACTIVITY RELATION; CELL MOTION; HUMAN; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DNA-BINDING PROTEINS; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; PROTEOLYSIS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELB; TRANSCRIPTION FACTORS;

EID: 84958672500     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2015.08.015     Document Type: Article

References (46)

1. Foord S.M., Bonner T.I., Neubig R.R., Rosser E.M., Pin J.P., Davenport A.P., Spedding M., Harmar A.J. Pharmacol. Rev. 2005, 57:279-288.
2. Paavola K.J., Hall R.A. Mol. Pharmacol. 2012, 82:777-783.
3. Osterhoff C., Ivell R., Kirchhoff C. DNA Cell Biol. 1997, 16:379-389.
4. Hamann J., Aust G., Arac D., Engel F.B., Formstone C., Fredriksson R., Hall R.A., Harty B.L., Kirchhoff C., Knapp B., Krishnan A., Liebscher I., Lin H.H., Martinelli D.C., Monk K.R., Peeters M.C., Piao X., Promel S., Schoneberg T., Schwartz T.W., Singer K., Stacey M., Ushkaryov Y.A., Vallon M., Wolfrum U., Wright M.W., Xu L., Langenhan T., Schioth H.B. Pharmacol. Rev. 2015, 67:338-367.
5. Arac D., Boucard A.A., Bolliger M.F., Nguyen J., Soltis S.M., Sudhof T.C., Brunger A.T. EMBO J. 2012, 31:1364-1378.
6. Kirchhoff C., Osterhoff C., Samalecos A. Reproduction 2008, 136:235-245.
7. Davies B., Baumann C., Kirchhoff C., Ivell R., Nubbemeyer R., Habenicht U.F., Theuring F., Gottwald U. Mol. Cell. Biol. 2004, 24:8642-8648.
8. Richter G.H., Fasan A., Hauer K., Grunewald T.G., Berns C., Rossler S., Naumann I., Staege M.S., Fulda S., Esposito I., Burdach S. J. Pathol. 2013, 230:70-81.
9. Koirala S., Jin Z., Piao X., Corfas G. J. Neurosci. 2009, 29:7439-7449.
10. Saito Y., Kaneda K., Suekane A., Ichihara E., Nakahata S., Yamakawa N., Nagai K., Mizuno N., Kogawa K., Miura I., Itoh H., Morishita K. Leukemia 2013, 27:1637-1649.
11. Iguchi T., Sakata K., Yoshizaki K., Tago K., Mizuno N., Itoh H. J. Biol. Chem. 2008, 283:14469-14478.
12. Tang X., Jin R., Qu G., Wang X., Li Z., Yuan Z., Zhao C., Siwko S., Shi T., Wang P., Xiao J., Liu M., Luo J. Cancer Res. 2013, 73:6206-6218.
13. Galle J., Sittig D., Hanisch I., Wobus M., Wandel E., Loeffler M., Aust G. Am. J. Pathol. 2006, 169:1802-1811.
14. Langenhan T., Aust G., Hamann J. Sci. Signal. 2013, 6:re3.
15. Liebscher I., Ackley B., Arac D., Ariestanti D.M., Aust G., Bae B.I., Bista B.R., Bridges J.P., Duman J.G., Engel F.B., Giera S., Goffinet A.M., Hall R.A., Hamann J., Hartmann N., Lin H.H., Liu M., Luo R., Mogha A., Monk K.R., Peeters M.C., Promel S., Ressl S., Schioth H.B., Sigoillot S.M., Song H., Talbot W.S., Tall G.G., White J.P., Wolfrum U., Xu L., Piao X. Ann. N. Y. Acad. Sci. 2014, 1333:43-64.
16. Krasnoperov V., Lu Y., Buryanovsky L., Neubert T.A., Ichtchenko K., Petrenko A.G. J. Biol. Chem. 2002, 277:46518-46526.
17. Arac D., Aust G., Calebiro D., Engel F.B., Formstone C., Goffinet A., Hamann J., Kittel R.J., Liebscher I., Lin H.H., Monk K.R., Petrenko A., Piao X., Promel S., Schioth H.B., Schwartz T.W., Stacey M., Ushkaryov Y.A., Wobus M., Wolfrum U., Xu L., Langenhan T. Ann. N. Y. Acad. Sci. 2012, 1276:1-25.
18. Liebscher I., Schon J., Petersen S.C., Fischer L., Auerbach N., Demberg L.M., Mogha A., Coster M., Simon K.U., Rothemund S., Monk K.R. Schoneberg T. Cell Rep. 2014, 9:2018-2026.
19. Stoveken H.M., Hajduczok A.G., Xu L., Tall G.G. Proceedings of the National Academy of Sciences of the United States of America 2015.
20. Okajima D., Kudo G., Yokota H. J. Recept. Signal Transduct. Res. 2010, 30:143-153.
21. Paavola K.J., Stephenson J.R., Ritter S.L., Alter S.P. Hall RA. J. Biol. Chem. 2011, 286:28914-28921.
22. Ward Y., Lake R., Yin J.J., Heger C.D., Raffeld M., Goldsmith P.K., Merino M., Kelly K. Cancer Res. 2011, 71:7301-7311.
23. Naffar-Abu-Amara S., Shay T., Galun M., Cohen N., Isakoff S.J., Kam Z. Geiger B. PLoS ONE 2008, 3:e1457.
24. Ezratty E.J., Partridge M.A., Gundersen G.G. Nat. Cell Biol. 2005, 7:581-590.
25. Carpenter A.E., Jones T.R., Lamprecht M.R., Clarke C., Kang I.H., Friman O., Guertin D.A., Chang J.H., Lindquist R.A., Moffat J., Golland P., Sabatini D.M. Genome Biol. 2006, 7:R100.
26. Yan K., Verbeek F. Leveraging Applications of Formal Methods, Verification and Validation. Applications and Case Studies 2012, 25-41. Springer, Berlin Heidelberg. T. Margaria, B. Steffen (Eds.).
27. Wink S., Hiemstra S., Huppelschoten S., Danen E., Niemeijer M., Hendriks G., Vrieling H., Herpers B., van de Water B. Chem. Res. Toxicol. 2014, 27:338-355.
28. Hodges R.S., Heaton R.J., Parker J.M., Molday L., Molday R.S. J. Biol. Chem. 1988, 263:11768-11775.
29. Guan X.M., Kobilka T.S., Kobilka B.K. J. Biol. Chem. 1992, 267:21995-21998.
30. Liu H., Naismith J.H. BMC Biotechnol. 2008, 8:91.
31. van Roosmalen W., Le Devedec S.E., Golani O., Smid M., Pulyakhina I., Timmermans A.M., Look M.P., Zi D., Pont C., de Graauw M., Naffar-Abu-Amara S., Kirsanova C., Rustici G., Hoen P.A., Martens J.W., Foekens J.A., Geiger B., van de Water B. J. Clin. Investig. 2015, 125:1648-1664.
32. Krishnan A., Almen M.S., Fredriksson R. Schioth HB. PLoS ONE 2012, 7:e29817.
33. Nordstrom K.J., Lagerstrom M.C., Waller L.M., Fredriksson R., Schioth H.B. Mol. Biol. Evol. 2009, 26:71-84.
34. Bjarnadottir T.K., Fredriksson R., Schioth H.B. Cell Mol. Life Sci. 2007, 64:2104-2119.
35. Cotton M., Claing A. Cell. Signal. 2009, 21:1045-1053.
36. Fraser C.C. Int. Rev. Immunol. 2008, 27:320-350.
37. Perkins N.D. Nature reviews. Mol. Cell. Biol. 2007, 8:49-62.
38. Siehler S. Br. J. Pharmacol. 2009, 158:41-49.
39. Riobo N.A., Manning D.R. Trends Pharmacol. Sci. 2005, 26:146-154.
40. Takashima S., Sugimoto N., Takuwa N., Okamoto Y., Yoshioka K., Takamura M., Takata S., Kaneko S., Takuwa Y. Cardiovasc. Res. 2008, 79:689-697.
41. Steen A., Thiele S., Guo D., Hansen L.S., Frimurer T.M., Rosenkilde M.M. J. Biol. Chem. 2013, 288:12511-12521.
42. Fredriksson R., Gloriam D.E., Hoglund P.J., Lagerstrom M.C., Schioth H.B. Biochem. Biophys. Res. Commun. 2003, 301:725-734.
43. Promel S., Waller-Evans H., Dixon J., Zahn D., Colledge W.H., Doran J., Carlton M.B., Grosse J., Schoneberg T., Russ A.P., Langenhan T. Dev. Dyn. 2012, 241:1591-1602.
44. Wang X., Belguise K., Kersual N., Kirsch K.H., Mineva N.D., Galtier F., Chalbos D., Sonenshein G.E. Nat. Cell Biol. 2007, 9:470-478.
45. Hamann J., Vogel B., van Schijndel G.M., van Lier R.A. J. Exp. Med. 1996, 184:1185-1189.
46. Luo R., Jeong S.J., Jin Z., Strokes N., Li S., Piao X. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:12925-12930.