Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: A single-center experience in Saudi Arabia

International Journal of Infectious Diseases

Volumn 29, Issue , 2014, Pages 301-306

  Saad, Mustafa ^a   Omrani, Ali S ^a,b   Baig, Kamran ^a   Bahloul, Abdelkarim ^a   Elzein, Fatehi ^a   Matin, Mohammad Abdul ^c   Selim, Mohei A A ^a   Mutairi, Mohammed Al ^c   Nakhli, Daifullah Al ^a   Aidaroos, Amal Y Al ^a   Sherbeeni, Nisreen Al ^a   Al Khashan, Hesham I ^a   Memish, Ziad A ^d   Albarrak, Ali M ^a  

^a The General Directorate of Armed Forces Health Services   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^d ALFAISAL UNIVERSITY   (Saudi Arabia)

Author keywords

Clinical; Epidemiology; Middle East respiratory syndrome coronavirus (MERS CoV); Saudi Arabia

Indexed keywords

ALBUMIN; ASPARTATE AMINOTRANSFERASE; HEMOGLOBIN;

ABDOMINAL PAIN; ABNORMAL LABORATORY RESULT; ACINETOBACTER BAUMANNII; ACUTE KIDNEY FAILURE; ACUTE LUNG INJURY; ADOLESCENT; ADULT; AGED; ARTHRALGIA; ARTICLE; BACTERIAL PNEUMONIA; BRADYCARDIA; CANDIDEMIA; CHARLSON COMORBIDITY INDEX; CHILD; CLINICAL FEATURE; CLOSTRIDIUM DIFFICILE INFECTION; CONCURRENT INFECTION; CONFUSION; CORONAVIRUS INFECTION; COUGHING; DIARRHEA; DISEASE TRANSMISSION; DYSPNEA; EPIDEMIC; EPIDEMIOLOGICAL DATA; FATIGUE; FEMALE; FEVER; GROUPS BY AGE; HEART ARRHYTHMIA; HEMOPTYSIS; HOSPITAL ADMISSION; HUMAN; INFANT; INFECTION CONTROL; INFECTION RISK; INTENSIVE CARE; LIVER DYSFUNCTION; LUNG INFILTRATE; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS INFECTION; MORTALITY; MYALGIA; NEWBORN; OUTCOME ASSESSMENT; PNEUMONIA; PREVENTIVE MEDICINE; RETROSPECTIVE STUDY; SAUDI ARABIA; SOFT TISSUE INFECTION; TACHYCARDIA; THORAX RADIOGRAPHY; URINARY TRACT INFECTION; VIRAL RESPIRATORY TRACT INFECTION; VOMITING; CORONAVIRUS INFECTIONS; MIDDLE AGED; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS;

AGED; CORONAVIRUS INFECTIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; RETROSPECTIVE STUDIES; SAUDI ARABIA;

EID: 84916891516     PISSN: 12019712     EISSN: 18783511     Source Type: Journal    
DOI: 10.1016/j.ijid.2014.09.003     Document Type: Article

References (22)

1. Zaki A.M., van Boheemen S., Bestebroer T.M., Osterhaus A.D., Fouchier R.A. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 2012, 367:1814-1820.
2. World Health Organization. Middle East respiratory syndrome coronavirus (MERS-CoV)-summary and literature update as of 11 June 2014. Geneva: WHO; 2014. Available at: (accessed September 20, 2014). http://www.who.int/csr/disease/coronavirus_infections/MERS-CoV_summary_update_20140611.pdf%3Fua=1.
3. Assiri A., Al-Tawfiq J.A., Al-Rabeeah A.A., Al-Rabiah F.A., Al-Hajjar S., Al-Barrak A., et al. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis 2013, 13:752-761.
4. State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans. PLoS Curr 2013, 5. The WHO MERS-CoV Research Group, pii: ecurrents.outbreaks.0bf719e352e7478f8ad85fa30127ddb8.
5. Dyall J., Coleman C.M., Hart B.J., Venkataraman T., Holbrook M.R., Kindrachuk J., et al. Repurposing of clinically developed drugs for treatment of Middle East respiratory coronavirus infection. Antimicrob Agents Chemother 2014, 58:4885-4893.
6. Al-Tawfiq J.A., Hinedi K., Ghandour J., Khairalla H., Musleh S., Ujayli A., et al. Middle East respiratory syndrome-coronavirus (MERS-CoV): a case-control study of hospitalized patients. Clin Infect Dis 2014, 59:160-165.
7. Arabi Y.M., Arifi A.A., Balkhy H.H., Najm H., Aldawood A.S., Ghabashi A., et al. Clinical course and outcomes of critically ill patients with middle East respiratory syndrome coronavirus infection. Ann Intern Med 2014, 160:389-397.
8. Assiri A., McGeer A., Perl T.M., Price C.S., Al Rabeeah A.A., Cummings D.A., et al. Hospital outbreak of Middle East respiratory syndrome coronavirus. N Engl J Med 2013, 369:407-416.
9. Bermingham A., Chand M.A., Brown C.S., Aarons E., Tong C., Langrish C., et al. Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012. Euro Surveill 2012, 17:pii: 20290.
10. Drosten C., Seilmaier M., Corman V.M., Hartmann W., Scheible G., Sack S., et al. Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection. Lancet Infect Dis 2013, 13:745-751.
11. Guery B., Poissy J., el Mansouf L., Sejourne C., Ettahar N., Lemaire X., et al. Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission. Lancet 2013, 381:2265-2272.
12. Memish Z.A., Zumla A.I., Al-Hakeem R.F., Al-Rabeeah A.A., Stephens G.M. Family cluster of Middle East respiratory syndrome coronavirus infections. N Engl J Med 2013, 368:2487-2494.
13. Omrani A.S., Matin M.A., Haddad Q., Al-Nakhli D., Memish Z.A., Albarrak A.M. A family cluster of Middle East respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case. Int J Infect Dis 2013, 17:e668-e672.
14. Puzelli S., Azzi A., Santini M.G., Di Martino A., Facchini M., Castrucci M.R., et al. Investigation of an imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in Florence, Italy, May to June 2013. Euro Surveill 2013, 18. pii: 20564.
15. Corman V.M., Muller M.A., Costabel U., Timm J., Binger T., Meyer B., et al. Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections. Euro Surveill 2012, 17. pii: 20285.
16. Memish Z.A., Cotten M., Watson S.J., Kellam P., Zumla A., Alhakeem R.F., et al. Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study. Int J Infect Dis 2014, 23:63-68.
17. Peiris J.S., Yuen K.Y., Osterhaus A.D., Stöhr K. The severe acute respiratory syndrome. N Engl J Med 2003, 349:2431-2441.
18. Breban R., Riou J., Fontanet A. Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk. Lancet 2013, 382:694-699.
19. Cauchemez S., Fraser C., Van Kerkhove M.D., Donnelly C.A., Riley S., Rambaut A., et al. Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility. Lancet Infect Dis 2014, 14:50-56.
20. Haagmans B.L., Al Dhahiry S.H., Reusken C.B., Raj V.S., Galiano M., Myers R., et al. Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation. Lancet Infect Dis 2014, 14:140-145.
21. Hemida M.G., Chu D.K., Poon L.L., Perera R.A., Alhammadi M.A., Ng H.Y., et al. MERS coronavirus in dromedary camel herd, Saudi Arabia. Emerg Infect Dis 2014, 20:1231-1234.
22. Memish Z.A., Cotten M., Meyer B., Watson S.J., Alsahafi A.J., Al Rabeeah A.A., et al. Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013. Emerg Infect Dis 2014, 20:1012-1015.