Polarization of monocytic myeloid-derived suppressor cells by hepatitis b surface antigen is mediated via ERK/IL-6/STAT3 signaling feedback and restrains the activation of T cells in chronic hepatitis B virus infection

Journal of Immunology

Volumn 195, Issue 10, 2015, Pages 4873-4883

  Fang, Zhong ^a,b   Li, Jin ^a   Yu, Xiaoyu ^a   Zhang, Dandan ^a   Ren, Guangxu ^a   Shi, Bisheng ^a   Wang, Cong ^a   Kosinska, Anna D ^a   Wang, Sen ^a   Zhou, Xiaohui ^a   Kozlowski, Maya ^a,c   Hu, Yunwen ^a   Yuan, Zhenghong ^a,b  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HEPATITIS B SURFACE ANTIGEN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; RETINOIC ACID; STAT3 PROTEIN; IL6 PROTEIN, HUMAN; INTERLEUKIN-6, MOUSE; STAT3 PROTEIN, HUMAN; STAT3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN FUNCTION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL POLARITY; CHRONIC HEPATITIS B; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MONOCYTE; MOUSE; MOUSE MODEL; MYELOID DERIVED SUPPRESSOR CELL; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SUPPRESSOR CELL; T LYMPHOCYTE ACTIVATION; VIRUS LOAD; ANIMAL; FEMALE; HEPATITIS B; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MALE; PATHOLOGY; TRANSGENIC MOUSE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; FEMALE; HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B, CHRONIC; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-6; LYMPHOCYTE ACTIVATION; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, TRANSGENIC; MONOCYTES; STAT3 TRANSCRIPTION FACTOR;

EID: 84958634252     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1501362     Document Type: Article

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