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Volumn 6, Issue , 2016, Pages

Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling

Author keywords

[No Author keywords available]

Indexed keywords

GRN PROTEIN, HUMAN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; RAPAMYCIN; SIGNAL PEPTIDE; TARGET OF RAPAMYCIN KINASE;

EID: 84958279314     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep21260     Document Type: Article
Times cited : (54)

References (60)
  • 2
    • 35348938581 scopus 로고    scopus 로고
    • Epidemiology of hepatocellular carcinoma in Hispanics in the United States
    • El-Serag, H. B., Lau, M., Eschbach, K., Davila, J., Goodwin, J. Epidemiology of hepatocellular carcinoma in Hispanics in the United States. Arch Intern Med 167, 1983-9 (2007).
    • (2007) Arch Intern Med , vol.167 , pp. 1983-1989
    • El-Serag, H.B.1    Lau, M.2    Eschbach, K.3    Davila, J.4    Goodwin, J.5
  • 3
    • 80053088189 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • El-Serag, H. B. Hepatocellular carcinoma. N Engl J Med 365, 1118-27 (2011).
    • (2011) N Engl J Med , vol.365 , pp. 1118-1127
    • El-Serag, H.B.1
  • 4
    • 84874642641 scopus 로고    scopus 로고
    • The inflammatory microenvironment in hepatocellular carcinoma: A pivotal role for tumor-associated macrophages
    • Capece, D. et al. The inflammatory microenvironment in hepatocellular carcinoma: a pivotal role for tumor-associated macrophages. Biomed Res Int 2013, 187204 (2013).
    • (2013) Biomed Res Int , vol.2013 , pp. 187204
    • Capece, D.1
  • 5
    • 84896494013 scopus 로고    scopus 로고
    • IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
    • Taniguchi, K., Karin, M. IL-6 and related cytokines as the critical lynchpins between inflammation and cancer. Semin Immunol 26, 54-74 (2014).
    • (2014) Semin Immunol , vol.26 , pp. 54-74
    • Taniguchi, K.1    Karin, M.2
  • 6
    • 0026691627 scopus 로고
    • Serum levels of cytokines in chronic liver diseases
    • Tilg, H. et al. Serum levels of cytokines in chronic liver diseases. Gastroenterology 103, 264-74 (1992).
    • (1992) Gastroenterology , vol.103 , pp. 264-274
    • Tilg, H.1
  • 7
    • 0142250392 scopus 로고    scopus 로고
    • Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: A review of the rationale and clinical evidence
    • Trikha, M., Corringham, R., Klein, B., Rossi, JF. Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence. Clin Cancer Res 9, 4653-65 (2003).
    • (2003) Clin Cancer Res , vol.9 , pp. 4653-4665
    • Trikha, M.1    Corringham, R.2    Klein, B.3    Rossi, J.F.4
  • 8
    • 70349849505 scopus 로고    scopus 로고
    • Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: An analysis based on gender differences
    • Nakagawa, H. et al. Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: an analysis based on gender differences. Int J Cancer 125, 2264-9 (2009).
    • (2009) Int J Cancer , vol.125 , pp. 2264-2269
    • Nakagawa, H.1
  • 9
    • 65649111667 scopus 로고    scopus 로고
    • High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B
    • Wong, V. et al. High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B. Int J Cancer 124, 2766-70 (2009).
    • (2009) Int J Cancer , vol.124 , pp. 2766-2770
    • Wong, V.1
  • 10
    • 0029780955 scopus 로고    scopus 로고
    • The hairpin stack fold, a novel protein architecture for a new family of protein growth factors
    • Hrabal, R., Chen, Z., James, S., Bennett, H. P., Ni, F. The hairpin stack fold, a novel protein architecture for a new family of protein growth factors. Nat Struct Biol 3, 747-52 (1996).
    • (1996) Nat Struct Biol , vol.3 , pp. 747-752
    • Hrabal, R.1    Chen, Z.2    James, S.3    Bennett, H.P.4    Ni, F.5
  • 11
    • 79955477738 scopus 로고    scopus 로고
    • The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice
    • Tang, W. et al. The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science 332, 478-84 (2011).
    • (2011) Science , vol.332 , pp. 478-484
    • Tang, W.1
  • 12
    • 84886270492 scopus 로고    scopus 로고
    • Deletion of progranulin exacerbates atherosclerosis in ApoE knockout mice
    • Kawase, R. et al. Deletion of progranulin exacerbates atherosclerosis in ApoE knockout mice. Cardiovasc Res 100, 125-33 (2013).
    • (2013) Cardiovasc Res , vol.100 , pp. 125-133
    • Kawase, R.1
  • 13
    • 84855430348 scopus 로고    scopus 로고
    • PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue
    • Matsubara, T. et al. PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue. Cell Metab 15, 38-50 (2012).
    • (2012) Cell Metab , vol.15 , pp. 38-50
    • Matsubara, T.1
  • 14
    • 84944474634 scopus 로고    scopus 로고
    • PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner
    • Wei, F. et al. PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner. Sci Rep 4, 7023 (2014).
    • (2014) Sci Rep , vol.4 , pp. 7023
    • Wei, F.1
  • 15
    • 84925237257 scopus 로고    scopus 로고
    • Progranulin knockout accelerates intervertebral disc degeneration in aging mice
    • Zhao, Y. P. et al. Progranulin knockout accelerates intervertebral disc degeneration in aging mice. Sci Rep 5, 9102 (2015).
    • (2015) Sci Rep , vol.5 , pp. 9102
    • Zhao, Y.P.1
  • 16
    • 70549109118 scopus 로고    scopus 로고
    • The granulin gene family: From cancer to dementia
    • Bateman, A., Bennett, H. P. The granulin gene family: from cancer to dementia. Bioessays 31, 1245-54 (2009).
    • (2009) Bioessays , vol.31 , pp. 1245-1254
    • Bateman, A.1    Bennett, H.P.2
  • 17
    • 0242320195 scopus 로고    scopus 로고
    • Progranulin (granulin-epithelin precursor PC-cell-derived growth factor acrogranin) mediates tissue repair and tumorigenesis
    • He, Z., Bateman, A. Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis. J Mol Med (Berl) 81, 600-12 (2003).
    • (2003) J Mol Med (Berl) , vol.81 , pp. 600-612
    • He, Z.1    Bateman, A.2
  • 18
    • 84866602930 scopus 로고    scopus 로고
    • Progranulin compensates for blocked IGF-1 signaling to promote myotube hypertrophy in C2C12 myoblasts via the PI3K/Akt/mTOR pathway
    • Hu, S. Y., Tai, C. C., Li, Y. H., Wu, J. L. Progranulin compensates for blocked IGF-1 signaling to promote myotube hypertrophy in C2C12 myoblasts via the PI3K/Akt/mTOR pathway. FEBS Lett 586, 3485-92 (2012).
    • (2012) FEBS Lett , vol.586 , pp. 3485-3492
    • Hu, S.Y.1    Tai, C.C.2    Li, Y.H.3    Wu, J.L.4
  • 19
    • 0035985214 scopus 로고    scopus 로고
    • Gene expression patterns in human liver cancers
    • Chen, X. et al. Gene expression patterns in human liver cancers. Mol Biol Cell 13, 1929-39 (2002).
    • (2002) Mol Biol Cell , vol.13 , pp. 1929-1939
    • Chen, X.1
  • 20
    • 9344229795 scopus 로고    scopus 로고
    • Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma
    • Cheung, S.T. et al. Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma. Clin Cancer Res 10, 7629-36 (2004).
    • (2004) Clin Cancer Res , vol.10 , pp. 7629-7636
    • Cheung, S.T.1
  • 21
    • 78650511134 scopus 로고    scopus 로고
    • Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance
    • Cheung, S. T., Cheung, P. F., Cheng, C. K., Wong, N. C., Fan, S.T. Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance. Gastroenterology 140, 344-55 (2011).
    • (2011) Gastroenterology , vol.140 , pp. 344-355
    • Cheung, S.T.1    Cheung, P.F.2    Cheng, C.K.3    Wong, N.C.4    Fan, S.T.5
  • 22
    • 84855170282 scopus 로고    scopus 로고
    • Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism
    • Frampton, G. et al. Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism. Gut 61, 268-77 (2012).
    • (2012) Gut , vol.61 , pp. 268-277
    • Frampton, G.1
  • 23
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: A target for cancer therapy
    • Bjornsti, M. A., Houghton, P. J. The TOR pathway: a target for cancer therapy. Nat Rev Cancer 4, 335-48 (2004).
    • (2004) Nat Rev Cancer , vol.4 , pp. 335-348
    • Bjornsti, M.A.1    Houghton, P.J.2
  • 24
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov, D. D., Guertin, D. A., Ali, S. M., Sabatini, D. M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-101 (2005).
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 25
    • 33947501692 scopus 로고    scopus 로고
    • Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation
    • Sieghart, W. et al. Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation. Transplantation 83, 425-32 (2007).
    • (2007) Transplantation , vol.83 , pp. 425-432
    • Sieghart, W.1
  • 26
    • 57349087153 scopus 로고    scopus 로고
    • Pivotal role of mTOR signaling in hepatocellular carcinoma
    • Villanueva, A. et al. Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology 135, 1972-83 (2008).
    • (2008) Gastroenterology , vol.135 , pp. 1972-1983
    • Villanueva, A.1
  • 28
    • 34047118033 scopus 로고    scopus 로고
    • Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma
    • Semela, D. et al. Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma. J Hepatol 46, 840-8 (2007).
    • (2007) J Hepatol , vol.46 , pp. 840-848
    • Semela, D.1
  • 29
    • 84938224557 scopus 로고    scopus 로고
    • Mechanisms of hepatocellular carcinoma and challenges and opportunities for molecular targeted therapy
    • Chen, C., Wang, G. Mechanisms of hepatocellular carcinoma and challenges and opportunities for molecular targeted therapy. World J Hepatol 7, 1964-70 (2015).
    • (2015) World J Hepatol , vol.7 , pp. 1964-1970
    • Chen, C.1    Wang, G.2
  • 30
    • 7044239399 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Current management and future trends
    • Carr, B. I. Hepatocellular carcinoma: current management and future trends. Gastroenterology 127, S218-24 (2004).
    • (2004) Gastroenterology , vol.127 , pp. S218-S224
    • Carr, B.I.1
  • 31
    • 0037308133 scopus 로고    scopus 로고
    • Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival
    • Llovet, J. M., Bruix, J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Hepatology 37, 429-42 (2003).
    • (2003) Hepatology , vol.37 , pp. 429-442
    • Llovet, J.M.1    Bruix, J.2
  • 32
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm, S. M. et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 64, 7099-109 (2004).
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1
  • 33
    • 80055013740 scopus 로고    scopus 로고
    • Safety and tolerance of sorafenib in Japanese patients with advanced hepatocellular carcinoma
    • Ogasawara, S. et al. Safety and tolerance of sorafenib in Japanese patients with advanced hepatocellular carcinoma. Hepatol Int 5, 850-6 (2011).
    • (2011) Hepatol Int , vol.5 , pp. 850-856
    • Ogasawara, S.1
  • 34
    • 84922391871 scopus 로고    scopus 로고
    • Efficacy of sorafenib in intermediate-stage hepatocellular carcinoma patients refractory to transarterial chemoembolization
    • Ogasawara, S. et al. Efficacy of sorafenib in intermediate-stage hepatocellular carcinoma patients refractory to transarterial chemoembolization. Oncology 87, 330-41 (2014).
    • (2014) Oncology , vol.87 , pp. 330-341
    • Ogasawara, S.1
  • 35
    • 77950346282 scopus 로고    scopus 로고
    • Immunity inflammation, and cancer
    • Grivennikov, S. I., Greten, F. R., Karin, M. Immunity, inflammation, and cancer. Cell 140, 883-99 (2010).
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 36
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • El-Serag, H. B., Rudolph, K. L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132, 2557-76 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 37
    • 84865422083 scopus 로고    scopus 로고
    • Interleukin-6 signaling pathway in targeted therapy for cancer
    • Guo, Y., Xu, F., Lu, T., Duan, Z., Zhang, Z. Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat Rev 38, 904-10 (2012).
    • (2012) Cancer Treat Rev , vol.38 , pp. 904-910
    • Guo, Y.1    Xu, F.2    Lu, T.3    Duan, Z.4    Zhang, Z.5
  • 38
    • 0036291101 scopus 로고    scopus 로고
    • Circulating IL-6 and sIL-6R in patients with hepatocellular carcinoma
    • Giannitrapani, L. et al. Circulating IL-6 and sIL-6R in patients with hepatocellular carcinoma. Ann N Y Acad Sci 963, 46-52 (2002).
    • (2002) Ann N y Acad Sci , vol.963 , pp. 46-52
    • Giannitrapani, L.1
  • 39
    • 38849106118 scopus 로고    scopus 로고
    • Circulating interleukin-6 as a tumor marker for hepatocellular carcinoma
    • Porta, C. et al. Circulating interleukin-6 as a tumor marker for hepatocellular carcinoma. Ann Oncol 19, 353-8 (2008).
    • (2008) Ann Oncol , vol.19 , pp. 353-358
    • Porta, C.1
  • 40
    • 33646458250 scopus 로고    scopus 로고
    • Interleukin-6 and its soluble receptor in patients with liver cirrhosis and hepatocellular carcinoma
    • Soresi, M. et al. Interleukin-6 and its soluble receptor in patients with liver cirrhosis and hepatocellular carcinoma. World J Gastroenterol 12, 2563-8 (2006).
    • (2006) World J Gastroenterol , vol.12 , pp. 2563-2568
    • Soresi, M.1
  • 41
    • 84885953929 scopus 로고    scopus 로고
    • Serum interleukin-6 associated with hepatocellular carcinoma risk: A nested case-control study
    • Ohishi, W. et al. Serum interleukin-6 associated with hepatocellular carcinoma risk: a nested case-control study. Int J Cancer 134, 154-63(2014).
    • (2014) Int J Cancer , vol.134 , pp. 154-163
    • Ohishi, W.1
  • 42
    • 84867982366 scopus 로고    scopus 로고
    • Serum interleukin-6 and C-reactive protein as a prognostic indicator in hepatocellular carcinoma
    • Jang, J. W. et al. Serum interleukin-6 and C-reactive protein as a prognostic indicator in hepatocellular carcinoma. Cytokine 60, 686-93 (2012).
    • (2012) Cytokine , vol.60 , pp. 686-693
    • Jang, J.W.1
  • 43
    • 84861697180 scopus 로고    scopus 로고
    • Plasticity and cross-talk of interleukin 6-type cytokines
    • Garbers, C. et al. Plasticity and cross-talk of interleukin 6-type cytokines. Cytokine Growth Factor Rev 23, 85-97(2012).
    • (2012) Cytokine Growth Factor Rev , vol.23 , pp. 85-97
    • Garbers, C.1
  • 44
    • 77953980528 scopus 로고    scopus 로고
    • IL-6: From its discovery to clinical applications
    • Kishimoto, T. IL-6: from its discovery to clinical applications. Int Immunol 22, 347-52 (2010).
    • (2010) Int Immunol , vol.22 , pp. 347-352
    • Kishimoto, T.1
  • 45
    • 0027499295 scopus 로고
    • Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6
    • Nakajima, T. et al. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci USA 90, 2207-11 (1993).
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2207-2211
    • Nakajima, T.1
  • 46
    • 0042316837 scopus 로고    scopus 로고
    • Subnuclear localization of C/EBP beta is regulated by growth hormone and dependent on MAPK
    • Piwien Pilipuk, G., Galigniana, M. D., Schwartz, J. Subnuclear localization of C/EBP beta is regulated by growth hormone and dependent on MAPK. J Biol Chem 278, 35668-77 (2003).
    • (2003) J Biol Chem , vol.278 , pp. 35668-35677
    • Piwien Pilipuk, G.1    Galigniana, M.D.2    Schwartz, J.3
  • 47
    • 0029849161 scopus 로고    scopus 로고
    • Structural and functional analysis of a promoter of the human granulin/epithelin gene
    • Bhandari, V., Daniel, R., Lim, P. S., Bateman, A. Structural and functional analysis of a promoter of the human granulin/epithelin gene. Biochem J 319, 441-7 (1996).
    • (1996) Biochem J , vol.319 , pp. 441-447
    • Bhandari, V.1    Daniel, R.2    Lim, P.S.3    Bateman, A.4
  • 48
  • 49
    • 84870535749 scopus 로고    scopus 로고
    • The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1
    • Frampton, G. et al. The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1. Am J Physiol Gastrointest Liver Physiol 303, G1202-11 (2012).
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.303 , pp. G1202-G1211
    • Frampton, G.1
  • 50
    • 33751348056 scopus 로고    scopus 로고
    • Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
    • Guertin, D. A. et al. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell 11, 859-71 (2006)
    • (2006) Dev Cell , vol.11 , pp. 859-871
    • Guertin, D.A.1
  • 51
    • 33749076673 scopus 로고    scopus 로고
    • SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    • Jacinto, E. et al. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127, 125-37 (2006).
    • (2006) Cell , vol.127 , pp. 125-137
    • Jacinto, E.1
  • 52
    • 80455176679 scopus 로고    scopus 로고
    • Applications of post-translational modifications of FoxO family proteins in biological functions
    • Zhao, Y., Wang, Y., Zhu, W. G. Applications of post-translational modifications of FoxO family proteins in biological functions. J Mol Cell Biol 3, 276-82 (2011).
    • (2011) J Mol Cell Biol , vol.3 , pp. 276-282
    • Zhao, Y.1    Wang, Y.2    Zhu, W.G.3
  • 53
    • 1342264308 scopus 로고    scopus 로고
    • Mammalian SIRT1 represses forkhead transcription factors
    • Motta, M. C. et al. Mammalian SIRT1 represses forkhead transcription factors. Cell 116, 551-63 (2004).
    • (2004) Cell , vol.116 , pp. 551-563
    • Motta, M.C.1
  • 54
    • 77956260966 scopus 로고    scopus 로고
    • Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization
    • Qiang, L., Banks, A. S., Accili, D. Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization. J Biol Chem 285, 27396-401 (2010).
    • (2010) J Biol Chem , vol.285 , pp. 27396-27401
    • Qiang, L.1    Banks, A.S.2    Accili, D.3
  • 55
    • 84872543209 scopus 로고    scopus 로고
    • MTor as a potential target for the prevention and treatment of hepatocellular carcinoma
    • Buitrago-Molina, L. E., Vogel, A. mTor as a potential target for the prevention and treatment of hepatocellular carcinoma. Curr Cancer Drug Targets 12, 1045-61 (2012)
    • (2012) Curr Cancer Drug Targets , vol.12 , pp. 1045-1061
    • Buitrago-Molina, L.E.1    Vogel, A.2
  • 56
    • 84896402390 scopus 로고    scopus 로고
    • Targeting the mTOR pathway in hepatocellular carcinoma: Current state and future trends
    • Matter, M. S., Decaens, T., Andersen, J. B., Thorgeirsson, S. S. Targeting the mTOR pathway in hepatocellular carcinoma: current state and future trends. J Hepatol 60, 855-65 (2014).
    • (2014) J Hepatol , vol.60 , pp. 855-865
    • Matter, M.S.1    Decaens, T.2    Andersen, J.B.3    Thorgeirsson, S.S.4
  • 57
    • 84899786058 scopus 로고    scopus 로고
    • Combination of cetuximab and rapamycin enhances the therapeutic efficacy in hepatocellular carcinoma
    • Geng, J. et al. Combination of cetuximab and rapamycin enhances the therapeutic efficacy in hepatocellular carcinoma. Technol Cancer Res Treat 13, 377-85 (2014).
    • (2014) Technol Cancer Res Treat , vol.13 , pp. 377-385
    • Geng, J.1
  • 58
    • 68449103037 scopus 로고    scopus 로고
    • Effective inhibition of xenografts of hepatocellular carcinoma (HepG2) by rapamycin and bevacizumab in an intrahepatic model
    • Ong, L. C. et al. Effective inhibition of xenografts of hepatocellular carcinoma (HepG2) by rapamycin and bevacizumab in an intrahepatic model. Mol Imaging Biol 11, 334-42 (2009).
    • (2009) Mol Imaging Biol , vol.11 , pp. 334-342
    • Ong, L.C.1
  • 59
    • 84905591734 scopus 로고    scopus 로고
    • Growth factor progranulin contributes to cervical cancer cell proliferation and transformation in vivo and in vitro
    • Lu, Y. et al. Growth factor progranulin contributes to cervical cancer cell proliferation and transformation in vivo and in vitro. Gynecol Oncol 134, 364-71 (2014).
    • (2014) Gynecol Oncol , vol.134 , pp. 364-371
    • Lu, Y.1
  • 60
    • 84929131583 scopus 로고    scopus 로고
    • Progranulin protects against renal ischemia/reperfusion injury in mice
    • Zhou, M. et al. Progranulin protects against renal ischemia/reperfusion injury in mice. Kidney Int 87, 918-29 (2015).
    • (2015) Kidney Int , vol.87 , pp. 918-929
    • Zhou, M.1


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