메뉴 건너뛰기




Volumn 7, Issue 15, 2015, Pages 1964-1970

Mechanisms of hepatocellular carcinoma and challenges and opportunities for molecular targeted therapy

Author keywords

Cancer stem cell; Hepatocellular carcinoma; Molecular targeted therapy; Oncogene; Signal pathway

Indexed keywords


EID: 84938224557     PISSN: None     EISSN: 19485182     Source Type: Journal    
DOI: 10.4254/wjh.v7.i15.1964     Document Type: Short Survey
Times cited : (113)

References (45)
  • 1
    • 84859237259 scopus 로고    scopus 로고
    • Trends in liver cancer mortality rates in Japan, USA, UK, France and Korea based on the WHO mortality database
    • PMID: 22457364
    • Matsuda T, Saika K. Trends in liver cancer mortality rates in Japan, USA, UK, France and Korea based on the WHO mortality database. Jpn J Clin Oncol 2012; 42: 360-361 [PMID: 22457364 DOI: 10.1093/jjco/hys048]
    • (2012) Jpn J Clin Oncol , vol.42 , pp. 360-361
    • Matsuda, T.1    Saika, K.2
  • 2
    • 84876833675 scopus 로고    scopus 로고
    • Longterm outcome of the first 150 liver transplant recipients: a singlecenter experience
    • PMID: 23622641
    • Sintra SN, Tomé L, Cipriano MA, Bento C, Furtado E. Longterm outcome of the first 150 liver transplant recipients: a singlecenter experience. Transplant Proc 2013; 45: 1119-1121 [PMID:23622641 DOI: 10.1016/j.transproceed.2013.02.101]
    • (2013) Transplant Proc , vol.45 , pp. 1119-1121
    • Sintra, S.N.1    Tomé, L.2    Cipriano, M.A.3    Bento, C.4    Furtado, E.5
  • 3
    • 67949120217 scopus 로고    scopus 로고
    • Dual knockdown of N-ras and epiregulin synergistically suppressed the growth of human hepatoma cells
    • PMID: 19563783
    • Zhao M, He HW, Sun HX, Ren KH, Shao RG. Dual knockdown of N-ras and epiregulin synergistically suppressed the growth of human hepatoma cells. Biochem Biophys Res Commun 2009; 387:239-244 [PMID: 19563783 DOI: 10.1016/j.bbrc.2009.06.128]
    • (2009) Biochem Biophys Res Commun , vol.387 , pp. 239-244
    • Zhao, M.1    He, H.W.2    Sun, H.X.3    Ren, K.H.4    Shao, R.G.5
  • 4
    • 84929727541 scopus 로고    scopus 로고
    • Key role of hepatitis B virus mutation in chronic hepatitis B development to hepatocellular carcinoma
    • PMID: 26019744
    • Zhang X, Ding HG. Key role of hepatitis B virus mutation in chronic hepatitis B development to hepatocellular carcinoma. World J Hepatol 2015; 7: 1282-1286 [PMID: 26019744 DOI:10.4254/wjh.v7.i9.1282]
    • (2015) World J Hepatol , vol.7 , pp. 1282-1286
    • Zhang, X.1    Ding, H.G.2
  • 5
    • 79960741865 scopus 로고    scopus 로고
    • Histology-directed matrixassisted laser desorption/ionization analysis reveals tissue origin and p53 status of primary liver cancers
    • PMID: 21790858
    • Jeon YE, Lee SC, Paik SS, Lee KG, Jin SY, Kim HR, Yoo CW, Park HM, Han SY, Choi DH, Kim HK. Histology-directed matrixassisted laser desorption/ionization analysis reveals tissue origin and p53 status of primary liver cancers. Pathol Int 2011; 61: 449-455 [PMID: 21790858 DOI: 10.1111/j.1440-1827.2011.02686.x]
    • (2011) Pathol Int , vol.61 , pp. 449-455
    • Jeon, Y.E.1    Lee, S.C.2    Paik, S.S.3    Lee, K.G.4    Jin, S.Y.5    Kim, H.R.6    Yoo, C.W.7    Park, H.M.8    Han, S.Y.9    Choi, D.H.10    Kim, H.K.11
  • 6
    • 30944459963 scopus 로고    scopus 로고
    • A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation
    • PMID: 16418486
    • Boiko AD, Porteous S, Razorenova OV, Krivokrysenko VI, Williams BR, Gudkov AV. A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation. Genes Dev 2006; 20: 236-252 [PMID: 16418486]
    • (2006) Genes Dev , vol.20 , pp. 236-252
    • Boiko, A.D.1    Porteous, S.2    Razorenova, O.V.3    Krivokrysenko, V.I.4    Williams, B.R.5    Gudkov, A.V.6
  • 7
    • 80051471114 scopus 로고    scopus 로고
    • Aberrant expression of the p53-inducible antiproliferative gene BTG2 in hepatocellular carcinoma is associated with overexpression of the cell cycle-related proteins
    • PMID: 21327578
    • Zhang Z, Chen C, Wang G, Yang Z, San J, Zheng J, Li Q, Luo X, Hu Q, Li Z, Wang D. Aberrant expression of the p53-inducible antiproliferative gene BTG2 in hepatocellular carcinoma is associated with overexpression of the cell cycle-related proteins. Cell Biochem Biophys 2011; 61: 83-91 [PMID: 21327578 DOI:10.1007/s12013-011-9164-x]
    • (2011) Cell Biochem Biophys , vol.61 , pp. 83-91
    • Zhang, Z.1    Chen, C.2    Wang, G.3    Yang, Z.4    San, J.5    Zheng, J.6    Li, Q.7    Luo, X.8    Hu, Q.9    Li, Z.10    Wang, D.11
  • 8
    • 84905571686 scopus 로고    scopus 로고
    • Molecular therapies in hepatocellular carcinoma: what can we target?
    • PMID: 24573715
    • Galuppo R, Ramaiah D, Ponte OM, Gedaly R. Molecular therapies in hepatocellular carcinoma: what can we target? Dig Dis Sci 2014; 59: 1688-1697 [PMID: 24573715 DOI: 10.1007/s10620-014-3058-x]
    • (2014) Dig Dis Sci , vol.59 , pp. 1688-1697
    • Galuppo, R.1    Ramaiah, D.2    Ponte, O.M.3    Gedaly, R.4
  • 9
    • 84900519241 scopus 로고    scopus 로고
    • Synergistic inhibition of HCC and liver cancer stem cell proliferation by targeting RAS/RAF/MAPK and WNT/β-catenin pathways
    • PMID: 24692700
    • Galuppo R, Maynard E, Shah M, Daily MF, Chen C, Spear BT, Gedaly R. Synergistic inhibition of HCC and liver cancer stem cell proliferation by targeting RAS/RAF/MAPK and WNT/β-catenin pathways. Anticancer Res 2014; 34: 1709-1713 [PMID: 24692700]
    • (2014) Anticancer Res , vol.34 , pp. 1709-1713
    • Galuppo, R.1    Maynard, E.2    Shah, M.3    Daily, M.F.4    Chen, C.5    Spear, B.T.6    Gedaly, R.7
  • 10
    • 80054113770 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma
    • PMID: 21992728
    • Zhou Q, Lui VW, Yeo W. Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma. Future Oncol 2011; 7: 1149-1167 [PMID: 21992728 DOI: 10.2217/fon.11.95]
    • (2011) Future Oncol , vol.7 , pp. 1149-1167
    • Zhou, Q.1    Lui, V.W.2    Yeo, W.3
  • 11
    • 84869194238 scopus 로고    scopus 로고
    • Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells
    • PMID: 23167739
    • Grabinski N, Ewald F, Hofmann BT, Staufer K, Schumacher U, Nashan B, Jücker M. Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells. Mol Cancer 2012; 11: 85 [PMID: 23167739 DOI:10.1186/1476-4598-11-85]
    • (2012) Mol Cancer , vol.11 , pp. 85
    • Grabinski, N.1    Ewald, F.2    Hofmann, B.T.3    Staufer, K.4    Schumacher, U.5    Nashan, B.6    Jücker, M.7
  • 12
    • 34248674146 scopus 로고    scopus 로고
    • WNT/beta-catenin signaling in liver health and disease
    • PMID:17464972
    • Thompson MD, Monga SP. WNT/beta-catenin signaling in liver health and disease. Hepatology 2007; 45: 1298-1305 [PMID:17464972]
    • (2007) Hepatology , vol.45 , pp. 1298-1305
    • Thompson, M.D.1    Monga, S.P.2
  • 14
    • 79952231921 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma: an update
    • PMID: 21374666
    • Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology 2011; 53: 1020-1022 [PMID: 21374666 DOI:10.1002/hep.24199]
    • (2011) Hepatology , vol.53 , pp. 1020-1022
    • Bruix, J.1    Sherman, M.2
  • 15
    • 0035266134 scopus 로고    scopus 로고
    • Activation of beta-catenin during hepatocarcinogenesis in transgenic mouse models: relationship to phenotype and tumor grade
    • PMID: 11280770
    • Calvisi DF, Factor VM, Loi R, Thorgeirsson SS. Activation of beta-catenin during hepatocarcinogenesis in transgenic mouse models: relationship to phenotype and tumor grade. Cancer Res 2001; 61: 2085-2091 [PMID: 11280770]
    • (2001) Cancer Res , vol.61 , pp. 2085-2091
    • Calvisi, D.F.1    Factor, V.M.2    Loi, R.3    Thorgeirsson, S.S.4
  • 16
    • 2542546650 scopus 로고    scopus 로고
    • Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells
    • PMID:15185310
    • Cha MY, Kim CM, Park YM, Ryu WS. Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells. Hepatology 2004; 39: 1683-1693 [PMID:15185310]
    • (2004) Hepatology , vol.39 , pp. 1683-1693
    • Cha, M.Y.1    Kim, C.M.2    Park, Y.M.3    Ryu, W.S.4
  • 18
    • 84883211035 scopus 로고    scopus 로고
    • Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells
    • PMID: 23504944
    • Wang Y, Han C, Lu L, Magliato S, Wu T. Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells. Hepatology 2013; 58: 995-1010 [PMID: 23504944 DOI:10.1002/hep.26394]
    • (2013) Hepatology , vol.58 , pp. 995-1010
    • Wang, Y.1    Han, C.2    Lu, L.3    Magliato, S.4    Wu, T.5
  • 20
    • 84869204689 scopus 로고    scopus 로고
    • Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X protein
    • PMID: 22986746
    • Arzumanyan A, Sambandam V, Clayton MM, Choi SS, Xie G, Diehl AM, Yu DY, Feitelson MA. Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X protein. Cancer Res 2012; 72: 5912-5920 [PMID: 22986746 DOI:10.1158/0008-5472]
    • (2012) Cancer Res , vol.72 , pp. 5912-5920
    • Arzumanyan, A.1    Sambandam, V.2    Clayton, M.M.3    Choi, S.S.4    Xie, G.5    Diehl, A.M.6    Yu, D.Y.7    Feitelson, M.A.8
  • 22
    • 34248571816 scopus 로고    scopus 로고
    • Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells
    • PMID: 17440069
    • Kim Y, Yoon JW, Xiao X, Dean NM, Monia BP, Marcusson EG. Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells. Cancer Res 2007; 67: 3583-3593 [PMID: 17440069]
    • (2007) Cancer Res , vol.67 , pp. 3583-3593
    • Kim, Y.1    Yoon, J.W.2    Xiao, X.3    Dean, N.M.4    Monia, B.P.5    Marcusson, E.G.6
  • 23
    • 84869765074 scopus 로고    scopus 로고
    • Notch signaling in hepatocellular carcinoma: guilty in association!
    • PMID: 23099244
    • Strazzabosco M, Fabris L. Notch signaling in hepatocellular carcinoma: guilty in association! Gastroenterology 2012; 143:1430-1434 [PMID: 23099244 DOI: 10.1053/j.gastro.2012.10.025]
    • (2012) Gastroenterology , vol.143 , pp. 1430-1434
    • Strazzabosco, M.1    Fabris, L.2
  • 26
    • 84909991205 scopus 로고    scopus 로고
    • Targeting the insulin-like growth factor pathway in hepatocellular carcinoma
    • PMID: 25349643
    • Enguita-Germán M, Fortes P. Targeting the insulin-like growth factor pathway in hepatocellular carcinoma. World J Hepatol 2014; 6: 716-737 [PMID: 25349643 DOI: 10.4254/wjh.v6.i10.716]
    • (2014) World J Hepatol , vol.6 , pp. 716-737
    • Enguita-Germán, M.1    Fortes, P.2
  • 28
    • 84875552108 scopus 로고    scopus 로고
    • Targeting the HGF/c-MET pathway in hepatocellular carcinoma
    • PMID: 23388504
    • Goyal L, Muzumdar MD, Zhu AX. Targeting the HGF/c-MET pathway in hepatocellular carcinoma. Clin Cancer Res 2013; 19: 2310-2318 [PMID: 23388504 DOI: 10.1158/1078-0432. CCR-12-2791]
    • (2013) Clin Cancer Res , vol.19 , pp. 2310-2318
    • Goyal, L.1    Muzumdar, M.D.2    Zhu, A.X.3
  • 29
    • 80052033164 scopus 로고    scopus 로고
    • c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma
    • PMID: 21618573
    • You H, Ding W, Dang H, Jiang Y, Rountree CB. c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma. Hepatology 2011; 54: 879-889 [PMID:21618573 DOI: 10.1002/hep.24450]
    • (2011) Hepatology , vol.54 , pp. 879-889
    • You, H.1    Ding, W.2    Dang, H.3    Jiang, Y.4    Rountree, C.B.5
  • 30
    • 84895074182 scopus 로고    scopus 로고
    • The EGFR signalling system in the liver:from hepatoprotection to hepatocarcinogenesis
    • PMID: 24318021
    • Berasain C, Avila MA. The EGFR signalling system in the liver:from hepatoprotection to hepatocarcinogenesis. J Gastroenterol 2014; 49: 9-23 [PMID: 24318021 DOI: 10.1007/s00535-013-0907-x]
    • (2014) J Gastroenterol , vol.49 , pp. 9-23
    • Berasain, C.1    Avila, M.A.2
  • 31
    • 84938273951 scopus 로고    scopus 로고
    • Turning hepatic cancer stem cells inside out--a deeper understanding through multiple perspectives
    • PMID: 25666349
    • Chan LH, Luk ST, Ma S. Turning hepatic cancer stem cells inside out--a deeper understanding through multiple perspectives. Mol Cells 2015; 38: 202-209 [PMID: 25666349 DOI: 10.14348/ molcells.2015.2356]
    • (2015) Mol Cells , vol.38 , pp. 202-209
    • Chan, L.H.1    Luk, S.T.2    Ma, S.3
  • 32
    • 84887336065 scopus 로고    scopus 로고
    • The biological implication of cancer stem cells in hepatocellular carcinoma: a possible target for future therapy
    • PMID: 24161136
    • Sukowati CH, Tiribelli C. The biological implication of cancer stem cells in hepatocellular carcinoma: a possible target for future therapy. Expert Rev Gastroenterol Hepatol 2013; 7: 749-757 [PMID: 24161136 DOI: 10.1586/17474124.2013.846826]
    • (2013) Expert Rev Gastroenterol Hepatol , vol.7 , pp. 749-757
    • Sukowati, C.H.1    Tiribelli, C.2
  • 33
    • 0033026045 scopus 로고    scopus 로고
    • Expression of the stem cell factor receptor c-kit in normal and diseased pediatric liver: identification of a human hepatic progenitor cell?
    • PMID: 10385646
    • Baumann U, Crosby HA, Ramani P, Kelly DA, Strain AJ. Expression of the stem cell factor receptor c-kit in normal and diseased pediatric liver: identification of a human hepatic progenitor cell? Hepatology 1999; 30: 112-117 [PMID: 10385646]
    • (1999) Hepatology , vol.30 , pp. 112-117
    • Baumann, U.1    Crosby, H.A.2    Ramani, P.3    Kelly, D.A.4    Strain, A.J.5
  • 34
    • 84872845149 scopus 로고    scopus 로고
    • Dysregulation of signaling pathways and putative biomarkers in liver cancer stem cells (Review)
    • PMID: 23076400
    • Song K, Wu J, Jiang C. Dysregulation of signaling pathways and putative biomarkers in liver cancer stem cells (Review). Oncol Rep 2013; 29: 3-12 [PMID: 23076400 DOI: 10.3892/or.2012.2082]
    • (2013) Oncol Rep , vol.29 , pp. 3-12
    • Song, K.1    Wu, J.2    Jiang, C.3
  • 35
    • 84255168800 scopus 로고    scopus 로고
    • Stem cells in liver diseases and cancer: recent advances on the path to new therapies
    • PMID: 22030746
    • Rountree CB, Mishra L, Willenbring H. Stem cells in liver diseases and cancer: recent advances on the path to new therapies. Hepatology 2012; 55: 298-306 [PMID: 22030746 DOI: 10.1002/ hep.24762]
    • (2012) Hepatology , vol.55 , pp. 298-306
    • Rountree, C.B.1    Mishra, L.2    Willenbring, H.3
  • 37
    • 84876736734 scopus 로고    scopus 로고
    • Field practice studies on sorafenib: lessons in systemic treatment of hepatocellular carcinoma
    • PMID: 23562444
    • Piscaglia F, Salvatore V, Venerandi L. Field practice studies on sorafenib: lessons in systemic treatment of hepatocellular carcinoma. Dig Liver Dis 2013; 45: 367-368 [PMID: 23562444 DOI: 10.1016/j.dld.2013.02.018]
    • (2013) Dig Liver Dis , vol.45 , pp. 367-368
    • Piscaglia, F.1    Salvatore, V.2    Venerandi, L.3
  • 38
    • 84867408207 scopus 로고    scopus 로고
    • Sorafenib-induced hepatocellular carcinoma cell death depends on reactive oxygen species production in vitro and in vivo
    • PMID: 22902857
    • Coriat R, Nicco C, Chéreau C, Mir O, Alexandre J, Ropert S, Weill B, Chaussade S, Goldwasser F, Batteux F. Sorafenib-induced hepatocellular carcinoma cell death depends on reactive oxygen species production in vitro and in vivo. Mol Cancer Ther 2012; 11: 2284-2293 [PMID: 22902857 DOI: 10.1158/1535-7163. MCT-12-0093]
    • (2012) Mol Cancer Ther , vol.11 , pp. 2284-2293
    • Coriat, R.1    Nicco, C.2    Chéreau, C.3    Mir, O.4    Alexandre, J.5    Ropert, S.6    Weill, B.7    Chaussade, S.8    Goldwasser, F.9    Batteux, F.10
  • 39
    • 84876996974 scopus 로고    scopus 로고
    • c-KIT: potential predictive factor for the efficacy of sorafenib in metastatic renal cell carcinoma with sarcomatoid feature
    • PMID: 23058498
    • Zhang HL, Zhu Y, Qin XJ, Wang CF, Yao XD, Zhang SL, Dai B, Zhu YP, Shi GH, Ye DW. c-KIT: potential predictive factor for the efficacy of sorafenib in metastatic renal cell carcinoma with sarcomatoid feature. Clin Genitourin Cancer 2013; 11: 134-140 [PMID: 23058498 DOI: 10.1016/j.clgc.2012.08.007]
    • (2013) Clin Genitourin Cancer , vol.11 , pp. 134-140
    • Zhang, H.L.1    Zhu, Y.2    Qin, X.J.3    Wang, C.F.4    Yao, X.D.5    Zhang, S.L.6    Dai, B.7    Zhu, Y.P.8    Shi, G.H.9    Ye, D.W.10
  • 40
    • 80051615717 scopus 로고    scopus 로고
    • Deferoxamine for advanced hepatocellular carcinoma
    • PMID: 21830988
    • Yamasaki T, Terai S, Sakaida I. Deferoxamine for advanced hepatocellular carcinoma. N Engl J Med 2011; 365: 576-578 [PMID: 21830988 DOI: 10.1056/NEJMc1105726]
    • (2011) N Engl J Med , vol.365 , pp. 576-578
    • Yamasaki, T.1    Terai, S.2    Sakaida, I.3
  • 42
    • 78650835158 scopus 로고    scopus 로고
    • Molecular targeted therapy for advanced hepatocellular carcinoma: current status and future perspectives
    • PMID: 20567987
    • Shen YC, Hsu C, Cheng AL. Molecular targeted therapy for advanced hepatocellular carcinoma: current status and future perspectives. J Gastroenterol 2010; 45: 794-807 [PMID: 20567987 DOI: 10.1007/s00535-010-0270-0]
    • (2010) J Gastroenterol , vol.45 , pp. 794-807
    • Shen, Y.C.1    Hsu, C.2    Cheng, A.L.3
  • 43
    • 77954374206 scopus 로고    scopus 로고
    • PTEN regulates angiogenesis and VEGF expression through phosphatase-dependent and -independent mechanisms in HepG2 cells
    • PMID: 20430845
    • Tian T, Nan KJ, Wang SH, Liang X, Lu CX, Guo H, Wang WJ, Ruan ZP. PTEN regulates angiogenesis and VEGF expression through phosphatase-dependent and -independent mechanisms in HepG2 cells. Carcinogenesis 2010; 31: 1211-1219PMID:20430845 DOI: 10.1093/carcin/bgq085]
    • (2010) Carcinogenesis , vol.31 , pp. 1211-1219
    • Tian, T.1    Nan, K.J.2    Wang, S.H.3    Liang, X.4    Lu, C.X.5    Guo, H.6    Wang, W.J.7    Ruan, Z.P.8
  • 45
    • 84857008164 scopus 로고    scopus 로고
    • Phase II, open-label study of brivanib as second-line therapy in patients with advanced hepatocellular carcinoma
    • PMID: 22238246
    • Finn RS, Kang YK, Mulcahy M, Polite BN, Lim HY, Walters I, Baudelet C, Manekas D, Park JW. Phase II, open-label study of brivanib as second-line therapy in patients with advanced hepatocellular carcinoma. Clin Cancer Res 2012; 18: 2090-2098 [PMID: 22238246 DOI: 10.1158/1078-0432.CCR-11-1991]
    • (2012) Clin Cancer Res , vol.18 , pp. 2090-2098
    • Finn, R.S.1    Kang, Y.K.2    Mulcahy, M.3    Polite, B.N.4    Lim, H.Y.5    Walters, I.6    Baudelet, C.7    Manekas, D.8    Park, J.W.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.