The Efficacy of Ginseng-Related Therapies in Type 2 Diabetes Mellitus

Medicine (United States)

Volumn 95, Issue 6, 2016, Pages

  Gui, Qi Feng ^a   Xu, Zhe Rong ^a   Xu, Ke Ying ^a   Yang, Yun Mei ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GINSENG EXTRACT; GINSENOSIDE RE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; INSULIN; LOW DENSITY LIPOPROTEIN; ORAL ANTIDIABETIC AGENT; TRIACYLGLYCEROL; ANTIDIABETIC AGENT; HERBACEOUS AGENT; PLANT EXTRACT; SHENYAN KANGFU;

ARTICLE; CHINESE MEDICINE; CHOLESTEROL BLOOD LEVEL; COCHRANE LIBRARY; DIABETIC PATIENT; DRUG EFFICACY; GINSENG; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPOPROTEIN BLOOD LEVEL; MEDLINE; META ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SEX RATIO; SYSTEMATIC REVIEW; TRIACYLGLYCEROL BLOOD LEVEL; DIABETES MELLITUS, TYPE 2; PANAX; PHYTOTHERAPY; STATISTICAL MODEL; TREATMENT OUTCOME;

DIABETES MELLITUS, TYPE 2; DRUGS, CHINESE HERBAL; HUMANS; HYPOGLYCEMIC AGENTS; MODELS, STATISTICAL; PANAX; PHYTOTHERAPY; PLANT EXTRACTS; TREATMENT OUTCOME;

EID: 84958259680     PISSN: 00257974     EISSN: 15365964     Source Type: Journal    
DOI: 10.1097/MD.0000000000002584     Document Type: Article

References (36)

1. Vogler BK, Pittler MH, Ernst E. The efficacy of ginseng. A systematic review of randomised clinical trials. Eur J Clin Pharmacol. 1999;55:567-575
2. Vuksan V, Sung MK, Sievenpiper JL, et al. Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well controlled, type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safety. Nutr Metab Cardiovasc Dis. 2008;18:46-56
3. Lu JM, Yao Q, Chen C. Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr Vasc Pharmacol. 2009;7:293-302
4. Stavro PM, Woo M, Heim TF, et al. North American ginseng exerts a neutral effect on blood pressure in individuals with hypertension. Hypertension. 2005;46:406-411
5. Stavro PM, Woo M, Leiter LA, et al. Long-term intake of North American ginseng has no effect on 24-hour blood pressure and renal function. Hypertension. 2006;47:791-796
6. Jang DJ, Lee MS, Shin BC, et al. Red ginseng for treating erectile dysfunction: a systematic review. Br J Clin Pharmacol. 2008;66:444-450
7. Helms S. Cancer prevention and therapeutics: Panax ginseng. Altern Med Rev. 2004;9:259-274
8. Reeds DN, Patterson BW, Okunade A, et al. Ginseng and ginsenoside Re do not improve beta-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes. Diabetes Care. 2011;34:1071-1076
9. Yin J, Zhang H, Ye J. Traditional chinese medicine in treatment of metabolic syndrome. Endocr Metab Immune Disord Drug Targets. 2008;8:99-111
10. Yoon JW, Kang SM, Vassy JL, et al. Efficacy and safety of ginsam, a vinegar extract from Panax ginseng, in type 2 diabetic patients: results of a double-blind, placebo-controlled study. J Diabetes Investig. 2012;3:309-317
11. Attele AS, Zhou YP, Xie JT, et al. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes. 2002;51:1851-1858
12. Waki I, Kyo H, Yasuda M, Kimura M. Effects of a hypoglycemic component of ginseng radix on insulin biosynthesis in normal and diabetic animals. J Pharmacobiodyn. 1982;5:547-554
13. De Souza LR, Jenkins AL, Sievenpiper JL, et al. Korean red ginseng (Panax ginseng C.A. Meyer) root fractions: differential effects on postprandial glycemia in healthy individuals. J Ethnopharmacol. 2011;137:245-250
14. Bang H, Kwak JH, Ahn HY, et al. Korean red ginseng improves glucose control in subjects with impaired fasting glucose, impaired glucose tolerance, or newly diagnosed type 2 diabetes mellitus. J Med Food. 2014;17:128-134
15. Vuksan V, Sievenpiper JL, Koo VY, et al. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med. 2000;160:1009-1013
16. Sievenpiper JL, Sung MK, Di Buono M, et al. Korean red ginseng rootlets decrease acute postprandial glycemia: results from sequential preparation-And dose-finding studies. J Am Coll Nutr. 2006;25:1 00-107
17. Oh MR, Park SH, Kim SY, et al. Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebocontrolled clinical trial. BMC Complement Altern Med. 2014;14:237
18. Wang H, Mu W, Zhai J, et al. The key role of Shenyan Kangfu tablets, a Chinese patent medicine for diabetic nephropathy: study protocol for a randomized, double-blind and placebo-controlled clinical trial. Trials. 2013;14:165
19. Higgins JGS. Cochrane handbook for systematic reviews of interventions Version 5.1. 0 [updated March 2011]. . Chichester, West Sussex, UK: The Cochrane Collaboration; 2011
20. Lau J, Ioannidis JP, Schmid CH. Quantitative synthesis in systematic reviews. Ann Intern Med. 1997;127:820-826
21. Higgins JP, Thompson SG. Quantifying heterogeneity in a metaanalysis. Stat Med. 2002;21:1539-1558
22. DerSimonian R, Laird N. Meta-Analysis in clinical trials. Control Clin Trials. 1986;7:177-188
23. Mucalo I, Jovanovski E, Vuksan V, et al. American ginseng extract (Panax quinquefolius l.) is safe in long-term use in type 2 diabetic patients. Evid Based Complement Alternat Med. 2014;2014:969168
24. Park SH, Oh MR, Choi EK, et al. An 8-wk, randomized, doubleblind, placebo-controlled clinical trial for the antidiabetic effects of hydrolyzed ginseng extract. J Ginseng Res. 2014;38:239243
25. Li AM, Zhao J. Effect of renshen jianxin capsule for alleviating insulin resistance in patients with coronary heart disease and glucose tolerance impairment. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009;29:830-833
26. Zhang Y LS, Liu YY. Effect of panax quinquefolius saponin on insulin sensitivity in patients of coronary heart disease with blood glucose abnormality. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007;27:1066-1069
27. Sutton AJ, Duval SJ, Tweedie RL, et al. Empirical assessment of effect of publication bias on meta-Analyses. BMJ. 2000;320: 1574-1577
28. Shishtar E, Sievenpiper JL, Djedovic V, et al. The effect of ginseng (the genus panax) on glycemic control: a systematic review and meta-Analysis of randomized controlled clinical trials. PLoS One. 2014;9:e107391
29. Ma SW, Benzie IF, Chu TT, et al. Effect of Panax ginseng supplementation on biomarkers of glucose tolerance, antioxidant status and oxidative stress in type 2 diabetic subjects: results of a placebo-controlled human intervention trial. Diabetes Obes Metab. 2008;10:1125-1127
30. Yuan HD, Kim JT, Kim SH, et al. Ginseng and diabetes: the evidences from in vitro, animal and human studies. J Ginseng Res. 2012;36:27-39
31. Quan HY, Yuan HD, Jung MS, et al. Ginsenoside Re lowers blood glucose and lipid levels via activation of AMP-Activated protein kinase in HepG2 cells and high-fat diet fed mice. Int J Mol Med. 2012;29:73-80
32. Kim SJ, Yuan HD, Chung SH. Ginsenoside Rg1 suppresses hepatic glucose production via AMP-Activated protein kinase in HepG2 cells. Biol Pharm Bull. 2010;33:325-328
33. Yuan HD, Kim do Y, Quan HY, et al. Ginsenoside Rg2 induces orphan nuclear receptor SHP gene expression and inactivates GSK3beta via AMP-Activated protein kinase to inhibit hepatic glucose production in HepG2 cells. Chem Biol Interact. 2012;195:35-42
34. Choi J, Kim TH, Choi TY, et al. Ginseng for health care: a systematic review of randomized controlled trials in Korean literature. PLoS One. 2013;8:e59978
35. Dharmananda S. The nature of ginseng. Traditional use, modern research, and the question of dosage. HerbalGram. 2002;54:34-51
36. Inzucchi SE. Oral antihyperglycemic therapy for type 2 diabetes: scientific review. JAMA. 2002;287:360-372