Ginsenoside Rg2 induces orphan nuclear receptor SHP gene expression and inactivates GSK3β via AMP-activated protein kinase to inhibit hepatic glucose production in HepG2 cells

Chemico-Biological Interactions

Volumn 195, Issue 1, 2012, Pages 35-42

  Yuan, Hai Dan ^a   Kim, Do Yeon ^a   Quan, Hai Yan ^a   Kim, Su Jung ^a   Jung, Mi Song ^a   Chung, Sung Hyun ^a  

^a Kyung Hee University   (South Korea)

Author keywords

AMP activated protein kinase; Ginsenoside Rg2; Glycogen synthase kinase 3 ; Hepatic glucose production; HepG2 cells; Small heterodimer partner

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GINSENOSIDE RG 2; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIVER ENZYME; LIVER KINASE B1; ORPHAN NUCLEAR RECEPTOR; ORPHAN NUCLEAR RECEPTOR SHP; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GLUCONEOGENESIS; HUMAN; HUMAN CELL; PROTEIN PROTEIN INTERACTION;

AMP-ACTIVATED PROTEIN KINASES; CREB-BINDING PROTEIN; GENE EXPRESSION REGULATION; GINSENOSIDES; GLUCONEOGENESIS; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; HEP G2 CELLS; HUMANS; HYPOGLYCEMIC AGENTS; LIVER; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PYRAZOLES; PYRIMIDINES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION;

PANAX GINSENG;

EID: 82055165570     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2011.10.006     Document Type: Article

References (23)

1. S. Wild, G. Roglic, A. Green, R. Sicree, and H. King Global prevalence of diabetes: estimates for the year 2000 and projections for 2030 Diabetes Care 27 2004 1047 1053 (Pubitemid 38579764)
2. M.L. Mohler, Y. He, D.J. Hwang, and D.D. Miller Recent and emerging anti-diabetes targets Med. Res. Rev. 1 2009 125 195
3. B. Viollet, M. Foretz, B. Guigas, S. Horman, R. Dentin, L. Bertrand, L. Hue, and F. Andreelli Activation of AMP-activated protein kinase in the liver" a new strategy for the management of metabolic hepatic disorders J. Physiol. 574 2006 41 53 (Pubitemid 43905795)
4. B. Viollet, B. Guigas, J. Leclerc, S. Herbrard, L. Lantier, R. Mounier, F. Andreelli, and M. Foretz AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives Acta Physiol. 196 2009 81 98
5. E. A Sotaniemi, E. Haapakoski, and A. Rautio Ginseng therapy in non-insulin-dependent diabetic patients Diabetes Care 18 1995 1373 1375
6. H.D. Yuan, S.J. Kim, and S.H. Chung Beneficial effects of IH-901 on glucose and lipid metabolisms via activating adenosine monophosphate-activated protein kinase and phosphatidylinositol-3 kinase pathways Metabolism 60 2011 43 51
7. H.J. Lee, Y.H. Lee, S.K. Park, E.S. Kang, H.J. Kim, Y.C. Lee, C.S. Choi, S.E. Park, C.W. Ahn, B.S. Cha, K.W. Lee, K.S. Kim, S.K. Lim, and H.C. Lee Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats Metabolism 58 2009 1170 1177
8. V. Vuksan, M.K. Sung, J.L. Sievenpiper, P.M. Stavro, A.L. Jenkins, M. Di Buono, K.S. Lee, L.A. Leiter, K.Y. Nam, J.T. Arnason, M. Choi, and A. Naeem Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safety Nutr. Metab. Cardiovasc. Dis. 18 2008 46 56 (Pubitemid 350297892)
9. S.J. Kim, H.D. Yuan, and S.H. Chung Ginsenoside Rg1 suppresses hepatic glucose production via AMP-activated protein kinase in HepG2 cells Biol. Pharm. Bull. 33 2010 325 328
10. H.Y. Quan, H.D. Yuan, M.S. Jung, S.K. Ko, Y.G. Park, and S.H. Chung Ginsenoside Re lowers blood glucose and lipid levels via activation of AMP-activated protein kinase in HepG2 cells and high-fat diet fed mice Int. J. Mol. Med. 29 2011 73 80
11. D.G. Hardie The AMP-activated protein kinase pathway - new players upstream and downstream J. Cell Sci. 117 2004 5479 5487 (Pubitemid 40012195)
12. M.J. Birnbaum Activating AMP-activated protein kinase without AMP Mol. Cell 19 2005 289 290 (Pubitemid 41074882)
13. N. Horike, H. Sakoda, A. Kushiyama, H. Ono, M. Fujishiro, H. Kamata, K. Nishiyama, Y. Uchijima, Y. Kurihara, H. Kurihara, and T. Asano AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3β and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver J. Biol. Chem. 283 2008 33902 33910
14. L. He, A. Sabet, S. Djedjos, R. Miller, X. Sun, M.A. Hussain, S. Radovick, and F.E. Wondisford Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein Cell 137 2009 635 645
15. S.H. Koo, L. Flechner, L. Qi, X. Zhang, R.A. Screaton, S. Jeffries, S. Hedrick, W. Xu, F. Boussouar, P. Brindle, H. Takemori, and M. Montminy The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism Nature 437 2005 1109-111
16. Y.D. Kim, K.G. Park, Y.S. Lee, Y.Y. Park, D.K. Kim, B. Nedumaran, W.G. Jang, W.J. Cho, J. Ha, I.K. Lee, C.H. Lee, and H.S. Choi Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP Diabetes 57 2008 306 314
17. D. Chanda, S.J. Kim, I.K. Lee, M.H. Shong, and H.S. Choi Sodium arsenite induces orphan nuclear receptor SHP gene expression via AMP-activated protein kinase to inhibit gluconeogenic enzyme gene expression Am. J. Physiol. Endocrinol. Metab. 295 2008 E368 E379
18. K.T. Lee, T.W. Jung, H.J. Lee, S.G. Kim, Y.S. Shim, and W.K. Whang The antidiabetic effect of ginsenoside Rb2 via activation of AMPK Arch. Pharm. Res. 34 2011 1201 1208
19. S.E. Ha, D.H. Shin, H.D. Kim, S.M. Shim, H.S. Kim, B.H. Kim, J.S. Lee, and J.K. Park Effects of ginsenoside Rg2 on the ultraviolet B-induced DNA damage responses in HaCaT cells Naunyn Schmiedebergs Arch Pharmacol. 382 2010 89 101
20. G. Zhang, A. Liu, Y. Zhou, X. San, T. Jin, and Y. Jin Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia J. Ethnopharmacol. 115 2008 441 448 (Pubitemid 50017508)
21. N. Li, B. Liu, D.E. Dluzen, and Y. Jin Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells J. Ethnopharmacol. 111 2007 458 463 (Pubitemid 46617084)
22. J.W. Tullai, J. Chen, M.E. Schaffer, e. Kamenetsky, S. Kasif, and G.M. Cooper Glycogen synthase kinase-3 represses cyclic AMP response element-binding protein (CREB)-targeted immediate early genes in Quiescent cells J. Biol. Chem. 282 2007 9482 9491 (Pubitemid 47104620)
23. J.M. Lee, W.Y. Seo, K.H. Song, D. Chanda, Y.D. Kim, D.K. Kim, M.W. Lee, D. Ryu, Y.H. Kim, J.R. Noh, C.H. Lee, J.Y. Chiang, S.H. Koo, and H.S. Choi AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB·CRTC2 complex by orphan nuclear receptor small heterodimer partner J. Biol. Chem. 285 2010 32182 32191