Korean red ginseng (Panax ginseng C.A. Meyer) root fractions: Differential effects on postprandial glycemia in healthy individuals

Journal of Ethnopharmacology

Volumn 137, Issue 1, 2011, Pages 245-250

  De Souza, Leanne R ^a,d   Jenkins, Alexandra L ^a   Sievenpiper, John L ^a,b   Jovanovski, Elena ^a   Rahelić, Dario ^c   Vuksan, Vladimir ^a,d,e  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c University of Zagreb School of Medicine   (Croatia)

^d UNIVERSITY OF TORONTO   (Canada)

^e ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Ginsenoside; Glycemia; Healthy individuals; Korean red ginseng root; Postprandial glucose

Indexed keywords

ANTIDIABETIC AGENT; GINSENOSIDE; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RG 3; GLUCOSE; HERBACEOUS AGENT; PLACEBO; PROTOPANAXADIOL;

ADULT; ANTHROPOMETRY; ARTICLE; BLOOD PRESSURE; BLOOD SAMPLING; BODY MASS; BODY WEIGHT; CALORIC INTAKE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; GINSENG; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; MALE; PLANT ROOT; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; AREA UNDER CURVE; BLOOD GLUCOSE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; GINSENOSIDES; HUMANS; HYPOGLYCEMIC AGENTS; MALE; ONTARIO; PANAX; PLANT EXTRACTS; PLANT ROOTS; POSTPRANDIAL PERIOD; TIME FACTORS; YOUNG ADULT;

PANAX GINSENG;

EID: 80052034073     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.05.015     Document Type: Article

References (44)

1. A.S. Attele, J.A. Wu, and C.S. Yuan Ginseng pharmacology: multiple constituents and multiple actions Biochemical Pharmacology 58 1999 1685 1693 10.1016/S0006-2952(99)00212-9 PMID: 10571242 (Pubitemid 29505408)
2. A.S. Attele, Y.P. Zhou, J.T. Xie, J.A. Wu, L. Zhang, and L. Dey Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component Diabetes 51 2002 1851 1858 10.2337/diabetes.51.6.1851 PMID: 12031973 (Pubitemid 34564298)
3. DECODE Study Group, and The European Diabetes Epidemiology Group Glucose tolerance and cardiovascular mortality - comparison of fasting and 2-hour diagnostic criteria Archives of International Medicine 161 2001 397 405 PMID: 11176766
4. S.H. Chung, C.G. Choi, and S.H. Park Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice Archives of Pharmacal Research 24 2001 214 218 10.1007/BF02978260 PMID: 11440080 (Pubitemid 33703564)
5. M. Dong, X.Z. Feng, L.J. Wu, B.X. Wang, and T. Ikejima Two new steroidal saponins from the rhizomes of Dioscorea panthaica and their cytotoxic activity Planta Medica 67 2001 853 857 10.1055/s-2001-18856 PMID: 11745024 (Pubitemid 34015551)
6. M.J. Franz, J.P. Bantle, C.A. Beebe, J.D. Brunzell, J.L. Chiasson, and A. Garg Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications Diabetes Care 25 2002 148 198 10.2337/diacare.25.1.148 PMID: 12502619
7. T. Hall, Z.Z. Lu, P.N. Yat, J.F. Fitzloff, J.F. Arnason, and D.V.C. Awang Evaluation of consistency of standardized Asian ginseng products in the Ginseng Evaluation Program HerbalGram, vol. 52 2001 American Botanical Council 31 45
8. H. Hasegawa, S. Matsumiya, C. Murakami, T. Kurokawa, R. Kasai, and S. Ishibashi Interactions of ginseng extract, ginseng separated fractions, and some triterpenoid saponins with glucose transporters in sheep erythrocytes Planta Medica 60 1994 153 157 10.1055/s-2006-959440 PMID: 8202566 (Pubitemid 24120902)
9. J.T. Hwang, M.S. Lee, H.J. Kim, M.J. Sung, H.Y. Kim, M.S. Kim, and D.Y. Kwon Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways Phytotherapy Research 23 2009 262 266 PMID: 18844326
10. C. Joo, and J. Kim Study on the hypoglycemic action of ginseng saponin on streptozotocin induced diabetic rats (I) Korean Journal of Ginseng Science 16 1992 190 197
11. C. Joo, S. Yoon, H.S. Lee, Y. Kim, H. Lee, and J. Koo Study on the hypoglycemic action of ginseng saponin on streptozotocin induced diabetic rats (II) Korean Journal of Ginseng Science 16 1992 198 209
12. K.S. Kang, N. Yamabe, H.Y. Kim, J.H. Park, and T. Yokozawa Therapeutic potential of 20(S)-ginsenoside Rg(3) against streptozotocin-induced diabetic renal damage in rats European Journal of Pharmacology 591 2008 266 272 PMID: 18611400
13. D.S. Kim, S.R. Oh, I.S. Lee, Y. Jung, D.P. Jong, and I.K. Shin Anticomplementary activity of ginseng saponins and their degradation products Phytochemistry 47 1998 397 399 10.1016/S0031-9422(97)00580-3 PMID: 9433814 (Pubitemid 28045815)
14. M. Kim, B.Y. Ahn, J.S. Lee, S.S. Chung, S. Lim, S.G. Park, H.S. Jung, H.K. Lee, and K.S. Park The ginsenoside Rg3 has a stimulatory effect on insulin signaling in L6 myotubes Biochemical and Biophysical Research Communications 389 2009 70 73 PMID: 19699714
15. S.Y. Lee, Y.K. Kim, N.I. Park, C.S. Kim, C.Y. Lee, and S.U. Park Chemical constituents and biological activities of the berry of Panax ginseng Journal of Medicinal Plants Research 4 2010 349 353
16. L.A. Leiter, A. Ceriello, J.A. Davidson, M. Hanefeld, L. Monnier, and D.R. Owens Postprandial glucose regulation: new data and new implications Clinical Therapy 27 2005 S42 S56 10.1016/j.clinthera.2005.11.020 PMID: 16519037
17. K.W. Leung, and A.S. Wong Pharmacology of ginsenosides: a literature review Chinese Medicine 5 2010 1 7 PMID: 20537195
18. T.S.C. Li, G. Mazza, A.C. Cottrell, and L. Gao Ginsenosides in roots and leaves of American ginseng Journal of Agricultural Food Chemistry 44 1996 717 720 10.1021/jf950309f (Pubitemid 126468425)
19. R.K. Murray, D.K. Granner, P.A. Mayes, and V. Rodwell Harper's Illustrated Biochemistry 2003 L.M. Publications, McGraw-Hill Companies New York
20. P.T. Pearce, I. Zois, K.N. Wynne, and J.W. Funder Panax ginseng and Eleuthrococcus senticosus extracts - in vitro studies on binding to steroid receptors Endocrinology Japonica 29 1982 567 573 PMID: 6303763
21. C. Shao, and G. Xu Isolation and identification of ginsenosides in the flowers and flower buds of Jilin ginseng Chinese Pharmaceutical Bulletin 17 1982 500
22. J.L. Sievenpiper, J.T. Arnason, L.A. Leiter, and V. Vuksan Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia European Journal of Clinical Nutrition 57 2003 243 248 10.1038/sj.ejcn.1601550 PMID: 12571655 (Pubitemid 36240475)
23. J.L. Sievenpiper, J.T. Arnason, L.A. Leiter, and V. Vuksan Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosides Journal of the American College of Nutrition 23 2004 248 258 PMID: 15190050 (Pubitemid 38746114)
24. J.L. Sievenpiper, J.T. Arnason, E. Vidgen, L.A. Leiter, and V. Vuksan A systematic quantitative analysis of the literature of the high variability in ginseng (Panax spp.): should ginseng be trusted in diabetes? Diabetes Care 27 2004 839 840 PMID: 14988315 (Pubitemid 38280564)
25. J.L. Sievenpiper, M.K. Sung, M. Di Buono, K. Seung-Lee, K.Y. Nam, and J.T. Arnason Korean red ginseng rootlets decrease acute postprandial glycemia: results from sequential preparation- and dose-finding studies Journal of the American College of Nutrition 25 2006 100 107 PMID: 16582025 (Pubitemid 46939848)
26. S.G. Sparg, M.E. Light, and J. van Staden Biological activities and distribution of plant saponins Journal of Ethnopharmacology 94 2004 219 243 10.1016/j.jep.2004.05.016 PMID: 15325725 (Pubitemid 39119924)
27. J. Sun, S. Hu, and X. Songa Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice Vaccine 25 2007 1114 1120 10.1016/j.vaccine.2006.09.054 PMID: 17069940 (Pubitemid 44937445)
28. Y. Suzuki, and H. Hikino Mechanisms of hypoglycemic activity of panaxans A and B, glycans of Panax ginseng roots: effects on plasma-level, secretion, sensitivity and binding of insulin in mice Phytotherapy Research 3 1989 20 24 10.1002/ptr.2650030106 (Pubitemid 19099254)
29. N. Unwin, J. Shaw, P. Zimmet, and K.G.M.M. Alberti Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention Diabetic Medicine 19 2002 708 723 PMID: 12207806 (Pubitemid 35013848)
30. V. Vuksan, and J.L. Sievenpiper Herbal remedies in the management of diabetes: lessons learned from the study of ginseng Nutrition, Metabolism, and Cardiovascular Diseases 15 2005 149 160 10.1016/j.numecd.2005.05.001 PMID: 15955462 (Pubitemid 40934158)
31. V. Vuksan, J.L. Sievenpiper, V.Y. Koo, T. Francis, U. Beljan-Zdravkovic, Z. Xu, and E. Vidgen American ginseng (Panax quinquefolius L.) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus Archives of International Medicine 160 2000 1009 1013 10.1001/archinte.160.7.1009 PMID: 10761967 (Pubitemid 30191931)
32. V. Vuksan, J.L. Sievenpiper, Z. Xu, U. Beljan-Zdravkovic, A.L. Jenkins, and J.T. Arnason Ginseng and Diabetes: a new way to use an old medicine Canadian Journal of Diabetes Care 25 2000 111 1120
33. V. Vuksan, M.P. Stavro, J.L. Sievenpiper, U. Beljan-Zdravkovic, L.A. Leiter, and R.G. Josse Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes Diabetes Care 23 2000 1221 1226 10.2337/diacare.23.9.1221 PMID: 10977009
34. V. Vuksan, M.P. Stavro, J.L. Sievenpiper, V.Y. Koo, E. Wong, and U. Beljan-Zdravkovic American ginseng improves glycemia in individuals with normal glucose tolerance: effect of dose and time escalation Journal of the American College of Nutrition 19 2000 738 744 PMID: 11194526 (Pubitemid 32065739)
35. V. Vuksan, J.L. Sievenpiper, J. Wong, Z. Xu, U. Beljan-Zdravkovic, and J.T. Arnason American ginseng (Panax quinquefolius L.) attenuates postprandial glycemia in a time-dependent but not dose-dependent manner in healthy individuals American Journal of Clinical Nutrition 73 2001 753 758 PMID: 11273850 (Pubitemid 32241810)
36. V. Vuksan, M.K. Sung, J.L. Sievenpiper, P.M. Stavro, A.L. Jenkins, and M. Di Buono Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safety Nutrition, Metabolism, and Cardiovascular Diseases 18 2008 46 56 PMID: 16860976 (Pubitemid 350297892)
37. A.B. Wang, C.Z. Wang, J.A. Wu, J. Osinski, and C.S. Yuan Determination of major ginsenosides in Panax quinquefolius (American ginseng) using high-performance liquid chromatography Phytochemical Analysis 1 2005 272 277 10.1002/pca.838 PMID: 16042154 (Pubitemid 40975415)
38. T.M.S. Wolever, D.J.A. Jenkins, A.L. Jenkins, and R.G. Josse The glycemic index: methodology and clinical implications American Journal of Clinical Nutrition 54 1991 846 854 PMID: 1951155
39. T.M.S. Wolever, J.L. Chiasson, A. Csima, J.A. Hunt, C. Palmason, and S.A. Ross Variation of postprandial plasma glucose, platability, and symptoms associated with a standardized mixed test meal versus 75 g oral glucose Diabetes Care 21 1998 336 340 10.2337/diacare.21.3.336 PMID: 9540012 (Pubitemid 28101065)
40. J.T. Xie, S. McHendale, and C.S. Yuan Ginseng and diabetes The American Journal of Chinese Medicine 33 2005 397 404 PMID: 16047557
41. 1 from Panax notoginseng in rats Journal of Ethnopharmacology 84 2003 187 192 10.1016/S0378-8741(02)00317-3 (Pubitemid 36324258)
42. S. Yahara, K. Kaji, and O. Tanaka Further study on dammarane-type saponins of roots, leaves, flower-buds, and fruits of Panax-ginseng C.A. Meyer Chemical and Pharmaceutical Bulletin 27 1979 88 92 (Pubitemid 9114501)
43. T. Yokozawa, T. Kobayashi, H. Oura, and Y. Kawashima Studies on the mechanism of the hypoglycemic activity of ginsenoside-Rb2 in streptozotocin-diabetic rats Chemical and Pharmaceutical Bulletin (Tokyo) 33 1985 869 872 PMID: 4017130 (Pubitemid 15075725)
44. T. Yokozawa, T. Kobayashi, H. Oura, and Y. Kawashima Hyperlipemia- improving effects of ginsenoside-Rb2 in streptozotocin-diabetic rats Chemical and Pharmaceutical Bulletin (Tokyo) 33 1985 3893 3898 PMID: 4092288 (Pubitemid 16235644)