Kinetic characterization of 100 glycoside hydrolase mutants enables the discovery of structural features correlated with kinetic constants

PLoS ONE

Volumn 11, Issue 1, 2016, Pages

  Carlin, Dylan Alexander ^a   Caster, Ryan W ^a   Wang, Xiaokang ^c   Betzenderfer, Stephanie A ^a   Chen, Claire X ^a   Duong, Veasna M ^a   Ryklansky, Carolina V ^a   Alpekin, Alp ^a   Beaumont, Nathan ^a   Kapoor, Harshul ^a   Kim, Nicole ^a   Mohabbot, Hosna ^a   Pang, Boyu ^a   Teel, Rachel ^a   Whithaus, Lillian ^a   Tagkopoulos, Ilias ^a   Siegel, Justin B ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of California Davis   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME VARIANT; GLYCOSIDASE; MUTANT PROTEIN;

ALGORITHM; ARTICLE; CHEMICAL PARAMETERS; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME STRUCTURE; ENZYME SYNTHESIS; MACHINE LEARNING; MATHEMATICAL COMPUTING; MOLECULAR MODEL; PREDICTION; COMPUTER SIMULATION; GENETICS; HUMAN; KINETICS; METABOLISM; MUTATION; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

COMPUTER SIMULATION; GLYCOSIDE HYDROLASES; HUMANS; KINETICS; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84958231511     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0147596     Document Type: Article

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