Therapeutic targeting of tumor-derived r-spondin attenuates b-catenin signaling and tumorigenesis in multiple cancer types

Cancer Research

Volumn 76, Issue 3, 2016, Pages 713-723

  Chartier, Cecile ^a   Raval, Janak ^a   Axelrod, Fumiko ^b   Bond, Chris ^b   Cain, Jennifer ^c   Dee Hoskins, Cristina ^c   Ma, Shirley ^d   Fischer, Marcus M ^d   Shah, Jalpa ^a   Wei, Jie ^a   Ji, May ^a   Lam, Andrew ^a   Stroud, Michelle ^a   Yen, Wan Ching ^a   Yeung, Pete ^a   Cancilla, Belinda ^a   O'Young, Gilbert ^a   Wang, Min ^a   Kapoun, Ann M ^a   Lewicki, John ^a   Hoey, Timothy ^a   Gurney, Austin ^a   more..

^a OncoMed Pharmaceuticals   (United States)

^b Centre for Drug Research and Development   (Canada)

^c Pfizer Inc ^*  (United States)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; GEMCITABINE; GROWTH FACTOR; IRINOTECAN; PACLITAXEL; R SPONDIN; R SPONDIN 1; R SPONDIN 2; R SPONDIN 3; UNCLASSIFIED DRUG; WNT PROTEIN; CTNNB1 PROTEIN, HUMAN; MONOCLONAL ANTIBODY; THROMBOSPONDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CANCER STEM CELL; CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; LUNG CANCER; MOUSE; NONHUMAN; OVARY CANCER; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RSPO GENE; TUMOR VOLUME; TUMOR XENOGRAFT; WNT SIGNALING PATHWAY; ANIMAL; BIOSYNTHESIS; DRUG SCREENING; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; METABOLISM; MOLECULARLY TARGETED THERAPY; NEOPLASMS; NONOBESE DIABETIC MOUSE; PATHOLOGY; SCID MOUSE; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; ANTIBODIES, MONOCLONAL; BETA CATENIN; CARCINOGENESIS; CELL LINE, TUMOR; HEK293 CELLS; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; MOLECULAR TARGETED THERAPY; NEOPLASMS; SIGNAL TRANSDUCTION; THROMBOSPONDINS; WNT PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84958191619     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-0561     Document Type: Article

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