Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness

Oncogene

Volumn 34, Issue 36, 2015, Pages 4692-4701

  Gong, X ^a,b   Yi, J ^a,b   Carmon, K S ^a,b   Crumbley, C A ^a,b   Xiong, W ^a,b   Thomas, A ^a,b   Fan, X ^a,b   Guo, S ^b   An, Z ^a,b   Chang, J T ^a,b   Liu, Q J ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA CATENIN; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBRONECTIN; G PROTEIN COUPLED RECEPTOR; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; K RAS PROTEIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 4; MESSENGER RNA; NERVE CELL ADHESION MOLECULE; PROTEIN P53; RELATED SECRETED PROTEIN 3; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; KEAP1 PROTEIN, HUMAN; LGR4 PROTEIN, HUMAN; ONCOPROTEIN; RSPO3 PROTEIN, HUMAN; SIGNAL PEPTIDE; THROMBOSPONDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER SURVIVAL; CELL ADHESION; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; COHORT ANALYSIS; COLON CANCER; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION; GENE FUSION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LUNG ADENOCARCINOMA; LUNG CANCER CELL LINE; MOUSE; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION SITE; TUMOR GROWTH; UPREGULATION; WNT SIGNALING PATHWAY; ADENOCARCINOMA; ANIMAL; BIOSYNTHESIS; CANCER STAGING; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; PATHOLOGY; TUMOR CELL LINE;

ADENOCARCINOMA; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG NEOPLASMS; MICE; NEOPLASM STAGING; ONCOGENE PROTEINS, FUSION; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; THROMBOSPONDINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84940954890     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.417     Document Type: Article

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